Malignant transformation of hamsterembryo cells was induced in vitro by rareearth iron mineral dusts(MP),naturalthorium(Th02) and MP plus Th02.Dusts of MP,MP plus Th02 or Th02 were added into themedium with the final ...Malignant transformation of hamsterembryo cells was induced in vitro by rareearth iron mineral dusts(MP),naturalthorium(Th02) and MP plus Th02.Dusts of MP,MP plus Th02 or Th02 were added into themedium with the final concentration of 17.0,展开更多
Cardiovascular disease is the leading cause of morbidity and mortality in both developed and developing countries,in which atherosclerosis triggered by dyslipidemia is the major pathological basis.Over the past 40 yea...Cardiovascular disease is the leading cause of morbidity and mortality in both developed and developing countries,in which atherosclerosis triggered by dyslipidemia is the major pathological basis.Over the past 40 years,small rodent animals,such as mice,have been widely used for understanding of human atherosclerosis-related cardiovascular disease(ASCVD)with the advantages of low cost and ease of maintenance and manipulation.However,based on the concept of precision medicine and high demand of translational research,the applications of mouse models for human ASCVD study would be limited due to the natural differences in metabolic features between mice and humans even though they are still the most powerful tools in this research field,indicating that other species with biological similarity to humans need to be considered for studying ASCVD in future.With the development and breakthrough of novel gene editing technology,Syrian golden hamster,a small rodent animal replicating the metabolic characteristics of humans,has been genetically modified,suggesting that gene-targeted hamster models will provide new insights into the precision medicine and translational research of ASCVD.The purpose of this review was to summarize the genetically-modified hamster models with dyslipidemia to date,and their potential applications and perspective for ASCVD.展开更多
文摘Malignant transformation of hamsterembryo cells was induced in vitro by rareearth iron mineral dusts(MP),naturalthorium(Th02) and MP plus Th02.Dusts of MP,MP plus Th02 or Th02 were added into themedium with the final concentration of 17.0,
基金supported by National Natural Science Foundation of China NSFC 31520103909 and 91739105 to G.L.,81770449 to Y.W.and 82070460 to X.X.Peking University BMU2020MX001 and BMU2020XY011 to X.X.G.L.
文摘Cardiovascular disease is the leading cause of morbidity and mortality in both developed and developing countries,in which atherosclerosis triggered by dyslipidemia is the major pathological basis.Over the past 40 years,small rodent animals,such as mice,have been widely used for understanding of human atherosclerosis-related cardiovascular disease(ASCVD)with the advantages of low cost and ease of maintenance and manipulation.However,based on the concept of precision medicine and high demand of translational research,the applications of mouse models for human ASCVD study would be limited due to the natural differences in metabolic features between mice and humans even though they are still the most powerful tools in this research field,indicating that other species with biological similarity to humans need to be considered for studying ASCVD in future.With the development and breakthrough of novel gene editing technology,Syrian golden hamster,a small rodent animal replicating the metabolic characteristics of humans,has been genetically modified,suggesting that gene-targeted hamster models will provide new insights into the precision medicine and translational research of ASCVD.The purpose of this review was to summarize the genetically-modified hamster models with dyslipidemia to date,and their potential applications and perspective for ASCVD.
