An increasing utilization of wound-related therapeutic materials and skin bioelectronics urges the development of multifunctional biogels for personal therapy and health management.Nevertheless,conventional dressings ...An increasing utilization of wound-related therapeutic materials and skin bioelectronics urges the development of multifunctional biogels for personal therapy and health management.Nevertheless,conventional dressings and skin bioelectronics with single function,mechanical mismatches,and impracticality severely limit their widespread applications in clinical.Herein,we explore a gelling mechanism,fabrication method,and functionalization for broadly applicable food biopolymers-based biogels that unite the challenging needs of elastic yet injectable wound dressing and skin bioelectronics in a single system.We combine our biogels with functional nanomaterials,such as cuttlefish ink nanoparticles and silver nanowires,to endow the biogels with reactive oxygen species scavenging capacity and electrical conductivity,and finally realized the improvement in diabetic wound microenvironment and the monitoring of electrophysiological signals on skin.This line of research work sheds light on preparing food biopolymers-based biogels with multifunctional integration of wound treatment and smart medical treatment.展开更多
基金supported by the National Natural Science Foundation of China(22274053,22274051)the director fund of Shanghai Key Lab for Urban Ecological Processes and Eco-Restoration(SHUES2022C03)+2 种基金the Shanghai Municipal Science and Technology Major Project(“Beyond Limits manufacture”),and the Fundamental Research Funds for the Central UniversitiesAll experiments with human research participants were approved by the Human Research Protection Committee of East China Normal University(approved number:HR 805-2022)Study Participation:Prior to participation in the experiments,informed consent was obtained from the volunteer in all experiments.All animal experiments were approved by the Animal Ethics Committee of East China Normal University(approved number:ARXM2022163).
文摘An increasing utilization of wound-related therapeutic materials and skin bioelectronics urges the development of multifunctional biogels for personal therapy and health management.Nevertheless,conventional dressings and skin bioelectronics with single function,mechanical mismatches,and impracticality severely limit their widespread applications in clinical.Herein,we explore a gelling mechanism,fabrication method,and functionalization for broadly applicable food biopolymers-based biogels that unite the challenging needs of elastic yet injectable wound dressing and skin bioelectronics in a single system.We combine our biogels with functional nanomaterials,such as cuttlefish ink nanoparticles and silver nanowires,to endow the biogels with reactive oxygen species scavenging capacity and electrical conductivity,and finally realized the improvement in diabetic wound microenvironment and the monitoring of electrophysiological signals on skin.This line of research work sheds light on preparing food biopolymers-based biogels with multifunctional integration of wound treatment and smart medical treatment.
