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An Analysis of A Farewell to Arms in Terms of Structuralism 被引量:1
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作者 刘冬梅 《海外英语》 2013年第14期204-205,228,共3页
A Farewell to Arms is a classical work in the history of American literature. The author, Hemingway, creates a kind of character in his works successfully, that is, the Hemingway Hero. Due to its excellency, this nove... A Farewell to Arms is a classical work in the history of American literature. The author, Hemingway, creates a kind of character in his works successfully, that is, the Hemingway Hero. Due to its excellency, this novel is appreciated and criticized by many people. The paper aims to analyze this story in terms of structuralism. Structuralism is the belief that things cannot be understood in isolation-they have to be seen in the context of the larger structures they are part of. Parallel and contrast are two main branches in structuralism. And this novel will be analyzed in three aspects, parallel and contras in imagery, parallel and contras in characters, and parallel and contras in structure. 展开更多
关键词 structuralism parallel and CONTRAST IMAGERY
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Structuralism and Postmodem Discourse
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作者 Thomas Hauer 《Journal of Philosophy Study》 2017年第4期191-196,共6页
The dominant features of the post-war intellectual scene in France were existentialism, phenomenology, and Marxism, as well as efforts to synthesize them. In the 1960s, these theoretical currents had to cope with new ... The dominant features of the post-war intellectual scene in France were existentialism, phenomenology, and Marxism, as well as efforts to synthesize them. In the 1960s, these theoretical currents had to cope with new perspectives and ideas brought to the world of theory by the linguistically-oriented discourse of Saussure's structuralism and Lacanian psychoanalysis. Structuralists tried to apply structurally-linguistic model to the humanities and designed the new concept of the language, subjectivity, and society. Levi-Strauss applied the structural-linguistic analysis to the study of myths and family relationships; Lacan developed psychoanalysis based on structuralism; Althusser comes with a structuralist interpretation of Marx. Structuralists attempted to analyse the unconscious codes, rules, and binary oppositions that create the meaning, thus organizing social systems, such as sexual behaviour, fashion, culinary arts, myths, etc. Structures are unconscious, because their product and effects always overlap them. Structuralism therefore does not study individual isolated phenomena, but it moves from the analysis of phenomena that are consciously understood or known to participants in the particular discourse to their "unconscious infrastructures." Structuralists always emphasized rigorously scientific status of their theories; at the same time, applying structurally-linguistic concepts on humanities was supposed to help to make them scientific again. 展开更多
关键词 linguistic structuralism PAROLE POST-structuralism postmodem philosophical theory
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Structuralism and Its Two Contributors
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作者 李宗宏 《河西学院学报》 1998年第1期26-31,35,共7页
1. A General View To Structuralism What does structuralism mean? In its broadest sense structuralism is a 20th century movement in the humanities and social sciences that attach relatively little importance to ca-sual... 1. A General View To Structuralism What does structuralism mean? In its broadest sense structuralism is a 20th century movement in the humanities and social sciences that attach relatively little importance to ca-sual explanation and maintains that to understand a phenomenon one must describe both its internal structure——the relations among its parts——and its relations with other phenome- 展开更多
关键词 structuralism and Its Two Contributors
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The Driving Force and Direction of China’’s Industrial Transformation:A Perspective Based on New Structuralism 被引量:1
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作者 巴曙松 郑军 《China Economist》 2013年第4期14-26,共13页
According to New Structural Economics, the ultimate direction of industrial transformation is determined by factor endowment structure and the relative price system of factors. In today's China, the predominant facto... According to New Structural Economics, the ultimate direction of industrial transformation is determined by factor endowment structure and the relative price system of factors. In today's China, the predominant factor in its labor endowment is shifting from population size to the regional movement of population and population quality, and its land endowment is changing from cheap, massive supply to expensive, limited supply, and the economy has potential of technological catch-up. Because of these three fundamental realities and the special situation that China is vast in territory and has a continuous industrial spectrum, its industrial transformation will be featured with "three unique regions within one country" and that the eastern region enters a new stage which focuses on the development of services, the six central provinces and the western triangle zone take over industries transferred from the east and the resource-rich western region becomes the "home front" as a major supplier of resources. However, this "three region differentiation" will not be automatically developed. Only in a competitive factor market, a flexible financial market and an elastic labor market can the persistent changes in endowment structure drive China's industrial structure towards its optimal form. To achieve this, we need to launch a series of necessary structural reforms. 展开更多
关键词 labor endowment endowment structure technological catch-up industrialtransformation
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THE COMPARATIVE STUDY OF STRUCTURALISM & DECONSTRUCTION 被引量:1
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作者 李薇 丁燕 《Chinese Journal of Applied Linguistics》 2007年第2期111-114,124,共5页
Deconstruction and Structuralism are two of the twentieth century western criticism schools, and their relationship still is an issue that needs to be systematically clarified. The paper presents a review study on the... Deconstruction and Structuralism are two of the twentieth century western criticism schools, and their relationship still is an issue that needs to be systematically clarified. The paper presents a review study on the particular relationship of Deconstruction and Structuralism by comparing these two criticism schools from the respects of their origins, features, and limitations in the chronological view. It tends to prove that Deconstruction stems from the Structuralism, however Deconstruction differs itself from Structuralism in certain key features and bases itself upon a certain characteristic critique of Structuralism. 展开更多
关键词 structuralism DECONSTRUCTION RELATIONSHIP
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Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts
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作者 Yong Hou Shuo Zhang +3 位作者 Jie Dang Jia Guo Hanghang Zhou Xuewei Lü 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS 2025年第1期70-79,共10页
Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this limitation.Unlike most studies that concentrated on... Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this limitation.Unlike most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina ores.The results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO concentration.Fourier transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO substitution.Deconvolution of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents increased.Structural analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO substitution.However,bond strength is another important factor affecting the slag viscosity.The occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO. 展开更多
关键词 ALUMINOSILICATE VISCOSITY STRUCTURE spectroscopy
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Regeneration mechanisms and therapeutic strategies for neuromuscular junctions in aging and diseases
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作者 Masashi Fujitani Abu Md Mamun Tarif Yoshinori Otani 《Neural Regeneration Research》 SCIE CAS 2025年第1期193-194,共2页
The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ ... The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout adulthood.Degenerated NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022). 展开更多
关键词 AGING STRUCTURE FIGURE
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Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms
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作者 Rita O.Teodoro Mafalda Ribeiro Ramos Lara Carvalho 《Neural Regeneration Research》 SCIE CAS 2025年第7期1995-1996,共2页
Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no exception.Cell-intrinsic properties such as membrane lipid compositi... Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no exception.Cell-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these forces.Intrinsic and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse formation.In the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called plasticity.Synaptic plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024). 展开更多
关键词 PLASTICITY STRUCTURAL MECHANISMS
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Nanograting‑Based Dynamic Structural Colors Using Heterogeneous Materials
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作者 Jingang Wang Haibo Yu +6 位作者 Jianchen Zheng Yuzhao Zhang Hongji Guo Ye Qiu Xiaoduo Wang Yongliang Yang Lianqing Liu 《Nano-Micro Letters》 SCIE EI CAS 2025年第3期138-151,共14页
Dynamic structuralcolors can change in response todifferent environmental stimuli.This ability remains effectiveeven when the size of the speciesresponsible for the structural coloris reduced to a few micrometers,prov... Dynamic structuralcolors can change in response todifferent environmental stimuli.This ability remains effectiveeven when the size of the speciesresponsible for the structural coloris reduced to a few micrometers,providing a promising sensingmechanism for solving microenvironmentalsensing problems inmicro-robotics and microfluidics.However, the lack of dynamicstructural colors that can encoderapidly, easily integrate, and accuratelyreflect changes in physical quantities hinders their use in microscale sensing applications. Herein, we present a 2.5-dimensionaldynamic structural color based on nanogratings of heterogeneous materials, which were obtained by interweaving a pH-responsive hydrogelwith an IP-L photoresist. Transverse gratings printed with pH-responsive hydrogels elongated the period of longitudinal grating in the swollenstate, resulting in pH-tuned structural colors at a 45° incidence. Moreover, the patterned encoding and array printing of dynamic structuralcolors were achieved using grayscale stripe images to accurately encode the periods and heights of the nanogrid structures. Overall, dynamicstructural color networks exhibit promising potential for applications in information encryption and in situ sensing for microfluidic chips. 展开更多
关键词 Dynamic structural colors Four-dimensional printing PH-RESPONSIVE Nanogrid Heterogeneous materials
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Role of iron ore in enhancing gasification of iron coke:Structural evolution,influence mechanism and kinetic analysis
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作者 Jie Wang Wei Wang +4 位作者 Xuheng Chen Junfang Bao Qiuyue Hao Heng Zheng Runsheng Xu 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS 2025年第1期58-69,共12页
The utilization of iron coke provides a green pathway for low-carbon ironmaking.To uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the micro... The utilization of iron coke provides a green pathway for low-carbon ironmaking.To uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was investigated.Furthermore,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric method.The findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and interconnect.This provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron coke.Accelerating the heating rate in non-isothermal gasification can enhance the reactivity of iron coke.The metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon atoms.The kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore structure.Moreover,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%. 展开更多
关键词 low-carbon ironmaking iron coke GASIFICATION structural evolution kinetic model
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Optimizing electronic structure through point defect engineering for enhanced electrocatalytic energy conversion
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作者 Wei Ma Jiahao Yao +6 位作者 Fang Xie Xinqi Wang Hao Wan Xiangjian Shen Lili Zhang Menggai Jiao Zhen Zhou 《Green Energy & Environment》 SCIE EI CAS 2025年第1期109-131,共23页
Point defect engineering endows catalysts with novel physical and chemical properties,elevating their electrocatalytic efficiency.The introduction of defects emerges as a promising strategy,effectively modifying the e... Point defect engineering endows catalysts with novel physical and chemical properties,elevating their electrocatalytic efficiency.The introduction of defects emerges as a promising strategy,effectively modifying the electronic structure of active sites.This optimization influences the adsorption energy of intermediates,thereby mitigating reaction energy barriers,altering paths,enhancing selectivity,and ultimately improving the catalytic efficiency of electrocatalysts.To elucidate the impact of defects on the electrocatalytic process,we comprehensively outline the roles of various point defects,their synthetic methodologies,and characterization techniques.Importantly,we consolidate insights into the relationship between point defects and catalytic activity for hydrogen/oxygen evolution and CO_(2)/O_(2)/N_(2) reduction reactions by integrating mechanisms from diverse reactions.This underscores the pivotal role of point defects in enhancing catalytic performance.At last,the principal challenges and prospects associated with point defects in current electrocatalysts are proposed,emphasizing their role in advancing the efficiency of electrochemical energy storage and conversion materials. 展开更多
关键词 Point defect engineering DOPING VACANCY ELECTROCATALYSIS Electronic structure
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Ultra‑High Sensitivity Anisotropic Piezoelectric Sensors for Structural Health Monitoring and Robotic Perception
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作者 Hao Yin Yanting Li +4 位作者 Zhiying Tian Qichao Li Chenhui Jiang Enfu Liang Yiping Guo 《Nano-Micro Letters》 SCIE EI CAS 2025年第2期432-446,共15页
Monitoring minuscule mechanical signals,both in magnitude and direction,is imperative in many application scenarios,e.g.,structural health monitoring and robotic sensing systems.However,the piezoelectric sensor strugg... Monitoring minuscule mechanical signals,both in magnitude and direction,is imperative in many application scenarios,e.g.,structural health monitoring and robotic sensing systems.However,the piezoelectric sensor struggles to satisfy the requirements for directional recognition due to the limited piezoelectric coefficient matrix,and achieving sensitivity for detecting micrometer-scale deformations is also challenging.Herein,we develop a vector sensor composed of lead zirconate titanate-electronic grade glass fiber composite filaments with oriented arrangement,capable of detecting minute anisotropic deformations.The as-prepared vector sensor can identify the deformation directions even when subjected to an unprecedented nominal strain of 0.06%,thereby enabling its utility in accurately discerning the 5μm-height wrinkles in thin films and in monitoring human pulse waves.The ultra-high sensitivity is attributed to the formation of porous ferroelectret and the efficient load transfer efficiency of continuous lead zirconate titanate phase.Additionally,when integrated with machine learning techniques,the sensor’s capability to recognize multi-signals enables it to differentiate between 10 types of fine textures with 100%accuracy.The structural design in piezoelectric devices enables a more comprehensive perception of mechanical stimuli,offering a novel perspective for enhancing recognition accuracy. 展开更多
关键词 Flexible piezoelectric filaments ANISOTROPIC Ultra-high sensitivity Structural health detection Texture recognition
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Molecular Structure Tailoring of Organic Spacers for High‑Performance Ruddlesden–Popper Perovskite Solar Cells
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作者 Pengyun Liu Xuejin Li +6 位作者 Tonghui Cai Wei Xing Naitao Yang Hamidreza Arandiyan Zongping Shao Shaobin Wang Shaomin Liu 《Nano-Micro Letters》 SCIE EI CAS 2025年第2期314-357,共44页
Layer-structured Ruddlesden–Popper(RP)perovskites(RPPs)with decent stability have captured the imagination of the photovoltaic research community and bring hope for boosting the development of perovskite solar cell(P... Layer-structured Ruddlesden–Popper(RP)perovskites(RPPs)with decent stability have captured the imagination of the photovoltaic research community and bring hope for boosting the development of perovskite solar cell(PSC)technology.However,two-dimensional(2D)or quasi-2D RP PSCs are encountered with some challenges of the large exciton binding energy,blocked charge transport and poor film quality,which restrict their photovoltaic performance.Fortunately,these issues can be readily resolved by rationally designing spacer cations of RPPs.This review mainly focuses on how to design the molecular structures of organic spacers and aims to endow RPPs with outstanding photovoltaic applications.We firstly elucidated the important roles of organic spacers in impacting crystallization kinetics,charge transporting ability and stability of RPPs.Then we brought three aspects to attention for designing organic spacers.Finally,we presented the specific molecular structure design strategies for organic spacers of RPPs aiming to improve photovoltaic performance of RP PSCs.These proposed strategies in this review will provide new avenues to develop novel organic spacers for RPPs and advance the development of RPP photovoltaic technology for future applications. 展开更多
关键词 Ruddlesden-Popper perovskites Low-dimensional perovskite solar cells Organic spacers Molecular structure Design strategies
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3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration
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作者 Ke Yao Gaoying Hong +11 位作者 Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong Li Yuewei Chen Nian Liu Jing He Jue Shi Zihe Hu Yanyan Zhou Zhijian Xie Yong He 《Nano-Micro Letters》 SCIE EI CAS 2025年第2期18-45,共28页
Hydrogel scaffolds have numerous potential applications in the tissue engineering field.However,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and hi... Hydrogel scaffolds have numerous potential applications in the tissue engineering field.However,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical properties.Inspired by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this gap.First,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent biocompatibility.Furthermore,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell growth.Interestingly,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT strategies.Animal experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries. 展开更多
关键词 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration BIOMATERIALS
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Advanced Functional Electromagnetic Shielding Materials:A Review Based on Micro‑Nano Structure Interface Control of Biomass Cell Walls
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作者 Yang Shi Mingjun Wu +14 位作者 Shengbo Ge Jianzhang Li Anoud Saud Alshammari Jing Luo Mohammed A.Amin Hua Qiu Jinxuan Jiang Yazeed M.Asiri Runzhou Huang Hua Hou Zeinhom M.El‑Bahy Zhanhu Guo Chong Jia Kaimeng Xu Xiangmeng Chen 《Nano-Micro Letters》 SCIE EI CAS 2025年第1期98-134,共37页
Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass materials.These materials offer numerous advantages such as being lightweight,porous,and... Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass materials.These materials offer numerous advantages such as being lightweight,porous,and hierarchical.Due to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EMI shielding materials.Despite concerted efforts on the EMI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EMI shielding materials.In particular,a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment,preparation process,and micro-control would be valuable.The preparation methods and characteristics of wood,bamboo,cellulose and lignin in EMI shielding field are critically discussed in this paper,and similar biomass EMI materials are summarized and analyzed.The composite methods and fillers of various biomass materials were reviewed.this paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field. 展开更多
关键词 Biomass materials Electromagnetic interference shielding Micro-nano structure interface control CONDUCTIVITY
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Graphene Aerogel Composites with Self‑Organized Nanowires‑Packed Honeycomb Structure for Highly Efficient Electromagnetic Wave Absorption
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作者 Xiao You Huiying Ouyang +6 位作者 Ruixiang Deng Qiuqi Zhang Zhenzhong Xing Xiaowu Chen Qingliang Shan Jinshan Yang Shaoming Dong 《Nano-Micro Letters》 SCIE EI CAS 2025年第2期533-547,共15页
With vigorous developments in nanotechnology,the elaborate regulation of microstructure shows attractive potential in the design of electromagnetic wave absorbers.Herein,a hierarchical porous structure and composite h... With vigorous developments in nanotechnology,the elaborate regulation of microstructure shows attractive potential in the design of electromagnetic wave absorbers.Herein,a hierarchical porous structure and composite heterogeneous interface are constructed successfully to optimize the electromagnetic loss capacity.The macro–micro-synergistic graphene aerogel formed by the ice template‑assisted 3D printing strategy is cut by silicon carbide nanowires(SiC_(nws))grown in situ,while boron nitride(BN)interfacial structure is introduced on graphene nanoplates.The unique composite structure forces multiple scattering of incident EMWs,ensuring the combined effects of interfacial polarization,conduction networks,and magnetic-dielectric synergy.Therefore,the as-prepared composites present a minimum reflection loss value of−37.8 dB and a wide effective absorption bandwidth(EAB)of 9.2 GHz(from 8.8 to 18.0 GHz)at 2.5 mm.Besides,relying on the intrinsic high-temperature resistance of SiC_(nws) and BN,the EAB also remains above 5.0 GHz after annealing in air environment at 600℃ for 10 h. 展开更多
关键词 Hierarchical porous structure Interface High-temperature resistance Graphene aerogel composites Electromagnetic wave absorption
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Beyond neurodegeneration:engineering amyloids for biocatalysis
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作者 Andrea Bartolomé-Nafría Javier García-Pardo Salvador Ventura 《Neural Regeneration Research》 SCIE CAS 2025年第10期2915-2916,共2页
Amyloid fibrils are highly organized protein or peptide aggregates,often characterized by a distinctive supramolecular cross-β-sheet structure.The formation and accumulation of these structures have been traditionall... Amyloid fibrils are highly organized protein or peptide aggregates,often characterized by a distinctive supramolecular cross-β-sheet structure.The formation and accumulation of these structures have been traditionally associated with neural or systemic human diseases,such as Alzheimer’s disease,Parkinson’s disease,type-2 diabetes,or amyotrophic lateral sclerosis(Wei et al.,2017;Wittung-Stafshede,2023). 展开更多
关键词 structure AMYLOID
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Toward understanding the role of genomic repeat elements in neurodegenerative diseases
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作者 Zhengyu An Aidi Jiang Jingqi Chen 《Neural Regeneration Research》 SCIE CAS 2025年第3期646-659,共14页
Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage se... Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements. 展开更多
关键词 Alzheimer's disease ATAXIA deep learning long-read sequencing NEURODEGENERATION neurodegenerative diseases Parkinson's disease repeat element structural variant
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An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells
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作者 Shuai Xu Youdi Zhang +6 位作者 Yanna Sun Pei Cheng Zhaoyang Yao Ning Li Long Ye Lijian Zuo Ke Gao 《Nano-Micro Letters》 SCIE EI CAS 2025年第2期372-375,共4页
Recently published in Joule,Feng Liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network act... Recently published in Joule,Feng Liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer deposition.This optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture capability.This approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs. 展开更多
关键词 Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management
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Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential
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作者 Jia Zhao Taixi Feng Guimin Lu 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS 2025年第2期439-449,共11页
The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La a... The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies. 展开更多
关键词 magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation
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