Objectives: Peripheral neuropathy (PN) is a significant contributor to disability in the elderly. It is also one of the most prevalent complications of type 2 diabetes, prediabetes and metabolic syndrome. PN is common...Objectives: Peripheral neuropathy (PN) is a significant contributor to disability in the elderly. It is also one of the most prevalent complications of type 2 diabetes, prediabetes and metabolic syndrome. PN is commonly associated with pain, numbness, tingling, burning, and cramping in the feet and legs. Current treatment options are limited to controlling pain, seizures and use of antidepressant medications. These treatments have undesirable side effects and don’t stop PN progression. Here we utilized a combination of individual-specific modalities to improve local circulation and relieve PN symptoms. Methods: We conducted an open-label, multicenter pilot trial with 34 subjects (19 males and 15 females ranging from 40 - 85 years of age). All of the participants were diagnosed with peripheral neuropathy and had bilateral symptoms in their feet, and many reported the same symptoms (pain, numbness, tingling, burning, and cramping) in their lower legs. The duration of symptoms ranged from four months to over six years. On Day 0, subjects were given a 90-day supply of the oral supplement with dosing instructions and a LED light therapy device. They also received three platelet-rich plasma (PRP) injections in their lower extremities. Subjects also received an extracorporeal shockwave therapy (ESWT) treatment for each foot and subsequently twice per week for the first six weeks, then once weekly for the duration of the study. Subjects filled out the Brief Pain Index (BPI) at weekly intervals. On Day 90, subjects completed the Patient Global Impression of Change (PGIC) survey. Results: There were significant responses to pain, as evidenced by BPI scores at weeks 8, 9, 10 and 11 (p = 0.02, 0.01, 0.02, and 0.003, respectively). Analysis of the final day PGIC survey showed a favorable outcome for 73% of participants (p = 0.003), with the majority reporting Very Much Improved. Conclusions: By utilizing a multi-modality treatment protocol that includes PRP, LED light therapy, ESWT and an oral dietary supplement, we observed significant reductions in BPI scores. Quality of life and their overall impression of change (PGIC) were significantly improved, and there were no significant side effects.展开更多
日光温室为中国特有的一种栽培设施结构,非对称的结构形式造成温室内南北光环境分布不均匀,一般墙体结构冬季夜间保温不能满足多数作物的生长需求。为构建具有保温蓄热能力、反射补光能力的多功能墙体结构,该研究设计了一种直接吸收太...日光温室为中国特有的一种栽培设施结构,非对称的结构形式造成温室内南北光环境分布不均匀,一般墙体结构冬季夜间保温不能满足多数作物的生长需求。为构建具有保温蓄热能力、反射补光能力的多功能墙体结构,该研究设计了一种直接吸收太阳能的红外分频补光板(infrared frequency divided and supplementary light panel,IFDSLP),可对室内光热环境进行调节。合成了基于氧化锡锑(antimony tin oxide,ATO)-三氧化钨(tungsten trioxide,WO_(3))的水基纳米流体,将该纳米流体补充进IFDSLP内腔,作为传热分光工质。当IFDSLP集热面积为7.2 m^(2),光程为10 mm、体积分数为0.005%时,该流体工质在300~800 nm的植物光合有效波段中的平均反射率为79.6%,在近红外光波段中的平均吸收率为85.4%。该结构在增加温室北侧作物光照的同时,兼具温室夜间升温能力。IFDSLP系统的太阳能总利用率为71.9%,光热转换效率为36.4%,相比传统砖墙光辐射增加25%~28%,夜间空气温度平均提高1.5~2.0℃。该系统依托于现有日光温室结构,进一步改善了温室内的光热环境,是提高温室北墙全光谱利用率的有效途径。展开更多
文摘Objectives: Peripheral neuropathy (PN) is a significant contributor to disability in the elderly. It is also one of the most prevalent complications of type 2 diabetes, prediabetes and metabolic syndrome. PN is commonly associated with pain, numbness, tingling, burning, and cramping in the feet and legs. Current treatment options are limited to controlling pain, seizures and use of antidepressant medications. These treatments have undesirable side effects and don’t stop PN progression. Here we utilized a combination of individual-specific modalities to improve local circulation and relieve PN symptoms. Methods: We conducted an open-label, multicenter pilot trial with 34 subjects (19 males and 15 females ranging from 40 - 85 years of age). All of the participants were diagnosed with peripheral neuropathy and had bilateral symptoms in their feet, and many reported the same symptoms (pain, numbness, tingling, burning, and cramping) in their lower legs. The duration of symptoms ranged from four months to over six years. On Day 0, subjects were given a 90-day supply of the oral supplement with dosing instructions and a LED light therapy device. They also received three platelet-rich plasma (PRP) injections in their lower extremities. Subjects also received an extracorporeal shockwave therapy (ESWT) treatment for each foot and subsequently twice per week for the first six weeks, then once weekly for the duration of the study. Subjects filled out the Brief Pain Index (BPI) at weekly intervals. On Day 90, subjects completed the Patient Global Impression of Change (PGIC) survey. Results: There were significant responses to pain, as evidenced by BPI scores at weeks 8, 9, 10 and 11 (p = 0.02, 0.01, 0.02, and 0.003, respectively). Analysis of the final day PGIC survey showed a favorable outcome for 73% of participants (p = 0.003), with the majority reporting Very Much Improved. Conclusions: By utilizing a multi-modality treatment protocol that includes PRP, LED light therapy, ESWT and an oral dietary supplement, we observed significant reductions in BPI scores. Quality of life and their overall impression of change (PGIC) were significantly improved, and there were no significant side effects.
文摘日光温室为中国特有的一种栽培设施结构,非对称的结构形式造成温室内南北光环境分布不均匀,一般墙体结构冬季夜间保温不能满足多数作物的生长需求。为构建具有保温蓄热能力、反射补光能力的多功能墙体结构,该研究设计了一种直接吸收太阳能的红外分频补光板(infrared frequency divided and supplementary light panel,IFDSLP),可对室内光热环境进行调节。合成了基于氧化锡锑(antimony tin oxide,ATO)-三氧化钨(tungsten trioxide,WO_(3))的水基纳米流体,将该纳米流体补充进IFDSLP内腔,作为传热分光工质。当IFDSLP集热面积为7.2 m^(2),光程为10 mm、体积分数为0.005%时,该流体工质在300~800 nm的植物光合有效波段中的平均反射率为79.6%,在近红外光波段中的平均吸收率为85.4%。该结构在增加温室北侧作物光照的同时,兼具温室夜间升温能力。IFDSLP系统的太阳能总利用率为71.9%,光热转换效率为36.4%,相比传统砖墙光辐射增加25%~28%,夜间空气温度平均提高1.5~2.0℃。该系统依托于现有日光温室结构,进一步改善了温室内的光热环境,是提高温室北墙全光谱利用率的有效途径。
文摘夜间补光已成为设施蔬菜生产的重要手段,但多采用强光,耗能大、成本高,而夜间弱光补光对蔬菜生产的影响尚不清楚。为探讨夜间弱光补光对番茄生长和源库间蔗糖转运的影响,以Micro Tom番茄为材料,从植株4叶1心时期到果实绿熟期,以不补光为对照(CK),每天关灯1 h后进行4 h 15(SL15)和30μmol·m^(-2)·s^(-1)(SL30)低于光补偿点的两种补光处理。结果表明,与CK相比,SL15和SL30两个处理均显著提高番茄株高、茎粗和鲜质量;补光明显改善了根系形态,显著增加了总根长、总表面积和根尖数;补光促进开花,表现为开花株数和总开花数显著高于CK。以上生理指标SL15和SL30两个处理之间没有显著差异。与CK相比,SL15处理显著降低了成熟叶片和茎(源)的蔗糖含量,提高了果实和根系(库)的蔗糖含量,促进了蔗糖转运基因SUT1、SUT4、SWEET10b、SWEET11b和SWEET14在叶片、茎、果实和根系不同程度地上调表达,但叶片、茎、果实和根系4个器官总体的蔗糖含量没有显著差异。此外,SL15处理显著提高了叶片、茎、果实和根系4个器官中与蔗糖转运相关激素脱落酸的含量及其合成和信号标志基因NCED1、AAO3和ABI5的表达量。综上所述,夜间弱光补光可促进番茄生长及源库间蔗糖转运,研究结果为推广夜间弱光补光、降低补光成本、促进设施蔬菜高效绿色发展提供了新思路。
