A new degraded sesquiterpene was isolated from the marine actinomycete Streptomyces sp. 0616208. Its structure was elucidated as （1α; 4aα; 5α, 7β, 8aβ）-5, 8a-dimethyl-decahydrona- phthalene-1, 4a, 7-triol on th...A new degraded sesquiterpene was isolated from the marine actinomycete Streptomyces sp. 0616208. Its structure was elucidated as （1α; 4aα; 5α, 7β, 8aβ）-5, 8a-dimethyl-decahydrona- phthalene-1, 4a, 7-triol on the basis of spectroscopic data.展开更多
The synthesis of racemic cedannycin B, an antibiotic from Streptomyces sp. TP-A0456 was achieved firstly from γ- butyrolactone. The key step was a Barbier-type addition of 3-bromomethyl-5H-furan-2-one to formaldehyde...The synthesis of racemic cedannycin B, an antibiotic from Streptomyces sp. TP-A0456 was achieved firstly from γ- butyrolactone. The key step was a Barbier-type addition of 3-bromomethyl-5H-furan-2-one to formaldehyde mediated by zinc, which afforded the sole γ-addition product 4-hydroxymethyl-3-methylene-dihydrofuran-2-one. The final compound was confirmed by 1H NMR, 13C NMR and HRMS. 2009 Xiao Hua Xu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.展开更多
文摘A new degraded sesquiterpene was isolated from the marine actinomycete Streptomyces sp. 0616208. Its structure was elucidated as （1α; 4aα; 5α, 7β, 8aβ）-5, 8a-dimethyl-decahydrona- phthalene-1, 4a, 7-triol on the basis of spectroscopic data.
基金the National Science Foundation of China(Nos.20421202,20572055)for financial support
文摘The synthesis of racemic cedannycin B, an antibiotic from Streptomyces sp. TP-A0456 was achieved firstly from γ- butyrolactone. The key step was a Barbier-type addition of 3-bromomethyl-5H-furan-2-one to formaldehyde mediated by zinc, which afforded the sole γ-addition product 4-hydroxymethyl-3-methylene-dihydrofuran-2-one. The final compound was confirmed by 1H NMR, 13C NMR and HRMS. 2009 Xiao Hua Xu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
