目的分析急性前循环缺血性卒中行血管内治疗后的预后因素。方法本研究为前瞻性队列研究,选取2019年1月至2020年5月常德市第一人民医院前循环缺血性卒中行血管内治疗的患者90例,根据患者术后90 d改良的Rankin量表(mRS)评分分为功能改善组...目的分析急性前循环缺血性卒中行血管内治疗后的预后因素。方法本研究为前瞻性队列研究,选取2019年1月至2020年5月常德市第一人民医院前循环缺血性卒中行血管内治疗的患者90例,根据患者术后90 d改良的Rankin量表(mRS)评分分为功能改善组(mRS评分0~2分)和功能不良组(mRS评分3~6分),应用单因素分析及多因素分析获得患者预后的影响因素并剔除混杂因素,再行曲线拟合分析预后因素与术后90 d mRS评分的关系。结果共有77例患者完成随访,其中功能改善组29例(37.6%),功能不良组48例(62.3%),单因素分析显示,两组年龄、房颤病史、侧枝循环代偿等级、淋巴细胞计数、血红蛋白、低密度脂蛋白、收缩压、C反应蛋白、D-二聚体、NIHSS评分比较差异有统计学意义(P<0.05);多因素分析显示,两组C反应蛋白、侧枝循环代偿等级比较差异有统计学意义(P<0.05)。结论急性缺血性卒中行血管内治疗后患者的预后可能与C反应蛋白、侧枝循环代偿等级相关。展开更多
OBJECTIVE: To determine differences in cerebral activity evoked by acupuncture and conventional stroke treatment, and identify the treatment targets.METHODS: In total, 21 patients were randomly divided into two groups...OBJECTIVE: To determine differences in cerebral activity evoked by acupuncture and conventional stroke treatment, and identify the treatment targets.METHODS: In total, 21 patients were randomly divided into two groups. Group A(11 patients) received both acupuncture and conventional treatment, while group B(10 patients) received conventional treatment only. Resting-state functional magnetic resonance imaging(f MRI) was performed on each participant before and after treatment. Regional homogeneity analysis was performed to investigate the potential mechanism of acupuncture treatment by comparing differences in cerebral activity between treatments.RESULTS: Group A showed higher Re Ho in the frontal lobe(BA6, BA46), supra-marginal gyrus(BA40),middle temporal gyrus(BA21), cerebellum, and insula. Group B showed higher Re Ho in the frontal lobe(BA6) and parietal lobe(BA3, BA7).CONCLUSION: Acupuncture and conventional treatment triggered relatively different clinical efficacy and brain responses. Acupuncture treatment more significantly improved the symptoms of stroke patients. More marked changes in sensory,emotional, and motor areas(including the frontal lobe, middle temporal gyrus, cerebellum, and insula) might reflect the specific acupuncture mechanism.展开更多
文摘目的分析急性前循环缺血性卒中行血管内治疗后的预后因素。方法本研究为前瞻性队列研究,选取2019年1月至2020年5月常德市第一人民医院前循环缺血性卒中行血管内治疗的患者90例,根据患者术后90 d改良的Rankin量表(mRS)评分分为功能改善组(mRS评分0~2分)和功能不良组(mRS评分3~6分),应用单因素分析及多因素分析获得患者预后的影响因素并剔除混杂因素,再行曲线拟合分析预后因素与术后90 d mRS评分的关系。结果共有77例患者完成随访,其中功能改善组29例(37.6%),功能不良组48例(62.3%),单因素分析显示,两组年龄、房颤病史、侧枝循环代偿等级、淋巴细胞计数、血红蛋白、低密度脂蛋白、收缩压、C反应蛋白、D-二聚体、NIHSS评分比较差异有统计学意义(P<0.05);多因素分析显示,两组C反应蛋白、侧枝循环代偿等级比较差异有统计学意义(P<0.05)。结论急性缺血性卒中行血管内治疗后患者的预后可能与C反应蛋白、侧枝循环代偿等级相关。
基金Supported by the National Natural Science Foundation of China(NSFC):Acupoint Sensitization Research(No.81590950)the State Key Program for Basic Research of China:Clinical Evaluation of the Basic Rules of Acupoint Specification and Basic Biological Study on CNS Targeting Integration(No.2012CB518501)NSFC:Study on the CNS Integration Mechanism of Spine-dredging Technique in Treating Ischemia Stroke(No.81072864)
文摘OBJECTIVE: To determine differences in cerebral activity evoked by acupuncture and conventional stroke treatment, and identify the treatment targets.METHODS: In total, 21 patients were randomly divided into two groups. Group A(11 patients) received both acupuncture and conventional treatment, while group B(10 patients) received conventional treatment only. Resting-state functional magnetic resonance imaging(f MRI) was performed on each participant before and after treatment. Regional homogeneity analysis was performed to investigate the potential mechanism of acupuncture treatment by comparing differences in cerebral activity between treatments.RESULTS: Group A showed higher Re Ho in the frontal lobe(BA6, BA46), supra-marginal gyrus(BA40),middle temporal gyrus(BA21), cerebellum, and insula. Group B showed higher Re Ho in the frontal lobe(BA6) and parietal lobe(BA3, BA7).CONCLUSION: Acupuncture and conventional treatment triggered relatively different clinical efficacy and brain responses. Acupuncture treatment more significantly improved the symptoms of stroke patients. More marked changes in sensory,emotional, and motor areas(including the frontal lobe, middle temporal gyrus, cerebellum, and insula) might reflect the specific acupuncture mechanism.
