Objective:To investigate the effect of parecoxib sodium preemptive analgesia on postoperative pain and stress response in patients with laparoscopic surgery.Methods:118 patients with asymptomatic gallbladder polyps wh...Objective:To investigate the effect of parecoxib sodium preemptive analgesia on postoperative pain and stress response in patients with laparoscopic surgery.Methods:118 patients with asymptomatic gallbladder polyps who underwent elective laparoscopic surgery in our hospital between January 2018 and January 2019 were divided into the control group(n=59)and the preemptive analgesia group(n=59)by random number table.Control group received routine total intravenous anesthesia,and preemptive analgesia group received intravenous injection of parecoxib sodium 0.7mg/kg during anesthesia induction.The differences in serum levels of pain mediators[prostaglandin E2(PGE2),substance P(SP)and neuropeptide Y(NPY)],inflammatory factors[interleukin-1β(IL-1β),interleukin-6(IL-6)and interleukin-12(IL-12)]as well as stress mediators[cortisol(Cor),norepinephrine(NE)and epinephrine(E)]at before surgery(T0),30min after extubation(T1),6h after surgery(T2)and 24h after surgery(T3)were compared between the two groups of patients.Results:At T0,there was no significant difference in VAS score as well as inflammatory factor or stress mediator levels between the two groups(P>0.05).At T1,T2 and T3,VAS scores of the preemptive analgesia group were lower than those of the control group;serum IL-1β,IL-6,IL-12 and TNF-αlevels were lower than those of the control group;serum Cor,NE and E levels were lower than those of the control group(P<0.05).Conclusion:Parecoxib sodium preemptive analgesia has a positive effect on reducing postoperative pain and systemic stress in patients with laparoscopic cholecystectomy.展开更多
Oxidative stress influences cell survival and homeostasis, but the mechanisms underlying the biological effects of oxidative stress remain to be elucidated. We have defined that the
Increasing evidence shows that pathological elevation of plasma fatty acids, especially long-chain saturated forms, which ordinarily occurs in obesity patients, increases the risk
基金2016 Key Technology Research Projects of Hebei Provincial Health and Planning Commission(No.182497-2)
文摘Objective:To investigate the effect of parecoxib sodium preemptive analgesia on postoperative pain and stress response in patients with laparoscopic surgery.Methods:118 patients with asymptomatic gallbladder polyps who underwent elective laparoscopic surgery in our hospital between January 2018 and January 2019 were divided into the control group(n=59)and the preemptive analgesia group(n=59)by random number table.Control group received routine total intravenous anesthesia,and preemptive analgesia group received intravenous injection of parecoxib sodium 0.7mg/kg during anesthesia induction.The differences in serum levels of pain mediators[prostaglandin E2(PGE2),substance P(SP)and neuropeptide Y(NPY)],inflammatory factors[interleukin-1β(IL-1β),interleukin-6(IL-6)and interleukin-12(IL-12)]as well as stress mediators[cortisol(Cor),norepinephrine(NE)and epinephrine(E)]at before surgery(T0),30min after extubation(T1),6h after surgery(T2)and 24h after surgery(T3)were compared between the two groups of patients.Results:At T0,there was no significant difference in VAS score as well as inflammatory factor or stress mediator levels between the two groups(P>0.05).At T1,T2 and T3,VAS scores of the preemptive analgesia group were lower than those of the control group;serum IL-1β,IL-6,IL-12 and TNF-αlevels were lower than those of the control group;serum Cor,NE and E levels were lower than those of the control group(P<0.05).Conclusion:Parecoxib sodium preemptive analgesia has a positive effect on reducing postoperative pain and systemic stress in patients with laparoscopic cholecystectomy.
文摘Oxidative stress influences cell survival and homeostasis, but the mechanisms underlying the biological effects of oxidative stress remain to be elucidated. We have defined that the
文摘Increasing evidence shows that pathological elevation of plasma fatty acids, especially long-chain saturated forms, which ordinarily occurs in obesity patients, increases the risk
