Iodine catalyzed efficient synthesis of symmetrical diaryl sulfoxides from arenes and thionyl chloride under solvent-free conditions

Synthesis of symmetrical diaryl sulfoxides from arenes and thionyl chloride in the presence of a catalytic amount of iodine at room temperature under solvent-free conditions is described. Mild reaction conditions, easy workup, high yield, and easily available catalyst are important features of this method.

A Novel Efficient Method for Synthesis of β-Organoseleno Substituted Allyl Sulfoxides

Hydroselenation of 1, 2-allenyl sulfoxides give 2-organoseleno substituted allyl sulfoxides in high yields and the reaction is absolute regioselective.

ADSORPTION OF SULFOXIDES ON SOLID FROM AQUEOUS SOLUTIONS——Ⅲ.THE ADSORPTION ON CARBON BLACK

The adsorption of decylmethylsulfoxide(DEMS)onto carbon black and the effects of temperature,salt(NaCl)and acid (HCl)have been measured.Typical two plateaux type adsorption isotherms were obtained.Applying the two step model of surfactant adsorption on solid/liquld interface and the general adsorption isotherm equation[9]the experimental results were interpreted qualitatively and quantitatively.

Selective and mild oxidation of sulfides to sulfoxides by H_2O_2 using DBUH-Br_3 as catalyst

DBUH-Br_3 catalyzed selective conversion of sulfides to sulfoxides in the presence of H_2O_2 as oxidizing agent is described.The reaction was performed selectively at room temperature and relatively short reaction times.

Efficient preparation of Zr(Ⅳ)-salen grafted mesoporous MCM-41catalyst for chemoselective oxidation of sulfides to sulfoxides and Knoevenagel condensation reactions

Zr（IV）-salen-MCM-41 was prepared by reaction of NH2-MCM-41 with salicylaldehyde to afford Schiff base ligands. Thereafter, ZrOCh.SH2O was reacted with the Schiff base ligands for complex formation. The structural properties of the synthesized materials were investigated by a number of analytical techniques including X-ray diffraction, N2 sorption-desorption, thermogravimetric analysis, Fourier transform infrared spectroscopy, inductively coupled plasma atomic emission spectroscpopy, and energy dispersive X-ray spectroscopy. Catalytic studies of the mesoporous materials functionalized with Zr（IV）-Schiff base complexes were investigated and extended to selective oxida- tion of sulfides to sulfoxides and the Knoevenagel condensation reactions of aldehydes with malo- nonitriles and ethyl cyanoacetate. Additionally, catalyst recycling of the Zr-salen-MCM-41 materials was also studied.

Electrooxidative trifunctionalization of alkenes with N-chlorosuccinimide and ArSSAr/ArSH to α,β-dichloride arylsulfoxides

An unprecedented electrochemical oxidative trifunctionalization of olefins with diaryl disulfides/aryl thiols and N-chlorosuccinimide in an aqueous system is developed.Two C-Cl bonds,one C-S bond,and one S=O bond are produced simultaneously in one step from simple and commercially available starting materials with clean energy.This tandem methodology features as mild reaction conditions,transition metal and additional oxidant free,broad substrate scope,good functional group compatibility,and gram scale preparation.

Oxidation of aromatic sulfides with molecular oxygen:Controllable synthesis of sulfoxides or sulfones

The recent development of selective oxidation of aromatic sulfides with molecular oxygen was highlighted.The sulfoxides and sulfones could be obtained by simply switching the reaction media,i.e.,bis(2-butoxyethyl)ether(BBE)or poly(ethylene glycol)dimethyl ether(PEGDME).The application of the high-boiling-point polyether as an initiator and green media can eliminate the need of large quantities of additives and volatile solvents.This strategy represents an economic and eco-friendly method that could find potential applications.

Synthesis of Chiral Sulfoxides and Application in Enantioselective Allylation of Aldehydes with Allyltrichlorosilane

1 Results The enantioselective addition of allylic organometallic reagents to aldehydes is a fundamental tool in organic synthesis.The high degree of both diastereo-and enantioselectivity gives the possibility to obtain a wide series of homoallylic alcohols,versatile intermediates in a great number of synthesis[1]. One of the most successful approaches is related to the discovery that organocatalytic activation of the nucleophilic allyltrichlorosilanes by means of neutral Lewis bases,such as formamides,...

Poly(4-vinylpyridinium tribromide) as metal-free,green and recoverable oxidizing polymer for the chemoselective oxidation of sulfides into sulfoxides

Poly（4-vinylpyridinium tribromide） was prepared from poly（4-vinylpyridin） and used for the selective oxidation of a variety of sulfides to the corresponding sulfoxides. The oxidation reaction was carried out heterogeneously in acetone/water, as green solvent, at room temperature.

Reaction of Alkanesulfinyl Chloride with Grignard Reagents： a Convenient Synthesis of Alkyl Sulfoxides

Alkyl sulfoxides were synthesized in good yields from the reaction of alkanesulfinyl chloride with Grignard reagents in the presence of zinc chloride.

Effect of EtOH on the E-Iodohydroxylation of 1,2-Allenylic Sulfoxides with I_(2)

The E-iodohydroxylation of 1,2-allenylic sulfoxides with I2 in the presence of EtOH afforded 3-phenylsulfinyl- 2-iodo-2(E)-alkenols in good yields and regio/stereo-selectivities under very mild conditions.

An effective'salt in dimethyl sulfoxide/water'electrolyte enables high-voltage supercapacitor operated at-50℃

Compared with organic electrolytes,aqueous electrolytes exhibit significantly higher ionic conductivity and possess inherent safety features,showcasing unique advantages in supercapacitors.However,challenges remain for low-salt aqueous electrolytes operating at high voltage and low temperature.Herein,we report a low-salt(0.87 m,m means mol kg^(-1))'salt in dimethyl sulfoxide/water'hybrid electrolyte with non-flammability via hybridizing aqueous electrolyte with an organic co-solvent of dimethyl sulfoxide(hydrogen bond acceptor).As a result,the 0.87 m hybrid electrolyte exhibits enhanced electrochemical stability,a freezing temperature below-50℃,and an outstanding ionic conductivity of 0.52mS cm~(-1)at-50℃.Dimethyl sulfoxide can anchor water molecules through intermolecular hydrogen bond interaction,effectively reinforcing the stability of water in the hybrid electrolyte.Furthermore,the interaction between dimethyl sulfoxide and water molecules diminishes the involvement of water in the generation of ordered ice crystals,finally facilitating the low-temperature performance of the hybrid electrolyte.When paired with the 0.87 m'salt in dimethyl sulfoxide/water'hybrid electrolyte,the symmetric supercapacitor presents a 2.0 V high operating voltage at 25℃,and can operate stably at-50℃.Importantly,the suppressed electrochemical reaction of water at-50℃further leads to the symmetric supercapacitor operated at a higher voltage of 2.6 V.This modification strategy opens an effective avenue to develop low-salt electrolytes for high-voltage and low-temperature aqueous supercapacitors.

磺化多孔碳和过氧化氢催化氧化有机化合物(英文)

The oxidation of organic compounds by sulfonated porous carbon and H2O2 was studied at room temperature. Alkyl and aryl sulfides were oxidized to the corresponding sulfoxides or sulfones in excellent yields. Secondary alcohols were also converted to the corresponding esters/lactones and aldehydes to methyl esters in good yields. Moreover,aliphatic tertiary amines and substituted pyridines were oxidized to N-oxides.

WO_(3)/Salan/30%H_(2)O_(2):a Heterogeneous Catalytic System for the Asymmetric Oxidation of Sulfides

The asymmetric oxidation of sulfides catalyzed by WO3 and 30% H2O2 in the presence of salan as chiral ligands under heterogeneous conditions is described. The reaction system is very easily to be operated. Mild to high chemical yields and moderate enantioselectivities were obtained.

Overview, prevention and management of chemotherapy extravasation

Chemotherapy extravasation remains an accidental complication of chemotherapy administration and may result in serious damage to patients. We review in this article the clinical aspects of chemotherapy extravasation and latest advances in definitions, classification, pre-vention, management and guidelines. We review the grading of extravasation and tissue damage according to various chemotherapeutic drugs and present an update on treatment and new antidotes including dexrazoxane for anthracyclines extravasation. We highlight the importance of education and training of the oncology team for prevention and prompt pharmacological and non-pharmacological management and stress the availability of new antidotes like dexrazoxane wherever anthracyclines are being infused.

Dimethyl sulfoxide inhibits zymosan-induced intestinal inflammation and barrier dysfunction

AIM: To investigate whether dimethyl sulfoxide(DMSO) inhibits gut inflammation and barrier dysfunction following zymosan-induced systemic inflammatoryresponse syndrome and multiple organ dysfunction syndrome.METHODS: Sprague-Dawley rats were randomly divided into four groups: sham with administration of normal saline(SS group); sham with administration of DMSO(SD group); zymosan with administration of normal saline(ZS group); and zymosan with administration of DMSO(ZD group). Each group contained three subgroups according to 4 h,8 h,and 24 h after surgery. At 4 h,8 h,and 24 h after intraperitoneal injection of zymosan(750 mg/kg),the levels of intestinal inflammatory cytokines [tumor necrosis factor-alpha(TNF-α) and interleukin(IL)-10] and oxides(myeloperoxidase,malonaldehyde,and superoxide dismutase) were examined. The levels of diamine oxidase(DAO) in plasma and intestinal mucosal blood flow(IMBF) were determined. Intestinal injury was also evaluated using an intestinal histological score and apoptosis of intestinal epithelial cells was determined by deoxynucleotidyl transferase d UTP nick end labeling(TUNEL) assay. The intestinal epithelial tight junction protein,ZO-1,was observed by immunofluorescence.RESULTS: DMSO decreased TNF-α and increased IL-10 levels in the intestine compared with the ZS group at the corresponding time points. The activity of intestinal myeloperoxidase in the ZS group was higher than that in the ZD group 24 h after zymosan administration(P < 0.05). DMSO decreased the content of malondialdehyde(MDA) and increased the activity of superoxide dehydrogenase(SOD) 24 h after zymosan administration. The IMBF was lowest at 24 h and was 49.34% and 58.26% in the ZS group and ZD group,respectively(P < 0.05). DMSO alleviated injury in intestinal villi,and the gut injury score was significantly lower than the ZS group(3.6 ± 0.2 vs 4.2 ± 0.3,P < 0.05). DMSO decreased the level of DAO in plasma compared with the ZS group(65.1 ± 4.7 U/L vs 81.1 ± 5.0 U/L,P < 0.05). DMSO significantly preserved ZO-1 protein expression and localization 24 h after zymosan administration. The TUNEL analysis indicated that the number of apoptotic intestinal cells in the ZS group was much higher than the ZD group(P < 0.05).CONCLUSION: DMSO inhibited intestinal cytokines and protected against zymosan-induced gut barrier dysfunction.

Extractive Desulfurization from Simulated Sulfur-Rich Naphtha

Upon extractive desulfurization of sulfur-rich oil obtained after recycling raffinate,the effects of single and compound extractants,temperature,and extractant/oil ratio on desulfurization rate,oil loss rate,extractant loss rate,and selectivity coefficient were investigated.The results showed that the thiophene existing in the simulated sulfur-rich oil could be further removed by extraction.The single-stage desulfurization rates achieved by dimethyl sulfoxide(DMSO)and sulfolane(SF)were 53.51%and 47.36%,respectively,while the selectivity coefficient of SF was 1.13,which was higher than that of DMSO(with a selectivity coefficient of 1.04).For the compound extractant,a single-stage desulfurization rate of 49.59%and a selectivity coefficient of 1.40 were obtained by using DMSO+10%MEA as the extractant,which was higher than that of SF.Upon using 50%SF+50%DMSO as the extractant,the single-stage desulfurization rate reached 50.92%with a selectivity coefficient of 1.32.Based on the comprehensive consideration,the DMSO+10%MEA extractant was selected as the best extractant for treating the sulfur-rich oil.

Synthesis, Characterization and Fluorescence of Phenylcarboxymethyl Sulfoxide Complexes with Lanthanide Nitrates

Phenylcarboxymethyl Sulfoxide, PhSOCH 2COOH(LH), complexes of six lanthanide nitrates: Ln 2L 2(NO 3) 4·2LH· n H 2O(where Ln=La, Ce, Pr, Nd, Sm, Eu) were synthesized. Elemental analyses, molar conductivities, IR, 1HNMR and TG DTA measurements were used to characterize the complexes. The results show that the ligand(L) is coordinated to metal ions through two oxygen atoms of the carboxyl group and one oxygen atom of the sulfoxide moieties. Neutral ligang (LH)is coordinated to two metal ions through two oxygen atoms of carboxyl group as an asymmetrical bridging bidentate. The fluorescence spectra of Eu 3+ complex indicates that there is no inversion symmetry at the site of Eu 3+ ion, but the emission intensity of fluorescence is quite good.The solubility of the complexes is very good in water.

Ab-initio and DFT Calculations of PdCl_2L_2 (L = DHSO, DPSO) Complexes

The substituent effect of sulfoxides in solvent extraction of palladium is investigated theoretically by using di-n-hexyl and diphenyl sulfoxide-palladium （Ⅱ） adducts as model complexes. RHF, DFT and two half-and-half functional （BHandHLYP and BHandH） methods have been applied in the geometry optimization, and BHandH method at the 6-31G^＊ level （Pd, 3-21G^＊） can give adequate accuracy for both free sulfoxides and their Pd （Ⅱ） complexes. As compared to diphenyl sulfoxide （DPSO）, the better affinity of di-n-hexyl sulfoxide （DHSO） towards Pd（Ⅱ） has been reasonably explained by a stronger electronic transfer, shorter Pd-S bond length and a larger binding energy in its Pd （Ⅱ） complex.

The pilot test of Pt-Pd and Pt-Rh feeds extracted and separated with a new sulfoxide extractant

Platinum, palladium and rhodium of the raw feeds extracted and separated with a new sulfoxide extractant （MSO） were studied in the paper. The pilot test results showed that the percentage extractions are more than 99% for platinum and palladium in Pt-Pd feed, and the percentage strippings are 100% and 99.2% with HCl and ammonia, respectively. The ratio of palladium to platinum is 0.0016 in stripping platinum solution, and the ratio of platinum to palladium is 0.0020 in stripping palladium solution. The percentage extraction of platinum is 99% in Pt-Rh feed, and the percentage stripping is 100%. The ratio of rhodium to platinum is 0.0002 in stripping platinum solution. Therefore, platinum, palladium, and rhodium feeds are separated effectively with MSO.