Neural stem cells,which are capable of multi-potential differentiation and self-renewal,have recently been shown to have clinical potential for repairing central nervous system tissue damage.However,the theme trends a...Neural stem cells,which are capable of multi-potential differentiation and self-renewal,have recently been shown to have clinical potential for repairing central nervous system tissue damage.However,the theme trends and knowledge structures for human neural stem cells have not yet been studied bibliometrically.In this study,we retrieved 2742 articles from the PubMed database from 2013 to 2018 using "Neural Stem Cells" as the retrieval word.Co-word analysis was conducted to statistically quantify the characteristics and popular themes of human neural stem cell-related studies.Bibliographic data matrices were generated with the Bibliographic Item Co-Occurrence Matrix Builder.We identified 78 high-frequency Medical Subject Heading(MeSH)terms.A visual matrix was built with the repeated bisection method in gCLUTO software.A social network analysis network was generated with Ucinet 6.0 software and GraphPad Prism 5 software.The analyses demonstrated that in the 6-year period,hot topics were clustered into five categories.As suggested by the constructed strategic diagram,studies related to cytology and physiology were well-developed,whereas those related to neural stem cell applications,tissue engineering,metabolism and cell signaling,and neural stem cell pathology and virology remained immature.Neural stem cell therapy for stroke and Parkinson’s disease,the genetics of microRNAs and brain neoplasms,as well as neuroprotective agents,Zika virus,Notch receptor,neural crest and embryonic stem cells were identified as emerging hot spots.These undeveloped themes and popular topics are potential points of focus for new studies on human neural stem cells.展开更多
The focus of this paper is on determination of the geometry and stratigraphic contact pattern of the Rustenburg Layered Suite (RLS) in the Northern Bushveld Complex area using available borehole data and trend surface...The focus of this paper is on determination of the geometry and stratigraphic contact pattern of the Rustenburg Layered Suite (RLS) in the Northern Bushveld Complex area using available borehole data and trend surface analysis technique. This technique was used to analyse over one hundred borehole log data in the Northern Bushveld Complex in order to describe the geometric pattern and trends of the RLS rocks. The results demonstrate the usefulness of this technique in identifying structural features. Regional trends of each of the stratigraphic units reveal the presence of regional structures that were not obvious at the surface. This first part of the paper focused on the Northern Bushveld Complex, while the second and the third part focused on the eastern and western Bushveld limbs respectively.展开更多
基金supported by the National Natural Science Foundation of China,No.81471308(to JL)the Stem Cell Clinical Research Project in China,No.CMR-20161129-1003(to JL)the Innovation Technology Funding of Dalian in China,No.2018J11CY025(to JL)
文摘Neural stem cells,which are capable of multi-potential differentiation and self-renewal,have recently been shown to have clinical potential for repairing central nervous system tissue damage.However,the theme trends and knowledge structures for human neural stem cells have not yet been studied bibliometrically.In this study,we retrieved 2742 articles from the PubMed database from 2013 to 2018 using "Neural Stem Cells" as the retrieval word.Co-word analysis was conducted to statistically quantify the characteristics and popular themes of human neural stem cell-related studies.Bibliographic data matrices were generated with the Bibliographic Item Co-Occurrence Matrix Builder.We identified 78 high-frequency Medical Subject Heading(MeSH)terms.A visual matrix was built with the repeated bisection method in gCLUTO software.A social network analysis network was generated with Ucinet 6.0 software and GraphPad Prism 5 software.The analyses demonstrated that in the 6-year period,hot topics were clustered into five categories.As suggested by the constructed strategic diagram,studies related to cytology and physiology were well-developed,whereas those related to neural stem cell applications,tissue engineering,metabolism and cell signaling,and neural stem cell pathology and virology remained immature.Neural stem cell therapy for stroke and Parkinson’s disease,the genetics of microRNAs and brain neoplasms,as well as neuroprotective agents,Zika virus,Notch receptor,neural crest and embryonic stem cells were identified as emerging hot spots.These undeveloped themes and popular topics are potential points of focus for new studies on human neural stem cells.
文摘The focus of this paper is on determination of the geometry and stratigraphic contact pattern of the Rustenburg Layered Suite (RLS) in the Northern Bushveld Complex area using available borehole data and trend surface analysis technique. This technique was used to analyse over one hundred borehole log data in the Northern Bushveld Complex in order to describe the geometric pattern and trends of the RLS rocks. The results demonstrate the usefulness of this technique in identifying structural features. Regional trends of each of the stratigraphic units reveal the presence of regional structures that were not obvious at the surface. This first part of the paper focused on the Northern Bushveld Complex, while the second and the third part focused on the eastern and western Bushveld limbs respectively.
