Purpose:To report indocyanine green angiography (ICGA) findings in one patient of diffuse choroidal hemangioma associated with Struge-Weber syndrome.Methods:Color fundus photography, fluorescein angiography (FA) and I...Purpose:To report indocyanine green angiography (ICGA) findings in one patient of diffuse choroidal hemangioma associated with Struge-Weber syndrome.Methods:Color fundus photography, fluorescein angiography (FA) and ICGA were performed in a patient with diffuse choroidal hemangioma associated with Sturge-Weber syndrome.Results:Three findings were unveiled by ICGA: rapid filling of diffuse choroidal hemangio’s vascular network in the early stages; diffuse hyperfluorescence visual up to the late phase; no "wash-out" phenomenon was observed in the late phase.Conclusion:Indocyanine green angiography can provide information that is not detected by clinical or fluorescence angiographic examination in the patient with Sturge-Weber syndrome. ICGA may be important and sensitive in detecting the diffuse choroidal hamangioma associated with Sturge-Weber syndrome.展开更多
AIM:To evaluate the efficacy of ruthenium-106 plaque brachytherapy for the treatment of diffuse choroidal hemangioma(DCH)in Sturge-Weber syndrome(SWS).METHODS:A total of 8 patients with DCH in SWS managed with plaque ...AIM:To evaluate the efficacy of ruthenium-106 plaque brachytherapy for the treatment of diffuse choroidal hemangioma(DCH)in Sturge-Weber syndrome(SWS).METHODS:A total of 8 patients with DCH in SWS managed with plaque brachytherapy were retrospectively included.Patients were treated with ruthenium-106 plaque therapy(median apex dose:83 Gy)at the thickest tumor region.On follow-up,we recorded the tumor thickness,the best-corrected visual acuity(BCVA),subretinal fluid(SRF)status,and complications following treatment.RESULTS:At a median follow-up of 43 mo,tumor regression was observed in all cases,with a complete resolution of SRF and reduction in tumor-thickness.No radiation complications were recorded during the follow up time.CONCLUSION:Ruthenium-106 plaque therapy to the thickest portion of the tumor seems to be a useful treatment in patients with DCH in SWS.展开更多
AIM： To compare the efficacy and safety of collagen matrix implant [Ologen（OLO） implant] versus mitomycin C（MMC） with subscleral trabeculectomy（SST） for the surgical treatment of congenital glaucoma（CG） in St...AIM： To compare the efficacy and safety of collagen matrix implant [Ologen（OLO） implant] versus mitomycin C（MMC） with subscleral trabeculectomy（SST） for the surgical treatment of congenital glaucoma（CG） in SturgeWeber Syndrome（SWS）.METHODS： A prospective comparative randomized study of 20 eyes of 16 patients with CG associated with SWS was divided into two groups. The first group（MMC Group） included 10 eyes that were subjected to SST with MMC. The second group（OLO Group） included 10 eyes that were subjected to trabeculectomy with a collagen matrix implant（OLO implant）. Postoperative evaluation included intraocular pressure（IOP） level, bleb evaluation, complications, and the need for further medication or surgical intervention. RESULTS： The mean preoperative IOP was 29±3.16 mm Hg in MMC and 29.8±3.08 mm Hg in OLO eyes. Mean 12-month percentage reduction in IOP was significant in both groups（57.9% and 56.3%）. At the end of the 12 postoperative follow-up month, in the MMC Group, 80% of eyes achieved the complete success, 20% of eyes had qualified success with no failed surgery in comparison to OLO Group which 70% of eyes achieved the complete success, 20% of eyes had qualified success with 10% failed surgery. In terms of complications, the MMC Group had a higher rate of complications than the OLO Group in the form of thin polycystic bleb in 6 eyes（60%）, blebitis in only one eye（10%） treated with topical antibiotics, shallow anterior chamber in two eyes（20%）.CONCLUSION： This study proves that the use of a collagen matrix implant yields equally effective results as MMC when combined with trabeculectomy for the treatment of CG in SWS. Furthermore, OLO implantation is safe and has low incidences of complications.展开更多
Dear Sir,I am Dong Hyun Lee from the Department of Ophthalmology at the Pusan National University Yangsan Hospital,Yangsan,Korea.Herein,I present the development of a lens-induced angle closed glaucoma and iris neovas...Dear Sir,I am Dong Hyun Lee from the Department of Ophthalmology at the Pusan National University Yangsan Hospital,Yangsan,Korea.Herein,I present the development of a lens-induced angle closed glaucoma and iris neovascularization in the patient with Sturge Weber syndrome(SWS)with open angle glaucoma.Informed consent was obtained from a patient before each procedure The study was conducted in accordance with the tenets of the Declaration of Helsinki.展开更多
目的应用动态磁敏感增强MR灌注成像(DSC-PI)技术对Sturge-Weber综合征(SWS)受累白质区的血流灌注进行定量测量,并和各种癫痫状态指标进行相关性分析,以期合理的解释SWS血流动力学与癫痫状态的关系。材料与方法 14例临床确诊为SWS的患儿...目的应用动态磁敏感增强MR灌注成像(DSC-PI)技术对Sturge-Weber综合征(SWS)受累白质区的血流灌注进行定量测量,并和各种癫痫状态指标进行相关性分析,以期合理的解释SWS血流动力学与癫痫状态的关系。材料与方法 14例临床确诊为SWS的患儿进行MRI检查,其中男6例,女8例,平均年龄4.0岁(0.8～10.0岁)。所有患儿的病变部位均为单侧大脑半球。MR扫描序列包括:矢状面及轴面T1WI、轴面FSET2WI、DSC-PI及增强后轴面T1WI。观察所有图像以确认脑内病变位置及范围;利用SPIN(signal process in neuroimage)软件分别测量病变白质区域及相应对侧位置的脑血流量(CBF)、脑血容量(CBV)和平均通过时间(MTT),并计算出灌注比值(CBFr、CBVr及MTTr)。根据CBFr值将患儿分为高灌注组(HP)及低灌注组(LP)。记录每例患儿的临床资料,尤其有无癫痫发作以及反映发作的各项参数:首次癫痫发作年龄、癫痫发作频率(SSF)及癫痫持续时间。对高、低灌注组病变侧与对侧的CBF、CBV及MTT值进行配对秩和检验;对癫痫状态的各临床参数与各项灌注参数进行Spearman相关分析。结果 14例SWS患者中,9例受累白质区CBF及CBV较对侧明显减低(CBFr值为-0.37±0.24,CBVr=-0.22±0.25,P值均<0.01),为LP组;5例脑内病变侧白质区CBF及CBV较对侧显著增高(CBFr值为0.31±0.05,CBVr值为0.40±0.17,P值均<0.01),为HP组。LP组年龄及癫痫发作频率得分(SSF)较HP组有增大趋势(年龄=63.80月,48.83月;SSF=2.50,1.33),但这差异缺乏统计学意义(P值分别为0.36、0.12)。病变侧CBFr值和CBV值与癫痫持续时间呈明显负相关(CBFr:r=-0.58;CBV:r=-0.55,P值均<0.05)。CBFr和CBVr与癫痫发作频率呈负相关,即癫痫发作越频繁,CBFr和CBVr越低(CBFr:r=-0.56;CBVr:r=-0.63,P值均<0.05)。结论 SWS受累白质区域的血流灌注并非持续降低,而存在相对高灌注状态;灌注异常与癫痫发作的频率和癫痫持续时间有关。展开更多
文摘Purpose:To report indocyanine green angiography (ICGA) findings in one patient of diffuse choroidal hemangioma associated with Struge-Weber syndrome.Methods:Color fundus photography, fluorescein angiography (FA) and ICGA were performed in a patient with diffuse choroidal hemangioma associated with Sturge-Weber syndrome.Results:Three findings were unveiled by ICGA: rapid filling of diffuse choroidal hemangio’s vascular network in the early stages; diffuse hyperfluorescence visual up to the late phase; no "wash-out" phenomenon was observed in the late phase.Conclusion:Indocyanine green angiography can provide information that is not detected by clinical or fluorescence angiographic examination in the patient with Sturge-Weber syndrome. ICGA may be important and sensitive in detecting the diffuse choroidal hamangioma associated with Sturge-Weber syndrome.
文摘AIM:To evaluate the efficacy of ruthenium-106 plaque brachytherapy for the treatment of diffuse choroidal hemangioma(DCH)in Sturge-Weber syndrome(SWS).METHODS:A total of 8 patients with DCH in SWS managed with plaque brachytherapy were retrospectively included.Patients were treated with ruthenium-106 plaque therapy(median apex dose:83 Gy)at the thickest tumor region.On follow-up,we recorded the tumor thickness,the best-corrected visual acuity(BCVA),subretinal fluid(SRF)status,and complications following treatment.RESULTS:At a median follow-up of 43 mo,tumor regression was observed in all cases,with a complete resolution of SRF and reduction in tumor-thickness.No radiation complications were recorded during the follow up time.CONCLUSION:Ruthenium-106 plaque therapy to the thickest portion of the tumor seems to be a useful treatment in patients with DCH in SWS.
文摘AIM： To compare the efficacy and safety of collagen matrix implant [Ologen（OLO） implant] versus mitomycin C（MMC） with subscleral trabeculectomy（SST） for the surgical treatment of congenital glaucoma（CG） in SturgeWeber Syndrome（SWS）.METHODS： A prospective comparative randomized study of 20 eyes of 16 patients with CG associated with SWS was divided into two groups. The first group（MMC Group） included 10 eyes that were subjected to SST with MMC. The second group（OLO Group） included 10 eyes that were subjected to trabeculectomy with a collagen matrix implant（OLO implant）. Postoperative evaluation included intraocular pressure（IOP） level, bleb evaluation, complications, and the need for further medication or surgical intervention. RESULTS： The mean preoperative IOP was 29±3.16 mm Hg in MMC and 29.8±3.08 mm Hg in OLO eyes. Mean 12-month percentage reduction in IOP was significant in both groups（57.9% and 56.3%）. At the end of the 12 postoperative follow-up month, in the MMC Group, 80% of eyes achieved the complete success, 20% of eyes had qualified success with no failed surgery in comparison to OLO Group which 70% of eyes achieved the complete success, 20% of eyes had qualified success with 10% failed surgery. In terms of complications, the MMC Group had a higher rate of complications than the OLO Group in the form of thin polycystic bleb in 6 eyes（60%）, blebitis in only one eye（10%） treated with topical antibiotics, shallow anterior chamber in two eyes（20%）.CONCLUSION： This study proves that the use of a collagen matrix implant yields equally effective results as MMC when combined with trabeculectomy for the treatment of CG in SWS. Furthermore, OLO implantation is safe and has low incidences of complications.
基金supported by clinical research grant from Pusan National University Yangsan Hospital 2014
文摘Dear Sir,I am Dong Hyun Lee from the Department of Ophthalmology at the Pusan National University Yangsan Hospital,Yangsan,Korea.Herein,I present the development of a lens-induced angle closed glaucoma and iris neovascularization in the patient with Sturge Weber syndrome(SWS)with open angle glaucoma.Informed consent was obtained from a patient before each procedure The study was conducted in accordance with the tenets of the Declaration of Helsinki.
文摘目的应用动态磁敏感增强MR灌注成像(DSC-PI)技术对Sturge-Weber综合征(SWS)受累白质区的血流灌注进行定量测量,并和各种癫痫状态指标进行相关性分析,以期合理的解释SWS血流动力学与癫痫状态的关系。材料与方法 14例临床确诊为SWS的患儿进行MRI检查,其中男6例,女8例,平均年龄4.0岁(0.8～10.0岁)。所有患儿的病变部位均为单侧大脑半球。MR扫描序列包括:矢状面及轴面T1WI、轴面FSET2WI、DSC-PI及增强后轴面T1WI。观察所有图像以确认脑内病变位置及范围;利用SPIN(signal process in neuroimage)软件分别测量病变白质区域及相应对侧位置的脑血流量(CBF)、脑血容量(CBV)和平均通过时间(MTT),并计算出灌注比值(CBFr、CBVr及MTTr)。根据CBFr值将患儿分为高灌注组(HP)及低灌注组(LP)。记录每例患儿的临床资料,尤其有无癫痫发作以及反映发作的各项参数:首次癫痫发作年龄、癫痫发作频率(SSF)及癫痫持续时间。对高、低灌注组病变侧与对侧的CBF、CBV及MTT值进行配对秩和检验;对癫痫状态的各临床参数与各项灌注参数进行Spearman相关分析。结果 14例SWS患者中,9例受累白质区CBF及CBV较对侧明显减低(CBFr值为-0.37±0.24,CBVr=-0.22±0.25,P值均<0.01),为LP组;5例脑内病变侧白质区CBF及CBV较对侧显著增高(CBFr值为0.31±0.05,CBVr值为0.40±0.17,P值均<0.01),为HP组。LP组年龄及癫痫发作频率得分(SSF)较HP组有增大趋势(年龄=63.80月,48.83月;SSF=2.50,1.33),但这差异缺乏统计学意义(P值分别为0.36、0.12)。病变侧CBFr值和CBV值与癫痫持续时间呈明显负相关(CBFr:r=-0.58;CBV:r=-0.55,P值均<0.05)。CBFr和CBVr与癫痫发作频率呈负相关,即癫痫发作越频繁,CBFr和CBVr越低(CBFr:r=-0.56;CBVr:r=-0.63,P值均<0.05)。结论 SWS受累白质区域的血流灌注并非持续降低,而存在相对高灌注状态;灌注异常与癫痫发作的频率和癫痫持续时间有关。
