The effect of Supplementing Qi and Nourishing Yin combined with chemotherapy for lung cancer： a meta-analysis

目的：明确益气养阴法联合化疗是否较单纯使用化疗治疗肺癌在增效、减毒等方面更有优势.方法：从网络数据库中检索2013年1月至2017年1月期间以中医益气养阴为治法联合化疗方案对比单纯化疗治疗肺癌并且运用了随机对照试验研究的国内外文献,然后采用RevMan5.3.5软件对搜集的文献质量进行评价、筛选.结果：成功筛选符合系统评价的文献10篇,总病例691例,治疗组共369例（益气养阴中药＋化疗）,对照组322例（单纯化疗）.Meta分析结果显示治疗组在改善肺癌临床症状方面具有显著统计学差异（P〈0.001）,在实体瘤情况方面、在生活质量改善情况方面、在不良反应发生情况方面两组对比均有显著统计学差异（P〈0.001）.结论：益气养阴法联合化疗能显著改善中晚期肺癌患者的临床症状,减少因化疗引起的毒副反应,提高患者生活质量.

Effect of Chinese Drugs for Supplementing Qi,Nourishing Yin and Activating Blood Circulation on Myocardial Perfusion in Patients with Acute Myocardial Infarction after Revascularization

Objective:To observe the effects of Chinese drugs for supplementing qi,nourishing yin and activating blood circulation on the myocardial perfusion in acute myocardial infarction(AMI) patients after revascularization.Methods:Eighty patients with anterior or inferior ventricular wall AMI,who had received revascularization by intravenous thrombolysis or coronary bypass,were randomized into the treated group and the control group equally,both treated with conventional Western medical treatment,but combined,resp...

Effect of Chinese Herbal Medicine for Nourishing Yin,Supplementing Qi,and Activating Blood on the Th1/Th2 Immune Balance in Peripheral Blood in Patients with Primary Sjogren's Syndrome

Objective： To observe the effect of Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood on the expression of interferen- γ （IFN-γ,）/interleukin-4 （IL-4） in peripheral blood and disease activity in primary Sjogren＇s syndrome （pSS） patients, and to study the relationship between the immune balance of Th1/Th2 and the disease activity. Methods： A total of 66 pSS patients were randomized with tossing coins method into two groups： the integrative therapy group （34 cases） and the control group （32 cases）; and 28 healthy subjects were taken as the normal group. The integrative therapy group was treated by Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood combined with hydroxychloroquine sulfate tablets and the control group was treated with hydroxychloroquine sulfate tablets. The treatment course was 3 months for both groups. The levels of serum immunoglobulin G （IgG）, erythrocyte sedimentation rate （ESR）, IFN-γand IL-4 in peripheral blood were measured before and after treatment. Results： Compared with the normal group, the levels of IgG, ESR, IFN- γ and IL-4 were significantly increased in pSS patients （P〈0.05）. Remarkably, after 3 months of treatment, these levels were dramatically decreased in both the integrative therapy group and the control group, although still higher than the normal group. The levels of IgG, ESR, IFN- and IL-4 in the integrative therapy group were lower than the control group and the same group before treatment （P〈0.05）. The ratio of IFN-γ/IL-4 also significantly decreased after treatment. Moreover, the level of IFN- γ, and the ratio of IFN- γ/IL-4 in the integrative theraphy group were significantly lower than the control group （P〈0.05）. For all patients the ratio of IFN-γ/IL-4 before and after treatment was positive correlated with the levels of IgG and ESR. Conclusion： Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood can alleviate the disease activity of pSS by regulating the immune balance of Th1/Th2.

Effect of Chinese Herbal Medicines for Nourishing Yin,Supplementing Qi,and Activating Blood on Reproductive Endocrine Activity and Immune Functions in Patients with Primary Sjogren's Syndrome

ABSTRACT Objective： To investigate the effect of Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood on the reproductive endocrine-immune network and its mechanisms in patients with primary Sjogren＇s syndrome （pSS）. Methods： Seventy pSS patients were randomly assigned to two groups using a randomized digital table： the integrative therapy group （36 cases） and the control group （34 cases）. Thirty healthy subjects were taken as a normal group. The control group was treated with hydroxychloroquine sulfate tablets alone, and the integrative therapy group was treated by Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood combined with hydroxychloroquine sulfate tablets. The treatment course was 6 months for both groups. Before and after treatment, serum estradiol （E2）, testosterone （T）, luteinizing hormone （LH）, prolactin （PRL） by radioimmunoassay and immunoglobulin （IgG） by immunodiffusion, erythrocyte sedimentation rate （ESR） by Westergren, interferon-γ （IFN-γ） and interleukin-4 （IL-4） by enzyme linked immunosorbent assay were determined. Results： E2 and T levels in all patients were lower than those of normal subjects before treatment （P〈0.05） and were increased significantly after 6-month treatment （P〈0.05）. ESR, FSH, LH, IgG, IFN - γ, IL - 4 and ratios of E2/T, and IFN --γ/IL in the patients were higher than those of normal subjects before the treatments （P〈0.05）, and were reduced significantly after the treatments （P〈0.05）. The T and IFN -γ levels and E2/T ratio in the patients treated with integrative therapy were reduced significantly compared with the control group （P〈0.05）. However, the PRL levels before and after treatment were not significantly changed in the two groups （P〉0.05）. The ratios of E2/T and IFN -γ/IL-4, and levels of IgG and ESR were positively correlated before and after treatment （P〈0.05）. Conclusions： The ratios of E2/T and IFN - γ/ IL-4 might be used as indicators of pSS activity. Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood combined with Western medicine could improve the therapeutic effect by regulating the reproductive endocrine-immune network in pSS patients.

Protective Effect of Chinese Herbs for Supplementing Qi,Nourishing Yin and Activating Blood Circulation on Heart Function of Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention

Objective： To investigate the effects of Chinese herbs for supplementing qi, nourishing yin and activating blood circulation on heart function of patients with acute coronary syndrome （ACS） after successful percutaneous coronary intervention （PCI）. Methods： One hundred patients with ACS after successful PCI were randomly assigned to a Western medicine （WM） treatment group （WMG） and a combined treatment group （CMG） treated by Chinese herbs for supplementing qi, nourishing yin and activating blood circulation, besides Western medicine treatment, with 50 cases in each group. Both treatment courses were 6 months. The follow- up was scheduled at baseline, 6 months and 1 year after PCI, and New York Heart Association （NYHA） functional class, Chinese medicine （CM） symptom scores, blood stasis syndrome scores, and major adverse cardiovascular events （MACE） were observed, serum levels of N-terminal pro-brain natriuretic peptide （NT-proBNP） and hyper-sensitivity C-reactive protein （Hs-CRP） were measured, an echocardiogram was conducted to examine left ventricular ejection fraction （LVEF）, left ventricular end-diastolic volume （LVEDV）, left ventricular end-systolic volume （LVESV）, inter-ventricular septal thickness （IVST）, left ventricular posterior wall thickness （LVPWT）, and ventricular wall motion index （VWMI）. Results： Compared with the baseline, LVEF significantly increased （P〈0.01）, and CM symptom scores, blood stasis syndrome scores, VWMI, LVEDV, LVESV, NT-proBNP, and Hs-CRP all decreased （P〈0.01） in both groups at 6 months and at 1 year after PCI. There were no significant differences in all the above parameters at 1 year vs those at 6 months after PCI （P〉0.05）. VWMI, LVEDV, LVESV, NT-proBNP, Hs-CRP, LVEF, and CM symptom and blood stasis syndrome scores were all improved obviously in CMG than those in WMG （P〈0.05 or P〈0.01） at 6 months and at 1 year after PCI. There were no significant differences in NYHA functional class between CMG and WMG at different follow-up timepoints; it was notable that P value was 0.054 when comparing the cases of NYHA functional class between the two groups at 1-year follow-up. During the 1-year follow-up, 3 MACE and 11 MACE occurred in CMG and WMG, respectively; the MACE rate in CMG was lower than that in WMG （6% vs 22%, P〈0.05）. Conclusion： Chinese herbs for supplementing qi, nourishing yin and activating blood circulation could improve heart function, reduce the CM symptom scores and blood stasis syndrome scores, and decrease the incidence of MACE in patients with ACS after successful PCI.

Multi-central Clinical Research into Treating 80 Cases of Chronic Thrombocytopenia with Qi-supplementing and Yin-nourishing Therapy and Western Medicine

Objective: To probe the effects of qi-supplementing and yin-nourishing therapy (blood-increasing decoction and blood generating powder) on chronic thrombocytopenia. Methods: Two hundred patients with chronic thrombocytopenia were randomly divided into control (n=100) and test groups (n = 100) with Amino-polypeptide as a basic treatment for both. Test group patients consumed a blood-increasing decoction and blood-generating powder for 1-3 months. Improvements in platelet counts and TCM syndrome were observed. Results: One hundred and sixty-four (80 in the test group and 84 in the control group) of 189 total participants were treated for 3 months. The total effective rate in improving TCM syndrome was 95.00% in the test group and 79.76% in the control group (P<0.05). There was significant difference (P<0.05) in the accumulated score of TCM syndrome between the two groups treated at different time points. The total effective rate of platelet counts was 86.25% in the test group and 59.52% in the control group (P<0.05). There was a significant difference in platelet counts before and after treatment in the two groups (P<0.05). There was no significant differences in platelet count between the two groups treated for 1-2 months; however, a significant difference was found between the two groups after treatment for 3 months (P<0.05). Conclusions: After a 3-month treatment of chronic thrombocytopenia patients with qi-supplementing and yin-nourishing therapy, TCM syndrome was improved and platelet counts increased with no obvious side effects, and the quality of life of the participants was enhanced with noticeable long-term curative effects.

益气养阴化瘀法对糖尿病视网膜病变患者微血管功能、动脉血流、微视野及血清Vaspin和SCUBE2水平的影响

目的:观察益气养阴化瘀法对糖尿病视网膜病变患者微血管功能、动脉血流、微视野及血清脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)和骨形态发生蛋白1-表皮生长样结构域蛋白2(SCUBE2)水平的影响。方法:选择2021年1月至2022年12月于该院治疗的糖尿病视网膜病变患者102例,以随机数字表法分组。对照组50例患者给予常规西医治疗,观察组52例患者在对照组的基础上给予益气养阴化瘀方治疗。比较两组患者的临床疗效、治疗前后的中医证候评分,检测视野平均敏感度、视力、收缩期血流速度峰值、眼动脉阻力指数(RI)和舒张期血流速度峰值,检测患者Vaspin、低氧诱导因子-1(HIF-1)、可溶性细胞黏附分子(sICAM-1)、SCUBE2、外周血内皮细胞(CEC)和循环祖细胞(CPC)水平。结果:观察组患者总有效率为98.08%(51/52),高于对照组的84.00%(42/50),差异有统计学意义(P<0.05)。治疗后,观察组患者的中医证候评分较对照组降低,差异有统计学意义(P<0.05)。治疗后,观察组患者的RI低于对照组,收缩期血流速度峰值、舒张期血流速度峰值、视野平均敏感度和最佳矫正视力高于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组患者的CPC水平较对照组升高,CEC水平较对照组降低,Vaspin、HIF-1、sICAM-1和SCUBE2水平较对照组降低,差异均有统计学意义(P<0.05)。结论:益气养阴化瘀法治疗糖尿病视网膜病变,可改善患者微血管功能、动脉血流、微视野和视力,提高临床疗效。

益气养阴活血法治疗2型糖尿病合并慢性心力衰竭患者的疗效观察

目的 探讨中医益气养阴活血法辨证治疗2型糖尿病(Type 2 diabetes, T2DM)合并慢性心力衰竭(Chronic heart failure, CHF)患者的临床疗效。方法 选取2021年1月—2022年1月期间唐山市中医医院内分泌一科收治的T2DM合并CHF患者102例作为研究对象,按随机数字表法分为对照组与治疗组,每组各51例。对照组给予常规西医治疗,治疗组在对照组基础上联合中医益气养阴活血法辨证治疗,均治疗12周。观察比较两组患者西医疗效、中医证候疗效、安全性及治疗前后血糖水平[空腹血糖(Fasting blood glucose, FPG)、餐后2 h血糖(Blood glucose 2 h after a meal, 2 h PG)、糖化血红蛋白(Glycosylated hemoglobin, HbAlc)]、心功能指标[6分钟步行试验距离(6 min walking test, 6MWT)、左室射血分数(Left ventricular ejection fraction, LVEF)、N末端B型脑钠肽前体(N-terminal B-type brain natriuretic peptide precursor, NT-pro BNP)]、生活质量评分[T2DM生活质量(Quality of life specific scale for diabetes patients, DSQL)、CHF生活质量(Minnesota Living with Heart Failure Questionnaire, MLHFQ)]变化。结果 临床疗效:治疗后治疗组西医疗效总有效率96.08%(49/51)高于对照组82.35%(42/51),差异有统计学意义(P<0.05);治疗组中医证候疗效总有效率92.16%(47/51)高于对照组68.63%(35/51),差异有统计学意义(P<0.05)。血糖水平:治疗后两组患者血糖FPG、2 h PG及HbAlc水平均较治疗前降低,差异有统计学意义(P<0.05);且治疗组血糖FPG、2 h PG及HbAlc水平均明显低于对照组,差异有统计学意义(P<0.05)。心功能指标:治疗后两组患者心功能6MWT、LVEF水平较治疗前升高,NT-pro BNP水平较治疗前降低,差异有统计学意义(P<0.05);且治疗组6MWT、LVEF水平高于对照组,NT-pro BNP水平低于对照组,差异有统计学意义(P<0.05)。生活质量:治疗后两组患者DSQL、MLHFQ评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组DSQL、MLHFQ评分均明显低于对照组,差异有统计学意义(P<0.05)。安全性:治疗期间,两组患者不良反应均为轻度或一过性,未影响治疗,且不良反应发生率组间比较,差异无统计学意义(P>0.05)。结论 中医益气养阴活血法辨证治疗T2DM合并CHF效果显著、安全性高,有利于控制患者血糖,改善心功能与生活质量。

陈健教授从“伏火”论治儿童周期性发热综合征经验

[目的]总结陈健教授从“伏火”论治儿童周期性发热综合征的临床经验。[方法]通过门诊跟诊学习、病案收集整理及查阅相关文献,探讨儿童周期性发热综合征的病因病机,总结陈教授从“伏火”论治该病的治疗经验,并举验案一则加以验证。[结果]陈教授认为,儿童周期性发热综合征的核心病机为“伏火”,“伏火”为发病之本,痰、毒、瘀既是病理产物,也是贯穿病程始终的重要致病因素,郁为存在于发病全过程的病理状态。治疗上以益气除热或养阴清热与调气之法并行,并以自拟方药为治疗儿童周期性发热综合征的有效验方。所举验案以周期性发热为主要症状,辨为阴虚发热证,投以养阴清热、行气解郁之法,取得了较好的疗效。[结论]陈教授从“伏火”论治儿童周期性发热综合征,疗效显著,具有一定的指导意义,值得临床参考借鉴。

Randomized Double-blinded and Controlled Clinical Trial on Treatment of HIV/AIDS by Zhongyan-4 (中研-4号)

Objective： To assess the efficacy and safety of Zhongyan-4 （中研-4号, ZY-4, a Chinese herbal preparation worked out according to the therapeutic principle of supplementing qi, nourishing Yin, clearing heat and detoxication） in treating HIV/AIDS patients in the early or middle stage. Methods： Adopted was randomized double-blinded and placebo-parallel-controlled method, with 72 HIV/AIDS patients randomly divided into the ZY-4 group （36 patients） treated with ZY-4 and the control group （36 patients） treated with placebo. The treatment course was six months. The index of OD4^＋, OD8^＋ counts, body weight, clinical symptom scoring were estimated at 4 time points （0, 1, 3 and 6 month in the course）, and also the viral load before and after treatment. The whole course of observation was completed in 63 patients, 30 in the ZY-4 group and 33 in the control group. Results： OD4^＋ count in the ZY-4 group got elevated by 7.70 4±150.96/mm^3 on average, while that in the control group lowered by 27.33 4±85.28 /mm^3 . Fifteen out of the 30 patients in the ZY-4 group had their OD4^＋ count increased, which was evidently much higher than that in the control group （8/33, P〈0. 05）, suggesting that the efficacy of ZY-4 is superior to that of placebo in elevating OD4^＋ count. Moreover, ZY-4 showed actions in elevating OD45RA^＋ and OD8^＋ count, reducing HIV virus load, improving clinical symptom/sign and increasing body weight of patients. No obvious adverse reaction was found in the clinical trial. Conclusion： ZY-4 has an immunity-protective and/or rebuilding function in HIV/AIDS patients in the early and middle stage, and also shows effects in lowering viral load, increasing body weight and improving symptoms and signs to a certain degree.

基于数据挖掘分析糖尿病肾病证候及用药规律

目的:应用数据挖掘技术分析总结相关文献中糖尿病肾病的证候及用药规律。方法:运用中国知网(CNKI)、维普资讯中文期刊服务平台,搜集2015年1月1日至2020年12月31日治疗糖尿病肾病的医案,提取用药信息,通过Microsoft Excel 2019建立数据库整理归纳数据,总结糖尿病肾病的证候分布情况、药物治疗分布情况以及药物组合关联规则等。结果:共检索相关文献923篇,根据证候分布情况,病位类证候要素主要为肾、脾、肝、肺、心等;病性类证候要素主要为瘀血、痰浊、阴虚、气虚、浊毒等。根据药物治疗分布情况,四气主要为平、温、寒、微温、微寒,五味多为甘、苦、辛、酸、淡、微苦,且归于肝、脾、肾、肺、心、胃、膀胱、大肠经。核心药物以黄芪、茯苓、山药、山茱萸、丹参等50味中药为主,可归纳为补虚药、活血化瘀药、清热药、利湿药、收涩药;药物组合关联规则显示,丹参、山药、山茱萸、茯苓均与黄芪联系密切。结论:益气养阴、活血通络法为糖尿病肾病主要治法,此为后续进一步开展临床研究提供了数据支撑。

基于“湿火”理论探讨糖尿病合并冠心病的诊治

[目的]基于“湿火”理论探究糖尿病合并冠心病的临床治疗方法。[方法]以“湿火”理论内涵为着手点,基于古今文献,分析论证“湿火”与糖尿病合并冠心病病理过程的关系,总结出从“湿火”治疗糖尿病合并冠心病的原则,并附上一则医案予以佐证。[结果]糖尿病合并冠心病在中医学属于消渴合并胸痹的范畴,“湿火”是其重要病机,中医学以“火热”并谈,然“湿火”“湿热”两异,“湿火”为湿热伤阴,因此应益气养阴以清“湿火”,进而治疗糖尿病合并冠心病。目前临床上鲜有基于“湿火”理论指导糖尿病合并冠心病治疗的报道。所列举医案即为“湿火”所致,以益气养阴为治法,治疗后症状改善明显。[结论]从“湿火”论治糖尿病合并冠心病,并予以临证加减,疗效颇佳,可为医者提供新颖的治疗思路。

从阴阳论治甲状腺功能亢进症

甲状腺功能亢进症(简称甲亢),是甲状腺激素增多导致身体机能亢进的一类内分泌疾病,以心慌手抖、多食易饥、体质量减轻、眼球突出、烦躁易怒为主要临床表现。西医通常选用抗甲状腺药物、甲状腺切除术等方法治疗该病,虽有疗效,但存在需要长期服药、复发率高、手术创伤大、不良反应多等问题。中医将该病归为“瘿病”范畴。贾颖教授具有多年的临床、科研、教学经验,主要运用调和阴阳的方法治疗该病,临床效果显著。文章以阴阳为切入点,通过查阅文献并结合医案分析,浅析贾颖教授治疗“甲亢”过程中的点滴感悟。贾师认为,甲亢主要病机为阴虚阳亢,其中的关键原因为七情郁结,阴虚气弱是基本病变,阴损及阳是转折点。贾师在汲取前人经验及对赵尚华老先生所提出的治疗理念进行全面传承的基础上,对其进行中医辨证分型,分为肝郁痰结、阴虚阳亢、气阴两虚、阴损及阳,并把现代医疗知识融入阴阳之道,在辨证施治的过程中形成了自身的诊疗特色,实现了使患者机体阴阳稳态平衡的治疗目的。

养阴益肺汤联合西医常规治疗气阴两虚型老年肺炎的临床观察

目的分析养阴益肺汤联合西医常规治疗气阴两虚型老年肺炎的临床疗效。方法围绕本院收治的90例患者气阴两虚型老年肺炎患者展开研究,均于2021年1月-2021年12月期间在本院就诊,并以随机抽样法为分组依据,将其分为对照组(n=45)及实验组(n=45),对照组以西医常规治疗,实验组在对照组基础上+养阴益肺汤治疗,针对两组治疗总有效率、症状缓解时间、炎症因子指标波动情况、中医症候积分波动情况及不良反应发生情况。结果实验组治疗效果优于对照组(P<0.05),总有效率分别为95.56%、67.27%;实验组咳嗽、咳痰、胸闷、肺部湿啰音、咳喘症状消失时间均短于对照组(P<0.05);治疗前两组各项炎性因子水平对比无意义(P>0.05),治疗后实验组C反应蛋白、降钙素原、肿瘤坏死因子α均低于对照组(P<0.05);治疗前两组气虚肝郁型失眠中医症候积分对比无意义(P>0.05),治疗后实验组咳嗽、咳痰、气促、发热积分均低于对照组(P<0.05);两组用药期间不良反应发生率对比无明显差异(P>0.05),分别为4.44%、6.67%。结论养阴益肺汤+西医常规治疗气阴两虚型老年肺炎的临床疗效显著,可加速患者康复,建议临床采纳。

中研2号治疗HIV/AIDS的临床和实验研究

目的:观察中研2号对HIV/AIDS患者和猴艾滋病毒SIVmac251感染猴的疗效,评价该方抗艾滋病毒和对机体的保护作用。方法:根据统一的诊断标准,对确诊的HIV/AIDS患者给予中研2号治疗,疗程为3个月,从免疫功能、病毒载量和临床症状体征等方面进行疗效判定;采用猴艾滋病模型,以病毒分离、酶联免疫法及流式细胞仪检测 SIV水平、CD_4^+、CD_8^+细胞及新喋呤水平,并进行病理学检查。结果:中研2号对治疗HIV/AIDS患者临床有效率为45％～55％;对猴艾滋病模型不仅能降低感染猴病毒血症及SIVp27抗原水平,同时能持续提高CD_4^+细胞数量,降低血清新喋呤含量,与叠氮胸苷阳性药对照结果近似,与生理盐水比较,差异有显著性。病理检查显示中研2号能激活并促进淋巴结中心细胞的增殖。结论:中研2号具有一定的临床效果,可抑制感染猴血浆病毒血症及保护机体免疫功能。

益气养阴活血法对早期糖尿病肾病患者一氧化氮的影响

目的:观察以益气养阴活血法为主治疗早期糖尿病肾病(DN)患者的疗效及对一氧化氮(NO)的影响。方法:将入选的65例患者随机分为对照组(31例)和治疗组(34例),对照组予糖尿病教育、常规降血糖及对症处理,治疗组加用以益气养阴活血为主的中药治疗。结果:早期糖尿病肾病患者NO明显升高,治疗8周后,两组均能较好地降低症状积分、空腹血糖(FBG)及24h尿微量白蛋白排泄量(UAE)。治疗组在改善患者症状、降低UAE及N0水平方面,疗效明显优于对照组(P<0.05或P<0.01),对照组对NO改善不明显。结论:提示DN早期高N0生成与肾小球高滤过有关,益气养阴活血法为主可能通过降低肾脏NO水平,改善肾小球的高滤过。

益气养阴、活血化瘀散结法治疗2型糖尿病肾病Ⅲ、Ⅳ期气阴两虚夹瘀型40例临床研究

目的:观察益气养阴、活血化瘀散结法治疗2型糖尿病肾病的临床疗效。方法:将40例糖尿病肾病患者随机分成治疗组和对照组,以安慰剂为对照,治疗组和安慰剂组的比例约为2∶1。治疗组以益气养阴、活血化瘀散结为主法,以黄芪、生地黄、制大黄、夏枯草、三七、卫矛、山茱萸、枳壳组方(以下称治疗方)治疗12周。观察治疗前后中医证候积分、尿微量白蛋白、24h尿蛋白定量、糖化血红蛋白、肝肾功能、血脂等指标。结果:治疗组中医证侯积分与服药前相比有所降低,服药时间越长降低越明显,服药8周后显示出统计学差异,服药12周总有效率达81.48%;治疗组患者尿蛋白较治疗前有所下降,与治疗前及与安慰剂组相比较均具有统计学差异。结论:益气养阴、活血化瘀散结法能够有效改善糖尿病肾病Ⅲ、Ⅳ期气阴两虚夹瘀型患者的临床症状,可以控制早期糖尿病肾病的进展,是中医药干预治疗早期糖尿病肾病可以选择的有效治疗方案。

益气养阴通络法对急性心肌梗死大鼠心肌细胞凋亡Bax、Bcl-2、Caspase3表达的影响

目的:观察益气养阴通络法对大鼠心肌细胞凋亡Bax、Bcl-2和Caspase3表达的影响,并探讨其作用机制。方法:健康SD大鼠60只,随机分为6组,正常组、模型组、西药组(盐酸地尔硫卓片)、中药低剂量组、中药中剂量组、中药高剂量组。对模型组、中药组、西药组实验动物进行造模,复制急性心肌缺血的模型。西药组及中药组分别给予盐酸地尔硫卓片、中药双参通脉颗粒灌胃2周。采用Western Blotting法检测各组心肌组织中Bax、Bcl-2、Caspase3的表达水平。结果:与正常组比较,模型组Bcl-2表达均显著降低,Bax、Caspase3表达升高(P<0.01或P<0.05)。与模型组比较,各组Bcl-2表达均显著升高,Bax、Caspase3表达均降低(P<0.01或P<0.05)。与模型组比较,中药治疗组中,高剂量组Bcl-2表达明显升高,Bax、Caspase3表达明显降低(P<0.05);西药组与模型组相比,Bcl-2表达明显升高(P<0.01),Caspase3表达明显降低(P<0.05),Bax表达有降低趋势(P>0.05)。中药组高剂量组与西药组相比,Bcl-2表达无明显差异(P>0.05)。结论:益气养阴通络法能够上调急性心肌梗死大鼠心肌细胞Bcl-2表达,下调Bax、Caspase3表达。

益气养阴活血法治疗脓毒症应激性高血糖的临床观察

目的探讨益气养阴活血法对脓毒症应激性高血糖患者血清C反应蛋白(C-reactive protein,CRP)、TNF-α、IL-1、IL-6水平及外周血单核细胞人白细胞抗原(human leukocyte antigen,HLA)-DR表达的影响。方法采用前瞻性随机对照研究方法 ,选择脓毒症应激性高血糖患者85例,随机分为试验组(45例)和对照组(40例),两组均给予常规抗感染、营养支持和胰岛素泵控制血糖,试验组按益气养阴活血法,加用参麦注射液和丹参酮ⅡA磺酸钠注射液静脉滴注,每天1次,连续7天。ELISA法检测两组患者治疗前及治疗第8天血清CRP、TNF-α、IL-1、IL-6水平及外周血单核细胞HLA-DR表达;比较两组患者胰岛素连续使用时间、胰岛素使用总量、低血糖发生率、APACHEⅡ评分以及住院28天病死率。结果与对照组比较,试验组胰岛素使用总量、胰岛素连续使用时间、低血糖发生率、治疗第8天APACHEⅡ评分以及住院28天病死率均明显下降(P<0.05,P<0.01)。两组患者治疗前血清CRP、TNF-α、IL-1和IL-6水平以及HLA-DR表达比较,差异均无统计学意义(P>0.05);治疗后两组血清CRP、TNF-α、IL-1和IL-6水平较治疗前降低,HLA-DR表达较治疗前升高,差异均有统计学意义(P<0.05),以试验组作用更优(P<0.05,P<0.01)。结论益气养阴活血法配合胰岛素强化治疗能更好地改善脓毒症患者免疫状态,降低应激性高血糖的血糖水平和持续时间,提高生存率,改善预后。

益气养阴方在甲亢治疗中的应用

文章全面系统的梳理和总结了甲状腺功能亢进症的病因病机,认为采用益气养阴法治疗甲状腺功能亢进症具有较好的疗效,其在减少西药用量及其副作用、降低复发率等方面具有独特的优势,同时也对益气养阴法治疗的现代机理方面进行了综述,以期为甲亢治疗提供全面的理论和数据支持。