Despite significant advances in imaging techniques, the incidence of colorectal cancer has been increasing in recent years, with many cases still being diagnosed in advanced stages. Early detection and accurate stagin...Despite significant advances in imaging techniques, the incidence of colorectal cancer has been increasing in recent years, with many cases still being diagnosed in advanced stages. Early detection and accurate staging remain the main factors that lead to a decrease in the cost and invasiveness of the curative techniques, significantly improving the outcome. However, the diagnosis of pedunculated early colorectal malignancy remains a current challenge. Data on the management of pedunculated cancer precursors, apart from data on nonpolypoid lesions, are still limited. An adequate technique for complete resection, which provides the best long-term outcome, is mandatory for curative intent. In this context, a discussion regarding the diagnosis of malignancy of pedunculated polyps, separate from nonpedunculated variants, is necessary. The purpose of this review is to provide a critical review of the most recent literature reporting the different features of malignant pedunculated colorectal polyps, including diagnosis and management strategies.展开更多
目的观察阿司匹林对结肠腺瘤术后复发及干细胞标志物亮氨酸重复序列G-蛋白偶联受体5(1eucine-rich repeat-containing G protein coupled receptor 5,Lgr5)的影响,分析阿司匹林在防治结肠腺瘤术后复发中的临床价值。方法选取2017年6月至...目的观察阿司匹林对结肠腺瘤术后复发及干细胞标志物亮氨酸重复序列G-蛋白偶联受体5(1eucine-rich repeat-containing G protein coupled receptor 5,Lgr5)的影响,分析阿司匹林在防治结肠腺瘤术后复发中的临床价值。方法选取2017年6月至2018年6月苏北人民医院手术治疗的结肠腺瘤患者85例,随机数字法分为干预组(43例,术后予以常规治疗+阿司匹林治疗)和对照组(42例,术后予以常规治疗)。对比两组的术后复发情况及干细胞标志物Lgr5表达的差异,分析干细胞标志物Lgr5与术后复发的相关性。结果与术前比较,对照组和干预组术后12月的Lgr5表达值均下降,但干预组Lgr5表达值降幅高于对照组(P<0.05)。在术后12月时,对照组的腺瘤复发率为45.24%,显著高于干预组的18.60%(P<0.05)。对照组术后12月的Lgr5阳性率54.76%,显著高于干预组的23.25%(P<0.05)。干细胞标志物Lgr5阳性与术后复发正相关(r=0.785,P=0.014)。结论阿司匹林对结肠腺瘤术后复发有较佳的预防作用,同时由于其可降低结肠腺癌干细胞标注物Lgr5阳性表达率,可能在预防术后结肠腺瘤术后复发中起到一定的作用。展开更多
文摘Despite significant advances in imaging techniques, the incidence of colorectal cancer has been increasing in recent years, with many cases still being diagnosed in advanced stages. Early detection and accurate staging remain the main factors that lead to a decrease in the cost and invasiveness of the curative techniques, significantly improving the outcome. However, the diagnosis of pedunculated early colorectal malignancy remains a current challenge. Data on the management of pedunculated cancer precursors, apart from data on nonpolypoid lesions, are still limited. An adequate technique for complete resection, which provides the best long-term outcome, is mandatory for curative intent. In this context, a discussion regarding the diagnosis of malignancy of pedunculated polyps, separate from nonpedunculated variants, is necessary. The purpose of this review is to provide a critical review of the most recent literature reporting the different features of malignant pedunculated colorectal polyps, including diagnosis and management strategies.
文摘目的观察阿司匹林对结肠腺瘤术后复发及干细胞标志物亮氨酸重复序列G-蛋白偶联受体5(1eucine-rich repeat-containing G protein coupled receptor 5,Lgr5)的影响,分析阿司匹林在防治结肠腺瘤术后复发中的临床价值。方法选取2017年6月至2018年6月苏北人民医院手术治疗的结肠腺瘤患者85例,随机数字法分为干预组(43例,术后予以常规治疗+阿司匹林治疗)和对照组(42例,术后予以常规治疗)。对比两组的术后复发情况及干细胞标志物Lgr5表达的差异,分析干细胞标志物Lgr5与术后复发的相关性。结果与术前比较,对照组和干预组术后12月的Lgr5表达值均下降,但干预组Lgr5表达值降幅高于对照组(P<0.05)。在术后12月时,对照组的腺瘤复发率为45.24%,显著高于干预组的18.60%(P<0.05)。对照组术后12月的Lgr5阳性率54.76%,显著高于干预组的23.25%(P<0.05)。干细胞标志物Lgr5阳性与术后复发正相关(r=0.785,P=0.014)。结论阿司匹林对结肠腺瘤术后复发有较佳的预防作用,同时由于其可降低结肠腺癌干细胞标注物Lgr5阳性表达率,可能在预防术后结肠腺瘤术后复发中起到一定的作用。
