Copper-catalyzed divergent annulations betweenα-diketones and alkynylα-diketones have been achieved,delivering a series of highly functionalized and biologically important cis-hexahydro-2Hcyclopenta[b]furan(HCPF)and...Copper-catalyzed divergent annulations betweenα-diketones and alkynylα-diketones have been achieved,delivering a series of highly functionalized and biologically important cis-hexahydro-2Hcyclopenta[b]furan(HCPF)and 2-hydroxydihydrofuran-3(2H)-one(HDFO)products with high levels of stereoselectivity under identical conditions.The protocol features the use of earth-abundant copper catalyst,mild conditions,shortening synthetic routes in constructing different molecular frameworks,and reducing the corresponding possible waste production.The substituents of the nucleophilicα-diketones play crucial roles in switching the reaction pathways.展开更多
基金the National Natural Science Foundation of China(Nos.22071242 and 21871260)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB20000000)+1 种基金Fujian Natural Science Foundation(No.2018J05035)Science and Technology Research Program of the Education Department of Jiangxi Province(No.GJJ1991151)。
文摘Copper-catalyzed divergent annulations betweenα-diketones and alkynylα-diketones have been achieved,delivering a series of highly functionalized and biologically important cis-hexahydro-2Hcyclopenta[b]furan(HCPF)and 2-hydroxydihydrofuran-3(2H)-one(HDFO)products with high levels of stereoselectivity under identical conditions.The protocol features the use of earth-abundant copper catalyst,mild conditions,shortening synthetic routes in constructing different molecular frameworks,and reducing the corresponding possible waste production.The substituents of the nucleophilicα-diketones play crucial roles in switching the reaction pathways.
