Breast Cancer in a Supernumerary Breast at the Yaoundé Gynaeco-Obstetric and Paediatric Hospital: About a Case

Accessory or ectopic breast tissue is an anomaly in the development of the breast. It is a rare condition that occurs along the embryological mammary line. In less than 1% of all breast cancers, supernumerary breast cancer is reported, with the axillary location being the most common in 60% to 90% of cases. Cancerous degeneration of this supernumerary breast tissue can pose a dual diagnostic and therapeutic problem. We report the case of locally advanced adenocarcinoma in a right supernumerary breast. This is a 75-year-old, grand-multiparous, postmenopausal, and known hypertensive patient on treatment. Family history was remarkable for brain cancer in her sister and oesophageal cancer in her mother. She consulted for a mass in the right axillary cavity on supernumerary breast evolving for a year. Clinical examination revealed a large, fixed, budding and haemorrhagic-ulcerated mass of the right axilla, with long axis measuring about 15 cm. There was as wella supernumerary breast on the left, but without particularity. A soft tissue ultrasound showed a large hypoechoicmass in the right axillary region of 116 mm with areas of central necrobiosis. Morphologically, the breasts were normal. A breast MRI revealed a subcutaneous mass in the right axillary cavity with skin ulceration and satellite lymphadenopathy. The extension assessment revealed liver metastases, and a biopsy of the mass revealed a breast adenocarcinoma. The case was the subject of a multidisciplinary consultation meeting following which a wide excision of the mass was indicated. The histo-pathology analysis results of the surgical specimen were in favour of a triple negative papillary adenocarcinoma. After a post-operative multidisciplinary consultation meeting, adjuvant chemotherapy was indicated. The development of supernumerary breasts depends on hormones, just like normal breasts. Breast cancer in accessory breast tissue is quite rare with the incidence being 6%. The most common pathology is invasive carcinoma (50% - 75%). It is usually located in the armpit (60% - 70%) although it can be present in other less common locations such as the inframammary region (5% - 10%) and rarely the thighs, perineum, groin and the vulva. Since accessory axillary breast tissue is not considered during breast screening examination, it is necessary for clinicians to be aware of this entity and associated pathologies. Their preventive excision in women at high risk can also be considered.

Effect of transcranial direct current stimulation on supernumerary phantom limb pain in spinal cord injured patient:A case report

BACKGROUND Supernumerary phantom limb(SPL)sensation is the experience of additional limbs,either single or a pair of limbs.Unique to traumatic spinal cord injuries,we report effect of transcranial direct current stimulation(tDCS)on SPL pain in a patient with cervical cord injury.CASE SUMMARY The subject was a 57-year-old man who was diagnosed with complete spinal cord injury(C6/C5,motor level;C5/C5,sensory level;AIS-A)approximately three months ago.After a period of 2 wk,we administered anodal tDCS over the motor cortex for 15 minutes at an intensity of 1.5 mA.Following that treatment,the patient experienced a decrease of SPL pain intensity and frequency,which lasted for 1 week after the end of treatment.CONCLUSION Targeting the motor cortex through neuromodulation appears to be a promising option for the management of SPL pain.

Review of Research and Development of Supernumerary Robotic Limbs

Supernumerary robotic limbs(SRLs) are a new type of wearable human auxiliary equipment, which is currently a hot research topic in the world. SRLs have broad applications in many fields, and will provide a reference and technical support for the realization of human-robot collaboration and integration,while playing an important role in improving social security and public services. In this paper, representative SRLs are summarized from the aspects of related literature analysis,research status, ontology structure design, control and driving,sensing and perception, and application fields. This paper also analyzes and summarizes the current technical challenges faced by SRLs, and reviews development progress and key technologies,thus giving a prospect of future technical development trends.

Impacted Lower Third Molar Fused with a Supernumerary Tooth—Diagnosis and Treatment Planning Using Cone-Beam Computed Tomography

This paper reported a case of fusion between an impacted third molar and a supernumerary tooth, in which a surgical intervention was carried out, with the objective of removing the dental elements. The panoramic radiography was complemented by the Donovan＇s radiographic technique; but because of the proximity of the dental element to the mandibular ramus, it was not possible to have a final fusion diagnosis. Hence, the Cone-Beam Computed Tomography--which provides precise three- dimensional information--was used to determinate the fusion diagnosis and also to help in the surgical planning. In this case report we observed that the periapical, occlusal and panoramic were not able to show details which could only be examined through the cone-beam computed tomo- graphy.

Application of digital positioning guide plates for the surgical extraction of multiple impacted supernumerary teeth:A case report and review of literature

BACKGROUND An extra tooth in the normal tooth sequence in any region of the dental arch is regarded as a supernumerary tooth(SNT).Due to the large variation in location and morphology,the extraction of impacted SNTs is an extensive and complex procedure with high risks of several complications.This report presents a rare case of seven impacted SNTs in the bilateral upper and lower arch that were successfully extracted with the use of digital positioning guide plates.CASE SUMMARY In January 2022,a 21-year-old male was referred to our department with a chief complaint of pain in relation to tooth#36.Clinical examination showed a deep carious lesion with pulpal involvement in tooth#36 and lingual swelling of the bilateral mandibular posterior area.Radiographic examination revealed seven deeply impacted SNTs in the bilateral posterior area and bilateral impacted mandibular third molars.Based on these findings,the patient was diagnosed with bilateral,multiple impacted SNTs and tooth#36 chronic pulpitis.A root canal treatment and an all-ceramic crown restoration for tooth#36 were performed.An individualized digital positioning guide plate was designed by computer-aided design/computer-aided manufacturing technology and cone-beam computed tomography for extraction of the impacted SNTs.During the operation,the digital positioning guide plate allowed rapid positioning and exposure of the SNTs while avoiding adjacent important anatomical structures.At 3-month follow-up,regeneration of bone and soft tissues was visible.CONCLUSION The application of digital positioning guide plates is useful for the individualized and minimalized extraction of impacted supernumerary teeth.

Effects of combined rTMS and visual feedback on the rehabilitation of supernumerary phantom limbs in a patient with spinal cord injury:A case report

BACKGROUND Supernumerary phantom limb(SPL)caused by spinal cord injury(SCI)has previously been reported in several studies.However,the mechanisms and management of SPL in SCI patients are still not fully understood.Herein,we report a rare case of SPL in a patient with incomplete SCI.CASE SUMMARY A 46-year-old man complained of four hands 7 d after SCI.He was diagnosed with SPL complicated with actual limb neuropathic pain.Following a period of treatment with neurotrophic agents and Chinese traditional and analgesic medications,SPL symptoms and actual limb pain did not improve.However,his symptoms gradually lessened after combined treatment with high-frequency repetitive transcranial magnetic stimulation(rTMS),a promising neuromodulation technique,over the M1 cortex and visual feedback.After 7 wk of this treatment,SPL disappeared completely and actual limb pain was significantly relieved.CONCLUSION Cerebral plasticity changes may be a mechanism underlying the occurrence of non-painful SPL in SCI patients,and high-frequency rTMS applied to the M1 cortex could be a promising treatment method for SPL.

Supernumerary brachioradialis-Anatomical variation with magnetic resonance imaging findings:A case report

BACKGROUND In this single case report study,we describe an anatomical variance of a brachioradialis muscle with two muscle bellies and two tendons with their common insertion on the suprastyloid crest of a distal radius.CASE SUMMARY After a self-mutilating forearm injury of a borderline personality patient,we observed the anatomical variation of brachioradialis tendon.After tendon repair and aftercare the muscle function recovered completely.Five months after surgery the forearm magnetic resonance imaging was done revealing a supernumerary brachioradialis muscle.CONCLUSION Anatomical variations of forearm muscles and tendons are not rare.The treating surgeons should be aware of their existence and anatomical relationships.

Prevalence and Pattern Occurrence of Supernumerary Teeth in the North-East Heilongjiang Population of China

Aims: The objective of the current research was to determine the prevalence of supernumerary teeth and investigate its characteristic and complications in the Chinese population from the North-East Heilongjiang region. Materials and Methods: It was a descriptive and retrospective study which used registered notes and panoramic radiographs of 12,984 patients who visited the Department of Oral and Maxillofacial Surgery in the 2nd Affiliated Hospital of Jiamusi University, China between June 2011 to November 2015. Patients diagnosed with any syndrome or hereditary diseases were excluded from the study. The features of supernumerary teeth were noted and the data were analyzed using SPSS program, (version 20, Inc., Chicago, USA). The Chi-square test was used to determine the differences in the distribution of supernumerary teeth. It was tested at the 5% level of significance. Results: The prevalence was 5.2% and the most prevalent supernumerary teeth was incisor with 3.39% (n = 441). The supernumerary teeth were seen more in maxilla than mandible. The male to female ratio was 2.9:1. Specifically, higher prevalence of supernumerary teeth in male gender was statistically significant (p = 0.03). The supernumerary teeth mostly occurred in children of 5 - 10 years (62.3%), followed by young adolescent between 11 - 16 years (26.5%). Conclusion: The prevalence of supernumerary teeth was widely seen in children and young adolescent of Chinese population. The occurrence was mostly seen in maxilla than mandible and significantly higher in male than female.

The phantom and the supernumerary phantom limb:historical review and new case

The way we experience the world is determined by the way our brain works.The phantom limb phenomenon,which is a delusional belief of the presence of a non-existent limb,has a particular fascination in neurology.This positive phenomenon of the phantom limb raises theoretical questions about its nature.After a stroke,some patients experience the perception of an extra limb in addition to the regular set of two arms and two legs.This complex cognitive and perceptual distortion is called supernumerary phantom limb.Here,we review the pathogenesis and historical aspects,and report a new case.

虹霓现象透析

虹霓是由太阳光照射在雨点上．经雨点折射和反射而产生的。而虹之内，霓之外的附属虹（supernumerary）则是由光的干涉和衍射产生的。同时，虹霓的光具有偏振性。

Accessory Breast Tissue in Pregnancy

Accessory breast tissue development frequently occurs in addition to physiologic breast development and is a common congenital condition with an occurrence of 0.4% to 6% in women and 1% - 3% in men. A 31-year-old G1P0 female presented to our triage at 20 + 4 weeks gestation with a one-week history of painful bilateral axillary lumps. Her last menstrual period was consistent with an estimated gestational age of 39 + 3 weeks by LMP. She had emigrated from Bengal three years earlier with no other gynecological complaints and knew of no abnormalities on physical exam. The painful axillary lumps were found to be accessory breast tissue. This entity is presented as a palpable thickening that is most prevalent along the milk line in the region immediately below the breasts, along the abdomen, in the axilla and in the groin region adjacent to the vulva. Affected individuals may undergo premenstrual changes such as tenderness, swelling, and difficulty with shoulder range of motion and irritation. The onset of pregnancy stimulates the tissue and makes it more evident as it did with our patient.

Using the Electromagnetics of Cancer’s Centrosome Clusters to Attract Therapeutic Nanoparticles

This paper summarizes recent research findings concerning centrioles, centriole duplication, centriole overduplication, supernumerary centrioles, centrosomes, and centrosome amplification. The paper then discusses the status of ongoing research on the use of nanoparticles for cancer treatment. The research findings show that a centriole produces an electromagnetic field apparently due to the longitudinal oscillation of its microtubules (MTs). A cluster of centrioles is therefore presumed to produce an enhanced electromagnetic field. Individual centrioles are immersed in a cloud of electron-dense material (proteins) which together with the centrioles is known as the centrosome. A cluster of centrioles thus produces a cluster of centrosomes—a hallmark of cancer cells. With enhanced electromagnetic fields, centrosome clusters provide an attraction for magnetically charged nanoparticles. These nanoparticles however are not attracted to normal cells which with only two (or at most four) centrioles, have a weaker magnetic field. The idea is simple: Magnetized and therapeutic nanoparticles are directed toward tumors and then attracted to the centrosome clusters of the tumor cells. Once inside the tumor cells, the nanoparticles can release their toxins.

Surgical and Orthodontic Treatment of Dental Retentions: A Case Report

This paper reports the case of K.Z, a 15 year-old child received in the Dental Surgery Unit of the Yalgado Ouédraogo Teaching Hospital for consultation for some aesthetic reasons due to dental retentions. On his X-ray, the premolars 25, 34, 35, 44, 45 and the molar 47 were deeply impacted, retained by supernumerary teeth. The treatment consisted in the removal of persistent temporary teeth and supernumerary teeth with poor radicular set, except one premolar. The removal of this premolar located between the roots of tooth 36, was source of major risk;therefore, it was put under clinical supervision. After these extractions, a fixed orthodontic appliance enabled bringing impacted teeth to a functional position. Orthodontic treatment lasted 3 years with a monthly check-up. Ours results are stable after one year of decline.

A Special Case of Renal Duplication Diagnosed on CT Imaging

Renal duplication or supernumerary kidney (SK) is a rare anomaly, poorly documented. It is often discovered fortuitously or after complications. Its preoperative diagnosis is difficult. We hereby report the case of a left supernumerary kidney discovered upon thoracic-abdominal pelvic CT staging in a 50-year-old woman monitored for squamous cell carcinoma of the cervix.

A Human Skull with a Tripartite Inca Bone: A Case Report

An adult human skull was discovered in a college osteological collection presenting with two Inca bones. Inca bones or interparietal (supernumerary) bones are rarely seen among dry human skulls. Their frequency of presentation is much less than that of sutural or Wormian bones. Inca bones or interparietal (supernumerary) bones are accepted as normal variants most often found in the occipitoparietal region of the skull. Their characteristic shape, a triangle, resembles a monument design of the Inca tribe of South America and Latin America. The significance of the presence of these variants is that Inca bones or interparietal bones may be mistaken for a skull fracture. They may also be very useful in forensic identification of an unknown individual.

The Mathematical Thoughts and Physics Interpretations of Rainbow from Ancient to Modern Times

With the aim of building a more precise mathematical model of better predictability for the formation of the supernumerary rainbow and fogbow and seeking a clearer and more elaborate physical interpretation, this paper examines the relationship between different rainbow patterns and droplet sizes through both analytical derivation and numerical simulation and develops a much more detailed model beyond previous explanations. From Newton’s geometric model of optics to Young’s wave model, the paper first establishes a solid foundation for the understanding of the formation of the rainbow in nature and through human vision, and then goes on examining the interferences of light, finally applying the model in reality for a better understanding of complex rainbow phenomena, with additional analysis on an unexpected finding about the correspondence of maximum view angle and shortest light path through hypothetical explanation based on the principle of least time and simulation of an elliptical droplet.

Cleidocranial dysplasia with a rare mutation:Study of a family with review of literature

Introduction: The present study was aimed at advancing the understanding of the pathogenesis of cleidocranial dysplasia (CCD) by presenting a case study based on history, physical examination, typical radiological features, and molecular analysis and a review of the literature. Methods: This study began with a 23-year-old boy (proband) who was referred to the department of oral and maxillofacial radiology with chief complaint of the upper-left first molar tooth and routine dental examination. While evaluating the panoramic radiograph, the patient had approximately 57 teeth in his both of the jaws. Clinical, radiographical and molecular features of the proband, two siblings and their parents were examined and then, DNA analysis was performed. Results: Overall, we present 3 CCD patients with a mutation in the VWRPY motif. The deletion of c. 1754_1757 delTTTG (NM_001024630.2) is determined and it leads to a frame shift mutation and stop codon, p. V585Gfs56X. Conclusions: The present study emphasized the importance of further clinical and molecular investigation when even a single case of CCD is identified within a family. This is the first study performed in Turkey about a family with a mutation in the VWRPY motif. Genotype-phenotype association studies in individuals with CCD are necessary to provide important insights into molecular mechanisms associated with this disease.

STUDY ON THE KARYOTYPES OF THREE SPECIES OF GENUS CARBULA(HETEROPTERA:PENTATOMIDAE)

The karyotypes and meiotic behaviors of three Carbula species( Carbula obtusangula Reuter, C.putoni (Jakovlev)and C. sinica Hsiao et Cheng)were studied.Karyotype analyses using specific software were made and model karyotype chart was presented.All three species have the typical diploid chromosome number of 14 for the family Pentatomidae and X Y sex chromosomal mechanism,but the behavior of autosomes and sex chromosomes during meiosis among three species are different,and one or two supernumerary chromosomes were detected in C.putoni. These characteristics may provide some useful clues on the study of pentatomid taxonomy and phylogeny.