AIM： To investigate the protective effect of stronger neo-minophafen C （SNMC） on fulminant hepatic failure （FHF） and its underlying mechanism. METHODS： A mouse model of FHF was established by intraperitoneal inj...AIM： To investigate the protective effect of stronger neo-minophafen C （SNMC） on fulminant hepatic failure （FHF） and its underlying mechanism. METHODS： A mouse model of FHF was established by intraperitoneal injection of galactosamine （D-Gal N） and lipopolysaccharide （LPS）. The survival rate, liver function, inflammatory factor and liver pathological change were obtained with and without SNMC treatment. Hepatoo/te survival was estimated by observing the stained mitochondria structure with terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate fluorescence nick end labeling （TUNEL） method and antibodies against cytochrome C （Cyt-C） and caspase-3. RESULTS： The levels of plasma tumor necrosis factor alpha （TNF-α）, nitric oxide （NO）, ET-1, interleukin-6 （IL-6）, and the degree of hepatic tissue injury were decreased in the SNMC-treated groups compared with those in the model group （P 〈 0.01）. However, there were no differences after different dosages administered at different time points. There was a significant difference in survival rates between the SNMC-treated groups and the model group （P 〈 0.01）. The apoptosis index was 32.3% at 6 h after a low dose of SNMC, which was considerably decreased from 32.3% ± 4.7% vs 5% ± 2.83% （P 〈 0.05） to 5% on d 7. The expression of Cyt-C and caspase-3 decreased with the prolongation of therapeutic time. Typical hepatocyte apoptosis was obviously ameliorated under electron microscope with the prolongation of therapeutic time. CONCLUSION： SNMC can effectively protect liver against FHF induced by LPS/D-Gal N. SNMC can prevent hepatocyte apoptosis by inhibiting inflammatory reaction and stabilizing mitochondria membrane to suppress the release of Cyt-C and sequent activation of caspase-3.展开更多
In this paper, we take occurrence process of early strong aftershocks of a main after shock type′s earthquake sequence as a complex grey system, and introduce predicting method for its stronger aftershocks by grey p...In this paper, we take occurrence process of early strong aftershocks of a main after shock type′s earthquake sequence as a complex grey system, and introduce predicting method for its stronger aftershocks by grey predicting theory. Through inspection prediction for 1998 Zhangbei M S=6.2 earthquake sequence, it shows that the grey predicting method maybe has active significance for the investigation of quick response prediction problems of stronger aftershocks of an earthquake sequence.展开更多
The hardness and ideal strength of P-carbon, i.e., a new carbon phase for the cold-compressed carbon with an orthogonal structure recently proposed and named as P-carbon, are investigated by means of first-principles ...The hardness and ideal strength of P-carbon, i.e., a new carbon phase for the cold-compressed carbon with an orthogonal structure recently proposed and named as P-carbon, are investigated by means of first-principles calculations. The strength calculations reveal that the failure mode in P-carbon is dominated by the tensile type. The ideal tensile strength of P-carbon is calculated to be 76.T GPa in the [001] direction, which is higher than that of the previously known most stable Z-carbon, of 71.4 GPa. Meanwhile, the theoretical Vickers hardness of P-carbon is estimated as 89 GPa, which is comparable with that of diamond. Especially, two types of bonds in P-carbon with hardness values of 114 GPa and 105 GPa are significantly stronger than those of diamond. The results provide insight into exploration of the ultra-hard P-carbon for potentially technological applications.展开更多
CHINESE President Xi Jinping pointed out that both China and the bigger world are in the midst of profound and complex changes in the report delivered at the 19th National Congress of the Communist Party of China(CPC)...CHINESE President Xi Jinping pointed out that both China and the bigger world are in the midst of profound and complex changes in the report delivered at the 19th National Congress of the Communist Party of China(CPC)in October.As the Party’s general secretary,he presented a review of the work and historic change over the past five years,and reached the important conclusion that展开更多
If one day,mobile phones and cameras can be bendable and foldable,and they are not taken as something stiff in our pockets or carried as a burden on our shoulders anymore;If one day,new energy vehicles no longer need ...If one day,mobile phones and cameras can be bendable and foldable,and they are not taken as something stiff in our pockets or carried as a burden on our shoulders anymore;If one day,new energy vehicles no longer need to be recharged every night for the next day’s commute or for long-distance journeys,and we would never be embarrassed and troubled by lack of power;展开更多
The biggest challenge to his diplomatic career-that s how Ethiopian Ambassador to China Teshom e Toga Chanaka describes 2020.The unexpected novel coronavims pan demic resulted in 300 Ethiopian students stuck in Wuhan,...The biggest challenge to his diplomatic career-that s how Ethiopian Ambassador to China Teshom e Toga Chanaka describes 2020.The unexpected novel coronavims pan demic resulted in 300 Ethiopian students stuck in Wuhan,the capital city of central China's Hubei Province(where the country's first case was reported).展开更多
A new research study suggests that just thinking of exercising can have the same effects as actually hitting the gym, officials say. A recent study published in the Journal of Neurophysiology found that simply imagini...A new research study suggests that just thinking of exercising can have the same effects as actually hitting the gym, officials say. A recent study published in the Journal of Neurophysiology found that simply imagining exercise can tone muscle, delay atrophy, and even make your muscles stronger.展开更多
THE exports of Beijing Haifu Trading Co. Ltd. last year were 4 percent higher than those in 2012. but the company didn＇t make much money, accord- ing to Li Haifu. owner of the company. Sitting in the Dahongmen area....THE exports of Beijing Haifu Trading Co. Ltd. last year were 4 percent higher than those in 2012. but the company didn＇t make much money, accord- ing to Li Haifu. owner of the company. Sitting in the Dahongmen area. Haifu is mainly engaged in the production of curtains and beddings. with most of its products being exported. According to Li. for exported products, the U.S. dollar is used at all stages from ordering to settling, and it takes four months for the company to collect the payment for goods. Owing to fierce competition in the textile market, the prices charged cannot be too high.展开更多
基金Supported by the Key Program During the Tenth Five-Year Plan of HeilongJiang Province, No. 200101031-00
文摘AIM： To investigate the protective effect of stronger neo-minophafen C （SNMC） on fulminant hepatic failure （FHF） and its underlying mechanism. METHODS： A mouse model of FHF was established by intraperitoneal injection of galactosamine （D-Gal N） and lipopolysaccharide （LPS）. The survival rate, liver function, inflammatory factor and liver pathological change were obtained with and without SNMC treatment. Hepatoo/te survival was estimated by observing the stained mitochondria structure with terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate fluorescence nick end labeling （TUNEL） method and antibodies against cytochrome C （Cyt-C） and caspase-3. RESULTS： The levels of plasma tumor necrosis factor alpha （TNF-α）, nitric oxide （NO）, ET-1, interleukin-6 （IL-6）, and the degree of hepatic tissue injury were decreased in the SNMC-treated groups compared with those in the model group （P 〈 0.01）. However, there were no differences after different dosages administered at different time points. There was a significant difference in survival rates between the SNMC-treated groups and the model group （P 〈 0.01）. The apoptosis index was 32.3% at 6 h after a low dose of SNMC, which was considerably decreased from 32.3% ± 4.7% vs 5% ± 2.83% （P 〈 0.05） to 5% on d 7. The expression of Cyt-C and caspase-3 decreased with the prolongation of therapeutic time. Typical hepatocyte apoptosis was obviously ameliorated under electron microscope with the prolongation of therapeutic time. CONCLUSION： SNMC can effectively protect liver against FHF induced by LPS/D-Gal N. SNMC can prevent hepatocyte apoptosis by inhibiting inflammatory reaction and stabilizing mitochondria membrane to suppress the release of Cyt-C and sequent activation of caspase-3.
文摘In this paper, we take occurrence process of early strong aftershocks of a main after shock type′s earthquake sequence as a complex grey system, and introduce predicting method for its stronger aftershocks by grey predicting theory. Through inspection prediction for 1998 Zhangbei M S=6.2 earthquake sequence, it shows that the grey predicting method maybe has active significance for the investigation of quick response prediction problems of stronger aftershocks of an earthquake sequence.
基金Support by the National Natural Science Foundation of China under Grant No 21403188the Natural Science Foundation of Hebei Province under Grant No B20150396+1 种基金the Autonomic Research Project of Yanshan University under Grant No 14LGA017the Key Technology Research and Development Program of Qinhuangdao under Grant No 201401A025
文摘The hardness and ideal strength of P-carbon, i.e., a new carbon phase for the cold-compressed carbon with an orthogonal structure recently proposed and named as P-carbon, are investigated by means of first-principles calculations. The strength calculations reveal that the failure mode in P-carbon is dominated by the tensile type. The ideal tensile strength of P-carbon is calculated to be 76.T GPa in the [001] direction, which is higher than that of the previously known most stable Z-carbon, of 71.4 GPa. Meanwhile, the theoretical Vickers hardness of P-carbon is estimated as 89 GPa, which is comparable with that of diamond. Especially, two types of bonds in P-carbon with hardness values of 114 GPa and 105 GPa are significantly stronger than those of diamond. The results provide insight into exploration of the ultra-hard P-carbon for potentially technological applications.
文摘CHINESE President Xi Jinping pointed out that both China and the bigger world are in the midst of profound and complex changes in the report delivered at the 19th National Congress of the Communist Party of China(CPC)in October.As the Party’s general secretary,he presented a review of the work and historic change over the past five years,and reached the important conclusion that
文摘If one day,mobile phones and cameras can be bendable and foldable,and they are not taken as something stiff in our pockets or carried as a burden on our shoulders anymore;If one day,new energy vehicles no longer need to be recharged every night for the next day’s commute or for long-distance journeys,and we would never be embarrassed and troubled by lack of power;
文摘The biggest challenge to his diplomatic career-that s how Ethiopian Ambassador to China Teshom e Toga Chanaka describes 2020.The unexpected novel coronavims pan demic resulted in 300 Ethiopian students stuck in Wuhan,the capital city of central China's Hubei Province(where the country's first case was reported).
文摘A new research study suggests that just thinking of exercising can have the same effects as actually hitting the gym, officials say. A recent study published in the Journal of Neurophysiology found that simply imagining exercise can tone muscle, delay atrophy, and even make your muscles stronger.
文摘THE exports of Beijing Haifu Trading Co. Ltd. last year were 4 percent higher than those in 2012. but the company didn＇t make much money, accord- ing to Li Haifu. owner of the company. Sitting in the Dahongmen area. Haifu is mainly engaged in the production of curtains and beddings. with most of its products being exported. According to Li. for exported products, the U.S. dollar is used at all stages from ordering to settling, and it takes four months for the company to collect the payment for goods. Owing to fierce competition in the textile market, the prices charged cannot be too high.
