Objective: To discuss the actual effect of ilaprazole enteric-coated tablets in the treatment of peptic ulcer patients. Methods: 200 peptic ulcer patients who received treatment from January to December 2023 were sele...Objective: To discuss the actual effect of ilaprazole enteric-coated tablets in the treatment of peptic ulcer patients. Methods: 200 peptic ulcer patients who received treatment from January to December 2023 were selected as the study sample, and all patients were randomly and evenly divided into the study group (n = 100) and the control group (n = 100), and the serum inflammatory factors and the disappearance time of symptoms were compared. Results: After treatment, the serum inflammatory factors in the observation group were better than those in the control group, and the time of belching and burning sensation in the observation group was shorter than that in the control group, all of which were statistically significant (P Conclusion: Ilaprazole enteric-coated tablets in the treatment of peptic ulcer have a good effect and can effectively improve the symptoms of patients with clinical signs, with reference significance.展开更多
Objective:To investigate and analyze the clinical effect of clopidogrel bisulfate tablets combined with aspirin enteric-coated tablets on acute myocardial infarction(AMI)patients.Methods:The study period was from Janu...Objective:To investigate and analyze the clinical effect of clopidogrel bisulfate tablets combined with aspirin enteric-coated tablets on acute myocardial infarction(AMI)patients.Methods:The study period was from January 2020 to December 2023,the sample source was 82 AMI patients admitted to our hospital,grouped into an observation group(n=41)and a control group(n=41)by the numerical table method.The patients in the control group were treated with aspirin enteric-coated tablets,and the patients in the observation group were treated with aspirin enteric-coated tablets combined with clopidogrel bisulfate.The clinical efficacy,coagulation indexes,and the incidence of cardiovascular adverse events between the two groups were compared.Results:The clinical efficacy of the observation group was higher than that of the control group(P<0.05);the platelet aggregation rate(PAR)of the observation group was lower than that of the con-trol group after treatment(P<0.05),and there was no significant difference in the prothrombin time(PT)and activated partial thromboplastin time(APTT)between the two groups(P>0.05).The incidence of cardiovascular adverse events in the observation group was lower than that of the control group(P<0.05).Conclusion:The treatment effect of clopidogrel bisulfate tablets combined with aspirin enteric-coated tablets on AMI patients is remarkable.It reduces the PAR and the incidence of cardiovascular adverse events,so this treatment method should be popularized.展开更多
A methodology(HPLC)proposed in this paper for simultaneously quantitative determination of ilaprazole and its related impurities in commercial tablets was developed and validated.The chromatographic separation was car...A methodology(HPLC)proposed in this paper for simultaneously quantitative determination of ilaprazole and its related impurities in commercial tablets was developed and validated.The chromatographic separation was carried out by gradient elution using an Agilent C8 column(4.6 mm×250 mm,5 mm)which was maintained at 25℃.The mobile phase composed of solvent A(methanol)and solvent B(solution consisting 0.02 mmol/l monopotassium phosphate and 0.025 mmol/l sodium hydroxide)was at a flow rate of 1.0 ml/min.The samples were detected and quantified at 237 nm using an ultraviolet absorbance detector.Calibration curves of all analytes from 0.5 to 3.5 mg/ml were good linearity(r≥0.9990)and recovery was greater than 99.5% for each analyte.The lower limit of detection(LLOD)and quantification(LOQ)of this analytical method were 10 ng/ml and 25 ng/ml for all impurities,respectively.The stress studies indicated that the degradation products could not interfere with the detection of ilaprazole and its related impurities and the assay can thus be considered stability-indicating.The method precisions were in the range of 0.41-1.21 while the instrument precisions were in the range of 0.38-0.95 in terms of peak area RSD% for all impurities,respectively.This method is considered stabilityindicating and is applicable for accurate and simultaneous measuring of the ilaprazole and its related impurities in commercial enteric-coated tablets.展开更多
BACKGROUND Enteric-coated medications are supposed to pass intact through the gastric environment and to release the drug content into the small intestine or the colon.Before dissolution of the enteric coating,they ma...BACKGROUND Enteric-coated medications are supposed to pass intact through the gastric environment and to release the drug content into the small intestine or the colon.Before dissolution of the enteric coating,they may appear hyperdense on computed tomography(CT).Unfortunately,few reports have been published on this topic so far.In this case report,the hyperdense appearance on contrastenhanced CT of an enteric-coated mesalamine tablet was initially misinterpreted as a jejunal gastrointestinal stromal tumor(GIST).CASE SUMMARY An asymptomatic 81-year-old male patient,who had undergone laparoscopic right nephrectomy four years earlier for stage 1 renal carcinoma,was diagnosed with a jejunal GIST at the 4-year follow-up thoraco-abdominal CT scan.He was referred to our hub hospital for gastroenterological evaluation,and subsequently underwent 18-fluorodeoxyglucose positron emission tomography,abdominal magnetic resonance imaging,and video capsule endoscopy.None of these examinations detected any lesion of the small intestine.After reviewing all the CT images in a multidisciplinary setting,the panel estimated that the hyperdense jejunal image was consistent with a tablet rather than a GIST.The tablet was an 800 mg delayed-release enteric-coated oral mesalamine tablet(Asacol®),which had been prescribed for non-specific colitis,while not informing the hospital physicians.CONCLUSION Delayed-release oral mesalamine(Asacol®),like other enteric-coated medications,can appear as a hyperdense image on a CT scan,mimicking a small intestinal GIST.Therefore,adetailed knowledge of the patients’medications and a multidisciplinary review of the images areessential.展开更多
目的:系统评价白芍总苷胶囊联合柳氮磺吡啶片对比柳氮磺吡啶片治疗强直性脊柱炎的疗效和安全性,为其临床应用提供循证参考。方法:计算机检索Pub Med、EMBase、Medline、Cochrane图书馆、中国期刊全文数据库、中文科技期刊数据库、万方...目的:系统评价白芍总苷胶囊联合柳氮磺吡啶片对比柳氮磺吡啶片治疗强直性脊柱炎的疗效和安全性,为其临床应用提供循证参考。方法:计算机检索Pub Med、EMBase、Medline、Cochrane图书馆、中国期刊全文数据库、中文科技期刊数据库、万方数据库中相关文献,收集白芍总苷胶囊联合柳氮磺吡啶片(试验组)对比单用柳氮磺吡啶片(对照组)治疗强直性脊柱炎疗效(总有效率、晨僵时间、扩胸度、关节疼痛指数、红细胞沉降率、C反应蛋白水平、Schober试验值)和安全性(腹泻、白细胞减少、肝功异常发生率)的随机对照试验(RCT),对符合纳入标准的文献进行资料提取,并采用Cochrane风险偏倚评估工具5.1.0进行质量评价后,采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入9项RCT,合计593例患者。Meta分析结果显示,试验组患者总有效率[OR=3.90,95%CI(2.24,6.80),P<0.01]、晨僵时间[MD=-5.05,95%CI(-6.96,-3.14),P<0.01]、扩胸度[MD=0.26,95%CI(0.07,0.46),P<0.01]、关节疼痛指数[MD=-1.28,95%CI(-2.13,-0.43),P<0.01]、C反应蛋白水平[MD=-0.78,95%CI(-1.44,-0.12),P=0.02]、肝功能异常发生率[MD=0.23,95%CI(0.10,0.50),P<0.01]等方面均优于对照组,而两组患者红细胞沉降率[MD=-2.68,95%CI(-8.45,3.08),P=0.36]、Schober试验值[MD=0.24,95%CI(-0.15,0.63),P=0.23]、腹泻发生率[OR=1.39,95%CI(0.62,3.12),P=0.43]、白细胞减少发生率[OR=0.33,95%CI(0.06,1.79),P=0.20]比较,差异均无统计学意义。结论:白芍总苷胶囊联合柳氮磺吡啶片可显著提高治疗强直性脊柱炎的总有效率,缩短晨僵时间,扩大扩胸度,降低关节疼痛指数和C反应蛋白水平,同时能降低肝功能异常的发生。展开更多
目的:建立用HPLC测定柳氮磺吡啶肠溶片含量的方法。方法:色谱柱为YMC-Pack Pro C_(18)RS(4.6mm×250 mm,5μm),流动相0.1mol·L^(-1)醋酸铵(冰醋酸调节pH值至4.8)-甲醇(60:40),检测波长362 nm。结果:柳氮磺吡啶浓度在2.9~735.8...目的:建立用HPLC测定柳氮磺吡啶肠溶片含量的方法。方法:色谱柱为YMC-Pack Pro C_(18)RS(4.6mm×250 mm,5μm),流动相0.1mol·L^(-1)醋酸铵(冰醋酸调节pH值至4.8)-甲醇(60:40),检测波长362 nm。结果:柳氮磺吡啶浓度在2.9~735.8μg·mL^(-1)范围内线性关系良好(r=0.999 9),平均回收率为99.1%(n=9)。结论:本方法准确,专属性强,可用于柳氮磺吡啶肠溶片的含量测定。展开更多
文摘Objective: To discuss the actual effect of ilaprazole enteric-coated tablets in the treatment of peptic ulcer patients. Methods: 200 peptic ulcer patients who received treatment from January to December 2023 were selected as the study sample, and all patients were randomly and evenly divided into the study group (n = 100) and the control group (n = 100), and the serum inflammatory factors and the disappearance time of symptoms were compared. Results: After treatment, the serum inflammatory factors in the observation group were better than those in the control group, and the time of belching and burning sensation in the observation group was shorter than that in the control group, all of which were statistically significant (P Conclusion: Ilaprazole enteric-coated tablets in the treatment of peptic ulcer have a good effect and can effectively improve the symptoms of patients with clinical signs, with reference significance.
文摘Objective:To investigate and analyze the clinical effect of clopidogrel bisulfate tablets combined with aspirin enteric-coated tablets on acute myocardial infarction(AMI)patients.Methods:The study period was from January 2020 to December 2023,the sample source was 82 AMI patients admitted to our hospital,grouped into an observation group(n=41)and a control group(n=41)by the numerical table method.The patients in the control group were treated with aspirin enteric-coated tablets,and the patients in the observation group were treated with aspirin enteric-coated tablets combined with clopidogrel bisulfate.The clinical efficacy,coagulation indexes,and the incidence of cardiovascular adverse events between the two groups were compared.Results:The clinical efficacy of the observation group was higher than that of the control group(P<0.05);the platelet aggregation rate(PAR)of the observation group was lower than that of the con-trol group after treatment(P<0.05),and there was no significant difference in the prothrombin time(PT)and activated partial thromboplastin time(APTT)between the two groups(P>0.05).The incidence of cardiovascular adverse events in the observation group was lower than that of the control group(P<0.05).Conclusion:The treatment effect of clopidogrel bisulfate tablets combined with aspirin enteric-coated tablets on AMI patients is remarkable.It reduces the PAR and the incidence of cardiovascular adverse events,so this treatment method should be popularized.
文摘A methodology(HPLC)proposed in this paper for simultaneously quantitative determination of ilaprazole and its related impurities in commercial tablets was developed and validated.The chromatographic separation was carried out by gradient elution using an Agilent C8 column(4.6 mm×250 mm,5 mm)which was maintained at 25℃.The mobile phase composed of solvent A(methanol)and solvent B(solution consisting 0.02 mmol/l monopotassium phosphate and 0.025 mmol/l sodium hydroxide)was at a flow rate of 1.0 ml/min.The samples were detected and quantified at 237 nm using an ultraviolet absorbance detector.Calibration curves of all analytes from 0.5 to 3.5 mg/ml were good linearity(r≥0.9990)and recovery was greater than 99.5% for each analyte.The lower limit of detection(LLOD)and quantification(LOQ)of this analytical method were 10 ng/ml and 25 ng/ml for all impurities,respectively.The stress studies indicated that the degradation products could not interfere with the detection of ilaprazole and its related impurities and the assay can thus be considered stability-indicating.The method precisions were in the range of 0.41-1.21 while the instrument precisions were in the range of 0.38-0.95 in terms of peak area RSD% for all impurities,respectively.This method is considered stabilityindicating and is applicable for accurate and simultaneous measuring of the ilaprazole and its related impurities in commercial enteric-coated tablets.
文摘BACKGROUND Enteric-coated medications are supposed to pass intact through the gastric environment and to release the drug content into the small intestine or the colon.Before dissolution of the enteric coating,they may appear hyperdense on computed tomography(CT).Unfortunately,few reports have been published on this topic so far.In this case report,the hyperdense appearance on contrastenhanced CT of an enteric-coated mesalamine tablet was initially misinterpreted as a jejunal gastrointestinal stromal tumor(GIST).CASE SUMMARY An asymptomatic 81-year-old male patient,who had undergone laparoscopic right nephrectomy four years earlier for stage 1 renal carcinoma,was diagnosed with a jejunal GIST at the 4-year follow-up thoraco-abdominal CT scan.He was referred to our hub hospital for gastroenterological evaluation,and subsequently underwent 18-fluorodeoxyglucose positron emission tomography,abdominal magnetic resonance imaging,and video capsule endoscopy.None of these examinations detected any lesion of the small intestine.After reviewing all the CT images in a multidisciplinary setting,the panel estimated that the hyperdense jejunal image was consistent with a tablet rather than a GIST.The tablet was an 800 mg delayed-release enteric-coated oral mesalamine tablet(Asacol®),which had been prescribed for non-specific colitis,while not informing the hospital physicians.CONCLUSION Delayed-release oral mesalamine(Asacol®),like other enteric-coated medications,can appear as a hyperdense image on a CT scan,mimicking a small intestinal GIST.Therefore,adetailed knowledge of the patients’medications and a multidisciplinary review of the images areessential.
文摘目的:系统评价白芍总苷胶囊联合柳氮磺吡啶片对比柳氮磺吡啶片治疗强直性脊柱炎的疗效和安全性,为其临床应用提供循证参考。方法:计算机检索Pub Med、EMBase、Medline、Cochrane图书馆、中国期刊全文数据库、中文科技期刊数据库、万方数据库中相关文献,收集白芍总苷胶囊联合柳氮磺吡啶片(试验组)对比单用柳氮磺吡啶片(对照组)治疗强直性脊柱炎疗效(总有效率、晨僵时间、扩胸度、关节疼痛指数、红细胞沉降率、C反应蛋白水平、Schober试验值)和安全性(腹泻、白细胞减少、肝功异常发生率)的随机对照试验(RCT),对符合纳入标准的文献进行资料提取,并采用Cochrane风险偏倚评估工具5.1.0进行质量评价后,采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入9项RCT,合计593例患者。Meta分析结果显示,试验组患者总有效率[OR=3.90,95%CI(2.24,6.80),P<0.01]、晨僵时间[MD=-5.05,95%CI(-6.96,-3.14),P<0.01]、扩胸度[MD=0.26,95%CI(0.07,0.46),P<0.01]、关节疼痛指数[MD=-1.28,95%CI(-2.13,-0.43),P<0.01]、C反应蛋白水平[MD=-0.78,95%CI(-1.44,-0.12),P=0.02]、肝功能异常发生率[MD=0.23,95%CI(0.10,0.50),P<0.01]等方面均优于对照组,而两组患者红细胞沉降率[MD=-2.68,95%CI(-8.45,3.08),P=0.36]、Schober试验值[MD=0.24,95%CI(-0.15,0.63),P=0.23]、腹泻发生率[OR=1.39,95%CI(0.62,3.12),P=0.43]、白细胞减少发生率[OR=0.33,95%CI(0.06,1.79),P=0.20]比较,差异均无统计学意义。结论:白芍总苷胶囊联合柳氮磺吡啶片可显著提高治疗强直性脊柱炎的总有效率,缩短晨僵时间,扩大扩胸度,降低关节疼痛指数和C反应蛋白水平,同时能降低肝功能异常的发生。
