General anesthesia with controlled ventilation through endotracheal tube is an anaesthetic technique used by the anesthesiologists all over the world. Laryngoscopy and endotracheal intubation is necessary to achieve t...General anesthesia with controlled ventilation through endotracheal tube is an anaesthetic technique used by the anesthesiologists all over the world. Laryngoscopy and endotracheal intubation is necessary to achieve this technique. Traditionally succinylcholine is drug of choice for induction due to its rapid onset of action. Aim: This study compared the efficiency of magnesium sulphate in reducing fasciculation and increase in serum potassium which are the common complications associated with suxamethonium administration. Methods: Fifty six patients being planned for lower abdominal surgery under general anaesthesia were randomized into two groups M and S. Serum potassium was taken in the theatre, three minutes before induction of anesthesia patients in M group were given 6 mg/kg of magnesium sulphate diluted in 10 ml normal saline intravenously while in S group 10 ml of normal saline was injected intravenously. The occurrence and degree of fasciculation were recorded after administration of suxamethonium in both groups while serum potassium was also taken at the end of fasciculations. The researcher was blinded to the content of the syringes until after the study. Results: More patients in the S group had fasciculations compared to the M group while the degree of fasciculations was more in the S group, the serum potassium increase was more in the saline group.展开更多
目的分析0.75-5 U A型肉毒毒素(BoNT-A)对电刺激坐骨神经引起蟾蜍腓肠肌单收缩作用。方法蟾蜍随机分为琥珀胆碱组(SC,n=44):右侧腓肠肌注射SC 0.04 mg,左侧注射0.2 mL任氏液(RGS);BoNT-A组(n=42):右侧腓肠肌分别注射0.75-5.0 U BoNT-A,...目的分析0.75-5 U A型肉毒毒素(BoNT-A)对电刺激坐骨神经引起蟾蜍腓肠肌单收缩作用。方法蟾蜍随机分为琥珀胆碱组(SC,n=44):右侧腓肠肌注射SC 0.04 mg,左侧注射0.2 mL任氏液(RGS);BoNT-A组(n=42):右侧腓肠肌分别注射0.75-5.0 U BoNT-A,左侧注射RGS。注射后分别于1、4、7、10、24、48 h制备坐骨神经腓肠肌标本,单电刺激(0.5 Hz,2 V)神经引腓肠肌等长收缩并经张力换能器计算机进行记录张力变化。结果 1～48 h SC仅第1小时抑制电刺激坐骨神经引发的腓肠肌单收缩;1.25、2.5、5.0 U BoNT-A 1～48 h均显著抑制电刺激坐骨神经引发的腓肠肌单收缩(P<0.05或P<0.01),该抑制作用在10～48 h比1～7 h更强(P<0.05)。1.25 U BoNT-A抑制效应显著,而随后剂量递增并不显著增强抑制效应。结论 BoNT-A呈时间依赖性抑制电刺激引起对骨骼肌但收缩,其有效剂量为1.25 U。展开更多
文摘General anesthesia with controlled ventilation through endotracheal tube is an anaesthetic technique used by the anesthesiologists all over the world. Laryngoscopy and endotracheal intubation is necessary to achieve this technique. Traditionally succinylcholine is drug of choice for induction due to its rapid onset of action. Aim: This study compared the efficiency of magnesium sulphate in reducing fasciculation and increase in serum potassium which are the common complications associated with suxamethonium administration. Methods: Fifty six patients being planned for lower abdominal surgery under general anaesthesia were randomized into two groups M and S. Serum potassium was taken in the theatre, three minutes before induction of anesthesia patients in M group were given 6 mg/kg of magnesium sulphate diluted in 10 ml normal saline intravenously while in S group 10 ml of normal saline was injected intravenously. The occurrence and degree of fasciculation were recorded after administration of suxamethonium in both groups while serum potassium was also taken at the end of fasciculations. The researcher was blinded to the content of the syringes until after the study. Results: More patients in the S group had fasciculations compared to the M group while the degree of fasciculations was more in the S group, the serum potassium increase was more in the saline group.
文摘目的分析0.75-5 U A型肉毒毒素(BoNT-A)对电刺激坐骨神经引起蟾蜍腓肠肌单收缩作用。方法蟾蜍随机分为琥珀胆碱组(SC,n=44):右侧腓肠肌注射SC 0.04 mg,左侧注射0.2 mL任氏液(RGS);BoNT-A组(n=42):右侧腓肠肌分别注射0.75-5.0 U BoNT-A,左侧注射RGS。注射后分别于1、4、7、10、24、48 h制备坐骨神经腓肠肌标本,单电刺激(0.5 Hz,2 V)神经引腓肠肌等长收缩并经张力换能器计算机进行记录张力变化。结果 1～48 h SC仅第1小时抑制电刺激坐骨神经引发的腓肠肌单收缩;1.25、2.5、5.0 U BoNT-A 1～48 h均显著抑制电刺激坐骨神经引发的腓肠肌单收缩(P<0.05或P<0.01),该抑制作用在10～48 h比1～7 h更强(P<0.05)。1.25 U BoNT-A抑制效应显著,而随后剂量递增并不显著增强抑制效应。结论 BoNT-A呈时间依赖性抑制电刺激引起对骨骼肌但收缩,其有效剂量为1.25 U。
