Objective:Based on the data mining method,explore the medication rules of Chinese patent medicines for the treatment of digestive system tumors.Method:Based on the"Chinese Traditional Medicine Prescription Databa...Objective:Based on the data mining method,explore the medication rules of Chinese patent medicines for the treatment of digestive system tumors.Method:Based on the"Chinese Traditional Medicine Prescription Database"in https://db.yaozh.com/,collect Chinese patent medicines for the treatment of digestive system tumors,establish an Excel table,and use the ancient and modern medical case cloud platform(V2.2.1)to perform frequency statistics,association rules,and drugs on the data Clustering and complex network analysis.Results:A total of 36 Chinese patent medicines for the treatment of digestive system tumors were screened.The medicinal properties were mainly warm and cold,the taste was bitter and sweet,and the meridians were mainly liver and spleen meridians.High frequency Chinese medicine include Astragalus,Scutellaria-barbata,Ginseng,Curcuma,Triangle,Atractylodes,Hedyotis diffusa,etc.Correlation analysis obtained 17 drug combinations,High-frequency drug pairs include Scutellaria-barbata-Astragalus,Ginseng-Astragalus,Curcuma-Astragalus,Scutellaria-barbata-Curcuma,etc.Cluster analysis found 3 types of drugs.The core drug network is composed of 27 drugs,and the core compatibility network consists of 3 groups of drugs.Conclusion:The Chinese patent compound medicine for the treatment of digestive system tumors has the characteristics of combining cold and warming,replenishing and reducing treatment,and treating the liver and spleen at the same time.The medicine is mainly used to replenish qi and invigorate the spleen,promote blood circulation and remove blood stasis,and clear away heat and detoxification.Replenish qi,nourish yin,invigorate blood,and detoxify are mainly compatible with each other,reflecting the pathogenesis characteristics of"deficiency,stasis,and toxin"in digestive system tumors.Data mining can provide references for the prescription and compatibility of Chinese patent medicines.展开更多
At present,the development of orthopedics,the conservative treatment of femoral head necrosis in the early and middle stages is still a difficult problem.With the progress of osteonecrosis,it may deteriorate into irre...At present,the development of orthopedics,the conservative treatment of femoral head necrosis in the early and middle stages is still a difficult problem.With the progress of osteonecrosis,it may deteriorate into irreversible bone destruction,affecting the hip joint and even causing severe disability of the hip.In traditional medicine,femoral head necrosis belongs to the category of"bone erosion"and"bone erosion".As a common disease in orthopedics,the treatment difficulty is relatively large.In the view of Chinese medicine,the pathogenesis of femoral head necrosis is kidney deficiency,stagnation and so on.Clinically,most doctors use the principle of promoting blood circulation,tonifying kidney and strengthening spleen.In the early and middle femoral head necrosis,traditional Chinese medicine treatment methods are more diverse and economical,and have always been valued by the modern medical community.This study reviews the latest research progress of traditional Chinese medicine in the treatment of early and mid-stage femoral head necrosis,in order to provide more basis for clinical medical research and related disease treatment.展开更多
Mercury（Hg）, mainly in cinnabar species, has been used in medicine for thousands of years in China, and worldwide concern has been raised on its toxicity. In this work, the amount of bioaccessible mercury in 16 Chin...Mercury（Hg）, mainly in cinnabar species, has been used in medicine for thousands of years in China, and worldwide concern has been raised on its toxicity. In this work, the amount of bioaccessible mercury in 16 Chinese patent medicines（CPMs） was measured by using an in vitro simulated digestion system, consisting of simulated gastric and intestinal fluid, to investigate the bioavailability of mercury in CPMs and evaluate its potential risk to human health. Total mercury and mercury in the gastrointestinal extracts were measured by inductively coupled plasma mass spectrometry（ICP-MS）. The levels of total Hg in 16 CPMs ranged from not detected to 11.89 mg/g, with a mean value of 1.13 mg/g, while the extractable Hg ranged from not detected to 4.37 μg/g, with a mean value of 0.42 μg/g.Mercury bioaccessibility varied significantly in the investigated CPMs, depending on the ingredient. Compared to the CPMs without cinnabar（2.5%–30.9%）, the percentage of mercury in the gastrointestinal supernatants for CPMs with cinnabar was quite a bit lower（0.037%）. By comparing with the Food and Agricultural Organization/World Health Organization Joint Expert Committee on Food Additives（FAO/WHO） safety guideline, the average daily intake dose（ADD） of Hg in the medicines was then calculated to access the risk of mercury to human health from taking CPMs.展开更多
目的 观察中医不同治法对大鼠骨质疏松症模型骨骼、骨骼肌中钙调神经磷酸酶(Calcineurin, CaN)、T细胞活化核因子(Nuclear Factor of the Activated T cell, NFAT)含量的影响,探讨中医药治疗骨质疏松症的分子机制。方法 将雌性SD大鼠随...目的 观察中医不同治法对大鼠骨质疏松症模型骨骼、骨骼肌中钙调神经磷酸酶(Calcineurin, CaN)、T细胞活化核因子(Nuclear Factor of the Activated T cell, NFAT)含量的影响,探讨中医药治疗骨质疏松症的分子机制。方法 将雌性SD大鼠随机分为正常组、模型对照组、补肾法组、健脾法组、活血法组。采用酶联免疫吸附(ELISA)法进行测定,比较不同组别CaN、NFAT的含量变化。结果 模型对照组与正常组比较,骨骼、骨骼肌的CaN含量有显著降低(P<0.01);补肾法组、健脾法组、活血法组与模型对照组比较,骨骼、骨骼肌的CaN的含量均明显升高(P<0.01),其中补肾法组升高程度比较明显,骨骼的CaN含量其次为活血法组,骨骼肌的CaN含量其次为健脾组。模型对照组与正常组比较,骨骼、骨骼肌的NFAT含量显著降低(P<0.01);补肾法组、健脾法组、活血法组与模型对照组比较,NFAT含量明显升高,其中补肾法组升高程度比较明显,其次为健脾法组。结论 (1)骨骼、骨骼肌中CaN、NFAT的含量变化可能与骨质疏松症的发生有一定的相关性。(2)补肾法和健脾法可明显改善骨质疏松症大鼠骨骼、骨骼肌中CaN、NFAT的含量,预防骨质疏松的发生发展。(3)中医不同治法能够有效改善骨质疏松,补肾法、健脾法是治疗骨质疏松的重要治法。展开更多
基金Beijing Municipal Administration of Traditional Chinese Medicine Project(No.2019-ZX-005)。
文摘Objective:Based on the data mining method,explore the medication rules of Chinese patent medicines for the treatment of digestive system tumors.Method:Based on the"Chinese Traditional Medicine Prescription Database"in https://db.yaozh.com/,collect Chinese patent medicines for the treatment of digestive system tumors,establish an Excel table,and use the ancient and modern medical case cloud platform(V2.2.1)to perform frequency statistics,association rules,and drugs on the data Clustering and complex network analysis.Results:A total of 36 Chinese patent medicines for the treatment of digestive system tumors were screened.The medicinal properties were mainly warm and cold,the taste was bitter and sweet,and the meridians were mainly liver and spleen meridians.High frequency Chinese medicine include Astragalus,Scutellaria-barbata,Ginseng,Curcuma,Triangle,Atractylodes,Hedyotis diffusa,etc.Correlation analysis obtained 17 drug combinations,High-frequency drug pairs include Scutellaria-barbata-Astragalus,Ginseng-Astragalus,Curcuma-Astragalus,Scutellaria-barbata-Curcuma,etc.Cluster analysis found 3 types of drugs.The core drug network is composed of 27 drugs,and the core compatibility network consists of 3 groups of drugs.Conclusion:The Chinese patent compound medicine for the treatment of digestive system tumors has the characteristics of combining cold and warming,replenishing and reducing treatment,and treating the liver and spleen at the same time.The medicine is mainly used to replenish qi and invigorate the spleen,promote blood circulation and remove blood stasis,and clear away heat and detoxification.Replenish qi,nourish yin,invigorate blood,and detoxify are mainly compatible with each other,reflecting the pathogenesis characteristics of"deficiency,stasis,and toxin"in digestive system tumors.Data mining can provide references for the prescription and compatibility of Chinese patent medicines.
基金Shenyang science and technology bureau science and technology talent application technology research project(No.18014405).
文摘At present,the development of orthopedics,the conservative treatment of femoral head necrosis in the early and middle stages is still a difficult problem.With the progress of osteonecrosis,it may deteriorate into irreversible bone destruction,affecting the hip joint and even causing severe disability of the hip.In traditional medicine,femoral head necrosis belongs to the category of"bone erosion"and"bone erosion".As a common disease in orthopedics,the treatment difficulty is relatively large.In the view of Chinese medicine,the pathogenesis of femoral head necrosis is kidney deficiency,stagnation and so on.Clinically,most doctors use the principle of promoting blood circulation,tonifying kidney and strengthening spleen.In the early and middle femoral head necrosis,traditional Chinese medicine treatment methods are more diverse and economical,and have always been valued by the modern medical community.This study reviews the latest research progress of traditional Chinese medicine in the treatment of early and mid-stage femoral head necrosis,in order to provide more basis for clinical medical research and related disease treatment.
基金supported by the National Basic Research Program (973) of China (No. 2013CB430004)the National Natural Science Foundation of China (Nos. 21120102040, 21075130)
文摘Mercury（Hg）, mainly in cinnabar species, has been used in medicine for thousands of years in China, and worldwide concern has been raised on its toxicity. In this work, the amount of bioaccessible mercury in 16 Chinese patent medicines（CPMs） was measured by using an in vitro simulated digestion system, consisting of simulated gastric and intestinal fluid, to investigate the bioavailability of mercury in CPMs and evaluate its potential risk to human health. Total mercury and mercury in the gastrointestinal extracts were measured by inductively coupled plasma mass spectrometry（ICP-MS）. The levels of total Hg in 16 CPMs ranged from not detected to 11.89 mg/g, with a mean value of 1.13 mg/g, while the extractable Hg ranged from not detected to 4.37 μg/g, with a mean value of 0.42 μg/g.Mercury bioaccessibility varied significantly in the investigated CPMs, depending on the ingredient. Compared to the CPMs without cinnabar（2.5%–30.9%）, the percentage of mercury in the gastrointestinal supernatants for CPMs with cinnabar was quite a bit lower（0.037%）. By comparing with the Food and Agricultural Organization/World Health Organization Joint Expert Committee on Food Additives（FAO/WHO） safety guideline, the average daily intake dose（ADD） of Hg in the medicines was then calculated to access the risk of mercury to human health from taking CPMs.
文摘目的 观察中医不同治法对大鼠骨质疏松症模型骨骼、骨骼肌中钙调神经磷酸酶(Calcineurin, CaN)、T细胞活化核因子(Nuclear Factor of the Activated T cell, NFAT)含量的影响,探讨中医药治疗骨质疏松症的分子机制。方法 将雌性SD大鼠随机分为正常组、模型对照组、补肾法组、健脾法组、活血法组。采用酶联免疫吸附(ELISA)法进行测定,比较不同组别CaN、NFAT的含量变化。结果 模型对照组与正常组比较,骨骼、骨骼肌的CaN含量有显著降低(P<0.01);补肾法组、健脾法组、活血法组与模型对照组比较,骨骼、骨骼肌的CaN的含量均明显升高(P<0.01),其中补肾法组升高程度比较明显,骨骼的CaN含量其次为活血法组,骨骼肌的CaN含量其次为健脾组。模型对照组与正常组比较,骨骼、骨骼肌的NFAT含量显著降低(P<0.01);补肾法组、健脾法组、活血法组与模型对照组比较,NFAT含量明显升高,其中补肾法组升高程度比较明显,其次为健脾法组。结论 (1)骨骼、骨骼肌中CaN、NFAT的含量变化可能与骨质疏松症的发生有一定的相关性。(2)补肾法和健脾法可明显改善骨质疏松症大鼠骨骼、骨骼肌中CaN、NFAT的含量,预防骨质疏松的发生发展。(3)中医不同治法能够有效改善骨质疏松,补肾法、健脾法是治疗骨质疏松的重要治法。
