Two substituted 3H-indole quaternary ammonium molecules were designed and synthesized using hexamethylphosphoramide (HMPA) as a solvent. The products were purified and characterized by IR, 1H NMR, MS and elemental ana...Two substituted 3H-indole quaternary ammonium molecules were designed and synthesized using hexamethylphosphoramide (HMPA) as a solvent. The products were purified and characterized by IR, 1H NMR, MS and elemental analysis.展开更多
The binding between three surface-active substituted 3H-indole fluorescence probes and bovine serum albumin (BSA) in aqueous solution was studied using fluorescence quenching. The binding constants of 3H-indole molecu...The binding between three surface-active substituted 3H-indole fluorescence probes and bovine serum albumin (BSA) in aqueous solution was studied using fluorescence quenching. The binding constants of 3H-indole molecules with BSA were obtained. According to the F?rster resonance energy transfer theory, the distances between 3H-indole molecules and tryptophan of BSA were calculated. The results show that the oligoethyloxyethylene chain of 3H-indole molecules is longer, the binding between them is stronger, the energy transfer efficiency is higher, and the distance between tryptophan and 3H-indole is nearer.展开更多
Four benzyl substituted pyridine bromide quaternary ammonium salts,1-benzyl-2′-methylpyridinium bromide([Bz-2-CH3Py]Br),1-benzyl-4′-methylpyridinium bromide([Bz-4-CH3Py]Br),1-benzyl-4′-aminopyridinium bromide([Bz-4...Four benzyl substituted pyridine bromide quaternary ammonium salts,1-benzyl-2′-methylpyridinium bromide([Bz-2-CH3Py]Br),1-benzyl-4′-methylpyridinium bromide([Bz-4-CH3Py]Br),1-benzyl-4′-aminopyridinium bromide([Bz-4-NH2Py]Br) and 1-benzyl-4′-dimethylaminopyridinium bromide([BzDMAP]Br),were synthesized by the reaction of benzyl bromide and 2-methylpyridine,4-methylpyridine,4-aminopyridine or 4-dimethylaminopyridine.Their components and structures were characterized by elemental analyses,infrared spectra,electronic spray mass spectra and conductivity.The experimental results of antibacterial activities indicated that the four salts exhibited good antibacterial properties for colibacillus,bacillus subtilus,aurococcus and bacillus thuringiensis.展开更多
In the synthesis N-chiral quaternary ammonium salts from(2S)-N-benzyl-N-methyl-L-tyrosine methyl ester and(3S)-N-methyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester,a substitution occur even with 1.0...In the synthesis N-chiral quaternary ammonium salts from(2S)-N-benzyl-N-methyl-L-tyrosine methyl ester and(3S)-N-methyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester,a substitution occur even with 1.0 eq allyl bromide.That is the benzyl and methyl are removed respectively,and two allyl are attatched,and the compounds are analyzed and characterized by IR,1H NMR,13C NMR and MS methods.展开更多
文摘Two substituted 3H-indole quaternary ammonium molecules were designed and synthesized using hexamethylphosphoramide (HMPA) as a solvent. The products were purified and characterized by IR, 1H NMR, MS and elemental analysis.
基金The work was supported by the National Natural Science Foundation of China(Grant No.90206020,29901001).
文摘The binding between three surface-active substituted 3H-indole fluorescence probes and bovine serum albumin (BSA) in aqueous solution was studied using fluorescence quenching. The binding constants of 3H-indole molecules with BSA were obtained. According to the F?rster resonance energy transfer theory, the distances between 3H-indole molecules and tryptophan of BSA were calculated. The results show that the oligoethyloxyethylene chain of 3H-indole molecules is longer, the binding between them is stronger, the energy transfer efficiency is higher, and the distance between tryptophan and 3H-indole is nearer.
文摘Four benzyl substituted pyridine bromide quaternary ammonium salts,1-benzyl-2′-methylpyridinium bromide([Bz-2-CH3Py]Br),1-benzyl-4′-methylpyridinium bromide([Bz-4-CH3Py]Br),1-benzyl-4′-aminopyridinium bromide([Bz-4-NH2Py]Br) and 1-benzyl-4′-dimethylaminopyridinium bromide([BzDMAP]Br),were synthesized by the reaction of benzyl bromide and 2-methylpyridine,4-methylpyridine,4-aminopyridine or 4-dimethylaminopyridine.Their components and structures were characterized by elemental analyses,infrared spectra,electronic spray mass spectra and conductivity.The experimental results of antibacterial activities indicated that the four salts exhibited good antibacterial properties for colibacillus,bacillus subtilus,aurococcus and bacillus thuringiensis.
文摘In the synthesis N-chiral quaternary ammonium salts from(2S)-N-benzyl-N-methyl-L-tyrosine methyl ester and(3S)-N-methyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester,a substitution occur even with 1.0 eq allyl bromide.That is the benzyl and methyl are removed respectively,and two allyl are attatched,and the compounds are analyzed and characterized by IR,1H NMR,13C NMR and MS methods.
