The coordination mechanism between the career development planning of vocational students and the management of vocational colleges is an important means to improve the quality of education and students’vocational co...The coordination mechanism between the career development planning of vocational students and the management of vocational colleges is an important means to improve the quality of education and students’vocational competitiveness.The application of synergy theory in the field of education emphasizes the interaction and coordination of various elements in the system and pursues the optimization of overall efficiency.Based on the theory of coordination and its relevance to the management of higher vocational colleges,this paper analyzes the current development status and problems of the coordination mechanism and puts forward the strategy of building an efficient coordination mechanism designed to enhance the students’employment competitiveness,promote the all-round development,and provide theoretical and practical support for the reform and development of higher vocational education.展开更多
The ever-increasing quantity of spent lithium-ion batteries(LIBs)is both a potential environmental pollutant and a valuable resource.The spent LIBs recycling mainly aimed at the separation of valuable elements.Some is...The ever-increasing quantity of spent lithium-ion batteries(LIBs)is both a potential environmental pollutant and a valuable resource.The spent LIBs recycling mainly aimed at the separation of valuable elements.Some issues still exist in these processes such as high energy consumption and complex separation procedures.This study avoided element separation and proposed a facile approach to transform spent LiCoO_(2) electrode into a lithium(Li)-doped graphitic carbon nitride(g-C_(3)N_(4))/Co_(3)O_(4) composite photocatalyst through one-pot in situ thermal reduction.During the thermal process,melamine served as the reductant for LiCoO_(2) decomposition and the raw material for g-C_(3)N_(4) production.Li was in situ doped in g-C_(3)N_(4) and the generated Co_(3)O_(4) was in situ integrated,forming a Li-doped g-C_(3)N_(4)/Co_(3)O_(4) composite photocatalyst.This special composite exhibited an enhanced photocatalytic performance,and its photocatalytic H2 production and RhB degradation rates were 8.7 and 6.8 times higher than those of g-C_(3)N_(4).The experiments combined with DFT calculation revealed that such enhanced photocatalytic efficiency was ascribed to the synergy effect of Li doping and Co_(3)O_(4) integrating,which extended the visible light absorption(450-900 nm)and facilitated the charge transfer and separation.This study transforms waste into a high-efficient catalyst,realizing high-valued utilization of waste and environmental protection.展开更多
Worldwide trends in mobile electrification will skyrocket demands for lithium-based battery production,driven by the popularity of electric vehicles.However,both lithium metal batteries and lithium ion batteries face ...Worldwide trends in mobile electrification will skyrocket demands for lithium-based battery production,driven by the popularity of electric vehicles.However,both lithium metal batteries and lithium ion batteries face severe safety issues due to dendrite nucleation and growth process.Li deposition is significantly influenced by interfacial factors and charging conditions.In this paper,an electrochemical model considering the internal and external factors is proposed based on Monte Carlo method.The influence of internal solid electrolyte interphase(SEI)porosity,thickness and the external conditions on dendrite growth process is systematically described.The simulation results support that the three factors investigated in this model could synergistically regulate the dendrite growth process.Three competition mechanisms are proposed to tailor lithium deposition for Li-based batteries and numerical solutions for variation pattern of dendrite growth with time are fitted.A three-step process describing kinetic process of lithium deposition is proposed.To achieve dendrite-free charging process,charging strategies and emerging materials design should be considered,including physicochemical materials engineering,artificial SEI,and design for dynamic safety boundary.This work could contribute to the foundation for insights of Li deposition mechanism,which is promising to provide guidelines for next-generation high-energy-density and safe batteries in CHAIN framework.展开更多
This paper explores the incentives of investment in renewable energy of two utility firms who compete or cooperate under either a cap-and-trade grandfathering mechanism(GM)or benchmarking mechanism(BM).We find that ut...This paper explores the incentives of investment in renewable energy of two utility firms who compete or cooperate under either a cap-and-trade grandfathering mechanism(GM)or benchmarking mechanism(BM).We find that utility firms will invest in renewable energy more under BM than under GM,in both competitive and cooperative markets,and they will invest more in a competitive market than in a cooperative market,under either GM or BM.Furthermore,utility firms will produce more electricity and generate more total carbon emissions under BM than under GM.The profits of two firms,however,are higher in cooperative market than in competitive market.The government will benefit from implementing a BM to encourage utility firms to invest in renewable energy in a competing market.展开更多
With the increasingly fiercer talented personnel competition, the introduction of a talented personnel competition mechanism has become imperative in the commercial age. In this paper, the necessities of introducing a...With the increasingly fiercer talented personnel competition, the introduction of a talented personnel competition mechanism has become imperative in the commercial age. In this paper, the necessities of introducing a talented personnel competition mechanism are analyzed, and then the guiding ideology and principles of the talented personnel competition mechanism are proposed, and finally the application strategies of the talented personnel competition mechanism are discussed展开更多
The tumour suppressor p53 is a transcription factor that regulates multiple biological functions including metabolism, DNA repair, cell cycle arrest, apoptosis and senescence. About half of human cancers show a normal...The tumour suppressor p53 is a transcription factor that regulates multiple biological functions including metabolism, DNA repair, cell cycle arrest, apoptosis and senescence. About half of human cancers show a normal TP53 gene and aberrant overexpression of Mdm2. This fact promotes a promising cancer therapeutic strategy by inhibiting the interactions between p53 and Mdm2. Various inhibitors have been designed to achieve this novel approach for cancer therapy. However, the detailed competition mechanism between these inhibitors and the p53 molecule in their binding process to Mdm2 is still unclear. We investigate this competition mechanism between Nutlin3 and p53 using molecular dynamics simulations. It is found that Nutlin3 binds faster than the p53 molecule to Mdm2 to prevent p53 binding to Mdm2 when Nutlin3 and p53 have equal distance from Mdm2. Nutlin3 can also bind to the p53-Mdm2 complex to disturb and weaken the interactions between p53 and Mdm2. Consequently, p53 cannot bind to Mdm2 and its tumour suppression function is reactivated. These results provide the detailed competition mechanism between Nutlin3 and p53 in their binding to Mdm2. Because the binding site of most other inhibitors to Mdm2 is the same as Nutlin3, therefore this competition mechanism can extend to most inhibitors which target the p53-Mdm2 interaction.展开更多
A high thrust-to-weight ratio poses challenges to the high-temperature performance of Ni-based superalloys. The oxidation behavior of GH4738 at extreme temperatures has been investigated by isothermal and non-isotherm...A high thrust-to-weight ratio poses challenges to the high-temperature performance of Ni-based superalloys. The oxidation behavior of GH4738 at extreme temperatures has been investigated by isothermal and non-isothermal experiments. As a result of the competitive diffusion of alloying elements, the oxide scale included an outermost porous oxide layer (OOL), an inner relatively dense oxide layer (IOL), and an internal oxide zone (IOZ), depending on the temperature and time. A high temperature led to the formation of large voids at the IOL/IOZ interface. At 1200℃, the continuity of the Cr-rich oxide layer in the IOL was destroyed, and thus, spallation occurred. Extension of oxidation time contributed to the size of Al-rich oxide particles with the increase in the IOZ. Based on this finding,the oxidation kinetics of GH4738 was discussed, and the corresponding oxidation behavior at 900-1100℃ was predicted.展开更多
Steam injection is a most effective way for improving heavy oil recovery efficiency, and it has academic and practical significance for the mechanism of multi-field synergy oil displacement. Mechanism of “diversified...Steam injection is a most effective way for improving heavy oil recovery efficiency, and it has academic and practical significance for the mechanism of multi-field synergy oil displacement. Mechanism of “diversified” oil displacement which is obtained by traditional study methods in the exploitation territory of oil and gas fields has both respective roles and mutual cross shortages. To describe and analyze the displacement process of multi-field coupling with exergy transfer can simplify this kind of problem by introducing a unified goal-driving exergy. It needs to use the method of theoretical modeling, numerical simulation and experimental validation to study the basic law of exergy transfer in the oil displacement process of multi-field synergy, make a thorough research for the flooding process of steam injection with exergy transfer theory and reveal the oil displacement mechanism in steam injection of multi-field synergy. Thus the theory instruction and technical support can be provided to improve reservoirs producing degree and extraction ratio.展开更多
BACKGROUND Competitive endogenous RNA(ceRNA)is an innovative way of gene expression modulation,which plays a crucial part in neoplasia.However,the intricacy and behavioral characteristics of the ceRNA network in hepat...BACKGROUND Competitive endogenous RNA(ceRNA)is an innovative way of gene expression modulation,which plays a crucial part in neoplasia.However,the intricacy and behavioral characteristics of the ceRNA network in hepatocellular carcinoma(HCC)remain dismal.AIM To establish a cyclin dependent kinase inhibitor 2A(CDKN2A)-related ceRNA network and recognize potential prognostic indicators for HCC.METHODS The mutation landscape of CDKN2A in HCC was first explored using the cBioPortal database.Differential expression analysis was implemented between CDKN2Ahigh and CDKN2Alow expression HCC samples.The targeted microRNAs were predicted by lncBasev3.0,and the targeted mRNAs were predicted by miRDB,and Targetscan database.The univariate and multivariate analysis were utilized to identify independent prognostic indicators.RESULTS CDKN2A was frequently mutated and deleted in HCC.The single-cell RNA-sequencing analysis revealed that CDKN2A participated in cell cycle pathways.The CDKN2A-related ceRNA network-growth arrest specific 5(GAS5)/miR-25-3p/SRY-box transcription factor 11(SOX11)was successfully established.GAS5 was recognized as an independent prognostic biomarker,whose overexpression was correlated with a poor prognosis in HCC patients.The association between GAS5 expression and methylation,immune infilt-ration was explored.Besides,traditional Chinese medicine effective components targeting GAS5 were obtained.CONCLUSION This CDKN2A-related ceRNA network provides innovative insights into the molecular mechanism of HCC formation and progression.Moreover,GAS5 might be a significant prognostic biomarker and therapeutic target in HCC.展开更多
Competition of hydrocarbon compounds with sulfides in gasoline has caused a not very high selectivity of sulfides in adsorption desulfurization so far,resulting in a reduction of catalyst lifetime as well as more sulf...Competition of hydrocarbon compounds with sulfides in gasoline has caused a not very high selectivity of sulfides in adsorption desulfurization so far,resulting in a reduction of catalyst lifetime as well as more sulfur oxide emissions.Tostudy the whole competitive process changing with the increase of the loading,the dynamic competition adsorption mechanism of cyclohexene and thiophene in siliceous faujasite(FAU)zeolite was analyzed by the Monte Carlo simulation.The results showed that with the increase of the loading,thiophene and cyclohexene had different performances before and after the inflection point of 40 molecule/UC.The adsorbates were distributed ideally at optimal sites during the stage that occurred before the inflection point,which is called the“optimal-displacement adsorption”stage.When approaching the inflection point,the competition became apparent and the displacement appeared accordingly,some thiophene molecules at S sites(refers to the sites inside the supercages)were displaced by cyclohexene.After the inflection point,the concentration of adsorbates at W sites(refers to the 12-membered ring connecting the supercages)was significantly reduced,whereas the adsorbates at S sites got more concentrated.The stage some cyclohexene molecules displaced by thiophene and inserted into the center of the supercage can be named as the“insertion-displacement adsorption”stage,and both the adsorption behavior and the competitive relationship became localized when the adsorption amount became saturated.This shift in the competitive adsorption mechanism was due to the sharp increase of interaction energy between the adsorbates.Besides,the increase in temperature and ratio of Si/Al will allow the adsorbates,especially thiophene molecules to occupy more adsorption sites,and it is beneficial to improve the desulfurization selectivity.展开更多
The selection of machining parameters directly affects the production time,quality,cost,and other process performance measures for multi-pass milling.Optimization of machining parameters is of great significance.Howev...The selection of machining parameters directly affects the production time,quality,cost,and other process performance measures for multi-pass milling.Optimization of machining parameters is of great significance.However,it is a nonlinear constrained optimization problem,which is very difficult to obtain satisfactory solutions by traditional optimization methods.A new optimization technique combined chaotic operator and imperialist competitive algorithm(ICA)is proposed to solve this problem.The ICA simulates the competition between the empires.It is a population-based meta-heuristic algorithm for unconstrained optimization problems.Imperialist development operator based on chaotic sequence is introduced to improve the local search of ICA,while constraints handling mechanism is introduced and an imperialist-colony transformation policy is established.The improved ICA is called chaotic imperialist competitive algorithm(CICA).A case study of optimizing machining parameters for multi-pass face milling operations is presented to verify the effectiveness of the proposed method.The case is to optimize parameters such as speed,feed,and depth of cut in each pass have yielded a minimum total product ion cost.The depth of cut of optimal strategy obtained by CICA are 4 mm,3 mm,1 mm for rough cutting pass 1,rough cutting pass 1 and finish cutting pass,respectively.The cost for each pass are$0.5366 US,$0.4473 US and$0.3738 US.The optimal solution of CICA for various strategies with at=8 mm is$1.3576 US.The results obtained with the proposed schemes are better than those of previous work.This shows the superior performance of CICA in solving such problems.Finally,optimization of cutting strategy when the width of workpiece no smaller than the diameter of cutter is discussed.Conclusion can be drawn that larger tool diameter and row spacing should be chosen to increase cutting efficiency.展开更多
Enterprises engaging in collaboration with competitors can increase their technological diversity and release a new product innovation, but also full of challenges. This complexity of co-opetition relationship require...Enterprises engaging in collaboration with competitors can increase their technological diversity and release a new product innovation, but also full of challenges. This complexity of co-opetition relationship requirements academia and enterprises to clarify the problem of competitive technology alliance risk formation mechanism, making the risk control to dispose. Based on the perspective of resources and capabilities, this paper firstly puts forward the double helix model of alliances' evolution on resources and capabilities ; then, with the deepe- ning of the cooperation, this evolutionary process leads to different innovation risk: opportunism, R and D inte- gration risk and flexible loss risk; next, analyzing the corresponding management path and constructing the conceptual framework of risk management mechanism to help enterprise using the co-opetition relationship to reduce risk and improve the potential competitive advantage.展开更多
A maritime target saliency detection method inspired by the stimulation competition and selection mechanism of raptor vision is presented for the airborne vision system of unmanned aerial vehicle(UAV)in an unknown mar...A maritime target saliency detection method inspired by the stimulation competition and selection mechanism of raptor vision is presented for the airborne vision system of unmanned aerial vehicle(UAV)in an unknown maritime environment.The stimulation competition and selection mechanism in the visual pathway of raptor vision based on the phenomenon of raptor capturing prey in complex scenes are studied.Then,the mathematical model of the stimulation competition and selection mechanism of raptor vision is established and employed for the salient object detection.Popular image datasets and practical scene datasets are applied to verify the effectiveness of the presented method.Results show that the detection performance of the proposed method is better than that of other comparison methods.The proposed algorithm provides an idea for maritime target salient detection and cross-domain joint mission for UAV or other unmanned equipment.展开更多
An uneven herbicide distribution can lead to reduced efficacy,and the release of herbicide residues and their transformation products into the environment through runoff increases their potential use risk.Understandin...An uneven herbicide distribution can lead to reduced efficacy,and the release of herbicide residues and their transformation products into the environment through runoff increases their potential use risk.Understanding the water distribution dynamics of commonly used paddy field herbicides,for example,oxadiazon,is imperative for the long-term management of weeds in paddy fields.To clarify the diffusion and sedimentation ability of oxadiazon with the addition of a nonionic surfactant—diffusion and settling agent(DSA)for subsequent commercial use in paddy field water layers,the synergistic mechanisms of DSA with butachlor and bensulfuron-methyl in paddy fields were studied.Bioassays,instrumental analysis and field experiments were conducted in this research to provide a relevant basis for improving the efficacy of paddy field herbicides.The field experiment results indicated that DSA could increase the plant and fresh weight control effects of oxadiazon(450 g a.i.·hm^(-2)),butachlor and bensulfuron-methyl to different degrees.These findings demonstrated that DSA could not only effectively improve oxadiazon diffusion and settling in water layers and significantly increase the control effects of butachlor and bensulfuron-methyl,but also promote crop growth and development to different degrees.展开更多
文摘The coordination mechanism between the career development planning of vocational students and the management of vocational colleges is an important means to improve the quality of education and students’vocational competitiveness.The application of synergy theory in the field of education emphasizes the interaction and coordination of various elements in the system and pursues the optimization of overall efficiency.Based on the theory of coordination and its relevance to the management of higher vocational colleges,this paper analyzes the current development status and problems of the coordination mechanism and puts forward the strategy of building an efficient coordination mechanism designed to enhance the students’employment competitiveness,promote the all-round development,and provide theoretical and practical support for the reform and development of higher vocational education.
基金supported by the National Natural Science Foundation of China(51534005)Postdoctoral Innovative Talent Support Program(BX20190200)China Postdoctoral Science Foundation(2020M671129)。
文摘The ever-increasing quantity of spent lithium-ion batteries(LIBs)is both a potential environmental pollutant and a valuable resource.The spent LIBs recycling mainly aimed at the separation of valuable elements.Some issues still exist in these processes such as high energy consumption and complex separation procedures.This study avoided element separation and proposed a facile approach to transform spent LiCoO_(2) electrode into a lithium(Li)-doped graphitic carbon nitride(g-C_(3)N_(4))/Co_(3)O_(4) composite photocatalyst through one-pot in situ thermal reduction.During the thermal process,melamine served as the reductant for LiCoO_(2) decomposition and the raw material for g-C_(3)N_(4) production.Li was in situ doped in g-C_(3)N_(4) and the generated Co_(3)O_(4) was in situ integrated,forming a Li-doped g-C_(3)N_(4)/Co_(3)O_(4) composite photocatalyst.This special composite exhibited an enhanced photocatalytic performance,and its photocatalytic H2 production and RhB degradation rates were 8.7 and 6.8 times higher than those of g-C_(3)N_(4).The experiments combined with DFT calculation revealed that such enhanced photocatalytic efficiency was ascribed to the synergy effect of Li doping and Co_(3)O_(4) integrating,which extended the visible light absorption(450-900 nm)and facilitated the charge transfer and separation.This study transforms waste into a high-efficient catalyst,realizing high-valued utilization of waste and environmental protection.
基金the financial supports from the National Natural Science Foundation of China(52102470)。
文摘Worldwide trends in mobile electrification will skyrocket demands for lithium-based battery production,driven by the popularity of electric vehicles.However,both lithium metal batteries and lithium ion batteries face severe safety issues due to dendrite nucleation and growth process.Li deposition is significantly influenced by interfacial factors and charging conditions.In this paper,an electrochemical model considering the internal and external factors is proposed based on Monte Carlo method.The influence of internal solid electrolyte interphase(SEI)porosity,thickness and the external conditions on dendrite growth process is systematically described.The simulation results support that the three factors investigated in this model could synergistically regulate the dendrite growth process.Three competition mechanisms are proposed to tailor lithium deposition for Li-based batteries and numerical solutions for variation pattern of dendrite growth with time are fitted.A three-step process describing kinetic process of lithium deposition is proposed.To achieve dendrite-free charging process,charging strategies and emerging materials design should be considered,including physicochemical materials engineering,artificial SEI,and design for dynamic safety boundary.This work could contribute to the foundation for insights of Li deposition mechanism,which is promising to provide guidelines for next-generation high-energy-density and safe batteries in CHAIN framework.
基金support from the National Natural Science Foundation of China(Grant No.71531003)Philosophy and Social Science Research Fund of Chengdu University of Technology(YJ2021-QN005)Center for Trans-Himalaya Studies(KX2022B01)。
文摘This paper explores the incentives of investment in renewable energy of two utility firms who compete or cooperate under either a cap-and-trade grandfathering mechanism(GM)or benchmarking mechanism(BM).We find that utility firms will invest in renewable energy more under BM than under GM,in both competitive and cooperative markets,and they will invest more in a competitive market than in a cooperative market,under either GM or BM.Furthermore,utility firms will produce more electricity and generate more total carbon emissions under BM than under GM.The profits of two firms,however,are higher in cooperative market than in competitive market.The government will benefit from implementing a BM to encourage utility firms to invest in renewable energy in a competing market.
文摘With the increasingly fiercer talented personnel competition, the introduction of a talented personnel competition mechanism has become imperative in the commercial age. In this paper, the necessities of introducing a talented personnel competition mechanism are analyzed, and then the guiding ideology and principles of the talented personnel competition mechanism are proposed, and finally the application strategies of the talented personnel competition mechanism are discussed
基金Supported by the National Natural Science Foundation of China under Grant No 11675018the Beijing Natural Science Foundation under Grant No 1172008the Fundamental Research Funds for the Central Universities under Grant No 2015KJJCB01
文摘The tumour suppressor p53 is a transcription factor that regulates multiple biological functions including metabolism, DNA repair, cell cycle arrest, apoptosis and senescence. About half of human cancers show a normal TP53 gene and aberrant overexpression of Mdm2. This fact promotes a promising cancer therapeutic strategy by inhibiting the interactions between p53 and Mdm2. Various inhibitors have been designed to achieve this novel approach for cancer therapy. However, the detailed competition mechanism between these inhibitors and the p53 molecule in their binding process to Mdm2 is still unclear. We investigate this competition mechanism between Nutlin3 and p53 using molecular dynamics simulations. It is found that Nutlin3 binds faster than the p53 molecule to Mdm2 to prevent p53 binding to Mdm2 when Nutlin3 and p53 have equal distance from Mdm2. Nutlin3 can also bind to the p53-Mdm2 complex to disturb and weaken the interactions between p53 and Mdm2. Consequently, p53 cannot bind to Mdm2 and its tumour suppression function is reactivated. These results provide the detailed competition mechanism between Nutlin3 and p53 in their binding to Mdm2. Because the binding site of most other inhibitors to Mdm2 is the same as Nutlin3, therefore this competition mechanism can extend to most inhibitors which target the p53-Mdm2 interaction.
基金financially supported by the National Key R&D Program of China (No.2021YFB3700400)the National Natural Science Foundation of China (Nos.52074030,51904021,and 52174294)。
文摘A high thrust-to-weight ratio poses challenges to the high-temperature performance of Ni-based superalloys. The oxidation behavior of GH4738 at extreme temperatures has been investigated by isothermal and non-isothermal experiments. As a result of the competitive diffusion of alloying elements, the oxide scale included an outermost porous oxide layer (OOL), an inner relatively dense oxide layer (IOL), and an internal oxide zone (IOZ), depending on the temperature and time. A high temperature led to the formation of large voids at the IOL/IOZ interface. At 1200℃, the continuity of the Cr-rich oxide layer in the IOL was destroyed, and thus, spallation occurred. Extension of oxidation time contributed to the size of Al-rich oxide particles with the increase in the IOZ. Based on this finding,the oxidation kinetics of GH4738 was discussed, and the corresponding oxidation behavior at 900-1100℃ was predicted.
文摘Steam injection is a most effective way for improving heavy oil recovery efficiency, and it has academic and practical significance for the mechanism of multi-field synergy oil displacement. Mechanism of “diversified” oil displacement which is obtained by traditional study methods in the exploitation territory of oil and gas fields has both respective roles and mutual cross shortages. To describe and analyze the displacement process of multi-field coupling with exergy transfer can simplify this kind of problem by introducing a unified goal-driving exergy. It needs to use the method of theoretical modeling, numerical simulation and experimental validation to study the basic law of exergy transfer in the oil displacement process of multi-field synergy, make a thorough research for the flooding process of steam injection with exergy transfer theory and reveal the oil displacement mechanism in steam injection of multi-field synergy. Thus the theory instruction and technical support can be provided to improve reservoirs producing degree and extraction ratio.
基金Supported by the Zhejiang Province Major Science and Technology Project for Medicine and Health,No.WKJ-ZJ-2329.
文摘BACKGROUND Competitive endogenous RNA(ceRNA)is an innovative way of gene expression modulation,which plays a crucial part in neoplasia.However,the intricacy and behavioral characteristics of the ceRNA network in hepatocellular carcinoma(HCC)remain dismal.AIM To establish a cyclin dependent kinase inhibitor 2A(CDKN2A)-related ceRNA network and recognize potential prognostic indicators for HCC.METHODS The mutation landscape of CDKN2A in HCC was first explored using the cBioPortal database.Differential expression analysis was implemented between CDKN2Ahigh and CDKN2Alow expression HCC samples.The targeted microRNAs were predicted by lncBasev3.0,and the targeted mRNAs were predicted by miRDB,and Targetscan database.The univariate and multivariate analysis were utilized to identify independent prognostic indicators.RESULTS CDKN2A was frequently mutated and deleted in HCC.The single-cell RNA-sequencing analysis revealed that CDKN2A participated in cell cycle pathways.The CDKN2A-related ceRNA network-growth arrest specific 5(GAS5)/miR-25-3p/SRY-box transcription factor 11(SOX11)was successfully established.GAS5 was recognized as an independent prognostic biomarker,whose overexpression was correlated with a poor prognosis in HCC patients.The association between GAS5 expression and methylation,immune infilt-ration was explored.Besides,traditional Chinese medicine effective components targeting GAS5 were obtained.CONCLUSION This CDKN2A-related ceRNA network provides innovative insights into the molecular mechanism of HCC formation and progression.Moreover,GAS5 might be a significant prognostic biomarker and therapeutic target in HCC.
基金the National Natural Science Foundation of China(21822810,21838011)the National Key Research and Development Program(2018YFC1902603).
文摘Competition of hydrocarbon compounds with sulfides in gasoline has caused a not very high selectivity of sulfides in adsorption desulfurization so far,resulting in a reduction of catalyst lifetime as well as more sulfur oxide emissions.Tostudy the whole competitive process changing with the increase of the loading,the dynamic competition adsorption mechanism of cyclohexene and thiophene in siliceous faujasite(FAU)zeolite was analyzed by the Monte Carlo simulation.The results showed that with the increase of the loading,thiophene and cyclohexene had different performances before and after the inflection point of 40 molecule/UC.The adsorbates were distributed ideally at optimal sites during the stage that occurred before the inflection point,which is called the“optimal-displacement adsorption”stage.When approaching the inflection point,the competition became apparent and the displacement appeared accordingly,some thiophene molecules at S sites(refers to the sites inside the supercages)were displaced by cyclohexene.After the inflection point,the concentration of adsorbates at W sites(refers to the 12-membered ring connecting the supercages)was significantly reduced,whereas the adsorbates at S sites got more concentrated.The stage some cyclohexene molecules displaced by thiophene and inserted into the center of the supercage can be named as the“insertion-displacement adsorption”stage,and both the adsorption behavior and the competitive relationship became localized when the adsorption amount became saturated.This shift in the competitive adsorption mechanism was due to the sharp increase of interaction energy between the adsorbates.Besides,the increase in temperature and ratio of Si/Al will allow the adsorbates,especially thiophene molecules to occupy more adsorption sites,and it is beneficial to improve the desulfurization selectivity.
基金supported by the National Natural Science Foundation of China under grant no.51705182.
文摘The selection of machining parameters directly affects the production time,quality,cost,and other process performance measures for multi-pass milling.Optimization of machining parameters is of great significance.However,it is a nonlinear constrained optimization problem,which is very difficult to obtain satisfactory solutions by traditional optimization methods.A new optimization technique combined chaotic operator and imperialist competitive algorithm(ICA)is proposed to solve this problem.The ICA simulates the competition between the empires.It is a population-based meta-heuristic algorithm for unconstrained optimization problems.Imperialist development operator based on chaotic sequence is introduced to improve the local search of ICA,while constraints handling mechanism is introduced and an imperialist-colony transformation policy is established.The improved ICA is called chaotic imperialist competitive algorithm(CICA).A case study of optimizing machining parameters for multi-pass face milling operations is presented to verify the effectiveness of the proposed method.The case is to optimize parameters such as speed,feed,and depth of cut in each pass have yielded a minimum total product ion cost.The depth of cut of optimal strategy obtained by CICA are 4 mm,3 mm,1 mm for rough cutting pass 1,rough cutting pass 1 and finish cutting pass,respectively.The cost for each pass are$0.5366 US,$0.4473 US and$0.3738 US.The optimal solution of CICA for various strategies with at=8 mm is$1.3576 US.The results obtained with the proposed schemes are better than those of previous work.This shows the superior performance of CICA in solving such problems.Finally,optimization of cutting strategy when the width of workpiece no smaller than the diameter of cutter is discussed.Conclusion can be drawn that larger tool diameter and row spacing should be chosen to increase cutting efficiency.
文摘Enterprises engaging in collaboration with competitors can increase their technological diversity and release a new product innovation, but also full of challenges. This complexity of co-opetition relationship requirements academia and enterprises to clarify the problem of competitive technology alliance risk formation mechanism, making the risk control to dispose. Based on the perspective of resources and capabilities, this paper firstly puts forward the double helix model of alliances' evolution on resources and capabilities ; then, with the deepe- ning of the cooperation, this evolutionary process leads to different innovation risk: opportunism, R and D inte- gration risk and flexible loss risk; next, analyzing the corresponding management path and constructing the conceptual framework of risk management mechanism to help enterprise using the co-opetition relationship to reduce risk and improve the potential competitive advantage.
基金supported by the National Natural Science Foundation of China under grant#62103040,#U1913602,#T2121003,#91948204,#U20B2071,and#U19B2033 and Open Fund/Postdoctoral Fund of the Laboratory of Cognition and Decision Intelligence for Complex Systems,Institute of Automation,Chinese Academy of Sciences under grant CASIA-KFKT-08.
文摘A maritime target saliency detection method inspired by the stimulation competition and selection mechanism of raptor vision is presented for the airborne vision system of unmanned aerial vehicle(UAV)in an unknown maritime environment.The stimulation competition and selection mechanism in the visual pathway of raptor vision based on the phenomenon of raptor capturing prey in complex scenes are studied.Then,the mathematical model of the stimulation competition and selection mechanism of raptor vision is established and employed for the salient object detection.Popular image datasets and practical scene datasets are applied to verify the effectiveness of the presented method.Results show that the detection performance of the proposed method is better than that of other comparison methods.The proposed algorithm provides an idea for maritime target salient detection and cross-domain joint mission for UAV or other unmanned equipment.
基金Supported by the National Natural Science Foundation of China(32072434)Scholar Backbone Project of Northeast Agricultural University(19XG02)。
文摘An uneven herbicide distribution can lead to reduced efficacy,and the release of herbicide residues and their transformation products into the environment through runoff increases their potential use risk.Understanding the water distribution dynamics of commonly used paddy field herbicides,for example,oxadiazon,is imperative for the long-term management of weeds in paddy fields.To clarify the diffusion and sedimentation ability of oxadiazon with the addition of a nonionic surfactant—diffusion and settling agent(DSA)for subsequent commercial use in paddy field water layers,the synergistic mechanisms of DSA with butachlor and bensulfuron-methyl in paddy fields were studied.Bioassays,instrumental analysis and field experiments were conducted in this research to provide a relevant basis for improving the efficacy of paddy field herbicides.The field experiment results indicated that DSA could increase the plant and fresh weight control effects of oxadiazon(450 g a.i.·hm^(-2)),butachlor and bensulfuron-methyl to different degrees.These findings demonstrated that DSA could not only effectively improve oxadiazon diffusion and settling in water layers and significantly increase the control effects of butachlor and bensulfuron-methyl,but also promote crop growth and development to different degrees.