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Efficacy of Baishao Luoshi decoction(白芍络石方)on synaptic plasticity in rats with post stroke spasticity
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作者 XIE Le MAO Guo +9 位作者 XIE Yao CAO Sijia ZHOU Shen JIANG Junlin YAO Ting FAN Jianhu LIU Dong KANG Fuliang WU Dahua GE Jinwen 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2023年第2期295-302,共8页
OBJECTIVE:To evaluate the efficacy of Baishao Luoshi decoction(白芍络石方,BD)on synaptic plasticity in rats with post stroke spasticity(PSS),and to study the mechanism behind the action.METHODS:The PSS model of rat wa... OBJECTIVE:To evaluate the efficacy of Baishao Luoshi decoction(白芍络石方,BD)on synaptic plasticity in rats with post stroke spasticity(PSS),and to study the mechanism behind the action.METHODS:The PSS model of rat was established by middle cerebral artery occlusion(MCAO).The neurological deficit symptoms were evaluated by modified neurological deficit score(mN SS).Muscle tension were evaluated by Modified Ashworth score(MAS).Transmission electron microscopy(TEM)was used to observe the synaptic ultrastructure.The expression of synaptic plasticity-related protein brain derived neurotrophic factor(BDNF),growth associated protein-43(GAP43),synaptophysin(p38)and microtubule-associated protein 2(MAP2)in the brain tissue around the infarct were detected by Western blotting.RESULTS:We found that mNSS were significantly improved and limb spasticity was ameliorated treated by BD.The thickness of postsynaptic density and the synaptic curvature increased significantly.The expression of synaptic plasticity-related protein BDNF,GAP43,p38,MAP2 in the brain tissue around the infarct were raised remarkably after treated by BD.CONCLUSIONS:Alleviating PSS by BD may be related to rescuing the synaptic plasticity,which provides a probable new therapeutic method for PSS. 展开更多
关键词 INFARCTION middle cerebral artery neuroprotection post stroke spasticity synaptic plasticity Baishaoluoshi decoction
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Using nerve segment insert grafting to reconstruct neural pathways of brain-derived paralysis 被引量:2
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作者 Wenbin Ding Shaocheng Zhang +13 位作者 Zhuo Wang Lin Chen Chuansen Zhang Ping Huang Shunfa Liu Laiqing Sun Yuhai Ma Jun Yang Fei Huang Chengjing Xue Yanxue Zhong Lei Yin Yongtai Pan Dajiang Wu 《Translational Neuroscience and Clinics》 2017年第4期188-195,共8页
Since 1992,task groups have used free nerve auto grafts to bridge partially transected nerves from the dominant area of the normal cerebral cortex to nerves that innervate spastic muscles from a diseased cerebral cort... Since 1992,task groups have used free nerve auto grafts to bridge partially transected nerves from the dominant area of the normal cerebral cortex to nerves that innervate spastic muscles from a diseased cerebral cortex,using transplanting sutures to alleviate the muscle spasm of cerebral palsy caused by different diseases. This has facilitated rebuilding of some of its neurological function. In this study,80 such patients were followed up,including 20 patients with traumatic brain injury,32 patients with stroke,and 28 pediatric patients with cerebral palsy. After postoperative follow-up of 3 to 21 years,the efficacy rate of this operation was 100% and the excellent and good spasm relief rate was 82.5%. 展开更多
关键词 cerebral trauma child cerebral pals functional reconstruction graft surgery hemiplegic paralysis nerve segment transplantation spastic paralysis stroke
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