A highly sensitive and selective electrochemical chiral sensor was developed based on the competitive supramolecular interaction of carbon nanofibers(CNFs)embedded sulfobutyl ether-b-cyclodextrin(SBEb-CD)with opticall...A highly sensitive and selective electrochemical chiral sensor was developed based on the competitive supramolecular interaction of carbon nanofibers(CNFs)embedded sulfobutyl ether-b-cyclodextrin(SBEb-CD)with optically active cationic drugs at glassy carbon electrode(GCE).The difference in intermolecular hydrogen bonding/stability constant/enantioselectivity coefficient and Gibbs free energy of anionic host SBE-b-CD with enantiomers of amlodipine(R-/S-AML),clenbuterol(R-/S-CBL)and metoprolol(R-/S-MET)as a guest paved the way for efficient discrimination.The proposed sensing platform(CNFs-SBE-b-CD/GCE)could recognize the aforementioned enantiomers based on the discernible difference of peak potential(S/R-AML(△Ep=135 mV),R/S-MET(△Ep=99 mV)and R/S-CBL(△Ep=111 mV).The binding mechanisms and thermodynamic study of the enantiospecific behavior have been investigated using the host-guest chemistry approach inside the nanocavity and results suggest that S-AML,RMET,and R-CBL show stronger stability constants than their antipodes.Formation of the diastereomeric complex was taken as a measure of enantioselectivity and experimental results indicated that anionic SBE-b-CD is a better chiral ligand than neutral cyclodextrins.The fabricated sensor could be a useful lowcost electrochemical tool for molecular recognition of a variety of cationic species not only of drugs but also from other sources.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.51672098 and 51632001).
文摘A highly sensitive and selective electrochemical chiral sensor was developed based on the competitive supramolecular interaction of carbon nanofibers(CNFs)embedded sulfobutyl ether-b-cyclodextrin(SBEb-CD)with optically active cationic drugs at glassy carbon electrode(GCE).The difference in intermolecular hydrogen bonding/stability constant/enantioselectivity coefficient and Gibbs free energy of anionic host SBE-b-CD with enantiomers of amlodipine(R-/S-AML),clenbuterol(R-/S-CBL)and metoprolol(R-/S-MET)as a guest paved the way for efficient discrimination.The proposed sensing platform(CNFs-SBE-b-CD/GCE)could recognize the aforementioned enantiomers based on the discernible difference of peak potential(S/R-AML(△Ep=135 mV),R/S-MET(△Ep=99 mV)and R/S-CBL(△Ep=111 mV).The binding mechanisms and thermodynamic study of the enantiospecific behavior have been investigated using the host-guest chemistry approach inside the nanocavity and results suggest that S-AML,RMET,and R-CBL show stronger stability constants than their antipodes.Formation of the diastereomeric complex was taken as a measure of enantioselectivity and experimental results indicated that anionic SBE-b-CD is a better chiral ligand than neutral cyclodextrins.The fabricated sensor could be a useful lowcost electrochemical tool for molecular recognition of a variety of cationic species not only of drugs but also from other sources.
