OBJECTIVE： A meta-analysis of published randomized controlled trials investigating the long- term effect of dexamethasone on the nervous system of preterm infants. DATA SOURCES： Online literature retrieval was condu...OBJECTIVE： A meta-analysis of published randomized controlled trials investigating the long- term effect of dexamethasone on the nervous system of preterm infants. DATA SOURCES： Online literature retrieval was conducted using The Cochrane Library （from January 1993 to June 2013）, EMBASE （from January 1980 to June 2013）, MEDLINE （from Janu- ary 1963 to June 2013）, OVID （from January 1993 to June 2013）, Springer （from January 1994 to June 2013） and Chinese Academic Journal Full-text Database （from January 1994 to June 2013）. Key words were preterm infants and dexamethasone in English and Chinese. STUDY SELECTION： Selected studies were randomized controlled trials assessing the effect of intravenous dexamethasone in preterm infants. The quality of the included papers was evaluated and those without the development of the nervous system and animal experiments were exclud- ed. Quality assessment was performed through bias risk evaluation in accordance with Cochrane Handbook 5.1.0 software in the Cochrane Collaboration. The homogeneous studies were analyzed and compared using Revman 5.2.6 software, and then effect model was selected and analyzed. Those papers failed to be included in the meta-analysis were subjected to descriptive analysis. MAIN OUTCOME MEASURES： Nervous system injury in preterm infants. RESULTS： Ten randomized controlled trials were screened, involving 1,038 subjects. Among them 512 cases received dexamethasone treatment while 526 cases served as placebo control group and blank control group. Meta-analysis results showed that the incidence of cerebral palsy, visual im- pairment and hearing loss in preterm infants after dexamethasone treatment within 7 days after birth was similar to that in the control group （RR = 1.47, 95%CI： 0.97-2.21; RR = 1.46, 95%CI： 0.97-2.20; RR = 0.80, 95%CI： 0.54-1.18; P 〉 0.05）, but intelligence quotient was significantly de- creased compared with the control group （MD = -3.55, 95%CI： -6.59 to -0.51; P = 0.02）. Prete rm infants treated with dexamethasone 7 days after birth demonstrated an incidence of cerebral palsy and visual impairment, and changes in intelligence quotient similar to those in the control group （RR = 1.26, 95%CI： 0.89-1.79; RR = 1.37, 95%CI： 0.73-2.59; RR = 0.53, 95%CI： 0.32-0.89; RR = 1.66, 95%CI： -4.7 to 8.01; P 〉 0.05）. However, the incidence of hearing loss was significantly increased compared with that in the control group （RR = 0.53, 95%CI： 0.32-0.89; P = 0.02）. CONCLUSION： Dexamethasone may affect the intelligence of preterm infants in the early stages after birth, but may lead to hearing impairment at later stages after birth. More reliable conclusions should be made through large-size, multi-center, well-designed randomized controlled trials.展开更多
While chemistry is popular for children of primary school age, its popularity drops dramatically in secondary schools. A potential solution to address this is to recognise the need for greater relevance-relevance to t...While chemistry is popular for children of primary school age, its popularity drops dramatically in secondary schools. A potential solution to address this is to recognise the need for greater relevance-relevance to the curriculum, to the needs of society and, in the eyes of the students. The paper tries to puts forward a rethink of the philosophy for school chemistry education, based on the underlying belief that chemistry education is an integral part of education. The target is labelled scientific and technological literacy for all (STL). STL rejects the notion that chemistry is taught solely to acquire the abilities to be a scientist and supports the vision of a single curriculum goal, applicable to all students. Besides being a philosophy, STL is also a teaching approach. This approach is to initiate the teaching of chemistry topics, starting from a carefully chosen society perspective and to introduce the conceptual learning on a need-to-know basis. A limitation is the professional development of teachers. Suggestion for overcoming this involve workshop on materials development. A concern is expressed in cases where teachers make use of ready-made teaching materials (a common practice), without first gaining an understanding and an appreciation of the intended philosophy related to these materials.展开更多
Knowledge of the environment is essential for the survival of organisms; but those organisms have to have the capacity to stabilize such knowledge. The aim of this article is to analyze the various strategies for stab...Knowledge of the environment is essential for the survival of organisms; but those organisms have to have the capacity to stabilize such knowledge. The aim of this article is to analyze the various strategies for stabilizing human knowledge, with a special focus on its material anchors and their interactions with other stabilization means. In particular, I consider how such stabilization is reflected in scientific activity and practice, and what its repercussions are for the models of science that have dominated the philosophical landscape of the 20th century. My starting hypothesis will be that the role of material anchors in stabilizing conceptual blends is analogous to that of technology in grounding scientific knowledge. The framework I adopt with regard to conceptualization is that of Fauconnier and Turner （2002） on conceptual blends. Just as technology intervenes in scientific practice in conjunction with conceptual elements, so do material anchors, which conjoin other non-material strategies of knowledge stabilization. Endowing knowledge with a material basis may be understood firstly as an element （sometimes a key element） for representing knowledge and offering an explanation, and secondly as a way of providing a scientific hypothesis with empirical grounding. It is this second sense that connects with scientific experimentation and the use of instruments and technology.展开更多
The methodology of science and technology is a theory concerning general scientific and technical research methods, and its essence belongs to the category of understanding and thinking. Through the study of science a...The methodology of science and technology is a theory concerning general scientific and technical research methods, and its essence belongs to the category of understanding and thinking. Through the study of science and technology methodologies and approaches on the general process of scientific research and technology research, one can grasp the mainstream of modern scientific thinking pattern and means, helping to solve the general regular problems of scientific and technological research. Starting from modern science and technology point of view, this article elaborated the impact of modern scientific progress had on the development of philosophical anthropology from different angles.展开更多
Corpus-based translation studies belong to a new translation study paradigm which rose at the beginning of 1990 s.The rise of corpus brings the update of research tools and research methods, and lead to the emerging o...Corpus-based translation studies belong to a new translation study paradigm which rose at the beginning of 1990 s.The rise of corpus brings the update of research tools and research methods, and lead to the emerging of Corpus Translation Studies. It is necessary to introduce the theory basis of Translational English Corpus and its application in the translation, especially in the science and technology translation. Besides, it makes an analysis and discussion about the potential of Corpus Translation Studies.展开更多
基金supported by the Science and Technology Plan Program of Hunan Province,No.2011SK3234
文摘OBJECTIVE： A meta-analysis of published randomized controlled trials investigating the long- term effect of dexamethasone on the nervous system of preterm infants. DATA SOURCES： Online literature retrieval was conducted using The Cochrane Library （from January 1993 to June 2013）, EMBASE （from January 1980 to June 2013）, MEDLINE （from Janu- ary 1963 to June 2013）, OVID （from January 1993 to June 2013）, Springer （from January 1994 to June 2013） and Chinese Academic Journal Full-text Database （from January 1994 to June 2013）. Key words were preterm infants and dexamethasone in English and Chinese. STUDY SELECTION： Selected studies were randomized controlled trials assessing the effect of intravenous dexamethasone in preterm infants. The quality of the included papers was evaluated and those without the development of the nervous system and animal experiments were exclud- ed. Quality assessment was performed through bias risk evaluation in accordance with Cochrane Handbook 5.1.0 software in the Cochrane Collaboration. The homogeneous studies were analyzed and compared using Revman 5.2.6 software, and then effect model was selected and analyzed. Those papers failed to be included in the meta-analysis were subjected to descriptive analysis. MAIN OUTCOME MEASURES： Nervous system injury in preterm infants. RESULTS： Ten randomized controlled trials were screened, involving 1,038 subjects. Among them 512 cases received dexamethasone treatment while 526 cases served as placebo control group and blank control group. Meta-analysis results showed that the incidence of cerebral palsy, visual im- pairment and hearing loss in preterm infants after dexamethasone treatment within 7 days after birth was similar to that in the control group （RR = 1.47, 95%CI： 0.97-2.21; RR = 1.46, 95%CI： 0.97-2.20; RR = 0.80, 95%CI： 0.54-1.18; P 〉 0.05）, but intelligence quotient was significantly de- creased compared with the control group （MD = -3.55, 95%CI： -6.59 to -0.51; P = 0.02）. Prete rm infants treated with dexamethasone 7 days after birth demonstrated an incidence of cerebral palsy and visual impairment, and changes in intelligence quotient similar to those in the control group （RR = 1.26, 95%CI： 0.89-1.79; RR = 1.37, 95%CI： 0.73-2.59; RR = 0.53, 95%CI： 0.32-0.89; RR = 1.66, 95%CI： -4.7 to 8.01; P 〉 0.05）. However, the incidence of hearing loss was significantly increased compared with that in the control group （RR = 0.53, 95%CI： 0.32-0.89; P = 0.02）. CONCLUSION： Dexamethasone may affect the intelligence of preterm infants in the early stages after birth, but may lead to hearing impairment at later stages after birth. More reliable conclusions should be made through large-size, multi-center, well-designed randomized controlled trials.
文摘While chemistry is popular for children of primary school age, its popularity drops dramatically in secondary schools. A potential solution to address this is to recognise the need for greater relevance-relevance to the curriculum, to the needs of society and, in the eyes of the students. The paper tries to puts forward a rethink of the philosophy for school chemistry education, based on the underlying belief that chemistry education is an integral part of education. The target is labelled scientific and technological literacy for all (STL). STL rejects the notion that chemistry is taught solely to acquire the abilities to be a scientist and supports the vision of a single curriculum goal, applicable to all students. Besides being a philosophy, STL is also a teaching approach. This approach is to initiate the teaching of chemistry topics, starting from a carefully chosen society perspective and to introduce the conceptual learning on a need-to-know basis. A limitation is the professional development of teachers. Suggestion for overcoming this involve workshop on materials development. A concern is expressed in cases where teachers make use of ready-made teaching materials (a common practice), without first gaining an understanding and an appreciation of the intended philosophy related to these materials.
文摘Knowledge of the environment is essential for the survival of organisms; but those organisms have to have the capacity to stabilize such knowledge. The aim of this article is to analyze the various strategies for stabilizing human knowledge, with a special focus on its material anchors and their interactions with other stabilization means. In particular, I consider how such stabilization is reflected in scientific activity and practice, and what its repercussions are for the models of science that have dominated the philosophical landscape of the 20th century. My starting hypothesis will be that the role of material anchors in stabilizing conceptual blends is analogous to that of technology in grounding scientific knowledge. The framework I adopt with regard to conceptualization is that of Fauconnier and Turner （2002） on conceptual blends. Just as technology intervenes in scientific practice in conjunction with conceptual elements, so do material anchors, which conjoin other non-material strategies of knowledge stabilization. Endowing knowledge with a material basis may be understood firstly as an element （sometimes a key element） for representing knowledge and offering an explanation, and secondly as a way of providing a scientific hypothesis with empirical grounding. It is this second sense that connects with scientific experimentation and the use of instruments and technology.
文摘The methodology of science and technology is a theory concerning general scientific and technical research methods, and its essence belongs to the category of understanding and thinking. Through the study of science and technology methodologies and approaches on the general process of scientific research and technology research, one can grasp the mainstream of modern scientific thinking pattern and means, helping to solve the general regular problems of scientific and technological research. Starting from modern science and technology point of view, this article elaborated the impact of modern scientific progress had on the development of philosophical anthropology from different angles.
文摘Corpus-based translation studies belong to a new translation study paradigm which rose at the beginning of 1990 s.The rise of corpus brings the update of research tools and research methods, and lead to the emerging of Corpus Translation Studies. It is necessary to introduce the theory basis of Translational English Corpus and its application in the translation, especially in the science and technology translation. Besides, it makes an analysis and discussion about the potential of Corpus Translation Studies.
