To determine the sensitivity and specificity of measurements of the retinal ne rve fiber layer (RNFL) using the StratusOCT in glaucoma subjects with visual fie ld (VF) defects. Prospective cross-sectional study. One h...To determine the sensitivity and specificity of measurements of the retinal ne rve fiber layer (RNFL) using the StratusOCT in glaucoma subjects with visual fie ld (VF) defects. Prospective cross-sectional study. One hundred nine normal and 63 glaucoma subjects. Fast RNFL scans were performed in one eye of each patient using the StratusOCT. Sensitivity and specificity of different optical coherenc e tomography (OCT) criteria for identifying glaucoma subjects with glaucomatous VF defects. Areas under the receiver operating characteristic curves (AROCs) for various OCT parameters. Severity of VF defects in the glaucoma group was distri buted between mild (18 subjects), moderate (21 subjects), and severe (24 subject s). The average mean deviation of the glaucoma fields was-8.4 decibels (dB), wi th a standard deviation of 6.0 dB and a range from-0.14 to -28.0 dB. The sensi tivity and specificity using a criterion of average RNFL thickness abnormal at t he < 5%level were 84%and 98%, respectively. The sensitivity and specificity u sing a criterion of average RNFL thickness abnormal at the < 1%level were 68%a nd 100%. The sensitivity and specificity of using a criterion of ≥1 quadrants abnormal at the < 5%level were 89%and 95%. The sensitivity and specificity of using a criterion of ≥1 quadrants abnormal at the < 1%level were 83%and 100 %. The sensitivity and specificity of using a criterion of ≥1 clock hours abno rmal at the < 5%level were 89%and 92%. The sensitivity and specificity of usi ng a criterion of ≥1 quadrants abnormal at the < 1%level were 83%and 100%. T he AROC for mean RNFL thickness was 0.966. Other high AROC values included the s uperior quadrant (0.952), inferior quadrant (0.971), inferotemporal clock hour a t 7-o’clock (right eye) and 5-o’clock (left eye) (0.959), 6-o’clock hour ( 0.940), superotemporal clock hour at 11-o’clock (right eye) and 1-o’clock (l eft eye) (0.935), and 12-o’clock hour (0.924). The sensitivity and specificity of RNFL measurements using the new StratusOCT for glaucoma with manifest VF def ects are excellent. The best parameters seem to be ≥1 quadrants abnormal at the ≤5%level or ≥1 clock hours abnormal at the ≤5%level. Future studies are ne eded to determine the sensitivity and specificity of this new technology for gla ucoma without VF defects.展开更多
脑小血管病(small vessel disease,SVD)是一类以脑内小血管受损为主的临床影像综合征,可能会导致卒中、血管性认知障碍、神经心理疾病与其他功能障碍等。自2013年血管性神经病变的影像报告标准(standards for reporting vascular change...脑小血管病(small vessel disease,SVD)是一类以脑内小血管受损为主的临床影像综合征,可能会导致卒中、血管性认知障碍、神经心理疾病与其他功能障碍等。自2013年血管性神经病变的影像报告标准(standards for reporting vascular changes on neuroimaging,STRIVE)发布以来,SVD的神经影像学特征得到了初步的分类与标准化。然而,在临床实践与科学研究中,对SVD影像特征的认识和应用仍存在诸多不一致和不规范之处。随着对SVD病理生理机制的深入探索与影像技术的不断进步,新的SVD影像特征和定量标志物被相继发现,为SVD的诊断和评估提供了更为全面且精准的信息。在此基础上,STRIVE-2应运而生,以期能更全面地揭示SVD对脑功能与结构的影响。为了规范中国SVD的神经影像学评估和诊断,本共识将在STRIVE-2的基础上,结合中国具体国情,对SVD的神经影像学特征进行深入解读,旨在推动SVD影像学诊断术语的标准化,提高临床诊断的准确性,进一步促进相关领域的研究与进步。展开更多
目的探讨在急性阑尾炎患儿诊断中,超声征象的特点及诊断意义。方法以81例急性阑尾炎患儿为研究对象,将81例急性阑尾炎患儿依病理检测结果分为2组:进展性阑尾炎患儿34例(41.98%),单纯性阑尾炎患儿47例(58.02%)。通过超声检测的间接征象...目的探讨在急性阑尾炎患儿诊断中,超声征象的特点及诊断意义。方法以81例急性阑尾炎患儿为研究对象,将81例急性阑尾炎患儿依病理检测结果分为2组:进展性阑尾炎患儿34例(41.98%),单纯性阑尾炎患儿47例(58.02%)。通过超声检测的间接征象、直接征象,以及病理检查资料,并借助ROC曲线分析超声征象联合应用的曲线下面积(area under curve,AUC),进行综合分析,对患儿超声检查结果进行评分。结果进展组患儿超声检测的管壁连续性中断/层次清晰度不高、管腔积液、阑尾周围或腹腔积液、阑尾周围高回声、盲肠、回肠壁增厚检出率均高于单纯组(P<0.05);进展组超声间接征象、直接征象、联合征象评分均高于单纯组(P<0.05);ROC(receiver oprating characteristic)曲线下,联合征象诊断灵敏度、特异度、阳性预测值和阴性预测值分别为98.77%、97.53%、98.77%、96.30%均高于间接征象、直接征象,AUC为0.902高于间接征象、直接征象(P<0.05)。结论超声检测征象联合诊断,能够为急性阑尾炎患儿的早期诊断提供客观证据,且还可实现对疾病动态监测,从而有利于临床治疗方案的制定。展开更多
文摘To determine the sensitivity and specificity of measurements of the retinal ne rve fiber layer (RNFL) using the StratusOCT in glaucoma subjects with visual fie ld (VF) defects. Prospective cross-sectional study. One hundred nine normal and 63 glaucoma subjects. Fast RNFL scans were performed in one eye of each patient using the StratusOCT. Sensitivity and specificity of different optical coherenc e tomography (OCT) criteria for identifying glaucoma subjects with glaucomatous VF defects. Areas under the receiver operating characteristic curves (AROCs) for various OCT parameters. Severity of VF defects in the glaucoma group was distri buted between mild (18 subjects), moderate (21 subjects), and severe (24 subject s). The average mean deviation of the glaucoma fields was-8.4 decibels (dB), wi th a standard deviation of 6.0 dB and a range from-0.14 to -28.0 dB. The sensi tivity and specificity using a criterion of average RNFL thickness abnormal at t he < 5%level were 84%and 98%, respectively. The sensitivity and specificity u sing a criterion of average RNFL thickness abnormal at the < 1%level were 68%a nd 100%. The sensitivity and specificity of using a criterion of ≥1 quadrants abnormal at the < 5%level were 89%and 95%. The sensitivity and specificity of using a criterion of ≥1 quadrants abnormal at the < 1%level were 83%and 100 %. The sensitivity and specificity of using a criterion of ≥1 clock hours abno rmal at the < 5%level were 89%and 92%. The sensitivity and specificity of usi ng a criterion of ≥1 quadrants abnormal at the < 1%level were 83%and 100%. T he AROC for mean RNFL thickness was 0.966. Other high AROC values included the s uperior quadrant (0.952), inferior quadrant (0.971), inferotemporal clock hour a t 7-o’clock (right eye) and 5-o’clock (left eye) (0.959), 6-o’clock hour ( 0.940), superotemporal clock hour at 11-o’clock (right eye) and 1-o’clock (l eft eye) (0.935), and 12-o’clock hour (0.924). The sensitivity and specificity of RNFL measurements using the new StratusOCT for glaucoma with manifest VF def ects are excellent. The best parameters seem to be ≥1 quadrants abnormal at the ≤5%level or ≥1 clock hours abnormal at the ≤5%level. Future studies are ne eded to determine the sensitivity and specificity of this new technology for gla ucoma without VF defects.
文摘脑小血管病(small vessel disease,SVD)是一类以脑内小血管受损为主的临床影像综合征,可能会导致卒中、血管性认知障碍、神经心理疾病与其他功能障碍等。自2013年血管性神经病变的影像报告标准(standards for reporting vascular changes on neuroimaging,STRIVE)发布以来,SVD的神经影像学特征得到了初步的分类与标准化。然而,在临床实践与科学研究中,对SVD影像特征的认识和应用仍存在诸多不一致和不规范之处。随着对SVD病理生理机制的深入探索与影像技术的不断进步,新的SVD影像特征和定量标志物被相继发现,为SVD的诊断和评估提供了更为全面且精准的信息。在此基础上,STRIVE-2应运而生,以期能更全面地揭示SVD对脑功能与结构的影响。为了规范中国SVD的神经影像学评估和诊断,本共识将在STRIVE-2的基础上,结合中国具体国情,对SVD的神经影像学特征进行深入解读,旨在推动SVD影像学诊断术语的标准化,提高临床诊断的准确性,进一步促进相关领域的研究与进步。
文摘目的探讨在急性阑尾炎患儿诊断中,超声征象的特点及诊断意义。方法以81例急性阑尾炎患儿为研究对象,将81例急性阑尾炎患儿依病理检测结果分为2组:进展性阑尾炎患儿34例(41.98%),单纯性阑尾炎患儿47例(58.02%)。通过超声检测的间接征象、直接征象,以及病理检查资料,并借助ROC曲线分析超声征象联合应用的曲线下面积(area under curve,AUC),进行综合分析,对患儿超声检查结果进行评分。结果进展组患儿超声检测的管壁连续性中断/层次清晰度不高、管腔积液、阑尾周围或腹腔积液、阑尾周围高回声、盲肠、回肠壁增厚检出率均高于单纯组(P<0.05);进展组超声间接征象、直接征象、联合征象评分均高于单纯组(P<0.05);ROC(receiver oprating characteristic)曲线下,联合征象诊断灵敏度、特异度、阳性预测值和阴性预测值分别为98.77%、97.53%、98.77%、96.30%均高于间接征象、直接征象,AUC为0.902高于间接征象、直接征象(P<0.05)。结论超声检测征象联合诊断,能够为急性阑尾炎患儿的早期诊断提供客观证据,且还可实现对疾病动态监测,从而有利于临床治疗方案的制定。
