The hollow strontium carbonate pompons was synthesized for the first time by a controlled reaction precipitation method with sodium dodecyl benzene sulfonate(SDBS)and polyvinyl pyrrolidone(PVP)work together as templat...The hollow strontium carbonate pompons was synthesized for the first time by a controlled reaction precipitation method with sodium dodecyl benzene sulfonate(SDBS)and polyvinyl pyrrolidone(PVP)work together as template.The sampled particles were characterized by scanning electron microscopy(SEM),transmission electron microscopy(TEM),nitrogen adsorption-desorption measurement,X-ray diffraction(XRD),Energy dispersive X-Ray spectroscopy(EDX),Fourier transform infrared spectroscopy(FTIR),Thermogravimetric analysis and differential scanning calorimetry(TGA-DSC),etc.It is shown that the assynthesized hollow strontium carbonate pompons with the size of about 2μm consist of flake-like particles under the optimal reaction conditions.The formation mechanism of hollow strontium carbonate pompons was preliminarily explored.展开更多
Spherical strontium carbonate was synthesized by the induction of microbial bacillus pasteurii at ambient temperature with strontium chloride and urea as the raw materials. The phase composition, particle size and mor...Spherical strontium carbonate was synthesized by the induction of microbial bacillus pasteurii at ambient temperature with strontium chloride and urea as the raw materials. The phase composition, particle size and morphology of the product were studied by XRD and SEM. The results indicated that the strontium carbonate synthesized by the induction of microbial bacillus pasteurii was of good dispersion and uniform particle size. The spherical strontium carbonate particles obtained by adding different control agents were constructed by numerous flakes or olive-shaped nano-particles. The products were orthorhombic according to their XRD patterns.展开更多
238 marine carbonate samples were collected from seven sedimentary sections ofthe entire late Palaeozoic (Permian, Carboniferous and Devonian) in the Upper Yangtze Plat-form, southwest China. Based on the absence of c...238 marine carbonate samples were collected from seven sedimentary sections ofthe entire late Palaeozoic (Permian, Carboniferous and Devonian) in the Upper Yangtze Plat-form, southwest China. Based on the absence of cathodoluminescence and very low Mn (gener-ally<50 ppm) contents of the samples, it is thought that they contain information on the orig-inal sea water geochemistry. The results of isotopic analyses of these samples are presented interms of δ^(13)C and ^(87)Sr/^(86)Sr ratios versus geological time. The strontium data, consistent withother similar data based on samples from North America, Europe, Africa and other areas inAsia, support the notion of a global consistency in strontium isotope composition of marinecarbonates. The strontium data exhibit three intervals of relatively low ^(87)Sr/^(86)Sr ratios in thelate Middle Devonian to early Late Devonian, Early Carboniferous and Early Permian, corre-sponding to global eustatic high sea level stands. The lowest ^(87)Sr/^(86)Sr ratio recorded in theLate Permian was probably caused by substantial basalt eruptions in the Upper Yangtze Plat-form at the time. Three corresponding periods of relatively high δ^(13)C values at roughly the samethe intervals were caused by a relatively high rate of accumulation of organic carbon duringsea level rises at these times. The deposition of coal was probably responsible for the increaseof sea water δ^(13)C at other times. The δ^(13)C values drop dramatically near theDevonian/Carboniferous, Carboniferous/Permian and Permian/Triassic boundaries, con-sistent with other similar data, which further support the notion that geological time boundariesare associated with mass extinction and subsequent rejuvenation.展开更多
The global Hangenberg Crisis or Hangenberg Extinction is a mass extinction near the Devonian-Carboniferous boundary.Comprehensive research of petrology and geochemistry on the Devonian-Carboniferous boundary,as expose...The global Hangenberg Crisis or Hangenberg Extinction is a mass extinction near the Devonian-Carboniferous boundary.Comprehensive research of petrology and geochemistry on the Devonian-Carboniferous boundary,as exposed in the Nanbiancun auxiliary stratotype section,South China,elucidates paleoenvironmental changes and controls on marine strontium(^(87)Sr/^(86)Sr)and carbonate carbon(δ^(13)C_(carb))isotopes during the Hangenberg Crisis.The new^(87)Sr/^(86)Sr data reveal a regression in the Middle Siphonodella praesulcata Zone,while the Hangenberg Extinction was occurring in South China.Moreover,theδ^(13)C_(carb)data records a negative excursion near the base of the Middle Siphonodella praesulcata Zone that may have been connected with the Hangenberg Extinction.A positiveδ^(13)C_(carb)excursion,corresponding with the Upper Siphonodella praesulcata Zone,may reflect the effects of a vigorous biological pump.The magnitude of the Hangenberg Carbon Isotopic Excursion in peakδ^(13)carb values andδ^(13)C_(carb)gradient in carbonate Devonian-Carboniferous boundary sections of the South China Craton during the Hangenberg Crisis,are a function of depositional water depth and distance from the shore.The carbon cycling during the Hangenberg Carbon Isotopic Excursion had a much stronger impact on oceanic surface waters than on the deep ocean and theδ^(13)C_(carb)gradient of local seawater was likely caused by enhanced marine productivity,associated with biological recovery in platform sediments during the Hangenberg Crisis.展开更多
The research on the trace elements of Ordovician carbonates plays an important part in the whole work on reservoir in Tazhong (塔中 ) area. This paper systematically studies the characteristics and sedimentary setti...The research on the trace elements of Ordovician carbonates plays an important part in the whole work on reservoir in Tazhong (塔中 ) area. This paper systematically studies the characteristics and sedimentary settings of Ordovician dolomites in Tazhong area, Tarim basin, and debates their enrichment of mechanisms and different element existing patterns. The study makes use of ICP-MS analysis technology to test the strontium and manganese content of 109 samples from four wells in the Tazhong area, Tarim basin and strontium isotope composition tests have also been done on 25 samples from wells Zhong-1 and Zhong-4 on VG354 solid isotope mass spectrograph. By means of analyzing contents of strontium and manganese elements, doing research on the strontium isotope composition characteristics from wells Zhong-1 and Zhong-4 and comparing the results of strontium analysis to the global Ordovician marine carbonate and its evolution trend, in the combination of sedimentary facies characteristics of isolated wells in this area, we can come to the following cognitions: (1) The marine carbonate strontium isotope curve in the Tazhong area of Tarim basin is consistent to the global evolution trend which is overall descending with time, the direct reason of which is the evolution of paleogeographic environment. The Ordovician paleogeographic environment goes through restricted platform to open platform and then shallow marine shelf in Tazhong area, Tarim basin. Dolomitization is another subordinate reason and the inversion of fluid with high manganese can lead to heavy strontium; (2) The fact that the 87 Sr/86 Sr ratios of the Upper Ordovician in Tazhong area have an apparent mono-decline trend with the time going by, which is similar to the global strontium isotope ratio, is suggesting that the variation of the Upper Ordo- vician sea level is starting, the overall trend of which is the rising of the sea level; (3) Compared to the global seawater strontium ratios, the ^87Sr/^86 Sr ratio of the Lower Ordovician is much high, and ^87Sr/^86Sr ratio of the Lower Ordovician is overall increasing with its maximum value reaching 0. 709 727, the reasons of which are dolomitization, evaporation of the supratidal and the reflux of high manganese haline, those reasons can lead to the increasing amount of the strontium and the rising of the ^87 Sr/^86 Sr ratio; (4) The manganese element content changes little. Dolomitization has little impact on it; (5) Big variation occurs in the strontium values of Ordovician carbonate in the region of Tazhong. Apart from paleogeographic environment and petrography, the factors which can affect the values of strontium are the content of the terrestrial clastics and the diagenesis modification which may result in the further changing of the strontium values.展开更多
Ceramic parts usually experience dynamic load in armor applications. Therefore, studying the dynamic behaviors of ceramics is important. Limited data are available on the dynamic behaviors of ceramics; thus, it is hel...Ceramic parts usually experience dynamic load in armor applications. Therefore, studying the dynamic behaviors of ceramics is important. Limited data are available on the dynamic behaviors of ceramics; thus, it is helpful to predict the dynamic strength of ceramics on the basis of their mechanical properties. In this paper, the addition of SrCO3 into zirconia-toughened alumina(ZTA) was demonstrated to improve the fracture toughness of ZTA due to the formation of the SrAl12O19(SA6) phase. The porosity of ZTA was found to be increased by the addition of SrCO3. These newly formed pores served as the nucleation sites of cracks under dynamic load; these cracks eventually coalesced to form damaged zones in the samples. Although the KIC values of the samples were improved, the dynamic strength was not enhanced because of the increase in porosity; in fact, the dynamic strength of ZTA ceramics decreased with the addition of SrCO3.展开更多
The effects of SrCO3 on the microstructure of AZ91 magnesium alloy were investigated by OM, SEM, EDS, XRD and DTA analyses. The results show that AZ91 magnesium alloy with 1.0% SrCO3 addition has the best refining eff...The effects of SrCO3 on the microstructure of AZ91 magnesium alloy were investigated by OM, SEM, EDS, XRD and DTA analyses. The results show that AZ91 magnesium alloy with 1.0% SrCO3 addition has the best refining effect at 730 ℃ for 20 min, the average size of the α-Mg grain in AZ91 matrix alloy is reduced from about 91 μm to 58 μm, with reduction of about 36%. Based on the analysis results of EDS, binding energy, and Gibbs free energy, it is evident that the grain is refined because of the generation of Al4C3 particles which can be used as the crystal nucleus of the magnesium alloy when SrCO3 is added. Owing to the generation of Al4C3 in AZ91 magnesium alloy, the grain boundary is pined and the grain growth is inhibited. In the accession to the Al4C3, small subcooling temperature difference leads to the formation of fine grain microstructure in alloy melt. Fine grain microstructure in AZ91 alloy melt with the addition of SrCO3 can be obtained on the condition of lower undercooling temperature according to the DTA analysis results.展开更多
In the Ordovician, a carbonate platform system grading from the platformal interior eastwards to basin was developed in the Tazhong area of the Tarim Basin, and the study column is located in the place where the paleo...In the Ordovician, a carbonate platform system grading from the platformal interior eastwards to basin was developed in the Tazhong area of the Tarim Basin, and the study column is located in the place where the paleoslope occurred. The isotope compositions of the carbonates there are thus considered as having reflected those of simultaneous sea waters in view of its good connection with the open seas. The carbon and strontium isotope compositions of the Ordovician carbonates in the Tazhong area are analyzed, and their relationships to the sea-level fluctuations are discussed as well. Studies have revealed that the carbon isotope composition is related positively with the sea-level fluctuations, whereas an opposing situation occurs to the strontium isotope variation. Similar responses of carbon and strontium isotope compositions to the sea-level fluctuations are reported elsewhere in the world, suggesting that the Ordovician sea-level fluctuations of the Tarim Basin were of eustatic implication.展开更多
Muscle necrosis and angiogenesis are two major challenges in the treatment of lower-limb ischemic diseases.In this study,a triple-functional Sr/Si-containing bioceramic/alginate composite hydrogel with simultaneous bi...Muscle necrosis and angiogenesis are two major challenges in the treatment of lower-limb ischemic diseases.In this study,a triple-functional Sr/Si-containing bioceramic/alginate composite hydrogel with simultaneous bioactivity in enhancing angiogenesis,regulating inflammation,and inhibiting muscle necrosis was designed to treat lower-limb ischemic diseases.In particular,sodium alginate,calcium silicate and strontium carbonate were used to prepare injectable hydrogels,which was gelled within 10 min.More importantly,this composite hydrogel sustainedly releases bioactive Sr^(2+)and SiO_(3)^(2-) ions within 28 days.The biological activity of the bioactive ions released from the hydrogels was verified on HUVECs,SMCs,C2C12 and Raw 264.7 cells in vitro,and the therapeutic effect of the hydrogel was confirmed using C57BL/6 mouse model of femoral artery ligation in vivo.The results showed that the composite hydrogel stimulated angiogenesis,developed new collateral capillaries,and re-established the blood supply.In addition,the bioactive hydrogel directly promoted the expression of muscle-regulating factors(MyoG and MyoD)to protect skeletal muscle from necrosis,inhibited M1 polarization,and promoted M2 polarization of macrophages to reduce inflammation,thereby protecting skeletal muscle cells and indirectly promoting vascularization.Our results indicate that these bioceramic/alginate composite bioactive hydrogels are effective biomaterials for treating hindlimb ischemia and suggest that biomaterial-based approaches may have remarkable potential in treating ischemic diseases.展开更多
The collection of different cations in the A and B sites of ABO3 was explored for the regularity of perovskites phase formability.Here,Sr2?,La3?,and Ce4?are selected as the cations of site A.The site B is considere...The collection of different cations in the A and B sites of ABO3 was explored for the regularity of perovskites phase formability.Here,Sr2?,La3?,and Ce4?are selected as the cations of site A.The site B is considered to be Mn or Co cations.XRD analysis and Fourier transform infrared spectroscopy results confirm the formation of perovskite structure for catalysts in which La3?and Sr2?are considered as the cations of site A.Ceria is detected as the main crystalline phase when Ce4?is selected to be cation of site A.It is found that the octahedral factor(rB/rO) takes the same important role as the tolerance factor to form cubic perovskite.Average crystallite size of the products was calculated by data of the XRD and measured by the TEM analysis.Results of the XRD and TEM studies were supported by the study of the particles size distribution,which was carried out in a particle size analyzer.The perovskite samples were also used for stoichiometric oxidation of carbon monoxide with air.展开更多
基金Funded by the National Natural Science Foundation of China(No.22002143)the Natural Science Foundation of Shanxi Province of China(No.201901D211223)the Postgraduate Students Scientific Research Project of North University of China(No.20201766)。
文摘The hollow strontium carbonate pompons was synthesized for the first time by a controlled reaction precipitation method with sodium dodecyl benzene sulfonate(SDBS)and polyvinyl pyrrolidone(PVP)work together as template.The sampled particles were characterized by scanning electron microscopy(SEM),transmission electron microscopy(TEM),nitrogen adsorption-desorption measurement,X-ray diffraction(XRD),Energy dispersive X-Ray spectroscopy(EDX),Fourier transform infrared spectroscopy(FTIR),Thermogravimetric analysis and differential scanning calorimetry(TGA-DSC),etc.It is shown that the assynthesized hollow strontium carbonate pompons with the size of about 2μm consist of flake-like particles under the optimal reaction conditions.The formation mechanism of hollow strontium carbonate pompons was preliminarily explored.
文摘Spherical strontium carbonate was synthesized by the induction of microbial bacillus pasteurii at ambient temperature with strontium chloride and urea as the raw materials. The phase composition, particle size and morphology of the product were studied by XRD and SEM. The results indicated that the strontium carbonate synthesized by the induction of microbial bacillus pasteurii was of good dispersion and uniform particle size. The spherical strontium carbonate particles obtained by adding different control agents were constructed by numerous flakes or olive-shaped nano-particles. The products were orthorhombic according to their XRD patterns.
基金This study was supported by the National Natural Science Foundation of China Grant No.48970116
文摘238 marine carbonate samples were collected from seven sedimentary sections ofthe entire late Palaeozoic (Permian, Carboniferous and Devonian) in the Upper Yangtze Plat-form, southwest China. Based on the absence of cathodoluminescence and very low Mn (gener-ally<50 ppm) contents of the samples, it is thought that they contain information on the orig-inal sea water geochemistry. The results of isotopic analyses of these samples are presented interms of δ^(13)C and ^(87)Sr/^(86)Sr ratios versus geological time. The strontium data, consistent withother similar data based on samples from North America, Europe, Africa and other areas inAsia, support the notion of a global consistency in strontium isotope composition of marinecarbonates. The strontium data exhibit three intervals of relatively low ^(87)Sr/^(86)Sr ratios in thelate Middle Devonian to early Late Devonian, Early Carboniferous and Early Permian, corre-sponding to global eustatic high sea level stands. The lowest ^(87)Sr/^(86)Sr ratio recorded in theLate Permian was probably caused by substantial basalt eruptions in the Upper Yangtze Plat-form at the time. Three corresponding periods of relatively high δ^(13)C values at roughly the samethe intervals were caused by a relatively high rate of accumulation of organic carbon duringsea level rises at these times. The deposition of coal was probably responsible for the increaseof sea water δ^(13)C at other times. The δ^(13)C values drop dramatically near theDevonian/Carboniferous, Carboniferous/Permian and Permian/Triassic boundaries, con-sistent with other similar data, which further support the notion that geological time boundariesare associated with mass extinction and subsequent rejuvenation.
基金financially supported by the National Natural Science Foundation of China(92055208)Guangxi Natural Science Foundation for Distinguished Young Scholars(2018GXNSFFA281009)+3 种基金the CAS‘Light of West China’Program(2018-XBYJRC-003)the Guangxi Science Innovation Base Construction Foundation(Guike ZY21195031)the Fifth Bagui Scholar Innovation Project of the Guangxi Province(to Xu Jifeng)the grant of the Laboratory for Marine Geology,Qingdao National Laboratory for Marine Science and Technology(MGQNLM201901)。
文摘The global Hangenberg Crisis or Hangenberg Extinction is a mass extinction near the Devonian-Carboniferous boundary.Comprehensive research of petrology and geochemistry on the Devonian-Carboniferous boundary,as exposed in the Nanbiancun auxiliary stratotype section,South China,elucidates paleoenvironmental changes and controls on marine strontium(^(87)Sr/^(86)Sr)and carbonate carbon(δ^(13)C_(carb))isotopes during the Hangenberg Crisis.The new^(87)Sr/^(86)Sr data reveal a regression in the Middle Siphonodella praesulcata Zone,while the Hangenberg Extinction was occurring in South China.Moreover,theδ^(13)C_(carb)data records a negative excursion near the base of the Middle Siphonodella praesulcata Zone that may have been connected with the Hangenberg Extinction.A positiveδ^(13)C_(carb)excursion,corresponding with the Upper Siphonodella praesulcata Zone,may reflect the effects of a vigorous biological pump.The magnitude of the Hangenberg Carbon Isotopic Excursion in peakδ^(13)carb values andδ^(13)C_(carb)gradient in carbonate Devonian-Carboniferous boundary sections of the South China Craton during the Hangenberg Crisis,are a function of depositional water depth and distance from the shore.The carbon cycling during the Hangenberg Carbon Isotopic Excursion had a much stronger impact on oceanic surface waters than on the deep ocean and theδ^(13)C_(carb)gradient of local seawater was likely caused by enhanced marine productivity,associated with biological recovery in platform sediments during the Hangenberg Crisis.
基金This paper is supported by the 973 Project of China ( No .2005CB422103) and by the China Petrochemical Corporation ( SI N-OPEC) .
文摘The research on the trace elements of Ordovician carbonates plays an important part in the whole work on reservoir in Tazhong (塔中 ) area. This paper systematically studies the characteristics and sedimentary settings of Ordovician dolomites in Tazhong area, Tarim basin, and debates their enrichment of mechanisms and different element existing patterns. The study makes use of ICP-MS analysis technology to test the strontium and manganese content of 109 samples from four wells in the Tazhong area, Tarim basin and strontium isotope composition tests have also been done on 25 samples from wells Zhong-1 and Zhong-4 on VG354 solid isotope mass spectrograph. By means of analyzing contents of strontium and manganese elements, doing research on the strontium isotope composition characteristics from wells Zhong-1 and Zhong-4 and comparing the results of strontium analysis to the global Ordovician marine carbonate and its evolution trend, in the combination of sedimentary facies characteristics of isolated wells in this area, we can come to the following cognitions: (1) The marine carbonate strontium isotope curve in the Tazhong area of Tarim basin is consistent to the global evolution trend which is overall descending with time, the direct reason of which is the evolution of paleogeographic environment. The Ordovician paleogeographic environment goes through restricted platform to open platform and then shallow marine shelf in Tazhong area, Tarim basin. Dolomitization is another subordinate reason and the inversion of fluid with high manganese can lead to heavy strontium; (2) The fact that the 87 Sr/86 Sr ratios of the Upper Ordovician in Tazhong area have an apparent mono-decline trend with the time going by, which is similar to the global strontium isotope ratio, is suggesting that the variation of the Upper Ordo- vician sea level is starting, the overall trend of which is the rising of the sea level; (3) Compared to the global seawater strontium ratios, the ^87Sr/^86 Sr ratio of the Lower Ordovician is much high, and ^87Sr/^86Sr ratio of the Lower Ordovician is overall increasing with its maximum value reaching 0. 709 727, the reasons of which are dolomitization, evaporation of the supratidal and the reflux of high manganese haline, those reasons can lead to the increasing amount of the strontium and the rising of the ^87 Sr/^86 Sr ratio; (4) The manganese element content changes little. Dolomitization has little impact on it; (5) Big variation occurs in the strontium values of Ordovician carbonate in the region of Tazhong. Apart from paleogeographic environment and petrography, the factors which can affect the values of strontium are the content of the terrestrial clastics and the diagenesis modification which may result in the further changing of the strontium values.
基金supported by research university grant (RU) of 1001/PBAHAN/811212 from Universiti Sains Malaysia
文摘Ceramic parts usually experience dynamic load in armor applications. Therefore, studying the dynamic behaviors of ceramics is important. Limited data are available on the dynamic behaviors of ceramics; thus, it is helpful to predict the dynamic strength of ceramics on the basis of their mechanical properties. In this paper, the addition of SrCO3 into zirconia-toughened alumina(ZTA) was demonstrated to improve the fracture toughness of ZTA due to the formation of the SrAl12O19(SA6) phase. The porosity of ZTA was found to be increased by the addition of SrCO3. These newly formed pores served as the nucleation sites of cracks under dynamic load; these cracks eventually coalesced to form damaged zones in the samples. Although the KIC values of the samples were improved, the dynamic strength was not enhanced because of the increase in porosity; in fact, the dynamic strength of ZTA ceramics decreased with the addition of SrCO3.
基金Funded by Shanxi Province Science and Technology Development Project(No.20090321085)
文摘The effects of SrCO3 on the microstructure of AZ91 magnesium alloy were investigated by OM, SEM, EDS, XRD and DTA analyses. The results show that AZ91 magnesium alloy with 1.0% SrCO3 addition has the best refining effect at 730 ℃ for 20 min, the average size of the α-Mg grain in AZ91 matrix alloy is reduced from about 91 μm to 58 μm, with reduction of about 36%. Based on the analysis results of EDS, binding energy, and Gibbs free energy, it is evident that the grain is refined because of the generation of Al4C3 particles which can be used as the crystal nucleus of the magnesium alloy when SrCO3 is added. Owing to the generation of Al4C3 in AZ91 magnesium alloy, the grain boundary is pined and the grain growth is inhibited. In the accession to the Al4C3, small subcooling temperature difference leads to the formation of fine grain microstructure in alloy melt. Fine grain microstructure in AZ91 alloy melt with the addition of SrCO3 can be obtained on the condition of lower undercooling temperature according to the DTA analysis results.
基金the National Natural Science Foundation of China (Grant No. 49872042).
文摘In the Ordovician, a carbonate platform system grading from the platformal interior eastwards to basin was developed in the Tazhong area of the Tarim Basin, and the study column is located in the place where the paleoslope occurred. The isotope compositions of the carbonates there are thus considered as having reflected those of simultaneous sea waters in view of its good connection with the open seas. The carbon and strontium isotope compositions of the Ordovician carbonates in the Tazhong area are analyzed, and their relationships to the sea-level fluctuations are discussed as well. Studies have revealed that the carbon isotope composition is related positively with the sea-level fluctuations, whereas an opposing situation occurs to the strontium isotope variation. Similar responses of carbon and strontium isotope compositions to the sea-level fluctuations are reported elsewhere in the world, suggesting that the Ordovician sea-level fluctuations of the Tarim Basin were of eustatic implication.
基金supported by the National Natural Science Foundation of China(grant number:82270415)Key Project Fund of Natural Science Foundation of Fujian Science and Technology Department(grant number:2021GGB030)+8 种基金Shanghai Municipal Science and Technology Commission Innovation Fund(grant number:22S31904800)Fudan Zhangjiang Clinical Medicine Innovation Fund(grant number:KP7202115)Fujian Province Health Science and Technology Fund(grant number:2021GGB030)the National Natural Science Foundation of China(grant number:81970412)Medical-Industrial Cooperation Project of Zhongshan Hospital Affiliated to Fudan University(grant number:MP2021Q2C018)National Clinical Research Center for Interventional Medicine Fund(grant number:2021-004)Xiamen Municipal Health Science And Technology Program Fund(grant number:3502Z20194034)Zhongshan hospital’s Talents Supporting Plan(grant number:2019ZSGG11)Shanghai Municipal Science and Technology Commission Innovation Fund(grant number:18441902400).
文摘Muscle necrosis and angiogenesis are two major challenges in the treatment of lower-limb ischemic diseases.In this study,a triple-functional Sr/Si-containing bioceramic/alginate composite hydrogel with simultaneous bioactivity in enhancing angiogenesis,regulating inflammation,and inhibiting muscle necrosis was designed to treat lower-limb ischemic diseases.In particular,sodium alginate,calcium silicate and strontium carbonate were used to prepare injectable hydrogels,which was gelled within 10 min.More importantly,this composite hydrogel sustainedly releases bioactive Sr^(2+)and SiO_(3)^(2-) ions within 28 days.The biological activity of the bioactive ions released from the hydrogels was verified on HUVECs,SMCs,C2C12 and Raw 264.7 cells in vitro,and the therapeutic effect of the hydrogel was confirmed using C57BL/6 mouse model of femoral artery ligation in vivo.The results showed that the composite hydrogel stimulated angiogenesis,developed new collateral capillaries,and re-established the blood supply.In addition,the bioactive hydrogel directly promoted the expression of muscle-regulating factors(MyoG and MyoD)to protect skeletal muscle from necrosis,inhibited M1 polarization,and promoted M2 polarization of macrophages to reduce inflammation,thereby protecting skeletal muscle cells and indirectly promoting vascularization.Our results indicate that these bioceramic/alginate composite bioactive hydrogels are effective biomaterials for treating hindlimb ischemia and suggest that biomaterial-based approaches may have remarkable potential in treating ischemic diseases.
文摘The collection of different cations in the A and B sites of ABO3 was explored for the regularity of perovskites phase formability.Here,Sr2?,La3?,and Ce4?are selected as the cations of site A.The site B is considered to be Mn or Co cations.XRD analysis and Fourier transform infrared spectroscopy results confirm the formation of perovskite structure for catalysts in which La3?and Sr2?are considered as the cations of site A.Ceria is detected as the main crystalline phase when Ce4?is selected to be cation of site A.It is found that the octahedral factor(rB/rO) takes the same important role as the tolerance factor to form cubic perovskite.Average crystallite size of the products was calculated by data of the XRD and measured by the TEM analysis.Results of the XRD and TEM studies were supported by the study of the particles size distribution,which was carried out in a particle size analyzer.The perovskite samples were also used for stoichiometric oxidation of carbon monoxide with air.