Objective To investigate the regulation of SP in the cochlea function.Methods Ten adult guinea pigs were used as experimental animals. The perilymph space of the guinea pigs cochlea was perfused with artificial peri...Objective To investigate the regulation of SP in the cochlea function.Methods Ten adult guinea pigs were used as experimental animals. The perilymph space of the guinea pigs cochlea was perfused with artificial perilymph solution containing 1 μg/μl SP receptor antagonist (D Arg 1, D Pro 2, D Trp 7,9 , Leu 11 ) SP (1 11) at a rate of 2.5 μl/min for 10 min while monitoring cochlear potentials evoked by 4 kHz tone burst.Results The perfusion of SP antagonist resulted in a suppression of the compound action potential of the auditory nerve (CAP, N1 P1), a prolongation of the N1 latency at threshold and suprathreshold levels, an elevation of the CAP threshold.Conclusions These results suggest that SP might play a role as a transmitter or modulator in the cochlear function.展开更多
文摘Objective To investigate the regulation of SP in the cochlea function.Methods Ten adult guinea pigs were used as experimental animals. The perilymph space of the guinea pigs cochlea was perfused with artificial perilymph solution containing 1 μg/μl SP receptor antagonist (D Arg 1, D Pro 2, D Trp 7,9 , Leu 11 ) SP (1 11) at a rate of 2.5 μl/min for 10 min while monitoring cochlear potentials evoked by 4 kHz tone burst.Results The perfusion of SP antagonist resulted in a suppression of the compound action potential of the auditory nerve (CAP, N1 P1), a prolongation of the N1 latency at threshold and suprathreshold levels, an elevation of the CAP threshold.Conclusions These results suggest that SP might play a role as a transmitter or modulator in the cochlear function.
