The karst immersion and waterlogging is one of the typical and the m os t harmful natural disasters in southern karst areas of China. It is threat to th e local production and life for a long time. In recent years, du...The karst immersion and waterlogging is one of the typical and the m os t harmful natural disasters in southern karst areas of China. It is threat to th e local production and life for a long time. In recent years, due to the constru ction of more reservoirs, the disaster became serious. This article takes immers ion and waterlogging of Banwen's subterranean rivers in Yantan reservoir area as an example, researches the daily rainfall's reflection to the water level of re servoir depression, discusses characteristics of immersion and waterlogging of t he valley, analyzes the disaster index in detail, such as water level process, t he highest water level, sensitive rainfall, original waterlogged rainfall and de layed day numbers etc., and provides the reference as a basis to the disaster an alysis.展开更多
Defining and visualizing the three-dimensional(3 D) structures of pharmaceuticals provides a new and important tool to elucidate the phenomenal behavior and underlying mechanisms of drug delivery systems. The mechanis...Defining and visualizing the three-dimensional(3 D) structures of pharmaceuticals provides a new and important tool to elucidate the phenomenal behavior and underlying mechanisms of drug delivery systems. The mechanism of drug release from complex structured dosage forms, such as bilayer osmotic pump tablets, has not been investigated widely for most solid 3 D structures. In this study, bilayer osmotic pump tablets undergoing dissolution, as well as after dissolution in a desiccated solid state were examined, and visualized by synchrotron radiation micro-computed tomography(SR-μCT). In situ formed 3 D structures at different in vitro drug release states were characterized comprehensively. A distinct movement pattern of NaCl crystals from the push layer to the drug layer was observed, beneath the semi-permeable coating in the desiccated tablet samples. The 3 D structures at different dissolution time revealed that the pushing upsurge in the bilayer osmotic pump tablet was directed via peripheral“roadways”. Typically, different regions of the osmotic front, infiltration region, and dormant region were classified in the push layer during the dissolution of drug from tablet samples. According to the observed3 D microstructures, a “subterranean river model” for the drug release mechanism has been defined to explain the drug release mechanism.展开更多
文摘The karst immersion and waterlogging is one of the typical and the m os t harmful natural disasters in southern karst areas of China. It is threat to th e local production and life for a long time. In recent years, due to the constru ction of more reservoirs, the disaster became serious. This article takes immers ion and waterlogging of Banwen's subterranean rivers in Yantan reservoir area as an example, researches the daily rainfall's reflection to the water level of re servoir depression, discusses characteristics of immersion and waterlogging of t he valley, analyzes the disaster index in detail, such as water level process, t he highest water level, sensitive rainfall, original waterlogged rainfall and de layed day numbers etc., and provides the reference as a basis to the disaster an alysis.
基金the National Nature Science Foundation of China (Nos.81803446,81803441 and 81773645)Key Program for International Science and Technology Cooperation Projects of China (2020YFE0201700)the Youth Innovation Promotion Association of CAS (2018323)。
文摘Defining and visualizing the three-dimensional(3 D) structures of pharmaceuticals provides a new and important tool to elucidate the phenomenal behavior and underlying mechanisms of drug delivery systems. The mechanism of drug release from complex structured dosage forms, such as bilayer osmotic pump tablets, has not been investigated widely for most solid 3 D structures. In this study, bilayer osmotic pump tablets undergoing dissolution, as well as after dissolution in a desiccated solid state were examined, and visualized by synchrotron radiation micro-computed tomography(SR-μCT). In situ formed 3 D structures at different in vitro drug release states were characterized comprehensively. A distinct movement pattern of NaCl crystals from the push layer to the drug layer was observed, beneath the semi-permeable coating in the desiccated tablet samples. The 3 D structures at different dissolution time revealed that the pushing upsurge in the bilayer osmotic pump tablet was directed via peripheral“roadways”. Typically, different regions of the osmotic front, infiltration region, and dormant region were classified in the push layer during the dissolution of drug from tablet samples. According to the observed3 D microstructures, a “subterranean river model” for the drug release mechanism has been defined to explain the drug release mechanism.
