Traditional Chinese Medicine prescription Suanzaoren decoction (SZRD) is composed of Ziziphi Spinosae Semen, Chuanxiong Rhizoma, Anemarrhenae rhizoma, Poria and Licorice. It was used to treat central nervous system di...Traditional Chinese Medicine prescription Suanzaoren decoction (SZRD) is composed of Ziziphi Spinosae Semen, Chuanxiong Rhizoma, Anemarrhenae rhizoma, Poria and Licorice. It was used to treat central nervous system diseases such as insomnia and anxiety for thousands of years. This paper aims to systematically understand varieties and quantities of compounds and clarify chemical components of SZRD, subsequently to further provide the reference for phytochemistry and pharmacology researches of SZRD. Our results showed that SZRD contained 145 components, including flavonoids, triterpenoids, steroids, coumarins, phthalides, and volatile oils, etc., while five-single herbs contain 1104 components. Only in terms of compound number, there were 80 common components in SZRD and its five herbs, which accounted for 6.8% of total compounds in all 5 herbs and 55.2% of compounds in SZRD. The components of SZRD were not simply the sum of one in every single herb. It is necessary to perform parallel studies among SZRD and its herbs. This review discussed the problems that existed in the chemical research of SZRD and pointed out the direction for its further research.展开更多
Objective:To study the curative effect of oral Suanzaoren Decoction(酸枣仁汤)combined with pressing beans at auricular points on insomnia.Methods:80 patients with insomnia were randomly divided into observation group ...Objective:To study the curative effect of oral Suanzaoren Decoction(酸枣仁汤)combined with pressing beans at auricular points on insomnia.Methods:80 patients with insomnia were randomly divided into observation group and control group with 40 cases in each group.The control group was treated by auricular points pressing beans therapy,while the observation group was treated with oral Suanzaoren Decoction combined with auricular points pressing beans therapy.Adjust auricular points pressing beans and decoction once a week,4 times as a course of treatment,totaling 2 courses of treatment.The time of falling asleep,the time of sleeping and the number of awakening before and after treatment were compared in the two groups,and the total effective rate of sleep quality between the two groups was compared.Results:After treatment,the quality of sleep in both groups was better than that before treatment(P<0.05 or P<0.01),and the total effective rate of grade I sleep quality in the observation group was higher than that in the control group(P<0.01).Conclusion:Oral Suanzaoren Decoction combined with pressing beans at auricular points has a significant effect on insomnia,which is superior to pressing beans at auricular points alone.展开更多
目的系统评价酸枣仁汤治疗脑卒中后失眠的有效性和安全性。方法检索PubMed、EMbase、中国知网、万方等数据库,时间均从建库至2023年9月15日,收集有关酸枣仁汤治疗脑卒中后失眠的随机对照试验(Randomized controlled trial,RCT)。由2名...目的系统评价酸枣仁汤治疗脑卒中后失眠的有效性和安全性。方法检索PubMed、EMbase、中国知网、万方等数据库,时间均从建库至2023年9月15日,收集有关酸枣仁汤治疗脑卒中后失眠的随机对照试验(Randomized controlled trial,RCT)。由2名评价员独立筛选文献、提取数据并进行文献质量评价,应用RevMan 5.3软件进行Meta分析。结果纳入13项RCT,涉及1002例患者。Meta分析结果示,酸枣仁汤治疗组临床治疗有效率高于对照组[OR=4.25,95%CI(2.79,6.46),P<0.00001];酸枣仁汤治疗组(联合其他治疗)在降低匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)评分方面优于对照组[MD=-2.78,95%CI(-3.24,-2.33),P<0.00001];酸枣仁汤治疗组在降低美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分改善神经功能缺损方面优于对照组[MD=-1.58,95%CI(-1.95,-1.21),P<0.00001];不良反应方面,酸枣仁汤组的不良反应发生率较西医常规治疗组更低[OR=0.38,95%CI(0.20,0.71),P=0.003]。结论酸枣仁汤可提高卒中后失眠患者的临床疗效、改善神经功能缺损程度,酸枣仁汤联合其他治疗可改善患者睡眠质量,且不良反应发生率更低。目前仍需更多高质量RCT研究予以进一步验证酸枣仁汤治疗卒中后失眠的有效性和安全性。展开更多
文摘Traditional Chinese Medicine prescription Suanzaoren decoction (SZRD) is composed of Ziziphi Spinosae Semen, Chuanxiong Rhizoma, Anemarrhenae rhizoma, Poria and Licorice. It was used to treat central nervous system diseases such as insomnia and anxiety for thousands of years. This paper aims to systematically understand varieties and quantities of compounds and clarify chemical components of SZRD, subsequently to further provide the reference for phytochemistry and pharmacology researches of SZRD. Our results showed that SZRD contained 145 components, including flavonoids, triterpenoids, steroids, coumarins, phthalides, and volatile oils, etc., while five-single herbs contain 1104 components. Only in terms of compound number, there were 80 common components in SZRD and its five herbs, which accounted for 6.8% of total compounds in all 5 herbs and 55.2% of compounds in SZRD. The components of SZRD were not simply the sum of one in every single herb. It is necessary to perform parallel studies among SZRD and its herbs. This review discussed the problems that existed in the chemical research of SZRD and pointed out the direction for its further research.
基金Pilot Project of Combination of Medical Care and Nursing in Haidian District,Beijing in 2017(20170020)。
文摘Objective:To study the curative effect of oral Suanzaoren Decoction(酸枣仁汤)combined with pressing beans at auricular points on insomnia.Methods:80 patients with insomnia were randomly divided into observation group and control group with 40 cases in each group.The control group was treated by auricular points pressing beans therapy,while the observation group was treated with oral Suanzaoren Decoction combined with auricular points pressing beans therapy.Adjust auricular points pressing beans and decoction once a week,4 times as a course of treatment,totaling 2 courses of treatment.The time of falling asleep,the time of sleeping and the number of awakening before and after treatment were compared in the two groups,and the total effective rate of sleep quality between the two groups was compared.Results:After treatment,the quality of sleep in both groups was better than that before treatment(P<0.05 or P<0.01),and the total effective rate of grade I sleep quality in the observation group was higher than that in the control group(P<0.01).Conclusion:Oral Suanzaoren Decoction combined with pressing beans at auricular points has a significant effect on insomnia,which is superior to pressing beans at auricular points alone.
文摘目的系统评价酸枣仁汤治疗脑卒中后失眠的有效性和安全性。方法检索PubMed、EMbase、中国知网、万方等数据库,时间均从建库至2023年9月15日,收集有关酸枣仁汤治疗脑卒中后失眠的随机对照试验(Randomized controlled trial,RCT)。由2名评价员独立筛选文献、提取数据并进行文献质量评价,应用RevMan 5.3软件进行Meta分析。结果纳入13项RCT,涉及1002例患者。Meta分析结果示,酸枣仁汤治疗组临床治疗有效率高于对照组[OR=4.25,95%CI(2.79,6.46),P<0.00001];酸枣仁汤治疗组(联合其他治疗)在降低匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)评分方面优于对照组[MD=-2.78,95%CI(-3.24,-2.33),P<0.00001];酸枣仁汤治疗组在降低美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分改善神经功能缺损方面优于对照组[MD=-1.58,95%CI(-1.95,-1.21),P<0.00001];不良反应方面,酸枣仁汤组的不良反应发生率较西医常规治疗组更低[OR=0.38,95%CI(0.20,0.71),P=0.003]。结论酸枣仁汤可提高卒中后失眠患者的临床疗效、改善神经功能缺损程度,酸枣仁汤联合其他治疗可改善患者睡眠质量,且不良反应发生率更低。目前仍需更多高质量RCT研究予以进一步验证酸枣仁汤治疗卒中后失眠的有效性和安全性。
