Robust NHC-palladacycles(NHC¼N-heterocyclic carbene)were synthesized and exhibited high catalytic activity towards SuzukiMiyaura cross-coupling reactions between inactive amides with N-acetyl/benzyl substituents ...Robust NHC-palladacycles(NHC¼N-heterocyclic carbene)were synthesized and exhibited high catalytic activity towards SuzukiMiyaura cross-coupling reactions between inactive amides with N-acetyl/benzyl substituents and aryl boronic acids,producing diverse ketones in good to excellent yields.This unprecedented and practical palladacycles-catalyzed SuzukiMiyaura cross-coupling of amides with boronic acids via selective C-N bond activation was attributed to the strongσ-donor and weakπ-acceptor properties of acenaphthoimidazolylidene,which may highlight their potential in other challenging coupling transformations involving inactive amides.展开更多
文摘Robust NHC-palladacycles(NHC¼N-heterocyclic carbene)were synthesized and exhibited high catalytic activity towards SuzukiMiyaura cross-coupling reactions between inactive amides with N-acetyl/benzyl substituents and aryl boronic acids,producing diverse ketones in good to excellent yields.This unprecedented and practical palladacycles-catalyzed SuzukiMiyaura cross-coupling of amides with boronic acids via selective C-N bond activation was attributed to the strongσ-donor and weakπ-acceptor properties of acenaphthoimidazolylidene,which may highlight their potential in other challenging coupling transformations involving inactive amides.
