Modern technology-based exploration of mechanism of traditional Chinese medicine in prevention and treatment of gastric cancer

This review comments on the article“To explore the mechanism of Yigong San anti-gastric cancer and immune regulation”.We are interested that the article applied network pharmacology and bioinformatics techniques to elucidate the mechanism of action of Yigong Sang,a traditional Chinese medicine(TCM),in the treatment of gastric cancer(GC).The mechanism of action of Yigong Sang in the treatment of GC has not yet been elucidated because it is composed of multiple Chinese medicines with multiple components and multiple targets.The emergence of network pharmacology and bioinformatics analysis helps explain the mechanism of action of TCM in preventing and treating GC,and provides a possibility for TCM to transform from empirical to evidence-based medicine.This is of great significance for the application of TCM in oncology,new drug development,formula optimization,and the improvement of clinical efficacy.

New treatment for gastroesophageal reflux disease:Traditional Chinese medicine Xiaochaihu decoction

Gastroesophageal reflux disease(GERD)has a high prevalence worldwide.Li et al performed a well-designed study on the efficacy of modified Xiaochaihu decoction(MXD)for GERD,which showed that MXD is an optional therapy for GERD beyond proton pump inhibitors(PPIs).The herbal granule administration mode minimized the bias from traditional herbal formula in clinical trials.One limitation of that study was that it lacked records of side effects and rescue medication.As a chronic disease with recurrent symptoms,GERD rehabilitation requires prolonged observation of the clinical course with MXD therapy.

Analysis of new therapeutic strategies for diabetes mellitus based on traditional Chinese medicine'xiaoke'formulae

Objective:To develop new therapeutic strategies for diabetes mellitus(DM)by analyzing the mechanisms of action of traditional Chinese medicine(TCM)'xiaoke'formulae(TCM prescriptions for remedying xiaoke).Methods:We characterized 291 xiaoke formulae,including the herbs contained,chemical composition,constituents'targets,and corresponding genes.Xiaoke-related genes were retrieved based on the relationships of constituents'targets and xiaoke formulae,and a threshold of over 95.88%occurrence of each constituent target in the 291 TCM formulae served as a definition for xiaoke-related genes.Upon comparison with DM-related genes in the DisGeNET database,the genes differing in expression between cases administered TCM and synthetic drugs were explored using a TCM grammar system.Results:The results showed that xiaoke formulae and 14 exclusively xiaoke-related genes were significantly associated with multiple biological processes closely related to DM and diabetic complications(P<.01).Moreover,intervention in the expression of these xiaoke-related genes would affect DM-related genes directly or indirectly.Conclusion:The 14 xiaoke-related genes APEX1,EHMT2,TSHR,CBX1,FEN1,GMNN,JUN,KMT2A,MAPT,POLl,USP1,PIN1,POLB,and POLK can serve as candidate genes for antidiabetic drug design.Compared with DM-related genes in DisGeNET,intervention in the expression of 14 xiaoke-related genes by TCM formulae has the potential to not only lower blood glucose,but also reduce the occurrence of some side effects and inhibit the development of diabetic complications.These findings will contribute to the discovery of new strategies for treating DM.

THE NEW YEAR MESSAGE FROM CHINESE JOURNAL OF INTEGRATIVE MEDICINE

Two months into the year 2003 and one month into the Chinese lunar NewYear of goat,on behalf of the editorial board of the Chinese Journal of Integra-tive Medicine,I wish our readers,contributors and board members around theworld a prosperous and successful new year.

A New Page for Women's Reproductive Health in Integrated Traditional Chinese and Western Medicine

The integrated traditional Chinese and western medicine (ICWM) of obstetrics and gynecology (OBS/GYN) emerged eventually with more than 40 years’ hard struggle, and one of the most promising articles is the integration of the masterpieces of menstrual disorder and infertility in TCM and the virtual explosion of new knowledge and methods in

China Association of Chinese Medicine Paper notice for seminar on clinical application of new technology of integrated Chinese and western medicine in treating sequelae of cerebrovascular diseases

Hosted by ChinaAssociation of Chinese Medicine,and organized by World Journal of Integrated traditional and western Medicine,seminar on clinical application of new technology of integrated Chinese and western medicine in treating sequelae of cerebrovascular diseases is planned to be held in Nanning,Guangxi in August.

Opportunities and challenges for the development of traditional Chinese medicinenursing under the new healthcare reform

Based on the “Opinions on Deepening the Reform of Medicine and Health”, “Strategic planning outline of thedevelopment of Traditional Chinese Medicine （2016-2030）” and the other relevant polices announced by StateAdministration of Traditional Chinese Medicine of the People’s Republic of China, this paper analyzes and summarizesthe opportunities and challenges for the development of Traditional Chinese Medicine nursing （TCM nursing） under thenew healthcare reform, in order to provide reference and thinking for the professional development of TCM nursing.

ETCM v2.0:An update with comprehensive resource and rich annotations for traditional Chinese medicine

Existing traditional Chinese medicine(TCM)-related databases are still insufficient in data standardization,integrity and precision,and need to be updated urgently.Herein,an Encyclopedia of Traditional Chinese Medicine version 2.0(ETCM v2.0,http://www.tcmip.cn/ETCM2/front/#/)was constructed as the latest curated database hosting 48,442 TCM formulas recorded by ancient Chinese medical books,9872 Chinese patent drugs,2079 Chinese medicinal materials and 38,298 ingredients.To facilitate the mechanistic research and new drug discovery,we improved the target identification method based on a two-dimensional ligand similarity search module,which provides the confirmed and/or potential targets of each ingredient,as well as their binding activities.Importantly,five TCM formulas/Chinese patent drugs/herbs/ingredients with the highest Jaccard similarity scores to the submitted drugs are offered in ETCM v2.0,which may be of significance to identify prescriptions/herbs/ingredients with similar clinical efficacy,to summarize the rules of prescription use,and to find alternative drugs for endangered Chinese medicinal materials.Moreover,ETCM v2.0 provides an enhanced Java Script-based network visualization tool for creating,modifying and exploring multi-scale biological networks.ETCM v2.0 may be a major data warehouse for the quality marker identification of TCMs,the TCM-derived drug discovery and repurposing,and the pharmacological mechanism investigation of TCMs against various human diseases.

新时代中医药学科专业人才培养的目标与路径剖析

中医药学科专业人才培养长期处于中医思维弱化阶段,其培养过程重知识、轻文化,导致执业中医医师在临床诊疗实践时运用中医思维和典籍理论、方药等力有未逮,中医药特色优势亟待强化。复兴新时代中华文化成为潮流,为培养中医药学科专业人才提供新机遇、提出新要求,以人才培养为切入点是解决影响中医药发展核心瓶颈问题、全面营造良好中医药生态环境、造就一批堪当时代大任的中医药行业学者专家的关键。遵循中医药自身规律,以马克思主义坚持问题导向的世界观、方法论为原则,提出新时代中医药学科专业人才培养的目标和路径,剖析面临的问题。新时代背景下中医药专业人才的培养可以从加强中医药经典古籍教学改革、优化中医药基层临床人才培养、大力开展卓越复合型优秀人才培养、建设一批中医药学科专业人才培养高地等方面实施。

中医医院新入职本科护士培训考核评价指标的构建

目的 构建中医医院新入职本科护士培训考核评价指标。方法 通过文献研究、小组讨论,建立中医医院新入职本科护士培训考核评价指标初稿,选取来自7个省份的中华护理学会中医中西医结合护理分会的15名专家进行2轮专家咨询,确定考核评价内容及其权重。结果 2轮专家函询问卷的有效回收率均为100%,专家权威系数分别是0.962、0.980,肯德尔协调系数分别是0.220、0.268(均P<0.05),最终形成的中医医院新入职本科护士培训考核评价指标包括5项一级指标、24项二级指标和77项三级指标。结论 构建的中医医院新入职本科护士培训考核评价指标具有较高的可靠性和科学性,可为中医医院管理者及培训者选拔人才提供参考。

基于培养新型高阶中医药人才的中药炮制教学改革

在实现中华民族伟大复兴中国梦的大背景下,我国政府出台多项政策推动中医药发展,同时也对培养符合时代和社会需求的中医药人才提出更高的要求。中药炮制是中医药的重要特色,该课程在中药人才培养中具有重要的地位。文章以培养新型高阶中医药人才为教育目标,从教学理念、教学方法、评价体系3个方面对中药炮制教学进行了大胆的改革与实践。结果表明,在教学相长的同时,教学改革不仅大大增强了学生们的专业自信、文化自信,更激发了学生们改革创新的意识、对行业发展的思考和对民族复兴的责任感。

探讨基于核心指标集构建中医特色的射血分数保留心力衰竭1+N模式疗效评价体系

核心指标集是就某一特定研究领域达成的所有临床研究都应该测量和报告的最少的临床结局,核心指标集可以提高临床疗效评价的规范性和可比性,是循证医学发展的必然、是中医药临床疗效评价的重要抓手、是推动中医药疗效评价与国际接轨的关键。如何运用核心指标集实现临床疗效国际化、标准化的同时,又能遵循中医诊疗特点体现自身优势是中医临床疗效评价的难点。针对这一难点,项目组创新性地提出了1+N模式的射血分数保留心衰(heart failure with preserved ejection fraction, HFpEF)疗效评价体系,即通用的核心指标集“1”+个性化指标集“N”,以满足循证医学和中医学疗效评价的双重需求。本文初探HFpEF疗效评价构建模式,主张在规范化基础上体现多样化和个性化的研究目的需求。结合HFpEF临床疗效评价的现状,综合业内专家意见,探讨了HFpEF 1+N模式疗效评价构建中核心指标集“1”的取舍以及“N”体系的构建思路,以期最大程度的形成符合中医药特色的临床评价体系新范式,推动中医药国际化进程。

“新质生产力”背景下的中药炮制智能化转型升级发展新路径探讨

当前中药饮片炮制生产存在主观性强、质量不稳定、生产效率低、智能化程度缺乏等问题,为加快推动中药炮制智能化转型升级,深入剖析当前中药饮片构建数字化、智能化生产模式面临的问题与挑战,针对传统中药炮制基础理论缺乏现代科学阐述、在线数字化质量表征技术缺失、生产装备智能化水平较低及优质饮片评价标准缺失等问题,以“新质生产力”形成为导向,提出以科技创新为驱动,通过多学科交叉融合手段深入探讨中药炮制机理,明晰饮片炮制过程“药性-质量”关联规律,应用仿生传感与人工智能实现饮片全息质量表征、云边协同大数据系统助推生产线智能升级,构建“物理-化学-生物”多模态数据融合的优质饮片评价体系,促使中药炮制过程向更高效、精准、可持续的方向发展,推动中药产业可持续发展,为中医药现代化提供理论和实践支撑。

新外来中药香蜂草的药性探讨

香蜂草为唇形科植物Melissa officinalis L.的叶。原产于欧洲地中海地区,欧洲、北美、亚洲各大洲均有分布,我国的中南、西南部以及台湾也有野生种分布。香蜂草在国外有长久的应用历史,被广泛应用于治疗精神和中枢神经系统疾病、心血管疾病等。也作为抗焦虑药、睡眠辅助剂以及解毒剂。目前香蜂草在我国作为香料使用,并有多种以香蜂草为原料的专利。中医药学自古就广泛吸收外来药物不断扩大我国中药资源,如藿香、丁香、木香等源自域外的“香药”至今也是我国的常用中药。将香蜂草列入中药潜在的引入对象进行研究,以其临床研究和应用文献为基础,结合中医药理论对香蜂草的中药药性进行理论分析。结果为香蜂草药性辛、凉,归心、肝经,具有宁心安神益智、疏肝解郁、缓急止痛的功效,用于治疗心神不宁,失眠,健忘,心悸;情志抑郁,烦躁多虑;腹痛、牙痛等症状。

新医科背景下中医院校创新能力提升策略研究——以河南中医药大学儿科医学院为例

十八大以来,国家高度重视中医药工作,中医药发展迎来了历史最好机遇。中医药高校创新教育应抢抓历史机遇,勇担职责使命,遵循中医药发展规律,树立“新医科”思维,以胜任能力为导向,坚持传承精华、守正创新。文章以河南中医药大学儿科医学院为例,从中医药文化认同、中医药体系传承、中医药发展创新三个维度,深入分析了制约中医药高校学生创新能力提升的深层次问题,并针对性地提出了加强传统文化教育,树立文化自信,增强中医药文化认同;遵循客观规律,构建中医药思维,擦亮中医药传承底色;树立新医科思维,拥抱现代科技,促进中医药创新发展三条对策及切实可行的具体举措。

新质生产力赋能中医药传承创新发展的策略与思考

文章探讨了新质生产力在推动中医药传承创新发展方面的策略与思考。科技创新交叉融合突破所产生的新质生产力,为中医药领域带来了前所未有的发展机遇。文章探讨了新质生产力在医药领域的潜力和发展方向,强调了其在推动中医药传承创新中的重要作用;分析了现代信息技术对中医药传承创新发展的影响,重点介绍了中药材大数据云服务平台、人工智能赋能、先进设备智能制造、大数据超算以及中医药循证研究证据库等方面的应用;展望了人工智能大模型在医药领域的发展方向,为未来中医药传承创新发展提供了新的视角和思路。

高等中医药院校西医内科学教学的创新探索

在高等中医药院校中医专业的学习中,西医内科学亦为重要的临床专业课程之一,但西医内科学教学面临与中医课程交叉、课时压缩、学生基础薄弱等相应问题,增加了该课程的学习难度。随着现代社会对医学人才的要求不断提高,中医药院校的临床专业学生也必须掌握西医的理论基础和临床疾病。为了贯彻国家“新医科”建设,提高中医专业西医内科学教学水平,提升本科生分析及解决临床问题的能力,笔者所在教研室总结出内科专业主讲教师+教学秘书责任制、现代化教学手段+问题/病例切入式教学、充分利用现代网络和床旁教学等不同教学模式,在实际运用中取得了很好的教学效果,得到授课教师和学生的广泛认可。文章就相关教学经验进行总结,以期为中医药院校本科生的西医内科学教学提供一定的有益建议,提高本科生的西医内科学教学水平。

中华人民共和国成立初期民间药方的收集与影响

中华人民共和国成立初期,由中国共产党领导开展的民间药方收集是各级卫生部门贯彻落实党的中医政策的结果,也是社会主义医疗卫生事业的重要组成部分。党和政府凭借强大的组织体系和社会动员能力使药方收集工作得以在全国迅速展开,并取得了明显成效。药方收集的普遍开展,在保障人民群众生命健康、继承和发扬祖国医学遗产、推动我国医学科学事业的发展以及提升民众的爱国热情等方面,都产生了积极的影响。

BOPPPS模式用于中西医临床医学本科药理学教学效果初探

目的探讨BOPPPS教学模式在药理学课程教学中的应用效果。方法以重庆医科大学中西医临床医学本科专业2020级(125人,对照组)和2021级(106人,观察组)全体学生为研究对象,以2018年科学出版社出版的《药理学(第二版)》“第24章甲状腺激素及抗甲状腺药”为教学内容。观察组学生采用BOPPPS教学模式(包括导入、提出学习目标、前测、开展参与式学习、后测、总结6个阶段),对照组采用传统教学模式。教学结束后通过理论考试和问卷调查综合评价教学效果。结果观察组学生理论考试成绩为(62.17±15.75)分,明显高于对照组的(56.59±16.46)分(P<0.05);观察组、对照组学生分别以60~<65分(22人,20.75%)及<40分(25人,20.00%)者居多;观察组学生在教学模式、启发式教学、教学效果3个方面教学质量和学习效果各方面的自我评价得分均明显高于对照组(P<0.05)。结论BOPPPS教学模式以学习成果为导向,利于提高学生学习效果,促进其思维能力和创新能力的培养,更贴合“新医科”人才培养的需要。