(E) -α- ( Methoxyimi no ) -2 - [ 1-(aryloxy) methyl ]-benzeneacetates, the analogues of Kresoxim-methyl, were ste- rcoselectively synthesized with the coupling reaction of 2-methylphenyldiazonium chloride and m...(E) -α- ( Methoxyimi no ) -2 - [ 1-(aryloxy) methyl ]-benzeneacetates, the analogues of Kresoxim-methyl, were ste- rcoselectively synthesized with the coupling reaction of 2-methylphenyldiazonium chloride and methyl 2-hydroxyiminoacetate in the presence of CuSO4/Na2SO3 as a key step, and it was first found that the coupling reaction could give the key intermediate material( E)- and(Z)-methyl 2-(hydroxyimino)-2-o-tolylacetate with a molar ratio of 14: 1. The (E)-configurations of all these compounds were assigned on the basis of their 2D-NOESY spectra of ^1H NMR. The preliminary bioassays indicate that most of the compounds show an activity against a wide variety of fungi.展开更多
文摘(E) -α- ( Methoxyimi no ) -2 - [ 1-(aryloxy) methyl ]-benzeneacetates, the analogues of Kresoxim-methyl, were ste- rcoselectively synthesized with the coupling reaction of 2-methylphenyldiazonium chloride and methyl 2-hydroxyiminoacetate in the presence of CuSO4/Na2SO3 as a key step, and it was first found that the coupling reaction could give the key intermediate material( E)- and(Z)-methyl 2-(hydroxyimino)-2-o-tolylacetate with a molar ratio of 14: 1. The (E)-configurations of all these compounds were assigned on the basis of their 2D-NOESY spectra of ^1H NMR. The preliminary bioassays indicate that most of the compounds show an activity against a wide variety of fungi.