Effect of the Haoqinqingdan decoction on damp-heat syndrome in rats with influenza viral pneumonia

Objective: To investigate the effect of Chinese medicine prescription-Haoqinqingdan decoction on damp-heat syndrome in rats with influenza viral pneumonia and its influence on the immune function. Methods: A total of 48 Wistar rats were randomly divided into the normal control group, the damp-heat syndrome model group, the Haoqinqingdan decoction group (high, medium and low dose group) and the ribavirin group. The body temperature and weight of rats in each group were recorded after modeling. After treatment for 6 d, the concentration of T lymphocyte subgroup (CD3+ CD4+ , CD3+ CD8+ ) was determined by flow cytometry. The OD value of IFN毭/IL-4 was detected by double-antibody sandwich ELISA method, and its concentration was acquired through conversion. Results: After modeling, the temperature and weight of rats in each modeling group showed the increasing trend ( P<0.01). From the second day of treatment, there was significant difference in the body mass between groups, and the rat weight of the control group was higher than in the modeling group ( P<0.05 or 0.01). With the advances of treatment, only the temperature in the medium and high dose Haoqinqingdan decoction groups declined significantly ( P<0.05). After treatment, the CD4+ /CD8+ ratio of the damp-heat syndrome model group decreased more significantly compared with the control group. Elevated CD3+ CD8+ percentages and declined CD4+ /CD8+ ratios can be observed in the low dose group and ribavirin group ( P<0.05). Moreover, the CD3+ CD4+ percentage of ribavirin group was lower than in the control group ( P<0.05). After treatment, the IFN-毭 and IFN-毭/ IL-4 levels in the peripheral blood of rats in the dampheat syndrome group were obviously higher than in the control group ( P<0.05). Conclusions: Compared with ribavirin, the high dose Haoqinqingdan decoction can improve the ratio of T lymphocyte subgroup and Th1/Th2 cell balance more effectively.

Clinicopathological features and expression of regulatory mechanism of the Wnt signaling pathway in colorectal sessile serrated adenomas/polyps with different syndrome types

BACKGROUND Colorectal cancer(CRC)is the third most common cancer worldwide,with the fourth highest mortality among all cancers.Reportedly,in addition to adenomas,serrated polyps,which account for 15%-30%of CRCs,can also develop into CRCs through the serrated pathway.Sessile serrated adenomas/polyps(SSAs/Ps),a type of serrated polyps,are easily misdiagnosed during endoscopy.AIM To observe the difference in the Wnt signaling pathway expression in SSAs/Ps patients with different syndrome types.METHODS From January 2021 to December 2021,patients with SSAs/Ps were recruited from the Endoscopy Room of Shanghai Traditional Chinese Medicine-Integrated Hospital,affiliated with Shanghai University of Traditional Chinese Medicine.Thirty cases each of large intestine damp-heat(Da-Chang-Shi-Re,DCSR)syndrome and spleen-stomach weakness(Pi-Wei-Xu-Ruo)syndrome were reported.Baseline comparison of the general data,typical tongue coating,colonoscopy findings,and hematoxylin and eosin findings was performed in each group.The expression of the Wnt pathway-related proteins,namelyβ-catenin,adenomatous polyposis coli,and mutated in colorectal cancer,were analyzed using immunohistochemistry.RESULTS Significant differences were observed with respect to the SSAs/Ps size between the two groups of patients with different syndrome types(P=0.001).The other aspects did not differ between the two groups.The Wnt signaling pathway was activated in patients with SSAs/Ps belonging to both groups,which was manifested asβ-catenin protein translocation into the nucleus.However,SSAs/Ps patients with DCSR syndrome had more nucleation,higherβ-catenin expression,and negative regulatory factor(adenomatous polyposis coli and mutated in colorectal cancer)expression(P<0.0001)than SSA/P patients with Pi-Wei-Xu-Ruo syndrome.In addition,the SSA/P size was linearly correlated with the related protein expression.CONCLUSION Patients with DCSR syndrome had a more obvious Wnt signaling pathway activation and a higher risk of carcinogenesis.A high-quality colonoscopic diagnosis was essential.The thorough assessment of clinical diseases can be improved by combining the diseases of Western medicine with the syndromes of traditional Chinese medicine.

The role of endothelial biomarkers in predicting damp-heat syndrome in diabetic kidney disease

Objective:To explore the role of endothelial biomarkers in predicting damp-heat syndrome in diabetic kidney disease(DKD).Methods:A total of 183 patients with DKD were divided into 3 groups:the early DKD group,established DKD group,and advanced DKD group.All patients were classified according to traditional Chinese medicine(TCM)syndrome type,and clinical indexes were collected for statistical analysis.Results:A total of 183 DKD patients were included in this study.Fibroblast growth factor 23(FGF23),chitinase-3-like protein 1(CHI3L1),endocan,tumor necrosis factor receptor 1(TNFR1),secretory leukocyte protease inhibitor(SLPI),and vascular endothelial growth factor A(VEGF-A)were increased in advanced DKD.FGF23,CHI3L1,endocan,SLPI,and TNFR1 showed a negative correlation with estimated glomerular filtration rate(eGFR),while they had a positive correlation with 24 h urine protein.After adjusting for age,gender,diabetes duration,body mass index(BMI),hemoglobin,glucose,uric acid,24 h urine protein,cholesterol,triglyceride,low-density lipoprotein,and hemoglobin A1c(HbA1c),the multiple regression analysis showed that FGF23,endocan,TNFR1,and SLPI significantly correlated with eGFR.Conclusions:FGF23,endocan,TNFR1,and SLPI are elevated in advanced DKD compared with early stage,and they may take part in the pathogenesis and progression of DKD.Our study provides useful biomarkers for predicting the appearance of damp-heat syndrome,including FGF23,endocan,TNFR1,and SLPI.

Efficacy of Pidan Jianqing decoction in treatment of type 2 diabetes with spleen deficiency and damp-heat syndrome

Introduction:This study aimed to assess the clinical efficacy of Pidan Jianqing decoction in the treatment of type 2 diabetes.Methods:A total of 72 patients with type 2 diabetes differentiated as spleen deficiency with damp-heat syndrome were randomly assigned to a treatment group(n=35)or control group(n=32).Patients in the control group received diet and exercise guidance and medication in the form of 0.5 g metformin hydrochloride tablets,while patients in the treatment group received Pidan Jianqing decoction in addition to the treatment given to the control group.Efficacy was evaluated after 8 weeks of treatment.Results:Efficacy was 91.4%in the treatment group versus 68.8%in the control group,which was a statistically significant difference(P<0.05).Significant group differences were also noted in the number of patients with improvement in symptoms such as dry mouth and polydipsia,frequency of urination and polyuria,abdominal distention and loss of appetite,fatigue and weakness,and sticky stools(all P<0.05),with greater improvement in the treatment group compared to the control group.The fasting blood glucose(FBG)and 2 h postprandial blood glucose levels significantly improved in both groups after treatment(P<0.05);however,there was no significant difference in glycated hemoglobin levels before and after treatment in both groups.Conclusion:Pidan Jianqing decoction can lower blood glucose levels and improve symptoms in patients with type 2 diabetes.

Factors associated with visceral fat accumulation in the general population in Okinawa, Japan

AIM:To investigate the clinical and biochemical factors associated with visceral fat accumulation in the general population.METHODS:We enrolled 1004 subjects who underwent a medical health checkup between April 2008 and March 2009.The medical health checkup included the following tests:Height,body weight,waist circumference(WC),systolic blood pressure,diastolic blood pressure,urinalysis,blood-cell counts,blood chemistry,electrocardiography,chest radiography,and abdominal computed tomography(CT)for visceral fat accumulation.The patients’medical history and lifestyle factors were collected privately by nurses using a selfadministered questionnaire,and they included questions regarding physical activity,sleep duration,dietary habits,smoking,and alcohol consumption.visceral fat area(VFA)was defined as the sum of the intraperitoneal fat area at the level of the umbilicus with CT density in the range of-150 to-50 Hounsfield units.RESULTS:The mean age and body mass index(BMI)of the study subjects were 57.0 years and 24.4 kg/m2.In both male and females,v FA was significantly andpositively correlated with WC(r=0.532,P<0.01;r=0.612,P<0.01).Subjects with high levels of v FA were primarily male with significantly higher age,height,body weight,BMI,systolic blood pressure(BP),diastolic BP,and hemoglobin in all subjects(P<0.05).A multivariate logistic regression analysis revealed that vF A had a positive relationship with age≥56,BMI≥25 kg/m2,and triglyceride level≥149 in males(P<0.05),whereas it had a positive relationship with age≥58,BMI≥24.4 kg/m2,high-density lipoprotein cholesterol level<40 mg/d L,and current drinking in females(P<0.05).CONCLUSION:These results suggest that gender differences exist in the clinical and biochemical parameters associated with visceral fat accumulation.

Lipid Accumulation Product: Reliable Marker for Cardiovascular Risk Detection?

The Lipid Accumulation Product (LAP) is a clinical marker of visceral obesity and has been proposed as a simple, inexpensive, and accurate tool to estimate cardiovascular risk and mortality. The aim of this study was to verify the association of LAP with anthropometric, biochemical, visceral adiposity index and IR in adults and the elderly. This single cross-section center clinical study, with experimental, analytical, primary, and observational design, included 210 participants. Anthropometric (Body Mass Index (BMI), Waist Circumference (WC), and Neck Circumference (NC)), LAP, Visceral Adipose Index (VAI), and biochemical parameters (fasting glycemia, insulinemia (to calculate the Homa-IR index), total cholesterol, LDL-c, HDL-c, and triglycerides) were evaluated. The results showed that by separating the sample into three groups (adequate BMI and WC, adequate BMI and elevated WC, and elevated BMI and WC), the group with high BMI and WC showed a high value of LAP and VAI compared to the other groups, with a significant difference. Still, the data show a positive and significant correlation when relating the LAP with VAI, HOMA-IR, BMI, WC, NC, total cholesterol, triglycerides, and Diastolic Blood Pressure. It also showed an inversely proportional relationship when associating LAP with HDL-c (p < 0.0001). Thus, we show that LAP is closely related to visceral adiposity, IR, altered lipid parameters, and blood pressure, especially diastolic in the patients included in our study. For these reasons, we suggest that LAP is a reliable indicator of promising visceral adiposity for early detection of cardiovascular risk in the adult and senior population.

新型乌蔹莓水凝胶对湿热蕴结型痛风性关节炎的干预效果

目的探讨新型乌蔹莓水凝胶对湿热蕴结型痛风性关节炎的干预效果及作用机制。方法选取90例符合痛风性关节炎西医诊断标准、中医辨证属湿热蕴结证的患者作为研究对象,随机分成治疗组、对照组和空白组,每组30例。空白组仅采用依托考昔治疗,对照组采用依托考昔联合乌蔹莓膏治疗,治疗组采用依托考昔联合外敷乌蔹莓水凝胶治疗。比较3组临床疗效、症状改善时间、安全性、舒适性和治疗前后中医证候积分、血清炎性因子[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、血沉(ESR)]、NF-κB信号通路相关蛋白、疼痛视觉模拟评分法(VAS)评分、关节活动度变化情况。结果治疗组、对照组治疗总有效率分别为93.33%、90.00%,高于空白组的70.00%,差异有统计学意义(P<0.05);治疗组疼痛、红肿、压痛、关节活动受限症状改善的时间短于对照组、空白组,差异有统计学意义(P<0.05);治疗7 d后,治疗组中医证候积分低于对照组、空白组,治疗组、对照组血清CRP、TNF-α、ESR水平和NF-κB信号通路相关蛋白P50、P65表达低于空白组,差异有统计学意义(P<0.05);治疗组治疗7 d后VAS评分低于对照组、空白组,且治疗组用药舒适度评分高于对照组,差异有统计学意义(P<0.05);3组不良反应发生率比较,差异无统计学意义(P>0.05)。结论乌蔹莓水凝胶对痛风性关节炎的治疗效果优于乌蔹莓膏,其作用机制可能与调控NF-κB通路、抑制炎性因子表达有关,且水凝胶使用方便卫生,舒适性高,有望成为安全、有效、便捷的痛风性关节炎外敷中药。

化浊通清饮治疗慢性萎缩性胃炎浊毒内蕴证的临床疗效观察

目的探讨化浊通清饮对慢性萎缩性胃炎(CAG)浊毒内蕴证的临床疗效。方法将159例CAG患者随机分为中药组、西药组和对照组,分别给予化浊通清饮、雷贝拉唑钠肠溶片和摩罗丹治疗。比较西医临床疗效、中医证候评分、病理改变、简明健康状况调查量表(SF-36)评分及治疗前后血清胃泌素-17(G-17)和前列腺素E2(PGE2)水平。结果中药组治疗总有效率为92.45%,西药组为62.26%,对照组为66.04%。与治疗前比较,3组治疗后腺体萎缩、肠上皮化生、异型增生、慢性炎症评分降低,且中药组上述评分低于对照组和西药组,差异有统计学意义(P<0.05)。治疗3个月后,3组胃脘疼痛、胃胀不舒、反酸烧心、嗳气、便黏评分均低于治疗前,且中药组胃脘疼痛、胃胀不舒、反酸烧心、嗳气、便黏评分低于对照组和西药组,差异有统计学意义(P<0.05)。3组患者治疗后1、2、3个月SF-36评分均提高,且中药组SF-36评分高于对照组和西药组,随访时中药组SF-36评分仍高于对照组和西药组,差异有统计学意义(P<0.05)。治疗后,3组患者血清G-17和PGE2水平均较治疗前升高,且中药组血清G-17和PGE2水平高于西药组和对照组,差异有统计学意义(P<0.05)。3组患者治疗期间均无不良反应发生。结论化浊通清饮治疗CAG能减轻患者症状,改善病理状态,提升患者生活质量。

宣肺降浊清肠汤治疗稳定期支气管扩张症疗效及对肠道微生态的影响

目的观察宣肺降浊清肠汤治疗稳定期支气管扩张患者的效果及对肠道微生态的影响。方法选取2022年1月—2023年1月广州医科大学附属第一医院收治的稳定期支气管扩张症痰湿蕴肺型患者90例为观察对象,随机分为西药组、中药组、中西医结合组,每组各30例;同时于广州医科大学附属第一医院体检中心随机选取30例健康者作为空白组,用于肠道菌群检测的对照。西药组给予氨溴索口服,中药组给予宣肺降浊清肠汤颗粒剂口服,中西医结合组给予宣肺降浊清肠汤联合氨溴索口服。连续治疗6个月后评估3组临床疗效,比较3组治疗前后肺功能指标[第一秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、呼气峰值流速(PEF)]、支气管扩张严重程度指数(BSI)评分、24 h痰量、急性加重次数、咳嗽-咳痰评估问卷(CASA-Q)评分、圣乔治呼吸问卷(SGRQ)评分及粪便标本中直肠真杆菌、多形拟杆菌表达量(采用PCR扩增法测定)。结果治疗结束后,中西医结合组临床总有效率明显高于中药组、西药组[93.3%(28/30)比63.3%(18/30)、76.7%(23/30),P均<0.05]。与治疗前比较,治疗后3组FEV_(1)、FVC、PEF均明显提高,BSI评分、SGRQ评分均明显降低,24 h痰量、急性加重次数均明显减少,CASA-Q评分均明显升高,且中西医结合组各指标改善情况均明显优于中药组及西药组,西药组各指标改善情况均明显优于中药组,差异均有统计学意义(P均<0.05)。治疗后中西医结合组和中药组粪便中直肠真杆菌、多形拟杆菌表达量均较治疗前明显改善(P均<0.05),西药组粪便直肠真杆菌、多形拟杆菌表达量均无明显变化(P均>0.05);治疗后中药组和中西医结合组直肠真杆菌表达量均明显低于西药组(P均<0.05),多形拟杆菌表达量均明显高于西药组(P均<0.05),中药组和中西医结合组直肠真杆菌、多形拟杆菌表达量比较差异均无统计学意义(P均>0.05)。结论宣肺降浊清肠汤联合氨溴索治疗稳定期支气管扩张症痰湿蕴肺型患者效果优于二者单独应用,可有效缓解患者病情,改善肺功能和生活质量,机制可能与宣肺降浊清肠汤可调节肠道菌群微生态相关。

中西医诊治儿童性早熟研究进展

目前,越来越多的无创诊断技术正在运用到儿童性早熟的诊断中,基因检测技术促进了该病遗传病因诊断的发展。对于该病的治疗,西医主要通过病因治疗继发性性早熟,对于特发性外周性性早熟没有特殊治疗方案,目前,中枢性性早熟治疗首选促性腺激素释放激素类似物(gonadotropin-releasing hormone agonist, GnRHa)。中医认为,性早熟病机为阴虚火旺,肝郁化火,痰湿壅滞,治以滋阴降火、疏肝解郁或燥湿化痰,可改善症状,抑制骨龄快速增长。但目前中医药治疗性早熟的临床研究证据等级不高,缺少样本量大、严格且全面的临床研究,未来可通过开展多中心的随机对照、大样本研究以验证中医药治疗性早熟的疗效。网络药理学和中药成分动物实验研究证明了中药治疗性早熟的部分机制,但中药方剂成分复杂,多通过胃肠道吸收后起效,是否可以调节肠道菌群、产生特异性菌群,该菌群是否改变了机体中某些代谢产物水平从而发挥治疗作用尚无相关研究,今后可开展更多的相关机制研究。

摩腹配合下推七节骨治疗食积内热型小儿便秘临床观察

目的 观察摩腹配合下推七节骨治疗食积内热型小儿便秘的临床效果。方法 门诊收集60例食积内热型便秘患儿,随机分为治疗组和对照组,每组30例。治疗组给予摩腹配合下推七节骨的推拿手法,对照组予口服乳果糖口服溶液,对比2组临床疗效。结果 2个疗程后,治疗组的治疗组愈显率90.00%(27/30)明显高于对照组的66.67%(20/30)(P<0.05);1个疗程后、2个疗程后,治疗组的中医证候疗效明显优于对照组(P<0.05)。2个疗程后,治疗组主证积分、次证积分及证候总积分均低于对照组(P<0.05)。结论 摩腹配合下推七节骨手法简单、易于操作,安全性高,治疗小儿食积内热型便秘效果确切,且易被患者接受,可在临床加强推广。

基于养正除积法运用杵针治疗肝郁脾虚型卒中后抑郁临床观察

目的研究基于养正除积法探讨杵针对肝郁脾虚型卒中后抑郁患者的影响。方法选择2021年3月—2022年3月广东省第二中医院脑病科门诊和病房收治的肝郁脾虚型卒中后抑郁患者80例,随机分为试验组和对照组,每组40例。对照组采用基础治疗结合草酸艾司西酞普兰治疗,试验组采用基础治疗结合杵针治疗,比较两组临床效果、汉密尔顿抑郁量表(HAMD)评分、脑卒中影响量表(SIS)评分及治疗依从性。结果试验组患者治疗总有效率为92.50%(37/40),高于对照组的75.00%(30/40),差异有统计学意义(P<0.05)。治疗后,试验组HAMD评分低于对照组,SIS评分及治疗总依从性高于对照组,差异有统计学意义(P<0.05)。结论基于养正除积法的杵针治疗可有效缓解肝郁脾虚型卒中后抑郁患者抑郁情绪,提高患者生活质量。

特应性皮炎脾虚湿蕴证患者的皮损表现特征分析

目的通过数据挖掘及临床横断面研究结合的方式,探讨特应性皮炎脾虚湿蕴证患者的皮损表现特征。方法现代文献研究方面,检索建库以来至2021年10月31日特应性皮炎脾虚湿蕴证的相关文献,提取并规范皮损特征,对所纳入皮损表现进行频数分析及关联分析;门诊招募于广东省中医院皮肤科就诊的特应性皮炎患者,分为脾虚湿蕴和非脾虚湿蕴2组,填写人口学资料及《特应性皮炎脾虚湿蕴证中医皮损特征采集表》,采用SPSS 27.0软件对数据进行非参数检验和二元Logistic回归分析,比较2组患者的皮损表现差异。结果文献研究共纳入符合要求的文献288篇,其中丘疹、鳞屑、瘙痒、糜烂及渗出等是特应性皮炎脾虚湿蕴证最常见的皮损表现;关联分析提示丘疹、瘙痒、糜烂、渗出、干燥与脾虚湿蕴证的关联性较强。门诊横断面研究共纳入受试者152例,差异分析提示2组患者在粗糙、鳞屑与潮红方面差异有统计学意义(P<0.05),其他皮损表现差异均未见统计学意义(P>0.05);单因素回归结果提示粗糙、鳞屑与潮红会显著影响患者是否为脾虚湿蕴证(P<0.05),而多因素回归结果提示,仅潮红为非脾虚湿蕴证的显著影响因素(P<0.05)。结论特应性皮炎脾虚湿蕴证患者的皮损表现以干燥、鳞屑、肥厚等干性皮损为主,符合亚急性、慢性期皮损表现;临床脾虚湿蕴证患者较少出现渗出、水疱、糜烂等湿性皮损。

五味消毒饮加减治疗急性痛风性关节炎(湿热蕴结证)的临床疗效观察

目的:探讨五味消毒饮加减治疗急性痛风性关节炎(AGA)(湿热蕴结证)的临床疗效。方法:选择2022年1月—2023年6月收治的AGA患者120例,采用随机数字表法分为对照组、观察组和联合组,每组40例。对照组予以依托考昔治疗,观察组予以五味消毒饮加减治疗,联合组予以依托考昔+五味消毒饮加减治疗,三组均连续治疗14 d。对比三组临床疗效、实验室指标、中医症候积分、关节肿痛指数及不良反应。结果:联合组治疗总有效率高于对照组和观察组,且观察组高于对照组(P<0.05);联合组治疗后白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子α(TNF-α)、尿酸水平及中医症候积分、关节肿胀指数低于对照组和观察组,且观察组低于对照组(P<0.05);三组不良反应发生率比较差异无统计学意义(P>0.05)。结论:在西药治疗基础上,联合五味消毒饮加减治疗AGA(湿热蕴结证)患者效果更佳,可有效降低炎症因子及尿酸水平,减轻关节肿痛,充分彰显中西医结合治疗优势,且中医药治疗具有毒副作用小的优势,可弥补西药不良反应多的不足,患者更易接受。

生姜泻心汤加减方在宠物临床的应用

生姜泻心汤出自于汉代张仲景的《伤寒论》,包含生姜、干姜、半夏、黄芩、人参、黄连、炙甘草、大枣八味中药,全方寒热并用,辛开苦降,攻补兼施,阴阳并调,未用理气之药,却有理气之效。该方应用广泛,尤其在胃肠疾病方面常作为基本方。笔者临床收治1例近3个月内间断呕吐、大便不成形的病猫,且应用抗菌药、抑制呕吐等西兽药等难以奏效。经中兽医诊断病猫久病而脾胃虚弱,胃失和降,浊气归于上,且寒热错杂,辨证为水热互结的痞证兼脾阳虚。治则为和胃降逆,宣散水气,健脾益气。药用生姜泻心汤加炒白术、陈皮,散水消痞,和胃降逆兼健脾,其中炒白术偏重健脾和胃,陈皮偏重于理气,服药1 d后未见呕吐,大便基本成形,食欲、精神明显好转,服药3 d病猫基本痊愈。本病例可为宠物临床治疗长期呕吐病例提供新思路,为生姜泻心汤方证的科学研究及临床应用提供借鉴。

二陈汤合三子养亲汤治疗慢性阻塞性肺疾病(痰湿蕴肺证)疗效及对肺功能、IFN-γ、ET-1的影响

目的探究二陈汤合三子养亲汤治疗慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)(痰湿蕴肺证)的疗效及对肺功能、伽马干扰素(interferon γ,IFN-γ)、内皮素(endothelin-1,ET-1)的影响。方法采用随机分组法将医院2019年2月—2022年3月收治的86例慢阻肺患者分为观察组与对照组,两组各43例。对照组采用西医常规治疗,观察组在此基础上联合使用二陈汤合三子养亲汤治疗。观察两组患者治疗前后肺功能、蛋白质羰基(protein carbonyl content,PC)、8-羟基脱氧鸟苷(8-hydroxy-2 deoxyguanosine,8-OHdG)、丙二醛(malonic aldehyde,MDA)含量和IFN-γ、ET-1。观察两组患者临床症状消失时间和临床疗效。结果两组患者治疗后FEV1、PEF和Ppeak水平显著高于治疗前(P<0.05)。治疗后,观察组FEV1、PEF和Ppeak水平显著高于对照组(P<0.05)。两组患者治疗后PC、8-OHdG和MDA水平显著低于治疗前(P<0.05)。治疗后,观察组PC、8-OHdG和MDA水平显著低于对照组(P<0.05)。两组患者治疗后IFN-γ和ET-1水平显著低于治疗前(P<0.05)。治疗后,观察组IFN-γ和ET-1水平显著低于对照组(P<0.05)。观察组临床症状消失时间显著快于对照组(P<0.05)。观察组总有效率为83.72%(36/43)显著高于对照组(65.12%,28/43)(χ^(2)=3.909,P=0.048)。结论二陈汤合三子养亲汤能有效改善慢阻肺患者肺功能,降低氧化应激相关产物蛋白质的含量,减少临床症状持续时间,利于降低FN-γ、ET-1水平,临床疗效得到显著提升。

排石汤联合间苯三酚对湿热蕴结证肾结石钬激光碎石术后辅助治疗的临床效果

目的探究排石汤联合间苯三酚对湿热蕴结证肾结石钬激光碎石术后辅助治疗的临床效果。方法前瞻性选取2020年5月—2022年5月行钬激光碎石术治疗的200例湿热蕴结证肾结石为研究对象,采用随机数字表法分为观察组1组、观察组2组、观察组3组和对照组,每组50例。对照组术后行常规治疗,在此基础上观察1组给予排石汤联合间苯三酚,观察2组给予排石汤,观察3组给予间苯三酚。比较4组结石清除效果,并比较治疗前后中医证候评分、肾主动脉血流动力学[收缩期间峰值流速(V_(max))、收缩期峰值流速(S)、舒张末期峰值流速(D)、阻力指数(RI)]、氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)、过氧化脂质(LPO)]、舒适度(导尿管相关性症状评分)及不良反应。结果观察1组结石清除率和结石排净率高于观察2组、观察3组、对照组(P<0.05)。治疗第3、7天,观察1组各中医证候评分、导尿管相关性症状评分、RI以及血清MDA、LPO水平低于观察2组、观察3组、对照组,且观察2组、观察3组低于对照组(P<0.05)。治疗第3、7天,观察1组V_(max)、S/D及血清SOD水平高于观察2组、观察3组、对照组,且观察2组、观察3组高于对照组(P<0.05)。4组不良反应发生率比较差异无统计学意义(P>0.05)。结论湿热蕴结证肾结石行钬激光碎石术后给予排石汤联合间苯三酚能提高结石清除效果,改善肾脏血流动力学,减轻氧化应激反应,缓解患者症状并提高舒适度,且安全性较高。

自拟养血除湿汤治疗湿热蕴结证特应性皮炎的临床研究

目的:探讨自拟养血除湿汤治疗湿热蕴结证特应性皮炎的临床效果。方法:选取2021年6月—2023年6月北京京城皮肤医院收治的100例湿热蕴结证特应性皮炎患者作为研究对象,随机分为对照组和观察组,各50例。对照组口服氯雷他定片,同时外用丁酸氢化可的松乳膏;观察组在对照组的基础上予以自拟养血除湿汤治疗。观察两组疗效、病情严重程度、炎症指标、生活质量及不良反应发生情况。结果:观察组的疗效优于对照组,差异有统计学意义(P<0.05)。治疗后,观察组特应性皮炎评分(SCORAD)低于对照组,差异有统计学意义(P<0.05);与治疗前相比,两组治疗后嗜酸性粒细胞(EOS)、血清总免疫球蛋白E(IgE)、白细胞介素-2(IL-2)水平均降低,且观察组均低于对照组,差异均有统计学意义(P<0.05);两组治疗后白细胞介素-4(IL-4)水平均升高,且观察组更高,差异均有统计学意义(P<0.05)。治疗后,观察组生活质量受损程度小于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:自拟养血除湿汤治疗湿热蕴结证特应性皮炎可减轻患者症状,改善炎症指标和生活质量,疗效显著且安全可靠。

石军牡蛎煎灌肠治疗湿热蕴结型慢性肝衰竭合并肝性脑病临床研究

目的:观察石军牡蛎煎灌肠联合西医基础疗法治疗慢性肝衰竭湿热蕴结证合并肝性脑病(HE)的临床疗效。方法:慢性肝衰竭湿热蕴结证合并HE患者74例,用随机数字法分为治疗组(37例)和对照组(37例),两组均给予西医基础治疗,治疗组患者予石军牡蛎煎灌肠,对照组患者予乳果糖溶液灌肠,治疗周期均为4周。4周后评价HE临床有效率、实验室指标、中医证候评分。结果:①治疗4周后,治疗组患者HE临床有效率为86.5%,对照组患者HE临床有效率为72.9%,差异有统计学意义(P<0.05)。②治疗4周后,治疗组患者TBil、ALT、AST、Alb、血氨较治疗前改善(P<0.05),对照组患者ALT、AST、血氨较治疗前改善(P<0.05),治疗组患者改善TBil、ALT、AST、Alb、血氨疗效优于对照组(P<0.05)。③治疗4周后,治疗组患者与对照组患者的PT、PTA较治疗前改善(P<0.05)。④治疗4周后,治疗组患者与对照组患者的中医证候侯评分较治疗前均降低(P<0.05),治疗组患者疗效优于对照组(P<0.05)。结论:石军牡蛎煎灌肠联合西医基础疗法治疗慢性肝衰竭湿热蕴结证合并HE能够提高HE临床疗效,改善肝功能及中医证候,疗效优于乳果糖溶液灌肠。

化浊解毒方联合硝黄通络散外敷治疗急性痛风性关节炎(湿热蕴结证)患者的临床观察

目的 观察化浊解毒方联合硝黄通络散外敷治疗急性痛风性关节炎(湿热蕴结证)的临床疗效。方法 将96例急性痛风性关节炎患者随机分为两组各48例。对照组采用化浊解毒方治疗,观察组给予化浊解毒方联合硝黄通络散外敷治疗,两组疗程均为2周。比较两组疗效、临床症状、血清尿酸(UA)、血沉(ESR)和炎症因子差异。结果 观察组治疗总有效率为93.75%,高于对照组的75.00%(P<0.05);两组治疗后中医证候积分、疼痛程度、活动受限、关节肿胀评分、血清UA、ESR、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平较治疗前降低(P<0.05),两组比较,观察组治疗后中医证候积分、疼痛程度、活动受限、关节肿胀评分血清UA、ESR、IL-1、IL-6、TNF-α水平低于对照组(P<0.05)。结论 化浊解毒方联合硝黄通络散外敷可促使急性痛风性关节炎患者临床症状消退,抑制炎症反应,提高临床治疗效果。