Logistic Regression Analysis the Risk Factors of Peripherally Inserted Central Catheter Related Blood Stream Infection of Tumor Patients

Objective: Our object is to study risk factors of tumor patients’ PICC catheter-related blood stream infection. Method: a retrospective analysis of data of 586 PICC catheterized patients was implemented, a univariate analysis of general data and catheterizing data of tumor patients was then carried out, and data of single factors with statistical significance were incorporated into multi-factor Logistic regression model for analysis. Results: PICC catheter-related blood stream infection occurred to 16 patients, and occurrence rate was 2.73%. Multi-factor Logistic regression analysis results showed that number of puncturing times, positioning method and maintenance frequency were risk factors for tumor patients’ peripherally inserted central catheter catheter-related blood stream infection, and odds risk values were respectively 8.762, 9.253 and 10.324. Conclusion: for tumor patients implanted with peripherally inserted central catheters, using ECG positioning during strict sterile operation and catheterizing process to avoid repeated puncturing and increasing maintenance frequency could effectively reduce occurrence of PICC catheter-related blood stream infection.

Analysis of risk factors for epilepsy after stroke

Objective To explore the risk factors for epilepsy induced by stroke. Methods There were 179 patients with epilepsy caused by stroke,and 1 447 patients with cerebrovascular disorders without epilepsy after stroke. Multivariate noncondition stepwise logistic model analysis was made after single variable analysis.Results The following four factors were associated with epilepsy, i.e., large size of cerebral hemorrhage or cerebral infarction,subarachnoid hemorrhage, electrolyte disturbances and cortical lesions.Conclusion Epilepsy induced by stroke is mainly associated with the size of brain tissue necrosis.

脾虚血瘀型结直肠腺瘤术后复发危险因素的Logistic回归分析

目的:基于Logistic回归分析探讨脾虚血瘀型结直肠腺瘤术后复发的危险因素。方法:将140例脾虚血瘀型结直肠腺瘤患者根据术后1年是否复发分为复发组(68例)与非复发组(72例),比较两组患者的基础信息、中医症状、术前腺瘤特征,并用Logistic回归模型分析脾虚血瘀型结直肠腺瘤术后复发的危险因素。结果:两组患者年龄、性别、腺瘤数量、最大腺瘤直径比较,差异均有统计学意义(P<0.05)。Logistic回归分析提示男性(OR=2.106)、年龄≥50岁(OR=2.090)、腺瘤数量≥3个(OR=2.318)和最大腺瘤直径≥10 mm(OR=2.508)为脾虚血瘀型结直肠腺瘤术后复发的危险因素(P<0.05)。结论:男性、年龄≥50岁、腺瘤数量≥3个和最大腺瘤直径≥10 mm的脾虚血瘀型结直肠腺瘤术后患者应在术后定期进行肠镜监测,预防复发。

影响结核性胸腔积液并发胸膜增厚的非条件Logistic回归分析

目的探讨影响结核性胸腔积液并发胸膜增厚的相关危险因素。方法回顾性分析2019年1月至2021年3月广州市胸科医院呼吸内科收治的123例结核性胸腔积液患者的临床资料,统计患者胸膜增厚情况,采用单因素及非条件Logistic回归法分析患者胸膜增厚的影响因素。结果胸膜未增厚与胸膜增厚患者性别、年龄、肺结核、胸水分布、用力肺活量(FVC)、第1秒用力呼气容积(FVE1)/FVC、胸水腺苷脱氨酶(ADA)、血清ADA、胸水白细胞、胸水淋巴细胞、胸水中性粒细胞和淋巴细胞比例比较差异无统计学意义;胸膜未增厚与胸膜增厚患者胸水量、胸水吸收时间、FVE1、胸水乳酸脱氢酶(LDH)、血清LDH、胸水蛋白、血清蛋白比较差异有统计学意义(P<0.05)。Logistic回归分析结果显示,胸水量(中大量)、FVE1、胸水LDH、血清LDH、胸水蛋白及血清蛋白是胸膜增厚发生的危险因素(P<0.05)。结论结核性胸腔积液并发胸膜增厚是多因素作用的结果,胸水量、FVE1、胸水吸收时间、胸水LDH、血清LDH、胸水蛋白和血清蛋白与胸膜增厚的发生密切相关,建议临床予以密切监测并积极采取针对性干预措施。

Risk factor analysis of post-ERCP cholangitis: A single-center experience

Background: Endoscopic retrograde cholangiopancreatography(ERCP) may have complications. Our study aimed to investigate the risk factors and prevention of post-ERCP cholangitis.Methods: We retrospectively analyzed 4234 cases undergone ERCP in the Affiliated Drum Tower Hospital of Nanjing University Medical School from January 2008 to December 2013. Patient-related factors and procedure-related factors were analyzed to find the risk factors of post-ERCP cholangitis. The time point of post-ERCP cholangitis was also analyzed. Univariate and multivariate analyses were performed to define the independent risk factors of post-ERCP cholangitis.Results: The success rate of ERCP was 96.8%(4099/4234). The overall complication rate was 9.4%(399/4234). Post-ERCP cholangitis occurred in 102 cases(2.4%, 102/4234). The most dangerous time of post-ERCP cholangitis was from 24 h–48 h after ERCP(45.1%, 46/102). Univariate analysis revealed that age, hypertension, diabetes, previous ERCP history, biliary stent insertion, pancreatography, endoscopic sphincterotomy, balloon dilation and hilar obstruction were risk factors of post-ERCP cholangitis(P < 0.05). Multivariate analysis indicated that age, previous ERCP history and hilar obstruction were independent risk factors(P < 0.05). While endoscopic stone extraction was the potential protective factor.Conclusions: Many risk factors are involved in post-ERCP cholangitis. Among them, old age, previous ERCP history and hilar obstruction were independently related to this post-ERCP complication.

Risk factors for intussusception in children with Henoch-Schönlein purpura:A case-control study

BACKGROUND The etiology of Henoch-Schönlein purpura(HSP)with intussusception remains undefined.AIM To investigate the risk factors for intussusception in children with HSP and gastrointestinal(GI)involvement.METHODS Sixty children with HSP and concomitant intussusception admitted to the Beijing Children’s Hospital of Capital Medical University between January 2006 and December 2018 were enrolled in this study.One hundred pediatric patients with HSP and GI involvement but without intussusception,admitted to the same hospital during the same period,were randomly selected as a control group.The baseline clinical characteristics of all patients,including sex,age of onset,duration of disease,clinical manifestations,laboratory test results,and treatments provided,were assessed.Univariate and multiple logistic regression analyses were performed to identify possible risk factors.RESULTS The 60 children in the intussusception group comprised 27 girls(45%)and 33 boys(55%)and the 100 children in the non-intussusception group comprised 62 girls(62%)and 38 boys(38%).The median age of all patients were 6 years and 5 mo.Univariate and multiple regression analyses revealed age at onset,not receiving glucocorticoid therapy within 72 h of emergence of GI symptoms,hematochezia,and D-dimer levels as independent risk factors for intussusception in children with HSP(P<0.05).CONCLUSION The four independent risk factors for intussusception in pediatric HSP with GI involvement would be a reference for early prevention and treatment of this potentially fatal disease.

Environmental risk factors in children with cerebral palsy in Jiamusi,China

Most current studies focus on statistics of the incidence, etiology, and rehabilitative treatment of cerebral palsy. However, very few studies focus on the environmental risk factors for this syndrome In the present study, a total of 202 children with cerebral palsy in the Jiamusi district of China were selected as the case group, and 404 children were randomly selected for the control group. The survey focused on environmental factors during pregnancy, which included indoor pollution as the most dangerous factor （odds ratio = 2.432, 95% confidence interval = 1.172-5.047; P = 0.017）, followed by use of high-radiation mobile phones, more than 5 hours of watching television per day, and cooking with a marble kitchen platform during pregnancy. Results demonstrated that environmental risk factors play a role in the development of cerebral palsy in children.

Risk factors and prediction of macrosomia in a cohort study

Objective: To investigate the risk factors of macrosomia and to predict the risk of macrosomia so as to reduce the incidence of macrosomia. Methods: A total of 2063 pregnant women who met the inclusion criteria were selected as the subjects from February 2016 to April 2017 in Jiading District Maternal and Child Health Hospital of Shanghai and Pudong New Area Maternal and Child Health Hospital. According to the birth weight of the neonates, the neonates were divided into the macrosomia group (neonatal weight > 4000 g, n=125) and the normal infant group (2500 g < neonatal weight < 4000 g, n=1938).The general data of age, number of pregnant women, BMI before pregnancy, gestational diabetes mellitus, glucose tolerance, weight gain during pregnancy, birth weight and gestational week were compared between the two groups. Multivariate logistic regression was used to analyze the risk factors of macrosomia. Results: ①There were significant differences in BMI, glucose tolerance, fasting blood sugar, weight gain in the second trimester, weight gain in the third trimester, birth weight and gestational week between the two groups (P<0.05). ②Single factor analysis showed that pre-pregnancy BMI, gestational week at first diagnosis, fasting blood glucose tolerance, weight gain in the second trimester, weight gain in the third trimester, gestational week and birth weight were the influencing factors of macrosomia (P<0.05). ③Multi-factor analysis showed that gestational weeks, gestational diabetes, fasting glucose tolerance and weight growth in the second trimester were the main factors affecting the production of macrosomia, among which gestational diabetes was the protective factor, while gestational weeks, fasting glucose tolerance and weight growth in the second trimester were the risk factors. Conclusion: The high risk factors for macrosomia are gestational weeks, glucose tolerance, fasting blood sugar and weight gain in the second trimester of pregnancy.We should strengthen regular obstetric examination, health care during pregnancy, reasonable diet and proper exercise, and strictly control the weight gain during the second trimester of pregnancy. At the same time, we should monitor blood sugar in time so as to reduce the incidence of macrosomia.

基于logistic回归分析下颌第三磨牙近中、垂直阻生的危险因素

目的:探讨下颌第三磨牙近中、垂直阻生的危险因素,并基于logistic回归分析构建预测模型。方法:收集2021年6月—2023年12月天津市口腔医院243颗下颌第三磨牙的临床资料,根据萌出类型分为萌出组和阻生组,阻生组包括近中阻生和垂直单侧阻生。单因素分析筛选出具有统计学意义的因素后,采用logistic回归分析方法进行多因素分析,进一步绘制列线图,预测下颌第三磨牙阻生的风险因素。采用SPSS 27.0软件包对数据进行统计学分析。结果:243颗下颌第三磨牙中,萌出组75例(30.86%),阻生组168例(69.14%)。2组年龄、性别、牙根数、Co-Go、Co-Cop、W2、W3、W4和L相比,差异无统计学意义(P>0.05)。萌出组与阻生组Nolla、L-6缺失、L-E缺失、Co-Pog、Co-Go/Co-Pog、L6-MP、α和W1相比,差异有统计学意义(P<0.05)。多因素回归分析显示,Nolla、L-6缺失、L-E缺失、Co-Pog、Co-Go/Co-Pog、L6-MP、α和W1是下颌第三磨牙发生近中、垂直阻生的独立危险因素(P<0.05)。列线图构建显示较高的预测准确性。受试者工作特征曲线(ROC)分析结果表明,独立危险因素联合预测下颌第三磨牙近中、垂直阻生的曲线下面积(AUC)为0.924,95%CI为0.887~0.960,灵敏度为86.9%,特异度为86.7%。结论:Nolla、L-6缺失、L-E缺失、Co-Pog、Co-Go/Co-Pog、L6-MP、α和W1是影响下颌第三磨牙近中、垂直阻生的主要危险因素,利用logistic回归分析和列线图可有效预测阻生风险,为临床治疗提供科学依据。

帕金森病患者用药依从性的Lasso-Logistic回归分析预测模型的建立

目的 基于Lasso-Logistic回归分析构建帕金森病患者用药依从性的评分模型。方法 选取2023年7-12月于安徽医科大学附属六安医院慢病门诊开具抗帕金森病药物的290例患者作为研究对象,分为训练集和验证集,收集其临床资料,采用单因素和多因素Lasso-Logistic回归分析筛选帕金森病患者用药依从性的影响因素,并建立评分模型。结果 290例患者中,依从性差的有99例,发生率为34.14%。年龄≥60岁(OR=6.238,95%CI:3.322~11.713)、个人月收入<2000元(OR=2.174,95%CI:1.007~4.691)、药品种类≥5种(OR=3.182,95%CI:1.501~6.745)、有药物不良反应(OR=4.030,95%CI:1.040~15.617)和社会支持量表评分<23分(OR=3.087,95%CI:1.581~6.029)为帕金森病患者用药依从性差的独立危险因素(P<0.05),接受用药宣教(OR=0.125,95%CI:0.031~0.513)为其保护因素(P<0.05)。基于上述因素构建预测模型:Logit(P)=-7.318+年龄×1.831+个人月收入×0.776+药品种类×1.157-接受用药宣教×2.078+药物不良反应×1.394+社会支持量表评分×1.127。模型验证结果显示,训练集和验证集的一致性指数(C-index)为0.945(95%CI:0.928~0.962)和0.897(95%CI:0.865~0.929);训练集和验证集的校准曲线均趋近于理想曲线,Hosmer-Lemeshow检验结果分别为χ^(2)=4.013、P=0.856和χ^(2)=3.303、P=0.770;训练集和验证集的ROC曲线下面积(AUC)为0.931(95%CI:0.897~0.966)和0.812(95%CI:0.719~0.904);决策曲线显示训练集和验证集的阈值概率分别为4%~100%和1%~75%。结论帕金森病患者用药依从性的影响因素较多,本次构建的评分模型对帕金森病患者用药依从性具有良好的预测能力。

基于Logistic回归分析建立慢性化脓性中耳炎合并听力损失的预测模型

目的:基于Logistic回归分析构建慢性化脓性中耳炎合并听力损失的预测模型。方法:选取2019年1月~2021年12月池州市第二人民医院收治的慢性化脓性中耳炎患者作为研究对象,依据听力损失发生情况分为听力损失组(n=117)和非听力损失组(n=102),使用单因素和多因素logistic回归分析慢性化脓性中耳炎合并听力损失的危险因素,并据此建立Logistic回归预测模型。结果:单因素分析显示,两组患者临床分类、慢性鼻窦炎、鼓室积脓和耳鸣障碍指数(THI)评分差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,活动期、慢性鼻窦炎、鼓室积脓和THI评分高是慢性化脓性中耳炎合并听力损失的独立危险因素(P<0.05)。模型验证结果显示,C-index为0.782(95%CI:0.748~0.816),校准曲线趋近于理想曲线,ROC曲线下面积(AUC)为0.774(95%CI:0.743~0.805),在0%~66%内,模型净获益值>0。结论:活动期、慢性鼻窦炎、鼓室积脓和THI评分高会增加慢性化脓性中耳炎合并听力损失的风险,根据危险因素构建的Logistic回归模型能有效预测慢性化脓性中耳炎合并听力损失的风险。

基于logistic回归分析影响头颈部肿瘤患者睡眠的危险因素以及心理弹性变化轨迹

目的:探讨基于logistic回归分析影响头颈部肿瘤患者睡眠的危险因素以及心理弹性变化轨迹与睡眠之间的相关性。方法:回顾性分析2021年1月—2022年12月河南省肿瘤医院收治的850例头颈部肿瘤患者的临床资料。采用肿瘤心理弹性量表(RS-SC)和匹兹堡睡眠质量指数(PSQI)对患者的睡眠情况和心理弹性变化轨迹进行分析,并将PSQI得分>7分的患者纳入睡眠质量异常组(n=160),PSQI得分≤7分者纳入睡眠质量正常组(n=690)。分析影响头颈部肿瘤患者睡眠质量的风险因素。结果:放疗后,患者的RS-SC评分短暂升高,随着治疗时间的延长,RS-SC评分呈现逐渐降低的趋势,其PSQI得分整体呈先下降后上升的趋势。本研究纳入患者的睡眠质量异常率为18.82%;文化程度较低、放疗晚期、生理因素、环境因素、心理因素及频繁疼痛等因素均是影响头颈部肿瘤者睡眠质量异常的危险因素(OR=1.143、1.125、1.339、1.670、1.250、10.740,P<0.05)。结论:在头颈部肿瘤患者接受治疗期间患者心理弹性和睡眠质量均会发生明显改变,其中文化程度、放疗阶段、疼痛、心理、环境及生理因素均与其睡眠质量相关,应针以上风险因素为患者制定更为科学的干预方案。

创伤性骨折患者合并胸部损伤危险因素的Logistic回归分析

目的探讨创伤性骨折患者合并胸部损伤的危险因素。方法回顾性分析2019-01/2021-12月作者医院收治的3656例骨折住院患者的临床资料,根据是否合并胸部损伤分为胸部损伤组(n=623)和无胸部损伤组(n=3033)。比较骨折合并与不合并胸部损伤患者的年龄、性别、体质量指数(body mass index,BMI)、骨折部位、致伤原因等因素的差异,并通过多因素Logistic回归分析探讨骨折患者合并胸部损伤的独立影响因素。结果骨折合并与不合并胸部损伤患者在年龄、BMI和骨折季节方面比较差异均无统计学意义(P>0.05),而在性别、婚姻状况、文化程度、职业、居住地、骨折类型、骨折部位、骨折原因、骨折地点及基础疾病方面比较差异有统计学意义(P均<0.05)。多因素Logistic回归分析结果显示,小学以下文化程度、农民职业、肩部骨折和车祸伤、坠落伤是骨折患者合并胸部损伤的独立危险因素(P<0.05);而文化程度为初中/中专和大专以上,职业为工人、技术人员、办事人员,骨折部位为上肢、下肢,骨折原因为其他的骨折患者不易发生胸部损伤(P<0.05)。结论肩部骨折、车祸伤及坠落伤的骨折患者更容易合并胸部损伤,而文化程度越高、职业越是轻体力劳动者发生创伤性骨折合并胸部损伤的风险越低。

夏季建筑工地食堂食物中毒调查及危险因素的Logistic回归分析

目的:调查夏季营口市鲅鱼圈区2处建筑工地食堂食物中毒事件,查找该事件发生原因及致病因素,为制定防控措施提供科学依据。方法:按照国家有关食品安全标准与调查技术规范,对营口市鲅鱼圈区建筑工地食堂进行食物中毒筛查,对发生食物中毒工地的相关人员进行流行病学调查,并对病例、食堂留样食物开展相关病原菌分离培养,记录实验室检测信息。结果:2处建筑工地食堂就餐274人,共计209人发生食物中毒。食物中毒符合点源暴露模式,病例临床主要表现为恶心、头晕、呕吐;通过回顾性队列研究和Logistic回归分析发现,荤素包子与梅菜扣肉为食物中毒事件的可疑食品。结论:综合分析流行病学调查结果、现场卫生学调查及病例临床症状等,确定此次事件是因细菌引起的食物中毒事件,荤素包子与梅菜扣肉为最终致病食品。

高校青年教师亚健康危险因素Logistic回归分析

目的 了解高校教师危险人群中亚健康状态的分布情况及其影响因素 ,为高校教师的保健工作提供科学依据。方法 采用统一的调查问卷对广东省 19所高校教师进行亚健康调查 ,并用Logistic回归分析亚健康影响因素。结果 30～ 40岁是高校教师亚健康危险年龄段 ,其中女性重度亚健康高于男性 ;工作不开心、工作时间长、缺乏体育活动等是高校青年教师亚健康状态的危险因素。结论 高校教师亚健康危险人群中应重视女性重度亚健康 ;提高教师对亚健康的认识 ,保持轻松健康心态 ,避免长时期的过度疲劳 ,化解压力 ,合理工作是预防与控制亚健康状态的重要措施。

耐多药结核病危险因素logistic回归分析

目的了解湖北省耐多药结核病产生的危险因素,为预防和控制耐多药结核病提供依据。方法采用1:1配对病例对照研究的方法,在湖北省五个地市结核病防治所整群抽取病例和对照各345例进行问卷调查,计算OR值和95%CI,并用条件logistic回归分析进行多因素分析。结果在单因素分析中,患者职业为农民、家庭人均月收入低、经常饮酒、既往有结核病史、有结核病接触史、既往治疗不规则或失败,其OR值分别为4.591、1.761、1.593、11.082、7.656、8.481(P值均<0.05)。在多因素分析中,既往有结核病史是湖北省耐多药结核病发生的主要危险因素。结论加强对有既往结核病史患者的治疗和管理,并针对其他危险因素采取措施对降低耐多药结核病疫情有重要意义。

脑卒中发病风险logistic回归综合评估模型研究——基于亚洲人群研究数据

目的:基于Meta分析结果,探讨亚洲人群脑卒中发病风险综合评估模型。方法:根据人群脑卒中发病危险因素的队列研究和病例对照研究资料,利用Meta分析方法对其发病危险因素进行合并,根据合并统计量比值比(odds ratio,OR),建立logistic回归综合评估模型。结果:纳入7个队列研究和21个病例对照研究,包含17个危险因素,通过数据筛选,有10个危险因素进入本次模型,包括:总胆固醇(total cholesterol,TC)≥6.00 mmol/L、收缩压(systolic blood pressure,SBP)≥140 mmHg、高血压病史、糖尿病病史、冠心病史、脑卒中家族史、吸烟、长期饮酒、长期运动和高盐饮食,其综合危险度分别为:1.99、5.09、3.97、1.82、2.10、2.64、1.69、1.37、0.60和1.95。结论:本次研究以系统评价为基础,建立了亚洲人群脑卒中风险评估模型,有效地避免了人群样本量偏少的因素,模型具有循证医学证据,为预防亚洲人群脑卒中的发病具有现实意义。

2型糖尿病危险因素的非条件Logistic回归分析

目的 了解广州市海珠区 16岁以上人群 2型糖尿病患病率以及其与膳食营养、经济水平、吸烟、饮酒、体力活动、年龄、性别、文化水平、性格等因素的关系 ,为评估本地区糖尿病现状并采取相应的预防措施提供依据。方法 采用整群抽样方法 ,对海珠区 13个社区 16岁以上居民共 1182 8人进行调查 ,并利用非条件 L ogistic回归进行危险因素分析。结果 筛选出性别、年龄、饮茶、高血压病史、冠心病史及糖尿病家族史等糖尿病危险因素。结论 根据危险因素分析结果 ,对糖尿病的重点监测人群采取有效的干预措施以降低发病。

新生儿重症监护病房多重耐药菌感染危险因素logistic回归分析

目的分析新生儿重症监护病房(NICU)多重耐药菌感染的危险因素。方法回顾性分析2011年6月至2015年7月284例NICU住院患儿的临床资料,比较59例多重耐药菌感染与225例非多重耐药菌感染患儿的差异,并进行多因素logistic分析。结果 284例患儿均为单胎。59例多重耐药菌感染患儿,男42例、女17例,日龄(13.13±9.03)d;225例非多重耐药菌感染患儿,男175例、女50例,日龄(14.21±8.34)d。单因素分析显示,患儿胎龄、出生体质量、住院天数、出生时Apgar评分、机械通气、使用肠外营养、使用抗菌药物种类及持续时间8个因素是患儿多重耐药菌感染的危险因素(P?<?0.05);多因素分析显示,出生体质量、联合使用抗菌药物及抗菌药物使用持续时间是NICU患儿多重耐药菌感染的最主要因素(P?<?0.05)。结论应针对相关危险因素采取有效防控措施,减少NICU患儿多重耐药菌感染。

北京市0～14岁儿童意外伤害危险因素的Logistic回归分析

目的了解北京市0～14岁儿童意外伤害发生现状,探讨伤害发生的危险因素,为控制儿童意外伤害提供流行病学资料.方法随机分层整群抽取北京市城市和农村各1个区县2 368例0～14岁儿童,采用家长问卷方式,调查2002年11月至2003年11月0～14岁儿童意外伤害发生及相关情况.采用非条件Logistic逐步回归分析.结果意外伤害总发生率为13.05%.与意外伤害发生有关的因素包括儿童性别、母亲文化程度、儿童与同龄人相处能力、家长是否担心儿童发生意外伤害、是否对家庭室内电源进行保护性处理等.结论北京市0～14岁儿童意外伤害发生是多因素相互作用的结果.应针对各种因素采取综合预防控制措施.