【目的】探讨海南省特发性性早熟(idiopathic central precocious puberty,ICPP)女童的中医证型分布特点。【方法】回顾性选取海南省妇女儿童医学中心于2019年1月至2021年12月收治的216例ICPP女童为研究对象,对其中医证候进行频数统计...【目的】探讨海南省特发性性早熟(idiopathic central precocious puberty,ICPP)女童的中医证型分布特点。【方法】回顾性选取海南省妇女儿童医学中心于2019年1月至2021年12月收治的216例ICPP女童为研究对象,对其中医证候进行频数统计和分级评分,并按阴虚火旺证、气血亏虚证和心肾不交证三大中医证型,探讨其中医证型分布特点。【结果】(1)发病年龄方面,216例ICPP女童的发病年龄在4~10岁之间,平均发病年龄为(7.15±1.06)岁,其中满7岁且不满8岁阶段的ICPP女童发病率最高,为49.54%。(2)中医证型方面,三大证型中,阴虚火旺证的占比最高(147例,占68.06%),其次是气血亏虚证(41例,占18.98%)及心肾不交证(28例,占12.96%)。(3)中医证候方面,临床常见证候(频率>25.0%)按出现频率由高到低依次为:怕热盗汗、手足心热、乳房胀痛、性情急躁、脉细数、大便干结、咽干口燥、潮热、多食肥甘、舌红少苔、抑郁、精神乏力、颧红、失眠多梦、舌红苔黄和口苦口干等16种。(4)各证型的年龄分布方面:阴虚火旺证和气血亏虚证均多见于满7岁且不满8岁年龄段的ICPP女童(占58.50%和51.22%),心肾不交证多见于满8岁且不满9岁年龄段的ICPP女童(占89.29%)。【结论】阴虚火旺证是海南省ICPP女童占比最高的中医证型。研究性早熟女童的中医证型分布,有助于性早熟女童的早期临床症状观察以及疾病的早期诊断,从而为ICPP女童的临床辨证用药提供线索和依据。展开更多
Objective： To assess the effectiveness of Tongjiang Granule （TJG, 通降颗粒） on the patients with nonerosive reflux disease （NERD） of Gan （肝）-Wei （胃） incoordination syndrome, its impact on their quality of l...Objective： To assess the effectiveness of Tongjiang Granule （TJG, 通降颗粒） on the patients with nonerosive reflux disease （NERD） of Gan （肝）-Wei （胃） incoordination syndrome, its impact on their quality of life, and its safety. Method： A randomized, controlled, double-blinded, and double-dummy method was adopted in the trial. There were 120 NERD patients enrolled in the study and randomly divided into the experiment and control groups, each with 60 patients; drugs were distributed according to the drug number by patients＇ inclusion sequences. In the experiment group, patients were given TJG 10 g and mosapdde citrate dummy 5 mg three times a day, and in the control group, patients were given mosapdde citrate 5 mg and TJG dummy 10 g three times a day. The treatment courses of both groups were 4 weeks. Results： Among 120 included patients, 112 were screened for full analysis set （FAS）, and 105 were screened per-protocol set （PPS）. The results were as follows： （1） the improvement of total scores of symptom in the experiment group （0-4 week） were 15.93 ± 7.88 scores by FAS and 16.22 ±7.75 scores by PPS, and they were 10.43± 10.16 scores and 10.79± 10.27 scores in the control group, respectively. The 95% CI of net scores improvement between the two groups were 2.10- 8.90 scores and 1.92-8.94 scores in FAS and PPS; it was significantly better in the experiment group than that in the control group （P〈0.05）. （2） The improvement of scores of major symptom in the experiment group （0-4 week） were 10.68±5.35 by FAS and 10.89±5.29 by PPS and 7.40±7.41 and 7.60±7.46 in the control group, respectively. The 95% CI of net scores improvement in the two groups were 0.85-5.71 and 0.71-5.69 in FAS and PPS separately, and the improvement in the experiment group was significantly better than that in the control group （P〈0.05）. （3） The total effective rates were 86.0% and 61.8% in the experiment and the control group separately, and the Ridit analysis results showed that it was better in the experiment group （P〈0.05）. （4） The improvement quality of life in the domain of physical functioning and general health in the experiment group was better than that in the control group （P〈0.05）. （5） One case of experiment group caught a cold and recovered in six days without drug suspension. No adverse event was found in the other cases. There was no meaningful safety examination indices change in pretreatment and posttreatment periods in both groups. Conclusion： TJG showed a definite effect on the treatment of NERD with Gan-Wei incoordination syndrome, and it could improve the quality of life of NERD patient without obvious toxic and side effects.展开更多
文摘【目的】探讨海南省特发性性早熟(idiopathic central precocious puberty,ICPP)女童的中医证型分布特点。【方法】回顾性选取海南省妇女儿童医学中心于2019年1月至2021年12月收治的216例ICPP女童为研究对象,对其中医证候进行频数统计和分级评分,并按阴虚火旺证、气血亏虚证和心肾不交证三大中医证型,探讨其中医证型分布特点。【结果】(1)发病年龄方面,216例ICPP女童的发病年龄在4~10岁之间,平均发病年龄为(7.15±1.06)岁,其中满7岁且不满8岁阶段的ICPP女童发病率最高,为49.54%。(2)中医证型方面,三大证型中,阴虚火旺证的占比最高(147例,占68.06%),其次是气血亏虚证(41例,占18.98%)及心肾不交证(28例,占12.96%)。(3)中医证候方面,临床常见证候(频率>25.0%)按出现频率由高到低依次为:怕热盗汗、手足心热、乳房胀痛、性情急躁、脉细数、大便干结、咽干口燥、潮热、多食肥甘、舌红少苔、抑郁、精神乏力、颧红、失眠多梦、舌红苔黄和口苦口干等16种。(4)各证型的年龄分布方面:阴虚火旺证和气血亏虚证均多见于满7岁且不满8岁年龄段的ICPP女童(占58.50%和51.22%),心肾不交证多见于满8岁且不满9岁年龄段的ICPP女童(占89.29%)。【结论】阴虚火旺证是海南省ICPP女童占比最高的中医证型。研究性早熟女童的中医证型分布,有助于性早熟女童的早期临床症状观察以及疾病的早期诊断,从而为ICPP女童的临床辨证用药提供线索和依据。
基金Supported by Fund of Capital Medical Development and Research （No. 03III10）.
文摘Objective： To assess the effectiveness of Tongjiang Granule （TJG, 通降颗粒） on the patients with nonerosive reflux disease （NERD） of Gan （肝）-Wei （胃） incoordination syndrome, its impact on their quality of life, and its safety. Method： A randomized, controlled, double-blinded, and double-dummy method was adopted in the trial. There were 120 NERD patients enrolled in the study and randomly divided into the experiment and control groups, each with 60 patients; drugs were distributed according to the drug number by patients＇ inclusion sequences. In the experiment group, patients were given TJG 10 g and mosapdde citrate dummy 5 mg three times a day, and in the control group, patients were given mosapdde citrate 5 mg and TJG dummy 10 g three times a day. The treatment courses of both groups were 4 weeks. Results： Among 120 included patients, 112 were screened for full analysis set （FAS）, and 105 were screened per-protocol set （PPS）. The results were as follows： （1） the improvement of total scores of symptom in the experiment group （0-4 week） were 15.93 ± 7.88 scores by FAS and 16.22 ±7.75 scores by PPS, and they were 10.43± 10.16 scores and 10.79± 10.27 scores in the control group, respectively. The 95% CI of net scores improvement between the two groups were 2.10- 8.90 scores and 1.92-8.94 scores in FAS and PPS; it was significantly better in the experiment group than that in the control group （P〈0.05）. （2） The improvement of scores of major symptom in the experiment group （0-4 week） were 10.68±5.35 by FAS and 10.89±5.29 by PPS and 7.40±7.41 and 7.60±7.46 in the control group, respectively. The 95% CI of net scores improvement in the two groups were 0.85-5.71 and 0.71-5.69 in FAS and PPS separately, and the improvement in the experiment group was significantly better than that in the control group （P〈0.05）. （3） The total effective rates were 86.0% and 61.8% in the experiment and the control group separately, and the Ridit analysis results showed that it was better in the experiment group （P〈0.05）. （4） The improvement quality of life in the domain of physical functioning and general health in the experiment group was better than that in the control group （P〈0.05）. （5） One case of experiment group caught a cold and recovered in six days without drug suspension. No adverse event was found in the other cases. There was no meaningful safety examination indices change in pretreatment and posttreatment periods in both groups. Conclusion： TJG showed a definite effect on the treatment of NERD with Gan-Wei incoordination syndrome, and it could improve the quality of life of NERD patient without obvious toxic and side effects.
