AIM： To investigate the protective effect of stronger neo-minophafen C （SNMC） on fulminant hepatic failure （FHF） and its underlying mechanism. METHODS： A mouse model of FHF was established by intraperitoneal inj...AIM： To investigate the protective effect of stronger neo-minophafen C （SNMC） on fulminant hepatic failure （FHF） and its underlying mechanism. METHODS： A mouse model of FHF was established by intraperitoneal injection of galactosamine （D-Gal N） and lipopolysaccharide （LPS）. The survival rate, liver function, inflammatory factor and liver pathological change were obtained with and without SNMC treatment. Hepatoo/te survival was estimated by observing the stained mitochondria structure with terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate fluorescence nick end labeling （TUNEL） method and antibodies against cytochrome C （Cyt-C） and caspase-3. RESULTS： The levels of plasma tumor necrosis factor alpha （TNF-α）, nitric oxide （NO）, ET-1, interleukin-6 （IL-6）, and the degree of hepatic tissue injury were decreased in the SNMC-treated groups compared with those in the model group （P 〈 0.01）. However, there were no differences after different dosages administered at different time points. There was a significant difference in survival rates between the SNMC-treated groups and the model group （P 〈 0.01）. The apoptosis index was 32.3% at 6 h after a low dose of SNMC, which was considerably decreased from 32.3% ± 4.7% vs 5% ± 2.83% （P 〈 0.05） to 5% on d 7. The expression of Cyt-C and caspase-3 decreased with the prolongation of therapeutic time. Typical hepatocyte apoptosis was obviously ameliorated under electron microscope with the prolongation of therapeutic time. CONCLUSION： SNMC can effectively protect liver against FHF induced by LPS/D-Gal N. SNMC can prevent hepatocyte apoptosis by inhibiting inflammatory reaction and stabilizing mitochondria membrane to suppress the release of Cyt-C and sequent activation of caspase-3.展开更多
This paper first introduced current situations of agricultural enterprises using B2C e-commerce to sell agricultural products.Then,using SWOT method,it analyzed strengths,weaknesses,opportunities,and threats of Wuding...This paper first introduced current situations of agricultural enterprises using B2C e-commerce to sell agricultural products.Then,using SWOT method,it analyzed strengths,weaknesses,opportunities,and threats of Wuding strong chicken farming enterprises implementing B2C e-commerce.Finally,it came up with recommendations for Wuding strong chicken farming enterprises implementing B2C e-commerce.展开更多
The infinite generator of α-times Integrated C semigroups and the properties of resolvent are given. At the same time, we discuss the relationship between the existence of strong solution of a class of nonhomogeneous...The infinite generator of α-times Integrated C semigroups and the properties of resolvent are given. At the same time, we discuss the relationship between the existence of strong solution of a class of nonhomogeneous abstract Cauchy problem and α-times integrated C semigroups, and a sufficient and necessary condition is obtained.展开更多
双碳政策推动下,乡村农业综合能源系统(integrated energy system,IES)的多能耦合关系更加复杂。为实现农业园区可靠运行,提出面向生态农业IES的多能互补与低碳运行优化调度策略。首先,基于农业园区的能量流动关系,建立沼气生产环节、...双碳政策推动下,乡村农业综合能源系统(integrated energy system,IES)的多能耦合关系更加复杂。为实现农业园区可靠运行,提出面向生态农业IES的多能互补与低碳运行优化调度策略。首先,基于农业园区的能量流动关系,建立沼气生产环节、多能耦合供应环节以及柔性负荷需求响应环节的数学模型。其次,考虑光伏、负荷和沼气的不确定性,建立生态农业IES两阶段鲁棒优化模型。模型引入碳排放成本和启停成本,可降低农业生产碳排放,防止机组频繁启停。然后,采用列与约束生成算法(column-and-constraint generation,C&CG),结合强对偶定理与线性化理论实现模型求解。最后,基于江西省某生态牧场IES进行算例仿真,验证所提策略的有效性。仿真结果表明,所提策略可实现生态农业IES的协调运行,提高系统经济性、低碳性和能效性。展开更多
基金Supported by the Key Program During the Tenth Five-Year Plan of HeilongJiang Province, No. 200101031-00
文摘AIM： To investigate the protective effect of stronger neo-minophafen C （SNMC） on fulminant hepatic failure （FHF） and its underlying mechanism. METHODS： A mouse model of FHF was established by intraperitoneal injection of galactosamine （D-Gal N） and lipopolysaccharide （LPS）. The survival rate, liver function, inflammatory factor and liver pathological change were obtained with and without SNMC treatment. Hepatoo/te survival was estimated by observing the stained mitochondria structure with terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate fluorescence nick end labeling （TUNEL） method and antibodies against cytochrome C （Cyt-C） and caspase-3. RESULTS： The levels of plasma tumor necrosis factor alpha （TNF-α）, nitric oxide （NO）, ET-1, interleukin-6 （IL-6）, and the degree of hepatic tissue injury were decreased in the SNMC-treated groups compared with those in the model group （P 〈 0.01）. However, there were no differences after different dosages administered at different time points. There was a significant difference in survival rates between the SNMC-treated groups and the model group （P 〈 0.01）. The apoptosis index was 32.3% at 6 h after a low dose of SNMC, which was considerably decreased from 32.3% ± 4.7% vs 5% ± 2.83% （P 〈 0.05） to 5% on d 7. The expression of Cyt-C and caspase-3 decreased with the prolongation of therapeutic time. Typical hepatocyte apoptosis was obviously ameliorated under electron microscope with the prolongation of therapeutic time. CONCLUSION： SNMC can effectively protect liver against FHF induced by LPS/D-Gal N. SNMC can prevent hepatocyte apoptosis by inhibiting inflammatory reaction and stabilizing mitochondria membrane to suppress the release of Cyt-C and sequent activation of caspase-3.
文摘This paper first introduced current situations of agricultural enterprises using B2C e-commerce to sell agricultural products.Then,using SWOT method,it analyzed strengths,weaknesses,opportunities,and threats of Wuding strong chicken farming enterprises implementing B2C e-commerce.Finally,it came up with recommendations for Wuding strong chicken farming enterprises implementing B2C e-commerce.
文摘The infinite generator of α-times Integrated C semigroups and the properties of resolvent are given. At the same time, we discuss the relationship between the existence of strong solution of a class of nonhomogeneous abstract Cauchy problem and α-times integrated C semigroups, and a sufficient and necessary condition is obtained.
文摘双碳政策推动下,乡村农业综合能源系统(integrated energy system,IES)的多能耦合关系更加复杂。为实现农业园区可靠运行,提出面向生态农业IES的多能互补与低碳运行优化调度策略。首先,基于农业园区的能量流动关系,建立沼气生产环节、多能耦合供应环节以及柔性负荷需求响应环节的数学模型。其次,考虑光伏、负荷和沼气的不确定性,建立生态农业IES两阶段鲁棒优化模型。模型引入碳排放成本和启停成本,可降低农业生产碳排放,防止机组频繁启停。然后,采用列与约束生成算法(column-and-constraint generation,C&CG),结合强对偶定理与线性化理论实现模型求解。最后,基于江西省某生态牧场IES进行算例仿真,验证所提策略的有效性。仿真结果表明,所提策略可实现生态农业IES的协调运行,提高系统经济性、低碳性和能效性。
