Some novel sulfonamide-derivatives were designed to develop novel kinase inhibitors. The molecular docking study was performed for the designed compounds against epidermal growth factor kinase receptor T790M/L858R (TM...Some novel sulfonamide-derivatives were designed to develop novel kinase inhibitors. The molecular docking study was performed for the designed compounds against epidermal growth factor kinase receptor T790M/L858R (TMLR) (PDB ID: 5EDQ) to identify new drug candidates for treating cancer. Binding free energy was calculated by Molegro virtual docker (MVD) to select the most promising hits. The corresponding docking score values into EGFR (TMLR) of 4b gave the best energy docking -147.213 Kcal/mol. And some of the designed sulfonamide derivatives have been synthesized by conventional method in addition to a microwave-assisted method of synthesis. The reaction of an amino group-containing drug;sulfamethoxazole and sulfanilamide with carbonyl group in benzoyl chloride and phthalic acid in basic media, generated a series of sulfonamide derivatives. The structures of all the synthesized compounds were well characterized by Mass spectrometry (MS), Infrared spectroscopy (IR), <sup><span style="font-family:Verdana;">1</span></sup><span style="font-family:Verdana;">H nuclear magnetic resonance (</span><sup><span style="font-family:Verdana;">1</span></sup><span style="font-family:Verdana;">H NMR), </span><sup><span style="font-family:Verdana;">13</span></sup><span style="font-family:Verdana;">C nuclear magnetic resonance (</span><sup><span style="font-family:Verdana;">13</span></sup><span style="font-family:Verdana;">C NMR) and elemental analysis. After obtaining experimental data regarding the yield and the time taken for the synthesis by both the approaches, conventional and microwave-assisted method, it was shown that the microwave-assisted method gave higher yield with shorter time and higher temperature compared to conventional heating methods.</span>展开更多
By orthodox experiment, the main influence factors of desulfurization by sulfolobas of pH value, temperature, coal slurry concentration and coal granularity are studied in detail and the optimal experimental condition...By orthodox experiment, the main influence factors of desulfurization by sulfolobas of pH value, temperature, coal slurry concentration and coal granularity are studied in detail and the optimal experimental conditions were also obtained. The experimental results demonstrate that sulfolobas being kind of linking-heat, acidophilic and self-supported bacterium with double characters can effectively remove inorganic and organic sulfur in coal. The superlatively desulfurization rate is up to 48.57% total sulfur and 41.71% inorganic sulfur within 10 d and its desulfurization rate can be greatly affected by the four factors above mentioned. Therefore, the optimum conditions of desulfurization are obtained by comprehensive experiment and they are as following: pH value 3, temperature 70℃, coal slurry concentration 10% and coal granularity 150 μm, respectively. Moreover, the repetition experimental results confirm that the desulfurization by sulfolobas is steady.展开更多
安哥拉Benguela Sul 220 kV变电站综合自动化系统按照“无人值班”(少人值守)的原则进行设计,计算机监控系统由站控层和间隔层组成,采用全开放分层分布式网络结构。站控层是整个变电站的一、二次设备管理、控制、监视、测量的中心,监控...安哥拉Benguela Sul 220 kV变电站综合自动化系统按照“无人值班”(少人值守)的原则进行设计,计算机监控系统由站控层和间隔层组成,采用全开放分层分布式网络结构。站控层是整个变电站的一、二次设备管理、控制、监视、测量的中心,监控系统采用双环形光纤以太网计算机局域网连接方式,间隔层通过100Mbps光纤交换式快速以太网或RS485总线与站控层设备通信。本站采用光纤通信+载波通信方式,计算机监控系统通过远动通信设备与调度中心通信。展开更多
Soil bioengineering has been applied more and more in different regions of Brazil in recent years. The study in hand presents the installation of “new” riparian forest based on soil bioengineering techniques. This r...Soil bioengineering has been applied more and more in different regions of Brazil in recent years. The study in hand presents the installation of “new” riparian forest based on soil bioengineering techniques. This riverbank restoration work was implemented in the year 2010 and two onsite vegetation surveys, one shortly after the construction, and one in 2013. Besides that, the structures of reinforcement work, and its effectiveness were evaluated. By means of the vegetation survey, the applied species were examined for their ability to establish the riverbank in an environmentally sustainable way. Most notably, the species Calliandra brevipes Benth. (Fabaceae, Mimosoideae), Phyllanthus sellowianus Müller Arg. (Euphorbiaceae), Salix humboldtiana Willd. (Salicaceae), Bauhinia forficate Link (Leguminosae), Inga marginata Willd. (Mimosoideae) and Ateleia glazioveana Baill. (Leguminosae, Papilionoideae) showed a good growth development. The proportion of spontaneous vegetation increased significantly, with Pennisetum purpureum Schumach. becoming a dominating species. Resulting from that, the intervention can be assessed as functional and safe, but the strong increase of spontaneous vegetation is undesirable due to less flood resistance. The vegetated riprap could be the best to meet the expectations of the construction elements. Partly, the anchored willows showed as well a good growth development whereas the species used for the hedge brush layer could not develop as expected in large parts of the construction.展开更多
文摘Some novel sulfonamide-derivatives were designed to develop novel kinase inhibitors. The molecular docking study was performed for the designed compounds against epidermal growth factor kinase receptor T790M/L858R (TMLR) (PDB ID: 5EDQ) to identify new drug candidates for treating cancer. Binding free energy was calculated by Molegro virtual docker (MVD) to select the most promising hits. The corresponding docking score values into EGFR (TMLR) of 4b gave the best energy docking -147.213 Kcal/mol. And some of the designed sulfonamide derivatives have been synthesized by conventional method in addition to a microwave-assisted method of synthesis. The reaction of an amino group-containing drug;sulfamethoxazole and sulfanilamide with carbonyl group in benzoyl chloride and phthalic acid in basic media, generated a series of sulfonamide derivatives. The structures of all the synthesized compounds were well characterized by Mass spectrometry (MS), Infrared spectroscopy (IR), <sup><span style="font-family:Verdana;">1</span></sup><span style="font-family:Verdana;">H nuclear magnetic resonance (</span><sup><span style="font-family:Verdana;">1</span></sup><span style="font-family:Verdana;">H NMR), </span><sup><span style="font-family:Verdana;">13</span></sup><span style="font-family:Verdana;">C nuclear magnetic resonance (</span><sup><span style="font-family:Verdana;">13</span></sup><span style="font-family:Verdana;">C NMR) and elemental analysis. After obtaining experimental data regarding the yield and the time taken for the synthesis by both the approaches, conventional and microwave-assisted method, it was shown that the microwave-assisted method gave higher yield with shorter time and higher temperature compared to conventional heating methods.</span>
文摘By orthodox experiment, the main influence factors of desulfurization by sulfolobas of pH value, temperature, coal slurry concentration and coal granularity are studied in detail and the optimal experimental conditions were also obtained. The experimental results demonstrate that sulfolobas being kind of linking-heat, acidophilic and self-supported bacterium with double characters can effectively remove inorganic and organic sulfur in coal. The superlatively desulfurization rate is up to 48.57% total sulfur and 41.71% inorganic sulfur within 10 d and its desulfurization rate can be greatly affected by the four factors above mentioned. Therefore, the optimum conditions of desulfurization are obtained by comprehensive experiment and they are as following: pH value 3, temperature 70℃, coal slurry concentration 10% and coal granularity 150 μm, respectively. Moreover, the repetition experimental results confirm that the desulfurization by sulfolobas is steady.
文摘安哥拉Benguela Sul 220 kV变电站综合自动化系统按照“无人值班”(少人值守)的原则进行设计,计算机监控系统由站控层和间隔层组成,采用全开放分层分布式网络结构。站控层是整个变电站的一、二次设备管理、控制、监视、测量的中心,监控系统采用双环形光纤以太网计算机局域网连接方式,间隔层通过100Mbps光纤交换式快速以太网或RS485总线与站控层设备通信。本站采用光纤通信+载波通信方式,计算机监控系统通过远动通信设备与调度中心通信。
文摘Soil bioengineering has been applied more and more in different regions of Brazil in recent years. The study in hand presents the installation of “new” riparian forest based on soil bioengineering techniques. This riverbank restoration work was implemented in the year 2010 and two onsite vegetation surveys, one shortly after the construction, and one in 2013. Besides that, the structures of reinforcement work, and its effectiveness were evaluated. By means of the vegetation survey, the applied species were examined for their ability to establish the riverbank in an environmentally sustainable way. Most notably, the species Calliandra brevipes Benth. (Fabaceae, Mimosoideae), Phyllanthus sellowianus Müller Arg. (Euphorbiaceae), Salix humboldtiana Willd. (Salicaceae), Bauhinia forficate Link (Leguminosae), Inga marginata Willd. (Mimosoideae) and Ateleia glazioveana Baill. (Leguminosae, Papilionoideae) showed a good growth development. The proportion of spontaneous vegetation increased significantly, with Pennisetum purpureum Schumach. becoming a dominating species. Resulting from that, the intervention can be assessed as functional and safe, but the strong increase of spontaneous vegetation is undesirable due to less flood resistance. The vegetated riprap could be the best to meet the expectations of the construction elements. Partly, the anchored willows showed as well a good growth development whereas the species used for the hedge brush layer could not develop as expected in large parts of the construction.
