The substantia nigra pars reticulate(SNr),which plays a pivotal role in motor control,is the key structure in integrating information for cortex,basal ganglia and thalamus.Abnormal gait and posture deficits can be rev...The substantia nigra pars reticulate(SNr),which plays a pivotal role in motor control,is the key structure in integrating information for cortex,basal ganglia and thalamus.Abnormal gait and posture deficits can be reversed by SNr deep brain stimulation(DBS)in certain Parkinson’s disease cases.However,functional characterization of SNr,which is the key for the optimization of DBS effect,remains elusive.In current study,we recorded extracellular single unit in SNr of urethane anesthetized rats.We have found that urethane can induce slow delta and theta oscillations in SNr local field potential.The high gamma oscillation observed is positively correlated with the occurrence of action potential.The putative GABAergic neurons have a mean firing rate of(20.82±2.04)Hz,of which 65.2%display a regular firing pattern and 34.8%show irregular firing.Our results demonstrated the heterogeneous property of SNr and provided possible theoretical basis for promoting the next generation of DBS electrode design and optimization of clinical DBS parameters.展开更多
基金the Science and Technology Commission of Shanghai Municipality(No.18JC1413100)the National Key Research and Development Program(No.2016YFC0906400)。
文摘The substantia nigra pars reticulate(SNr),which plays a pivotal role in motor control,is the key structure in integrating information for cortex,basal ganglia and thalamus.Abnormal gait and posture deficits can be reversed by SNr deep brain stimulation(DBS)in certain Parkinson’s disease cases.However,functional characterization of SNr,which is the key for the optimization of DBS effect,remains elusive.In current study,we recorded extracellular single unit in SNr of urethane anesthetized rats.We have found that urethane can induce slow delta and theta oscillations in SNr local field potential.The high gamma oscillation observed is positively correlated with the occurrence of action potential.The putative GABAergic neurons have a mean firing rate of(20.82±2.04)Hz,of which 65.2%display a regular firing pattern and 34.8%show irregular firing.Our results demonstrated the heterogeneous property of SNr and provided possible theoretical basis for promoting the next generation of DBS electrode design and optimization of clinical DBS parameters.
