The Development of the “Monitoring Application for Inappropriate Expressions in Nursing Records”for PsyNACS©

Lengthening periods of hospitalization, increasing numbers of patients with age-related complications, and a shortage of nursing staff have been of great concern in medical psychiatry in Japan. Under these circumstances, countries such as Japan that face a super-aging society and a decline in the working-age population, have been recommended for use of advanced information and communications technology (ICT) to improve the efficiency of medical treatment and care. This study aims to develop the “Monitoring Application for Inappropriate Expressions in Nursing Records” for using PsyNACS©, which will enable psychiatric nursing plans to harness the advantages of ICT. The functions considered necessary are as follows: 1) identification of users who enter information;2) a necessary database for lists of inappropriate expressions;3) development of a matching function to recommend proper writing input and a warning function;and 4) a management function for an inappropriate expression list database. A demonstration experiment for developing the application in this study was conducted at a specialized psychiatric hospital. To introduce them to the application, nurses and nurse managers were informed about the system developed in this study, and a survey regarding their opinions on the functions of the application was conducted with ten nurse managers. The results were evaluated in terms of usefulness for nursing care, documentation, and the education of nurses from an ethical perspective. This study suggests that matching their input with an inappropriate expression database will allow nurses to record more appropriate expressions. From an ethical perspective, the ability to use appropriate expressions makes records more likely to withstand disclosure requests from patients and their families.

Enhancement in Bioavailability of CurCousin®, A Minor Metabolite from Curcuma longa by Addition of BioPerine® —A Pharmacokinetic Study

In recent years, metabolic syndrome has been a growing health concern across the world. The role of nutraceuticals and functional foods in this area has a significant place due to the adverse effects of contemporary modes of treatment. CurCousin® is a nutritional ingredient containing bioactive Calebin A, (analog of Curcumin) with self-affirmed GRAS status. CurCousin® has been a clinically studied dietary supplement ingredient with a positive impact on body weight, lipid levels and metabolic health. Bioenhancers play an important role in increasing the bioavailability of the active in turn enhancing efficacy as well as reducing the dosage required to achieve the therapeutic effect. This study investigated the possible pharmacokinetic interaction between CurCousin® at two different doses (2.25 and 4.5 mg/kg) in the presence and absence of BioPerine® (0.27 mg/kg), a natural bioenhancer in Sprague-Dawley rats. The results revealed that the addition of BioPerine® into CurCousin® (2.25 mg/kg) half the dose when administered enhances the bioavailability and was equipotent to CurCousin® (4.5 mg/kg) double the dose without BioPerine®. Thus, leading to future clinical studies to evaluate its improved pharmacological efficacy as well as reduced therapeutic dosage.

18F-FES PET/CT Research Progress in the Diagnosis and Treatment of Breast Cancer

Estrogen receptor(ER) is a vital biomarker in the development and development of breast cancer, and its status has great clinical value in clinical treatment strategy, endocrine therapy efficacy prediction, and breast cancer prognosis. By specifically combining 18F-FES with ER, 18F-FES PET/CT imaging uses standard uptake value(SUV) to semi-quantitatively reflect the distribution of ER and its biological activity in patients, and assesses the expression of ER in breast cancer patients about primary and metastases before or after treatment, to provide a basis for personalized treatment of breast cancer. In this review, we will review the imaging principles of a new ER detection method 18F-FES PET/CT, and the research progress in the clinical application of breast cancer, and compare its diagnostic and treatment value with non-specific tumor imaging 18F-FDG PET/CT in breast cancer.

Sup20沥青混合料VMA指标的重要意义

本文通过简要论述Sup20配合比设计中存在的VMA技术指标问题,展开一些基础论述,并简要概述了VMA指标对于沥青混合料设计的重要性,以及存在问题后如何及时去调整设计,最终能够设计出优秀的配合比。对比了高速和地方国省干线道路使用的结果,验证了VMA指标对于长寿命沥青路面的重要贡献,帮助初学者尽快领悟悟Sup20的设计精髓,最大程度发挥该种结构带来的优秀效果。

Treatment of Vulvovaginal Candidiasis with A Strategy Based on Phototherapy (M.A.C.® Scar Acceleration Method)

Candidiasis, also known as candidiasis vulvovaginitis, is an infection caused by different types of Candida fungi, the most frequent being Candida albicans. The present study reports an effective strategy, which opens new avenues for the treatment of this public health problem. The MAC® Methodology, conventional laser light-emitting (LLLT)/LED) methods are based on the biphasic response demonstrated many times in LLLT research and as with other forms of drugs, a “drug” (irradiation parameters) and a “dose” (irradiation times) and the “Arndt-Schulz Law” is often cited as a suitable model to describe the dose-dependent effects of LLLT. This method uses photopharmaceuticals, cell markers and the use of correct parameters for each case to induce the acceleration of tissue repair. The present study shows a case of a 32-year-old patient diagnosed with recurrent candidiasis 4 years ago. Eighteen sessions were performed (every other day) using a photoactivated component (Methylene blue 1% + Clotrimazole 1%) and LED phototherapy (red, blue and violet) with emission times of 60 - 260 seconds for each applicator, according to the dose recommendations of the scar acceleration method (MAC®). At the sixth treatment session there was a noticeable decrease in the itching sensation reported by the patient. In session 11 she reported feeling a great improvement, indicating that she no longer felt itching in any area after 18 sessions. The present case demonstrates new methodologies to treat common problems in the population that have a positive impact on the quality of life. This methodology has a promising future because it is non-invasive and requires a great biological transformation for inflammatory, fungal and viral control.

Predictive Value of the Neutrophil to Lymphocyte Ratio (NLR) to Predict the Development of Preeclampsia and Pregnancy Induced Hypertension at 1st Trimester

Introduction: Hypertensive disorder in pregnancy affects 4 to 6 percent of all pregnancies and carries risks for the both baby and the mother. Only a few groups of women who are at high-risk pregnancies are received prophylaxis Aspirin, more than 15 percent of women develop pre-eclampsia with a single minor risk factor. Methods: This descriptive cross-sectional study was conducted to compare the 1st trimester NLR value of normotensive, pregnancy induced hypertensive and pre-eclamptic pregnant women. The study was conducted with a sample of 416, antenatal patients who were admitted to ward 25, at Colombo North Teaching Hospital Ragama. Data was collected as separated three groups. NLR value was calculated separately and ANOVA test was used to analyze the 3 categorical data. Post HOC test was done to assess the multiple comparison. Results: The prevalence rates of pregnancy induced hypertension and pre-eclampsia among the pregnant women were 8.6% and 5.7%. The mean NLR values of normotensive group was 2.708, pregnancy induced hypertensive group was 2.650 and pre eclamptic group was 3.789. There was a significant difference in NLR value between pre eclamptic group and other two groups with P value of Conclusion: The 1st trimester NLR value of pre eclamptic patients significantly increased compared to normotensive women.

水上运动项目SUP桨板的个性化体能训练

本论文探讨了SUP桨板运动中个性化体能训练的重要性及实施方法。介绍了SUP桨板运动的发展历史和技术要素,探讨了不同水域环境下的运动特点。详细分析了体能对桨板运动技术和表现的影响,强调了耐力、力量和灵活性在运动中的作用。进而探讨了个性化训练的概念、不同运动员体能需求分析和针对性训练计划的制定。研究着重评估了不同训练计划对运动员的效果和影响。个性化体能训练在提高运动员表现和乐趣方面具有显著作用。

Evaluation of the Neurodevelopmental Outcome of Toddlers with Spinal Dysraphism after Surgical Repair Using ASQ-3™ Scores

Background: Spinal dysraphism represents a wide spectrum of congenital abnormalities of the spine. Myelomeningocele is considered the most common malformation and the most common we saw in our community, with its morbidity problems seen commonly in the postoperative period. ASQ-3TM Scores are the ages and stages questionnaire, third edition, and represent a tool to assess the development progress, especially in toddlers. Objectives: Evaluation of neurodevelopmental outcome among Sudanese toddlers with spinal dysraphism after surgical closure with or without a VP shunt using ASQ-3TM Scores. Methodology: This is a retrospective hospital-based study of 84 patients who underwent myelomeningocele repair at the National Center for Neurological Sciences (NCNS) during the period from 2017 up to 2019. Data were collected through a constructed questionnaire, including ASQ-3TM Scores. Data were processed and analyzed using the Statistical Package for Social Science (SPSS) computer program. Version 25. Results: 84 patients were included in this study;all patients were diagnosed with spinal dysraphism. Out of them, 51 (60.7%) were 2 years old, 33 (39.3%) were 3 years old, 45 (53.6%) were male, 45 (53.6%) of patients mothers attended ANC irregularly, and 54 (64.3%) their mothers didn’t receive folate supplements. 44 (52.3%) of patients underwent MMC repair only, while 40 (47.7%) underwent MMC repair and VP shunt. The commonest postoperative complication was infection, reported in 12 (14.3%) of patients, followed by VP shunt revision in 9 (10.7%) of patients. Neurological assessment showed that the majority of patients need further assessment with a professional, 57 (67.9%) of children don’t walk, run, or climb like other toddlers as their parent’s state;also, half of patients (42, 50%) had medical problems, and 27 (32.1%) of their parent’s state that they do not talk like other toddlers their age. There was a statistically significant association between post-operative complications and communication development, problem-solving development, and personal social development (P value = 0.05), and a statistically significant association was found between age at repair and neurological development (P value = 0.05). Conclusion: The majority of patients had motor deficiency (particularly gross motor) and poor personal and social skills. Age at repair and postoperative complications significantly influenced the neurological development.

基于分档替换的RAP精分料Sup-20沥青混合料路用性能研究

为研究不同档位的沥青混合料回收料(RAP)精分料对沥青混合料性能的影响,依托油石分离技术,利用物理碰撞方式将RAP精分为粒径16~25 mm、10~16 mm、5~10 mm、3~5 mm、0~3 mm五档料,采用70#道路石油沥青为新加沥青,进行分档替换RAP精分料的Sup-20配合比设计,从高温稳定性、低温抗裂性和水稳定性等方面验证其路用性能。研究表明:分档替换对沥青混合料最佳综合油石比影响不大,皆在4.5%左右;对混合料的高温稳定性影响不大;替换的档位越小,低温抗裂性和水稳定性方面性能越优;包括100%掺量在内的6种替换,其低温抗裂性皆不满足规范要求。因此在RAP精分料的设计过程中应严格控制细档料的添加。

基于SUP-LightGBM的跨社交网络用户识别

对同一用户在多个社交网络中的信息进行整合,以支持用户画像、个性化推荐等应用需求,跨社交网络用户身份识别成为研究热点,但现有识别方法存在数据难获取、真实性不足、识别精度不高等问题。针对这些问题,论文设计网络爬虫程序,从真实社交网络Facebook和Twitter网站中获取用户好友关系数据,解决了数据难获取与真实性不足的问题,并首次加入好友昵称特征(SUP),使用SUP-LightGBM算法对Facebook和Twitter中相同的用户进行识别,提高了识别精度。实验结果表明,SUP-LightGBM算法的精确率、召回率、F_(1)值和准确率分别达到了98.35%、96.08%、97.19%和97.09%;相比不使用SUP特征时分别提高11.06%、21.43%、16.74%和15.8%,证实了文中方法的有效性。

Grating lobes suppression method for stepped frequency GB-SAR system

A grating lobes suppression method for chirp-subpulse stepped frequency（CSSF） signals is proposed, which is applied to deformation monitoring using the ground based synthetic aperture radar（GB-SAR） system. This method is based on accurate estimation and correction of the phase and amplitude error along two dimensions（range and azimuth）, i.e., the error estimation inside the subpulse（in-subpulse error） and across the stepped frequency subpulses（cross-subpulse error） of transmitted CSSF signals. Validated both with simulated data and experimental data recorded in the deformation monitoring campaign, it can be seen that the method as well as the relative conclusions can be fully and effectively applied to most of the stepped frequency systems.

Fourth-Order Adjoint Sensitivity Analysis of an OECD/NEA Reactor Physics Benchmark: II. Mathematical Expressions and CPU-Time Comparisons for Computing 4^th-Order Sensitivities

This work extends to fourth-order previously published work on developing the adjoint sensitivity and uncertainty analysis of the numerical model of a polyethylene-reflected plutonium (acronym: PERP) OECD/NEA reactor physics benchmark. Previous works showed that the third-order sensitivities of the PERP leakage response with respect to these total microscopic cross sections are far larger than the corresponding 1st-order and 2nd-order ones, thereby having the largest impact on the uncertainties induced in the PERP benchmark’s response. This finding has motivated the development of the original 4th-order formulas presented in this work, which are valid not only for the PERP benchmark but can also be used for computing the 4th-order sensitivities of response of any nuclear system involving fissionable material and internal or external neutron sources. Subsequent works will use the adjoint-based mathematical expressions obtained in this work to compute exactly and efficiently the numerical values of the largest fourth-order sensitivities of the PERP benchmark’s response to the total microscopic cross sections, and use them for a pioneering fourth-order uncertainty analysis of the PERP benchmark’s response.

Suppression of Sup35 amyloid fibril formation by group II chaperonin from <i>Thermoplasma acidophilum</i>

The Group II chaperonin from Thermoplasma acidophilum was added to the in vitro amyloid fibrillation reaction of yeast Sup35NM protein to assess its effects. By measuring the formation of Sup35NM fibrils in real time using the fluorescent dye Thioflavin T, we found that the addition of T. acidophilum-cpn α16, α1, and β1 proteins suppressed fibril formation. Addition of a 0.1 molar-equivalent T. acidophilum-cpn α16 relative to Sup35NM prolonged the initial lag-time of fibril formation and decreased the rate of fibril extension. Addition of 1 or 3 molar-equivalents of T. acidophilum-cpn monomers also produced a similar effect. Delayed addition of these chaperonins after the initial lag phase did not suppress fibril formation. Interestingly, these effects were also observed upon adding only the apical domain segments of α and β-subunits, and we also found that deletion of the helical protrusion in the apical domain of these segments led to an abolishment of the suppression effects. A synthetic peptide whose sequence corresponded to the helical protrusion also displayed a suppression effect, which indicated that archaeal group II chaperonin binds to Sup35NM through the helical protrusion of the apical domain. These findings suggest that group II chaperonin might be actively involved in suppressing amyloid fibril formation, in addition to acting as a protein folding assistant.

高粘弹橡胶沥青及其SUP13混合料的工程应用

为优化路用改性沥青的粘弹性能以及改善传统橡胶沥青的难加工性、性能不稳定性和高成本等问题,采用微纳胶粉复合SBS制备了高粘弹橡胶沥青,并工程化应用于高速公路SUP13上面层。结果表明,与常规路用SBS改性沥青相比,高粘弹橡胶沥青的低温模量较低、高温模量较高,其混合料高低温性能都优于常规SBS改性沥青混合料,而且耐老化性能和水稳定性均优异。工程应用效果表明,高粘弹橡胶沥青具有类似SBS改性沥青的易加工易施工特点,适合用于国内西部高等级沥青路面的铺筑及推广应用。

The Mechanisms of CD8+ T Cells Exhaustion in the Tumor Microenvironment and Immune Therapy

In the tumor immune microenvironment, CD8+ T cells differentiate towards functional failure. The exhaustion of CD8+ T cells (Tex) showed varying degrees of effect dysfunction, loss of proliferation ability, and sustained high expression of a variety of inhibitory receptors, with metabolic and epigenetic changes. Tex cells are heterogeneous, including several subsets with different characteristics at different stages of differentiation. Immune checkpoint inhibitors (ICIs) can restore the effect or function of Tex cells, indicating that this T cell subset plays a key role in tumor immunotherapy. The understanding of the mechanism of CD8+ T cell exhaustion will be helpful to the implementation of tumor immunotherapy. This article reviews the production, differentiation and functional characteristics of Tex cells and their relationship with tumor immunotherapy.

The Contribution of the Xpert® MTB/RIF Assay to the Surveillance of Drug-Resistant Tuberculosis in the Central African Republic

Introduction: The Central African Republic is one of the 30 high Tuberculosis burden countries in the world, with an incidence of 540 cases per 100,000 population and a mortality of 91 deaths per 100,000 population. Since 2020, following WHO recommendations, the National Reference Laboratory for Tuberculosis has been using the Xpert® MTB/RIF assay as a first-line diagnostic test for the early detection of Drug Resistance Tuberculosis. The goal of this study was to evaluate the contribution of the Xpert® MTB/RIF assay to the surveillance of rifampicin resistance in new and previously treated tuberculosis cases. Materials and Methods: The data relative to the Xpert® MTB/RIF assay carried out on various categories of tuberculosis patients registered at the National Reference Laboratory for Tuberculosis in 2020 were analyzed retrospectively. The categories of tuberculosis patients were new cases, failed treatment cases, relapse cases, lost-to-follow-up cases and multidrug-resistant tuberculosis contact cases. Results: A total of 1404 tuberculosis patients were registered at the NRL-TB in 2020;the mean age was 39.2 years (2 - 90 years) and the male-to-female sex ratio was 1.16:1. Overall, 32.7% (454/1404) proved infected with tuberculosis, of which 22.5% (102/454) cases showed resistance to rifampicin. The primary resistance rate was 9.1% (27/298) and the secondary resistance rate was 46.6% (75/161). Treatment failures and relapsed cases were significantly associated with rifampicin resistance (p 0.005). Conclusion: Large-scale use of Xpert® MTB/RIF, especially in the provinces of the Central African Republic, will help the Ministry of Health to better control Drug Resistance Tuberculosis in the country.

Jungian Advanced Motor ProcessingTM (JAMPTM) the Future of Mental Health Treatment: 38 Cases on Its Efficacy & Validation to Induce Measurable Positive Change

This paper is about an advanced treatment method known as Jungian Advanced Motor Processing (JAMPTM) and its effects on healing trauma using three scales: Post-Traumatic Cognitive Inventory (PTCI) [1], Adverse Childhood Experiences Questionnaire (ACE) [2] and Somatic Symptom Scale (SSS or PHQ15) [3]. JAMPTM is a new treatment that addresses issues such as complex trauma, illnesses, and mental health disorders. During a 90-minute session with a JAMPTM therapist, the client will listen to a heartbeat sound while viewing a calming image where a positive affirmation appears on the screen. The combination of image and sound, as well as the bilateral stimulation, accesses the triggered defensive mechanism of the traumatic part of the person (the Complex). This traumatized person begins to associate points in their life where a pattern of behavior was learned in order to cope with the event that originally caused disassociation. The JAMPTM Transformational Coach will lead the client safely through this journey using verbal affirmations such as, “I am not afraid,” to disperse the fear. By the end of the session, threads are strung together to paint a picture of pain that forms an image which becomes a symbol that can be transformed into healing.

公路路面施工中Superpave的应用分析

以某公路工程为依托,分析公路路面施工中Superpave的应用。研究结果表明,在Sup沥青路面施工中,通过优选施工原材料,合理设计配合比,加强Sup混合料拌制、摊铺、碾压和接缝处理关键工序控制,能够进一步保证高质量完成路面工程施工任务。

Effect of Hashimoto’s Thyroiditis on Efficacy of 131I Ablation Therapy in Intermediate- and High-Risk of Thyroid Papillary Carcinoma

Objective: The purpose of this study was to investigate the effect of Hashimoto’s thyroiditis on efficacy of 131I ablation in intermediate- and high-risk of thyroid papillary carcinoma patients. The findings will help to develop a personalized treatment plan for patients with thyroid papillary carcinoma complicated with Hashimoto’s thyroiditis. Material and Methods: From January 2016 to December 2020, patients who were diagnosed with intermediate- and high-risk PTC with lymph node metastasis were analyzed retrospectively, excluding patients with incomplete clinical data, distant metastasis, positive TGAb, TSH Results: A total of 525 patients (166 males and 359 females) were included in the study, including 368 patients in ER group (70.1%) and 157 patients in NER group (29.9%). Eleven factors including combining Hashimoto’s thyroiditis, pre-ablative Tg levels, sex, tumor diameter, extraglandular invasion, multifocal, bilateral lesions, central lymph node metastasis, lateral lymph node metastasis, lymph node metastasis rate, thyroglobulin were statistically different between ER group and NER group with significance at P Conclusion: Hashimoto’s thyroiditis, Ps-Tg level and lateral lymph node metastasis are potential predictors for short-term efficacy of 131I treatment in intermediate- and high-risk thyroid papillary carcinoma. Hashimoto’s thyroiditis, high Ps-Tg level and increased number of lateral lymph node metastasis reduce the efficacy of 131I therapy in patients with intermediate and high risk thyroid papillary carcinoma.

History Lessons from the 5th Solvay Meeting, 1927

Largely drawn from “Quantum Theory at the Crossroads: Reconsidering the 1927 Solvay Conference” by Guido Bacciagaluppi and Antony Valentini, but also from several books by Pais (“Inward Bound” and “Subtle is the Lord”), plus other sources, we examine some of the very contemporary themes as to quantum measurement which were debated in the 5th Solvay meeting. In addition, we also discuss some issues given by Roland Omnes in “Understanding Quantum Mechanics” as to the problem of classical and quantum properties, which is at the forefront of the Quantum Gravity issues of how to reconcile semi classical physics with the presumed bridge between Planckian physics (presumably quantum in nature) with the rest of cosmology. The issues argued in part by the Solvay meeting as to Quantum measurements and the competing Pilot theory, as brought up by De Broglie, and how that plays out as to the later Hidden Variables and the alleged determinism foundations of an embedding structure for Quantum physics, still are with us, and make the Solvay meeting, 1927 a stellar event, still worth revisiting 90 years later.