Addiction to synthetic cannabinoids(SCs) is a growing social and health problem worldwide. Chronic use of SCs may cause adverse effects in the gastrointestinal system. We describe a very rare case of acute gastric dil...Addiction to synthetic cannabinoids(SCs) is a growing social and health problem worldwide. Chronic use of SCs may cause adverse effects in the gastrointestinal system. We describe a very rare case of acute gastric dilatation(AGD) and hepatic portal venous gas(HPVG),with findings of acute abdomen resulting from chronic use of a SC, Bonzai. AGD and HPVG were detected by computerized tomography examination. Patchy mucosal ischemia was seen in endoscopic examination. Despite the findings of an acute abdomen, a non-surgical approach with nasogastric decompression, antibiotic therapy, and close radiologic and endoscopic followup was preferred in the presented case. Clinical and radiologic findings decreased dramatically on the first day, and endoscopic findings gradually disappeared over 7 d. In conclusion, this case shows that chronic use of a SC may cause AGD and accompanying HPVG,which can be managed non-surgically despite the findings of acute abdomen.展开更多
Th e synthesis of mesoporous molecular sieve(MMS)abstract:by ultrasonic method was investiga ted under different ultrasonic power and time.The resultant samples were charact erized through measurements of XRD,SEM,TEM,...Th e synthesis of mesoporous molecular sieve(MMS)abstract:by ultrasonic method was investiga ted under different ultrasonic power and time.The resultant samples were charact erized through measurements of XRD,SEM,TEM,IR,TG,and N 2 adsorption isotherm.Nanometer mesoporous silica analogous to the hexagonal M CM - 41could be obtained over a range of irradiation power above200W within short synthesis time(20min)abstract:and a quiescent time(5h)abstract:.The samples have larger BET surfa ce area and thicker pore wall while its pore size and pore volume are similar to that obtained without ultrasonic.The crystallinity of MMS increase and the size of unit cell reduce as the increasing of ultrasonic power and time.The yield of products increases with the increasing of ultrasonic power.Therefore,ultrasonic irradiation synthesis is a way to save time and energy in preparation of the me so - porous molecular sieve.展开更多
There is growing evidence that metabolic alterations play an important role in cancer development and progression.The metabolism of cancer cells is reprogrammed in order to support their rapid proliferation.Elevated f...There is growing evidence that metabolic alterations play an important role in cancer development and progression.The metabolism of cancer cells is reprogrammed in order to support their rapid proliferation.Elevated fatty acid synthesis is one of the most important aberrations of cancer cell metabolism.An enhancement of fatty acids synthesis is required both for carcinogenesis and cancer cell survival,as inhibition of key lipogenic enzymes slows down the growth of tumor cells and impairs their survival.Based on the data that serum fatty acid synthase(FASN),also known as oncoantigen 519,is elevated in patients with certain types of cancer,its serum level was proposed as a marker of neoplasia.This review aims to demonstrate the changes in lipid metabolism and other metabolic processes associated with lipid metabolism in pancreatic ductal adenocarcinoma(PDAC),the most common pancreatic neoplasm,characterized by high mortality.We also addressed the influence of some oncogenic factors and tumor suppressors on pancreatic cancer cell metabolism.Additionally the review discusses the potential role of elevated lipid synthesis in diagnosis and treatment of pancreatic cancer.In particular,FASN is a viable candidate for indicator of pathologic state,marker of neoplasia,as well as,pharmacological treatment target in pancreatic cancer.Recent research showed that,in addition to lipogenesis,certain cancer cells can use fatty acids from circulation,derived from diet(chylomicrons),synthesized in liver,or released from adipose tissue for their growth.Thus,the interactions between de novo lipogenesis and uptake of fatty acids from circulation by PDAC cells require further investigation.展开更多
文摘Addiction to synthetic cannabinoids(SCs) is a growing social and health problem worldwide. Chronic use of SCs may cause adverse effects in the gastrointestinal system. We describe a very rare case of acute gastric dilatation(AGD) and hepatic portal venous gas(HPVG),with findings of acute abdomen resulting from chronic use of a SC, Bonzai. AGD and HPVG were detected by computerized tomography examination. Patchy mucosal ischemia was seen in endoscopic examination. Despite the findings of an acute abdomen, a non-surgical approach with nasogastric decompression, antibiotic therapy, and close radiologic and endoscopic followup was preferred in the presented case. Clinical and radiologic findings decreased dramatically on the first day, and endoscopic findings gradually disappeared over 7 d. In conclusion, this case shows that chronic use of a SC may cause AGD and accompanying HPVG,which can be managed non-surgically despite the findings of acute abdomen.
文摘Th e synthesis of mesoporous molecular sieve(MMS)abstract:by ultrasonic method was investiga ted under different ultrasonic power and time.The resultant samples were charact erized through measurements of XRD,SEM,TEM,IR,TG,and N 2 adsorption isotherm.Nanometer mesoporous silica analogous to the hexagonal M CM - 41could be obtained over a range of irradiation power above200W within short synthesis time(20min)abstract:and a quiescent time(5h)abstract:.The samples have larger BET surfa ce area and thicker pore wall while its pore size and pore volume are similar to that obtained without ultrasonic.The crystallinity of MMS increase and the size of unit cell reduce as the increasing of ultrasonic power and time.The yield of products increases with the increasing of ultrasonic power.Therefore,ultrasonic irradiation synthesis is a way to save time and energy in preparation of the me so - porous molecular sieve.
基金Supported by Medical University of Gdansk Grants ST-41,ST-40
文摘There is growing evidence that metabolic alterations play an important role in cancer development and progression.The metabolism of cancer cells is reprogrammed in order to support their rapid proliferation.Elevated fatty acid synthesis is one of the most important aberrations of cancer cell metabolism.An enhancement of fatty acids synthesis is required both for carcinogenesis and cancer cell survival,as inhibition of key lipogenic enzymes slows down the growth of tumor cells and impairs their survival.Based on the data that serum fatty acid synthase(FASN),also known as oncoantigen 519,is elevated in patients with certain types of cancer,its serum level was proposed as a marker of neoplasia.This review aims to demonstrate the changes in lipid metabolism and other metabolic processes associated with lipid metabolism in pancreatic ductal adenocarcinoma(PDAC),the most common pancreatic neoplasm,characterized by high mortality.We also addressed the influence of some oncogenic factors and tumor suppressors on pancreatic cancer cell metabolism.Additionally the review discusses the potential role of elevated lipid synthesis in diagnosis and treatment of pancreatic cancer.In particular,FASN is a viable candidate for indicator of pathologic state,marker of neoplasia,as well as,pharmacological treatment target in pancreatic cancer.Recent research showed that,in addition to lipogenesis,certain cancer cells can use fatty acids from circulation,derived from diet(chylomicrons),synthesized in liver,or released from adipose tissue for their growth.Thus,the interactions between de novo lipogenesis and uptake of fatty acids from circulation by PDAC cells require further investigation.
