Objective:To explore the clinical effect of integrated traditional Chinese and Western medicine in the treatment of liver-stomach disharmony functional dyspepsia.Methods:Sixty patients with functional dyspepsia of liv...Objective:To explore the clinical effect of integrated traditional Chinese and Western medicine in the treatment of liver-stomach disharmony functional dyspepsia.Methods:Sixty patients with functional dyspepsia of liver-stomach disharmony type admitted to our hospital from January to August 2022 were selected as research subjects and randomly divided into two groups,a study group and a control group,with 30 cases in each group.The main observations were stomachache or pain over bilateral flanks,emotionally depressed,belching,fullness and discomfort over the abdomen and flanks,acid regurgitation,loss of appetite,frequent sighing,noisy epigastric,and the treatment effect.Results:According to the classification of symptom severity on the traditional Chinese medicine(TCM)symptom score table,statistics were made on the corresponding severity of the main symptoms and secondary symptoms of the two groups of patients,and the data of the two groups were compared by Wilcoxon test.The results showed that there was no significant difference in the distribution of TCM symptoms between the two groups;the study group’s total effective rate of pain relief(recovery+markedly effective+effective)was 96.67%,and Fisher’s χ^(2) test indicated a significant difference in the total effective rate of pain relief between the two groups(P=0.027<0.05).Conclusion:The use of integrated traditional Chinese and western medicine is clearly better than the simple application of western medicine.It is safe and has no side effects.It can be used as a treatment for patients with functional dyspepsia.展开更多
BACKGROUND Tong Xie Yao Fang is a representative traditional Chinese prescription for the treatment of liver and spleen deficiency,abdominal pain and diarrhea.It has a unique function in the treatment of gastrointesti...BACKGROUND Tong Xie Yao Fang is a representative traditional Chinese prescription for the treatment of liver and spleen deficiency,abdominal pain and diarrhea.It has a unique function in the treatment of gastrointestinal dysfunction including irritable bowel syndrome(IBS),is a common functional bowel disease.Its main symptoms are recurrent abdominal pain,diarrhea,constipation or alternations between diarrhea and constipation.There are obvious differences in metabolites between TCM syndromes.By comparing the body fluid metabolism maps of model animals,metabolomics can discover disease biomarkers,analyze the differences in metabolic pathways and understand the pathological process and the metabolic pathways of substances in the body.Thus,the evaluation of animal models tends to be comprehensive and objective.This may provide further understanding between the interaction between Tong Xie Yao Fang and the IBS model.AIM To evaluate the effect of Tong Xie Yao Fang on IBS rats by using metabolomics method.METHODS Wistar rats were used to establish IBS models,and then randomly divided into four groups:A model control group and three Tong Xie Yao Fang treatment groups(high,medium and low doses).A normal,non-IBS group was established.The rats were treated for 2 wk.On days 0 and 14 of the experimental model,urine was collected for 12 h and was analyzed by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry.Nine potential biomarkers were identified,and six major metabolic pathways were found to be related to IBS.RESULTS In the study of metabonomics,nine potential biomarkers including L-serine,4-methylgallic acid,L-threonine,succinylacetone,prolyl-hydroxyproline,valylserine,acetyl citrate,marmesin rutinoside and 5-hydroxy-L-tryptophan were identified in urine,which were assigned to amino acids,organic acids,succinyl and glycosides.Furthermore,the metabolic pathway of L-serine,L-threonine and 5-hydroxy-L-tryptophan was found in the Kyoto Encyclopedia of Genes and Genomes,which mainly involved the metabolism of cysteine and methionine,vitamin B6 metabolism,serotonin synapse,tryptophan metabolism,sphingolipid metabolism,digestion,absorption of protein and amino acid metabolism.These pathways are related to intestinal dysfunction,inflammatory syndrome,nervous system dysfunction and other diseases.CONCLUSION Tong Xie Yao Fang has pharmacological effects on IBS,and its mechanism may be related to the metabolism of the nine potential biomarkers identified above in urine.展开更多
OBJECTIVE:To systematically assess the clinical effectiveness of traditional Chinese medicine(TCM) in the treatment of functional dyspepsia(FD) of liver-stomachdisharmonysyndromebymeta-analysis.METHODS:Random controll...OBJECTIVE:To systematically assess the clinical effectiveness of traditional Chinese medicine(TCM) in the treatment of functional dyspepsia(FD) of liver-stomachdisharmonysyndromebymeta-analysis.METHODS:Random controlled trials(RCTs) were retrieved from databases,including Pubmed,China national knowledge infrastructure,Wanfang Data,VIP Information,and the Cochrane Library.Trials were selected according to inclusion criteria.The effects of traditional Chinese medicine(TCM) versus prokinetic agents in the treatment of functional dyspepsia(FD) of liver-stomach disharmony syndrome were compared by meta-analysis.RevMan 5.0.24 was used for data analysis.The effective rate was assessed by odds ratios(ORs),and 95% confidence intervals(CIs) were calculated.The cure rate was analyzed by the Peto OR.Simple statistical analysis was chosen to assess the frequency of prescribed Chinese herbs in treating this syndrome.RESULTS:Thirteen trials were included,involving 1153 patients,and these were of poor methodological quality.Twelve studies mentioned the effective rate and cure rate.TCM therapy showed a better clinical effect rate compared with that with prokinetic agents [OR:3.2,95% CI(2.27,4.51)].The TCM group also had a better cure rate than that in the group of prokinetic agents [Peto OR:2.26,95% CI(1.61,3.18)].With regard to the frequency of Chinese herbs used in these 13 trials,Baishao(Radix Paeoniae),Chaihu(Radix Bupleuri),and Gancao(Radix Glycyrrhizae) were mostly prescribed,followed by Xiangfu(Rhizoma Cyperi),Zhishi(Fructus Aurantii Immaturus),Zhiqiao(Fructus Aurantii),Foshou(Citrus medica var.sarcodactylis),and Chenpi(Pericarpium Citri Reticulatae).No serious adverse effects were reported.CONCLUSION:TCM therapy shows a superior effective rate and cure rate compared with those in prokinetic agents in the treatment of FD of liver-stomach disharmony syndrome.However,further strictly designed RCTs are required because of the poor quality of included trials.展开更多
文摘Objective:To explore the clinical effect of integrated traditional Chinese and Western medicine in the treatment of liver-stomach disharmony functional dyspepsia.Methods:Sixty patients with functional dyspepsia of liver-stomach disharmony type admitted to our hospital from January to August 2022 were selected as research subjects and randomly divided into two groups,a study group and a control group,with 30 cases in each group.The main observations were stomachache or pain over bilateral flanks,emotionally depressed,belching,fullness and discomfort over the abdomen and flanks,acid regurgitation,loss of appetite,frequent sighing,noisy epigastric,and the treatment effect.Results:According to the classification of symptom severity on the traditional Chinese medicine(TCM)symptom score table,statistics were made on the corresponding severity of the main symptoms and secondary symptoms of the two groups of patients,and the data of the two groups were compared by Wilcoxon test.The results showed that there was no significant difference in the distribution of TCM symptoms between the two groups;the study group’s total effective rate of pain relief(recovery+markedly effective+effective)was 96.67%,and Fisher’s χ^(2) test indicated a significant difference in the total effective rate of pain relief between the two groups(P=0.027<0.05).Conclusion:The use of integrated traditional Chinese and western medicine is clearly better than the simple application of western medicine.It is safe and has no side effects.It can be used as a treatment for patients with functional dyspepsia.
基金Supported by the National Natural Science Foundation of China,No.81573870the Eighth Special Subsidy Project of China Post Doctoral Science Foundation,No.2015T80376+4 种基金Postdoctoral Science Research Developmental Foundation of China,No.2013M531079National Science Foundation of Heilongjiang Province,No.H2015020Heilongjiang University of Traditional Chinese Medicine Outstanding Innovative Talents Support Project(Outstanding Young Academic Leaders),Postdoctoral Science-Research Developmental Foundation of Heilongjiang Province,No.LBHQ12009Youth Academic Backbone Fund of Heilongjiang Province Education Department,No.1253G053Youth Science and Technology Project of Traditional Chinese Medicine Department of Heilongjiang Province,No.ZQG-034
文摘BACKGROUND Tong Xie Yao Fang is a representative traditional Chinese prescription for the treatment of liver and spleen deficiency,abdominal pain and diarrhea.It has a unique function in the treatment of gastrointestinal dysfunction including irritable bowel syndrome(IBS),is a common functional bowel disease.Its main symptoms are recurrent abdominal pain,diarrhea,constipation or alternations between diarrhea and constipation.There are obvious differences in metabolites between TCM syndromes.By comparing the body fluid metabolism maps of model animals,metabolomics can discover disease biomarkers,analyze the differences in metabolic pathways and understand the pathological process and the metabolic pathways of substances in the body.Thus,the evaluation of animal models tends to be comprehensive and objective.This may provide further understanding between the interaction between Tong Xie Yao Fang and the IBS model.AIM To evaluate the effect of Tong Xie Yao Fang on IBS rats by using metabolomics method.METHODS Wistar rats were used to establish IBS models,and then randomly divided into four groups:A model control group and three Tong Xie Yao Fang treatment groups(high,medium and low doses).A normal,non-IBS group was established.The rats were treated for 2 wk.On days 0 and 14 of the experimental model,urine was collected for 12 h and was analyzed by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry.Nine potential biomarkers were identified,and six major metabolic pathways were found to be related to IBS.RESULTS In the study of metabonomics,nine potential biomarkers including L-serine,4-methylgallic acid,L-threonine,succinylacetone,prolyl-hydroxyproline,valylserine,acetyl citrate,marmesin rutinoside and 5-hydroxy-L-tryptophan were identified in urine,which were assigned to amino acids,organic acids,succinyl and glycosides.Furthermore,the metabolic pathway of L-serine,L-threonine and 5-hydroxy-L-tryptophan was found in the Kyoto Encyclopedia of Genes and Genomes,which mainly involved the metabolism of cysteine and methionine,vitamin B6 metabolism,serotonin synapse,tryptophan metabolism,sphingolipid metabolism,digestion,absorption of protein and amino acid metabolism.These pathways are related to intestinal dysfunction,inflammatory syndrome,nervous system dysfunction and other diseases.CONCLUSION Tong Xie Yao Fang has pharmacological effects on IBS,and its mechanism may be related to the metabolism of the nine potential biomarkers identified above in urine.
基金Supported by Shenyang Municipal Program for Science and Technology 2011(F11-155-9-00)
文摘OBJECTIVE:To systematically assess the clinical effectiveness of traditional Chinese medicine(TCM) in the treatment of functional dyspepsia(FD) of liver-stomachdisharmonysyndromebymeta-analysis.METHODS:Random controlled trials(RCTs) were retrieved from databases,including Pubmed,China national knowledge infrastructure,Wanfang Data,VIP Information,and the Cochrane Library.Trials were selected according to inclusion criteria.The effects of traditional Chinese medicine(TCM) versus prokinetic agents in the treatment of functional dyspepsia(FD) of liver-stomach disharmony syndrome were compared by meta-analysis.RevMan 5.0.24 was used for data analysis.The effective rate was assessed by odds ratios(ORs),and 95% confidence intervals(CIs) were calculated.The cure rate was analyzed by the Peto OR.Simple statistical analysis was chosen to assess the frequency of prescribed Chinese herbs in treating this syndrome.RESULTS:Thirteen trials were included,involving 1153 patients,and these were of poor methodological quality.Twelve studies mentioned the effective rate and cure rate.TCM therapy showed a better clinical effect rate compared with that with prokinetic agents [OR:3.2,95% CI(2.27,4.51)].The TCM group also had a better cure rate than that in the group of prokinetic agents [Peto OR:2.26,95% CI(1.61,3.18)].With regard to the frequency of Chinese herbs used in these 13 trials,Baishao(Radix Paeoniae),Chaihu(Radix Bupleuri),and Gancao(Radix Glycyrrhizae) were mostly prescribed,followed by Xiangfu(Rhizoma Cyperi),Zhishi(Fructus Aurantii Immaturus),Zhiqiao(Fructus Aurantii),Foshou(Citrus medica var.sarcodactylis),and Chenpi(Pericarpium Citri Reticulatae).No serious adverse effects were reported.CONCLUSION:TCM therapy shows a superior effective rate and cure rate compared with those in prokinetic agents in the treatment of FD of liver-stomach disharmony syndrome.However,further strictly designed RCTs are required because of the poor quality of included trials.
