Objective: To observe the effect of subarachnoid nerve block anesthesia on glutamate transporter glutamate-aspartate transporter(GLAST) and GLT-1 expressions in rabbits, and to investigate the effect of peripheral ner...Objective: To observe the effect of subarachnoid nerve block anesthesia on glutamate transporter glutamate-aspartate transporter(GLAST) and GLT-1 expressions in rabbits, and to investigate the effect of peripheral nerve anesthesia on the morphology and function of the spinal cord. Methods: Twenty healthy New Zealand white rabbits were randomly divided into two groups: the experimental group and control group; with 10 rabbits in each group. For spinal nerve anesthesia, 5 g/L of bupivacaine was used in the experimental group, and sterile saline was used in the control group. After 30 min of cardiac perfusion, GLAST and GLT-1 protein expression in spinal neurons were detected by immunohistochemistry and immunofluorescence staining. Results: GLAST and GLT-1 protein-positive cells increased in neurons in the experimental group, compared with the control group(P<0.05). Conclusions: After subarachnoid nerve block anesthesia, rabbit glutamate transporter GLAST and GLT-1 expression is increased; and spinal cord nerve cell function is inhibited.展开更多
OBJECTIVE:To explore the prevention of urine retention after subabdominal surgery by electro-acupuncture Yin Ling Quan(SP 9),Zhao Hai(KI 6) acupoints with the assistance of subarachnoid acupoint anesthesia by observin...OBJECTIVE:To explore the prevention of urine retention after subabdominal surgery by electro-acupuncture Yin Ling Quan(SP 9),Zhao Hai(KI 6) acupoints with the assistance of subarachnoid acupoint anesthesia by observing the postoperative voiding time and urine volume of postoperative patients undergoing Electroacupuncture plus subarachnoid block anesthesia.METHODS:60 cases of preoperative expected for subarachnoid block surgery patients were randomly divided into two groups,the treatment group and the control group,with 30 cases in each group.The control group underwent routine subarachnoid anesthesia after surgery without acupuncture treatment group;The treatment group was treated with acupuncture bilateral Yin Ling Quan and Zhaohai acupoints 15 minutes before anesthesia,and then received unilateral electric anesthesia instrument treatment,the intensity of the patient was tolerable(generally 1.5 ~ 2.0 m A),and the routine subarachnoid block anesthesia was performed;The first urination time,urine volume,lower abdominal pain and assistant catheterization were recorded in the two groups.RESULTS:The first postoperative voiding time of the treatment group was significantly earlier compared with that of the control group,there was significant difference(P<0.05);the amount of urine was significantly more than that of the control group in reservation time,there was significant difference(P<0.05);the abdominal pain was light in the treatment group,there was significant difference(P<0.05);the cases of assisted catheterization of the control group were significantly more thanthose of the treatment group,there was significant difference(P< 0.05).CONCLUSION:Electro-acupuncture Yin Ling Quan(SP 9),Zhao Hai(KI 6) acupoints with the assistance of subarachnoid acupoint anesthesia could significantly reduce the urine retention after subabdominal surgery in postoperative patients with ubarachnoid block anesthesiau,accelerate the recovery of bladder function and promote early postoperative urination in addition to relieving the abdominal symptoms after operation.展开更多
目的探究小剂量罗哌卡因蛛网膜下腔麻醉在剖宫产中的应用及对患者疼痛程度、并发症发生率影响。方法选濮阳市妇幼保健院妇产科2020年1月-2022年5月期间96例足月剖宫产产妇,均应用罗哌卡因蛛网膜下腔麻醉,以随机数字表法分为A组(32例,1 m...目的探究小剂量罗哌卡因蛛网膜下腔麻醉在剖宫产中的应用及对患者疼痛程度、并发症发生率影响。方法选濮阳市妇幼保健院妇产科2020年1月-2022年5月期间96例足月剖宫产产妇,均应用罗哌卡因蛛网膜下腔麻醉,以随机数字表法分为A组(32例,1 mL 0.75%罗哌卡因)、B组(32例,1.5 mL 0.75%罗哌卡因)、C组(32例,2 mL 0.75%罗哌卡因),比较三组麻醉效果及不良反应。结果麻醉前、麻醉后10 min时三组平均动脉压(MAP)、心率(HR)水平相近,三组麻醉起效时间、达到阻滞平面时间、痛觉恢复时间水平及术后不同时间三组疼痛视觉模拟法(VAS)评分均相近(P>0.05);C组麻黄碱使用率为18.75%,较A组(3.13%)、B组(3.13%)高,C组术后并发症发生率为21.88%,较A组(3.13%)高(P>0.05)。结论剖宫产产妇罗哌卡因蛛网膜下腔麻醉中,0.75%罗哌卡因用药剂量1 mL、1.5 mL、2 mL在麻醉后血流动力学指标、麻醉效果、术后不同时间疼痛感受中效果相近,且1 mL 0.75%罗哌卡因可减少麻黄碱使用率,并降低并发症发生率。展开更多
目的探讨不同剂量轻比重丁哌卡因蛛网膜下腔麻醉在高龄患者髋关节骨折手术中的应用效果。方法选取60例行髋关节骨折手术的高龄患者,随机分成A组、B组、C组,每组20例。3组患者分别采用1.4 mL 0.25%轻比重丁哌卡因、1.8 mL 0.25%轻比重丁...目的探讨不同剂量轻比重丁哌卡因蛛网膜下腔麻醉在高龄患者髋关节骨折手术中的应用效果。方法选取60例行髋关节骨折手术的高龄患者,随机分成A组、B组、C组,每组20例。3组患者分别采用1.4 mL 0.25%轻比重丁哌卡因、1.8 mL 0.25%轻比重丁哌卡因、2.2 mL 0.25%轻比重丁哌卡因进行蛛网膜下腔麻醉。比较3组患者的感觉神经及运动神经阻滞起效时间、持续时间,以及麻醉后15 min手术侧单侧阻滞发生率、术中追加局麻药的比例及给药后48 h内不良反应发生情况。结果 3组患者感觉神经阻滞起效时间、运动神经阻滞起效时间及麻醉后15 min术侧单侧阻滞发生率差异均无统计学意义(P均>0.05),而3组患者感觉神经阻滞持续时间和运动神经阻滞持续时间均为C组>B组>A组(均P<0.05)。A组术中追加硬膜外麻醉药的比例均高于B组与C组(均P<0.05),而B组与C组之间差异无统计学意义(P>0.05);C组术中低血压发生率高于B组(P<0.05),而A组与B组之间差异无统计学意义(P>0.05);3组患者均无寒战和术后头痛发生,且心动过缓、恶心呕吐及术后腰背痛发生率均无统计学差异(均P>0.05)。结论在高龄患者髋关节骨折手术中采用1.8 mL 0.25%轻比重丁哌卡因腰麻液进行蛛网膜下腔麻醉,可获得满意的麻醉效果,保持血流动力学稳定,且不良反应少。展开更多
基金supported by Natural Science Foundation of Shandong Province(Y2006C02)
文摘Objective: To observe the effect of subarachnoid nerve block anesthesia on glutamate transporter glutamate-aspartate transporter(GLAST) and GLT-1 expressions in rabbits, and to investigate the effect of peripheral nerve anesthesia on the morphology and function of the spinal cord. Methods: Twenty healthy New Zealand white rabbits were randomly divided into two groups: the experimental group and control group; with 10 rabbits in each group. For spinal nerve anesthesia, 5 g/L of bupivacaine was used in the experimental group, and sterile saline was used in the control group. After 30 min of cardiac perfusion, GLAST and GLT-1 protein expression in spinal neurons were detected by immunohistochemistry and immunofluorescence staining. Results: GLAST and GLT-1 protein-positive cells increased in neurons in the experimental group, compared with the control group(P<0.05). Conclusions: After subarachnoid nerve block anesthesia, rabbit glutamate transporter GLAST and GLT-1 expression is increased; and spinal cord nerve cell function is inhibited.
文摘OBJECTIVE:To explore the prevention of urine retention after subabdominal surgery by electro-acupuncture Yin Ling Quan(SP 9),Zhao Hai(KI 6) acupoints with the assistance of subarachnoid acupoint anesthesia by observing the postoperative voiding time and urine volume of postoperative patients undergoing Electroacupuncture plus subarachnoid block anesthesia.METHODS:60 cases of preoperative expected for subarachnoid block surgery patients were randomly divided into two groups,the treatment group and the control group,with 30 cases in each group.The control group underwent routine subarachnoid anesthesia after surgery without acupuncture treatment group;The treatment group was treated with acupuncture bilateral Yin Ling Quan and Zhaohai acupoints 15 minutes before anesthesia,and then received unilateral electric anesthesia instrument treatment,the intensity of the patient was tolerable(generally 1.5 ~ 2.0 m A),and the routine subarachnoid block anesthesia was performed;The first urination time,urine volume,lower abdominal pain and assistant catheterization were recorded in the two groups.RESULTS:The first postoperative voiding time of the treatment group was significantly earlier compared with that of the control group,there was significant difference(P<0.05);the amount of urine was significantly more than that of the control group in reservation time,there was significant difference(P<0.05);the abdominal pain was light in the treatment group,there was significant difference(P<0.05);the cases of assisted catheterization of the control group were significantly more thanthose of the treatment group,there was significant difference(P< 0.05).CONCLUSION:Electro-acupuncture Yin Ling Quan(SP 9),Zhao Hai(KI 6) acupoints with the assistance of subarachnoid acupoint anesthesia could significantly reduce the urine retention after subabdominal surgery in postoperative patients with ubarachnoid block anesthesiau,accelerate the recovery of bladder function and promote early postoperative urination in addition to relieving the abdominal symptoms after operation.
文摘目的探究小剂量罗哌卡因蛛网膜下腔麻醉在剖宫产中的应用及对患者疼痛程度、并发症发生率影响。方法选濮阳市妇幼保健院妇产科2020年1月-2022年5月期间96例足月剖宫产产妇,均应用罗哌卡因蛛网膜下腔麻醉,以随机数字表法分为A组(32例,1 mL 0.75%罗哌卡因)、B组(32例,1.5 mL 0.75%罗哌卡因)、C组(32例,2 mL 0.75%罗哌卡因),比较三组麻醉效果及不良反应。结果麻醉前、麻醉后10 min时三组平均动脉压(MAP)、心率(HR)水平相近,三组麻醉起效时间、达到阻滞平面时间、痛觉恢复时间水平及术后不同时间三组疼痛视觉模拟法(VAS)评分均相近(P>0.05);C组麻黄碱使用率为18.75%,较A组(3.13%)、B组(3.13%)高,C组术后并发症发生率为21.88%,较A组(3.13%)高(P>0.05)。结论剖宫产产妇罗哌卡因蛛网膜下腔麻醉中,0.75%罗哌卡因用药剂量1 mL、1.5 mL、2 mL在麻醉后血流动力学指标、麻醉效果、术后不同时间疼痛感受中效果相近,且1 mL 0.75%罗哌卡因可减少麻黄碱使用率,并降低并发症发生率。
文摘目的探讨不同剂量轻比重丁哌卡因蛛网膜下腔麻醉在高龄患者髋关节骨折手术中的应用效果。方法选取60例行髋关节骨折手术的高龄患者,随机分成A组、B组、C组,每组20例。3组患者分别采用1.4 mL 0.25%轻比重丁哌卡因、1.8 mL 0.25%轻比重丁哌卡因、2.2 mL 0.25%轻比重丁哌卡因进行蛛网膜下腔麻醉。比较3组患者的感觉神经及运动神经阻滞起效时间、持续时间,以及麻醉后15 min手术侧单侧阻滞发生率、术中追加局麻药的比例及给药后48 h内不良反应发生情况。结果 3组患者感觉神经阻滞起效时间、运动神经阻滞起效时间及麻醉后15 min术侧单侧阻滞发生率差异均无统计学意义(P均>0.05),而3组患者感觉神经阻滞持续时间和运动神经阻滞持续时间均为C组>B组>A组(均P<0.05)。A组术中追加硬膜外麻醉药的比例均高于B组与C组(均P<0.05),而B组与C组之间差异无统计学意义(P>0.05);C组术中低血压发生率高于B组(P<0.05),而A组与B组之间差异无统计学意义(P>0.05);3组患者均无寒战和术后头痛发生,且心动过缓、恶心呕吐及术后腰背痛发生率均无统计学差异(均P>0.05)。结论在高龄患者髋关节骨折手术中采用1.8 mL 0.25%轻比重丁哌卡因腰麻液进行蛛网膜下腔麻醉,可获得满意的麻醉效果,保持血流动力学稳定,且不良反应少。
