In this work,we report long-term trends in the abundance and breeding performance of Adélie penguins(Pygoscelis adeliae)nesting in three Antarctic colonies(i.e.,at Martin Point,South Orkneys Islands;Stranger Poin...In this work,we report long-term trends in the abundance and breeding performance of Adélie penguins(Pygoscelis adeliae)nesting in three Antarctic colonies(i.e.,at Martin Point,South Orkneys Islands;Stranger Point/Cabo Funes,South Shetland Islands;and Esperanza/Hope Bay in the Antarctic Peninsula)from 1995/96 to 2022/23.Using yearly count data of breeding groups selected,we observed a decline in the number of breeding pairs and chicks in crèche at all colonies studied.However,the magnitude of change was higher at Stranger Point than that in the remaining colonies.Moreover,the index of breeding success,which was calculated as the ratio of chicks in crèche to breeding pairs,exhibited no apparent trend throughout the study period.However,it displayed greater variability at Martin Point compared to the other two colonies under investigation.Although the number of chicks in crèche of Adélie penguins showed a declining pattern,the average breeding performance was similar to that reported in gentoo penguin colonies,specifically,those undergoing a population increase(even in sympatric colonies facing similar local conditions).Consequently,it is plausible to assume a reduction of the over-winter survival as a likely cause of the declining trend observed,at least in the Stranger Point and Esperanza colonies.However,we cannot rule out local effects during the breeding season affecting the Adélie population of Martin Point.展开更多
[Objectives]To monitor the stability of open-pit coal mine slopes in real time and ensure the safety of coal mine production.[Methods]The automatic monitoring system of coal mine slope was explored in depth,and the co...[Objectives]To monitor the stability of open-pit coal mine slopes in real time and ensure the safety of coal mine production.[Methods]The automatic monitoring system of coal mine slope was explored in depth,and the core functions of the system were designed comprehensively.According to the design function of the automatic monitoring system,the slope automatic monitoring system was constructed.Besides,in accordance with the actual situation of the slope,the monitoring frequency of slopes was set scientifically,and the key indicators such as rainfall,deep displacement and surface displacement of the slopes were monitored in an all-round and multi-angle way.[Results]During the monitoring period,the overall condition of the slope remained good,and no landslides or other geological disasters occurred.At the same time,the overall rainfall in the slope area remained low.In terms of monitoring data,the horizontal displacement and settlement of the slopes increased first and then tended to be stable.Specifically,the maximum horizontal displacement during the monitoring period was 22.74 mm,while the maximum settlement was 18.65 mm.[Conclusions]The automatic slope monitoring system has obtained remarkable achievements in practical application.It not only improves the accuracy and efficiency of slope stability monitoring,but also provides valuable reference experience for similar projects.展开更多
As an important rice disease, rice bacterial leaf blight (RBLB, caused by the bacterium Xanthomonas oryzae pv.oryzae), has become widespread in east China in recent years. Significant losses in rice yield occurred as ...As an important rice disease, rice bacterial leaf blight (RBLB, caused by the bacterium Xanthomonas oryzae pv.oryzae), has become widespread in east China in recent years. Significant losses in rice yield occurred as a result ofthe disease’s epidemic, making it imperative to monitor RBLB at a large scale. With the development of remotesensing technology, the broad-band sensors equipped with red-edge channels over multiple spatial resolutionsoffer numerous available data for large-scale monitoring of rice diseases. However, RBLB is characterized by rapiddispersal under suitable conditions, making it difficult to track the disease at a regional scale with a single sensorin practice. Therefore, it is necessary to identify or construct features that are effective across different sensors formonitoring RBLB. To achieve this goal, the spectral response of RBLB was first analyzed based on the canopyhyperspectral data. Using the relative spectral response (RSR) functions of four representative satellite or UAVsensors (i.e., Sentinel-2, GF-6, Planet, and Rededge-M) and the hyperspectral data, the corresponding broad-bandspectral data was simulated. According to a thorough band combination and sensitivity analysis, two novel spectralindices for monitoring RBLB that can be effective across multiple sensors (i.e., RBBRI and RBBDI) weredeveloped. An optimal feature set that includes the two novel indices and a classical vegetation index was formed.The capability of such a feature set in monitoring RBLB was assessed via FLDA and SVM algorithms. The resultdemonstrated that both constructed novel indices exhibited high sensitivity to the disease across multiple sensors.Meanwhile, the feature set yielded an overall accuracy above 90% for all sensors, which indicates its cross-sensorgenerality in monitoring RBLB. The outcome of this research permits disease monitoring with different remotesensing data over a large scale.展开更多
The integration of wearable technologies and artificial intelligence (AI) has revolutionized healthcare, enabling advanced personal health monitoring systems. This article explores the transformative impact of wearabl...The integration of wearable technologies and artificial intelligence (AI) has revolutionized healthcare, enabling advanced personal health monitoring systems. This article explores the transformative impact of wearable technologies and AI on healthcare, highlighting the development and theoretical application of the Integrated Personal Health Monitoring System (IPHMS). By integrating data from various wearable devices, such as smartphones, Apple Watches, and Oura Rings, the IPHMS framework aims to revolutionize personal health monitoring through real-time alerts, comprehensive tracking, and personalized insights. Despite its potential, the practical implementation faces challenges, including data privacy, system interoperability, and scalability. The evolution of healthcare technology from traditional methods to AI-enhanced wearables underscores a significant advancement towards personalized care, necessitating further research and innovation to address existing limitations and fully realize the benefits of such integrated health monitoring systems.展开更多
Smart energy monitoring and management system lays a foundation for the application and development of smart energy. However, in recent years, the work efficiency of smart energy development enterprises has generally ...Smart energy monitoring and management system lays a foundation for the application and development of smart energy. However, in recent years, the work efficiency of smart energy development enterprises has generally been low, and there is an urgent need to improve the application efficiency, resilience and sustainability of smart energy monitoring and management system. Digital twin technology provides a data-centric solution to improve smart energy monitoring and management system, bringing an opportunity to transform passive infrastructure assets into data-centric systems. This paper expounds on the concept and key technologies of digital twin, and designs a smart energy monitoring and management system based on digital twin technology, which has dual significance for promoting the development of smart energy field and promoting the application of digital twin.展开更多
This article proposes a comprehensive monitoring system for tunnel operation to address the risks associated with tunnel operations.These risks include safety control risks,increased traffic flow,extreme weather event...This article proposes a comprehensive monitoring system for tunnel operation to address the risks associated with tunnel operations.These risks include safety control risks,increased traffic flow,extreme weather events,and movement of tectonic plates.The proposed system is based on the Internet of Things and artificial intelligence identification technology.The monitoring system will cover various aspects of tunnel operations,such as the slope of the entrance,the structural safety of the cave body,toxic and harmful gases that may appear during operation,excessively high and low-temperature humidity,poor illumination,water leakage or road water accumulation caused by extreme weather,combustion and smoke caused by fires,and more.The system will enable comprehensive monitoring and early warning of fire protection systems,accident vehicles,and overheating vehicles.This will effectively improve safety during tunnel operation.展开更多
An automatic monitoring method of the 3-D deformation is presented for crustal fault based on laser and machine vision.The laser source and screen are independently set up in the headwall and footwall,the collimated l...An automatic monitoring method of the 3-D deformation is presented for crustal fault based on laser and machine vision.The laser source and screen are independently set up in the headwall and footwall,the collimated laser beam creates a circular spot on the screen,meanwhile,the industrial camera captures the tiny deformation of the crustal fault by monitoring the change of the spot position.This method significantly reduces the cost of equipment and labor,provides daily sampling to ensure high continuity of data.A prototype of the automatic monitoring system is developed,and a repeatability test indicates that the error of spot jtter can be minimized by consecutive samples.Meanwhile,the environmental correction model is determined to ensure that environmental changes do not disturb the system.Furthermore,the automatic monitoring system has been applied at the deformation monitoring station(KJX02)of China Beishan underground research laboratory,where continuous deformation monitoring is underway.展开更多
To ensure the safety of residents’lives and property by using automatic opening and closing of ordinary windows,this article designs an intelligent window automatic monitoring system.The article proposes a software a...To ensure the safety of residents’lives and property by using automatic opening and closing of ordinary windows,this article designs an intelligent window automatic monitoring system.The article proposes a software and hardware design scheme for the system,which comprises a microcontroller control module,temperature and humidity detection module,harmful gas detection module,rainfall detection module,human thermal radiation induction module,Organic Light-Emitting Diode(OLED)display module,stepper motor drive module,Wi-Fi communication module,etc.Users use this system to monitor environmental data such as temperature,humidity,rainfall,harmful gas concentrations,and human health.Users can control the opening and closing of windows through manual,microcontroller,and mobile application(app)remote methods,providing users with a more convenient,comfortable,and safe living environment.展开更多
Volatile organic compounds(VOC)gas detection devices based on semiconductor sensors have become a common method due to their low cost,simple principle,and small size.However,with the continuous development of material...Volatile organic compounds(VOC)gas detection devices based on semiconductor sensors have become a common method due to their low cost,simple principle,and small size.However,with the continuous development of materials science,various new materials have been applied in the fabrication of gas sensors,but these new materials have more stringent requirements for operating temperature,which cannot be met by existing sensor modules on the market.Therefore,this paper proposes a temperature-adjustable sensor module and designs an environmental monitoring system based on the STM32F103RET6 microprocessor.This system primarily utilizes multiple semiconductor gas sensors to monitor and record the concentrations of various harmful gases in different environments.It can also monitor real-time temperature,humidity,and latitude and longitude in the current environment,and upload the data to the Internet of Things via 4G communication.This system has the advantages of small size,portability,and low cost.Experimental results show that the sensor module can achieve precise control of operating temperature to a certain extent,with an average temperature error of approximately 3%.The monitoring system demonstrates a certain level of accuracy in detecting target gases and can promptly upload the data to a cloud platform for storage and processing.A comparison with professional testing equipment shows that the sensitivity curves of each sensor exhibit similarity.This study provides engineering and technical references for the application of VOC gas sensors.展开更多
Blood loss in peacetime is mainly due to the normal menstrual cycle in women or diseases with surgical intervention. In wartime, blood loss in military personnel is a characteristic sign of a closed or open injury of ...Blood loss in peacetime is mainly due to the normal menstrual cycle in women or diseases with surgical intervention. In wartime, blood loss in military personnel is a characteristic sign of a closed or open injury of the body during internal or external bleeding. Access to clinical care for wounded military personnel injured on the battlefield is limited and has long delays compared to patients in peacetime. Most of the deaths of wounded military personnel on the battlefield occur within the first hour after being wounded. The most common causes are delay in providing medical care, loss of time for diagnosis, delay in stabilization of pain shock and large blood loss. Some help in overcoming these problems is provided by the data in the individual capsule, which each soldier of the modern army possesses;however, data in an individual capsule is not sufficient to provide emergency medical care in field and hospital conditions. This paper considers a project for development of a smart real-time monitoring wearable system for blood loss and level of shock stress in wounded persons on the battlefield, which provides medical staff in field and hospital conditions with the necessary information to give timely medical care. Although the hospital will require additional information, the basic information about the victims will already be known before he enters the hospital. It is important to emphasize that the key term in this approach is monitoring. It is tracking, and not a one-time measurement of indicators, that is crucial in a valid definition of bleeding.展开更多
Indonesia is a producer in the fisheries sector,with production reaching 14.8 million tons in 2022.The production potential of the fisheries sector can be optimally optimized through aquaculture management.One of the ...Indonesia is a producer in the fisheries sector,with production reaching 14.8 million tons in 2022.The production potential of the fisheries sector can be optimally optimized through aquaculture management.One of the most important issues in aquaculture management is how to efficiently control the fish pond water conditions.IoT technology can be applied to support a fish pond aquaculture monitoring system,especially for catfish species(Siluriformes),in real-time and remotely.One of the technologies that can provide this convenience is the IoT.The problem of this study is how to integrate IoT devices with Firebase’s cloud data system to provide reliable and precise data,which makes it easy for fish cultivators to monitor fishpond conditions in real time and remotely.The IoT aquaculture fishpond monitoring use 3 parameters:(1)water temperature;(2)pHwater level;and(3)turbidity level of pond water.IoT devices use temperature sensors,pH sensors,and turbidity sensors,which are integrated with a microcontroller and Wi-Fi module.Data from sensor readings are sent to the Firebase cloud via theWi-Fi module so that it can be accessed in real time by end users with an Androidbased mobile app.The findings are(1)the IoT-based aquaculture monitoring system device has a low error rate in measuring temprature,pH,and turbidity with a percentage of 1.75%,1.94% and 9.78%,respectively.Overall,the total average error of the three components is 4.49%;(2)in cost analysis,IoT-based has a cost-effectiveness of 94.21% compared to labor costs.An IoT-based aquaculture monitoring system using Firebase can be effectively used as a technology for monitoring fish pond conditions in real-time and remotely for fish cultivators that contribute to providing an IoT-based aquaculture monitoring system that produces valid data,is precise,is easy to implement,and is a low-cost system.展开更多
The real-time dynamic deformation monitoring of offshore platforms under environmental excitation is crucial to their safe operation.Although Global Navigation Satellite System-Precise Point Positioning(GNSS-PPP)has b...The real-time dynamic deformation monitoring of offshore platforms under environmental excitation is crucial to their safe operation.Although Global Navigation Satellite System-Precise Point Positioning(GNSS-PPP)has been considered for this purpose,its monitoring accuracy is relatively low.Moreover,the influence of background noise on the dynamic monitoring accuracy of GNSS-PPP remains unclear.Hence,it is imperative to further validate the feasibility of GNSS-PPP for deformation monitoring of offshore platforms.To address these concerns,vibration table tests with different amplitudes and frequencies are conducted.The results demonstrate that GNSS-PPP can effectively monitor horizontal vibration displacement as low as±30 mm,which is consistent with GNSS-RTK.Furthermore,the spectral characteristic of background noise in GNSS-PPP is similar to that of GNSS-RTK(Real Time Kinematic).Building on this observation,an improved Complete Ensemble Empirical Mode Decomposition with Adaptive Noise(CEEMDAN)has been proposed to de-noise the data and enhance the dynamic monitoring accuracy of GNSS-PPP.Field monitoring application research is also undertaken,successfully extracting and analyzing the dynamic deformation of an offshore platform structure under environmental excitation using GNSS-PPP monitoring in conjunction with improved CEEMDAN de-noising.By comparing the de-noised dynamic deformation trajectories of the offshore platform during different periods,it is observed that the platform exhibits reversible alternating vibration responses under environmental excitation,with more pronounced displacement deformation in the direction of load action.The research results confirm the feasibility and potential of GNSS-PPP for dynamic deformation monitoring of offshore platforms.展开更多
Central nervous system injuries have a high rate of resulting in disability and mortality;however,at present,effective treatments are lacking.Programmed cell death,which is a genetically determined fo rm of active and...Central nervous system injuries have a high rate of resulting in disability and mortality;however,at present,effective treatments are lacking.Programmed cell death,which is a genetically determined fo rm of active and ordered cell death with many types,has recently attra cted increasing attention due to its functions in determining the fate of cell survival.A growing number of studies have suggested that programmed cell death is involved in central nervous system injuries and plays an important role in the progression of brain damage.In this review,we provide an ove rview of the role of programmed cell death in central nervous system injuries,including the pathways involved in mitophagy,pyroptosis,ferroptosis,and necroptosis,and the underlying mechanisms by which mitophagy regulates pyroptosis,ferroptosis,and necro ptosis.We also discuss the new direction of therapeutic strategies to rgeting mitophagy for the treatment of central nervous system injuries,with the aim to determine the connection between programmed cell death and central nervous system injuries and to identify new therapies to modulate programmed cell death following central nervous system injury.In conclusion,based on these properties and effects,interventions targeting programmed cell death could be developed as potential therapeutic agents for central nervous system injury patients.展开更多
With the advantages of lightweight and high resource utilization,cloud-native technology with containers as the core is gradually becoming themainstreamtechnical architecture for information infrastructure.However,mal...With the advantages of lightweight and high resource utilization,cloud-native technology with containers as the core is gradually becoming themainstreamtechnical architecture for information infrastructure.However,malware attacks such as Doki and Symbiote threaten the container runtime’s security.Malware initiates various types of runtime anomalies based on process form(e.g.,modifying the process of a container,and opening the external ports).Fortunately,dynamic monitoring mechanisms have proven to be a feasible solution for verifying the trusted state of containers at runtime.Nevertheless,the current routine dynamic monitoring mechanisms for baseline data protection are still based on strong security assumptions.As a result,the existing dynamicmonitoringmechanismis still not practical enough.To ensure the trustworthiness of the baseline value data and,simultaneously,to achieve the integrity verification of the monitored process,we combine blockchain and trusted computing to propose a process integrity monitoring system named IPMS.Firstly,the hardware TPM 2.0 module is applied to construct a trusted security foundation for the integrity of the process code segment due to its tamper-proof feature.Then,design a new format for storing measurement logs,easily distinguishing files with the same name in different containers from log information.Meanwhile,the baseline value data is stored on the blockchain to avoidmalicious damage.Finally,trusted computing technology is used to perform fine-grained integrity measurement and remote attestation of processes in a container,detect abnormal containers in time and control them.We have implemented a prototype system and performed extensive simulation experiments to test and analyze the functionality and performance of the PIMS.Experimental results show that PIMS can accurately and efficiently detect tampered processes with only 3.57% performance loss to the container.展开更多
Increasing renewable energy targets globally has raised the requirement for the efficient and profitable operation of solar photovoltaic(PV)systems.In light of this requirement,this paper provides a path for evaluatin...Increasing renewable energy targets globally has raised the requirement for the efficient and profitable operation of solar photovoltaic(PV)systems.In light of this requirement,this paper provides a path for evaluating the operating condition and improving the power output of the PV system in a grid integrated environment.To achieve this,different types of faults in grid-connected PV systems(GCPVs)and their impact on the energy loss associated with the electrical network are analyzed.A data-driven approach using neural networks(NNs)is proposed to achieve root cause analysis and localize the fault to the component level in the system.The localized fault condition is combined with a parallel operation of adaptive neurofuzzy inference units(ANFIUs)to develop a power mismatch-based control unit(PMCU)for improving the power output of the GCPV.To develop the proposed framework,a 10-kW single-phase GCPV is simulated for training the NN-based anomaly detection approach with 14 deviation signals.Further,the developed algorithm is combined with the PMCU implemented with the experimental setup of GCPV.The results identified 98.2%training accuracy and 43000 observations/sec prediction speed for the trained classifier,and improved power output with reduced voltage and current harmonics for the grid-connected PV operation.展开更多
This research presents the remote sensing data on hotspots in four national parks located in Chiang Mai province, Thailand: Sri Lanna National Park, Huai Nam Dang National Park, Doi Pahom Pok National Park, and Doi In...This research presents the remote sensing data on hotspots in four national parks located in Chiang Mai province, Thailand: Sri Lanna National Park, Huai Nam Dang National Park, Doi Pahom Pok National Park, and Doi Inthanon National Park. To mitigate the devastating impacts of these wildfires, effective monitoring and management strategies are necessary. Remote sensing technology provides a promising approach for mapping burnt areas and understanding fire regimes at a regional scale. The primary focus of this research is to employ the MODIS Aqua/Terra satellite system for obtaining historical remote sensing data on hotspots. The advantages of remote sensing include accurate identification and mapping of burnt areas, regular monitoring, rapid data acquisition, and historical data analysis. The MODIS sensor, specifically designed for fire monitoring, offers enhanced fire detection and diagnosis, multiple channels for qualitative and quantitative analysis, and precision positioning capabilities. The research results presented in the analysis contribute to the understanding of fire incidents and hotspot occurrences within the four national parks studied. This paper suggests the optimization of early detection of forest and land fires through the utilization of Artificial Intelligence (AI), presenting it as a recommendation for future endeavors. The research emphasizes the significance of implementing efficient policies and management strategies to effectively tackle the challenges associated with fires in these ecologically significant areas.展开更多
Natural disaster risk monitoring is an important task for disaster prevention and reduction.In the case of immovable cultural relics,however,the feedback mechanism,risk factors,monitoring logic,and monitoring indicato...Natural disaster risk monitoring is an important task for disaster prevention and reduction.In the case of immovable cultural relics,however,the feedback mechanism,risk factors,monitoring logic,and monitoring indicators of natural disaster risk monitoring are complex.How to achieve intelligent perception and monitoring of natural disaster risk for immovable cultural relics has always been a focus and a challenge for researchers.Based on the analysis of the concepts and issues related to the natural disaster risk of immovable cultural relics,this paper proposes a framework for natural disaster risk monitoring for immovable cultural relics based on the digital twin.This framework focuses on risk monitoring,including the physical entities of natural disaster risk for immovable cultural relics,monitoring indicators,and virtual entity construction.A platform for monitoring the natural disaster risk of immovable cultural relics is proposed.Using the Puzhou Ancient City Site as a test bed,the proposed concept can be used for monitoring the natural disaster risk of immovable cultural relics at different scales.展开更多
Many Internet of Things(IoT)systems are based on the intercommunication among different devices and centralized systems.Nowadays,there are several commercial and research platforms available to simplify the creation o...Many Internet of Things(IoT)systems are based on the intercommunication among different devices and centralized systems.Nowadays,there are several commercial and research platforms available to simplify the creation of such IoT systems.However,developing these systems can often be a tedious task.To address this challenge,a proposed solution involves the implementation of a unified program or script that encompasses the entire system,including IoT devices functionality.This approach is based on an abstraction,integrating the control of the devices in a single program through a programmable object.Subsequently,the proposal processes the unified script to generate the centralized system code and a controller for each device.By adopting this approach,developers will be able to create IoT systems with significantly reduced implementation costs,surpassing current platforms by more than 10%.The results demonstrate that the single program approach can significantly accelerate the development of IoT systems relying on device communication.展开更多
Learning Management System(LMS)is an application software that is used in automation,delivery,administration,tracking,and reporting of courses and programs in educational sector.The LMS which exploits machine learning...Learning Management System(LMS)is an application software that is used in automation,delivery,administration,tracking,and reporting of courses and programs in educational sector.The LMS which exploits machine learning(ML)has the ability of accessing user data and exploit it for improving the learning experience.The recently developed artificial intelligence(AI)and ML models helps to accomplish effective performance monitoring for LMS.Among the different processes involved in ML based LMS,feature selection and classification processesfind beneficial.In this motivation,this study introduces Glowworm-based Feature Selection with Machine Learning Enabled Performance Monitoring(GSO-MFWELM)technique for LMS.The key objective of the proposed GSO-MFWELM technique is to effectually monitor the performance in LMS.The pro-posed GSO-MFWELM technique involves GSO-based feature selection techni-que to select the optimal features.Besides,Weighted Extreme Learning Machine(WELM)model is applied for classification process whereas the parameters involved in WELM model are optimallyfine-tuned with the help of May-fly Optimization(MFO)algorithm.The design of GSO and MFO techniques result in reduced computation complexity and improved classification performance.The presented GSO-MFWELM technique was validated for its performance against benchmark dataset and the results were inspected under several aspects.The simulation results established the supremacy of GSO-MFWELM technique over recent approaches with the maximum classification accuracy of 0.9589.展开更多
BACKGROUND Commonly used glucocorticoids replacement regimens in patients with hypopituitarism have difficulty mimicking physiological cortisol rhythms and are usually accompanied by risks of over-treatment,with adver...BACKGROUND Commonly used glucocorticoids replacement regimens in patients with hypopituitarism have difficulty mimicking physiological cortisol rhythms and are usually accompanied by risks of over-treatment,with adverse effects on glucose metabolism.Disorders associated with glucose metabolism are established risk factors of cardiovascular events,one of the life-threatening ramifications.AIM To investigate the glycometabolism profile in patients with hypopituitarism receiving prednisone(Pred)replacement,and to clarify the impacts of different Pred doses on glycometabolism and consequent adverse cardiovascular outcomes.METHODS Twenty patients with hypopituitarism receiving Pred replacement[patient group(PG)]and 20 normal controls(NCs)were recruited.A flash glucose monitoring system was used to record continuous glucose levels during the day,which provided information on glucose-target-rate,glucose variability(GV),period glucose level,and hypoglycemia occurrence at certain periods.Islet β-cell function was also assessed.Based on the administered Pred dose per day,the PG was then regrouped into Pred>5 mg/d and Pred≤5 mg/d subgroups.Comparative analysis was carried out between the PG and NCs.RESULTS Significantly altered glucose metabolism profiles were identified in the PG.This includes significant reductions in glucose-target-rate and nocturnal glucose level,along with elevations in GV,hypoglycemia occurrence and postprandial glucose level,when compared with those in NCs.Subgroup analysis indicated more significant glucose metabolism impairment in the Pred>5 mg/d group,including significantly decreased glucose-target-rate and nocturnal glucose level,along with increased GV,hypoglycemia occurrence,and postprandial glucose level.With regard to islet β-cell function,PG showed significant difference in homeostasis model assessment(HOMA)-β compared with that of NCs;a notable difference in HOMA-βwas identified in Pred>5 mg/d group when compared with those of NCs;as for Pred≤5 mg/d group,significant differences were found in HOMA-β,and fasting glucose/insulin ratio when compared with NCs.CONCLUSION Our results demonstrated that Pred replacement disrupted glycometabolic homeostasis in patients with hypopituitarism.A Pred dose of>5 mg/d seemed to cause more adverse effects on glycometabolism than a dose of≤5 mg/d.Comprehensive and accurate evaluation is necessary to consider a suitable Pred replacement regimen,wherein,flash glucose monitoring system is a kind of promising and reliable assessment device.The present data allows us to thoroughly examine our modern treatment standards,especially in difficult cases such as hormonal replacement mimicking delicate natural cycles,in conditions such as diabetes mellitus that are rapidly growing in worldwide prevalence.展开更多
基金Nacional de Promoción Científica y Tecnológica(Grant:PICTO 2010-0111)the Instituto Antártico Argentino-Dirección Nacional del Antártico(PINST-05)provided financial and logistical support.
文摘In this work,we report long-term trends in the abundance and breeding performance of Adélie penguins(Pygoscelis adeliae)nesting in three Antarctic colonies(i.e.,at Martin Point,South Orkneys Islands;Stranger Point/Cabo Funes,South Shetland Islands;and Esperanza/Hope Bay in the Antarctic Peninsula)from 1995/96 to 2022/23.Using yearly count data of breeding groups selected,we observed a decline in the number of breeding pairs and chicks in crèche at all colonies studied.However,the magnitude of change was higher at Stranger Point than that in the remaining colonies.Moreover,the index of breeding success,which was calculated as the ratio of chicks in crèche to breeding pairs,exhibited no apparent trend throughout the study period.However,it displayed greater variability at Martin Point compared to the other two colonies under investigation.Although the number of chicks in crèche of Adélie penguins showed a declining pattern,the average breeding performance was similar to that reported in gentoo penguin colonies,specifically,those undergoing a population increase(even in sympatric colonies facing similar local conditions).Consequently,it is plausible to assume a reduction of the over-winter survival as a likely cause of the declining trend observed,at least in the Stranger Point and Esperanza colonies.However,we cannot rule out local effects during the breeding season affecting the Adélie population of Martin Point.
文摘[Objectives]To monitor the stability of open-pit coal mine slopes in real time and ensure the safety of coal mine production.[Methods]The automatic monitoring system of coal mine slope was explored in depth,and the core functions of the system were designed comprehensively.According to the design function of the automatic monitoring system,the slope automatic monitoring system was constructed.Besides,in accordance with the actual situation of the slope,the monitoring frequency of slopes was set scientifically,and the key indicators such as rainfall,deep displacement and surface displacement of the slopes were monitored in an all-round and multi-angle way.[Results]During the monitoring period,the overall condition of the slope remained good,and no landslides or other geological disasters occurred.At the same time,the overall rainfall in the slope area remained low.In terms of monitoring data,the horizontal displacement and settlement of the slopes increased first and then tended to be stable.Specifically,the maximum horizontal displacement during the monitoring period was 22.74 mm,while the maximum settlement was 18.65 mm.[Conclusions]The automatic slope monitoring system has obtained remarkable achievements in practical application.It not only improves the accuracy and efficiency of slope stability monitoring,but also provides valuable reference experience for similar projects.
基金the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA28010500)National Natural Science Foundation of China(Grant Nos.42371385,42071420)Zhejiang Provincial Natural Science Foundation of China(Grant No.LTGN23D010002).
文摘As an important rice disease, rice bacterial leaf blight (RBLB, caused by the bacterium Xanthomonas oryzae pv.oryzae), has become widespread in east China in recent years. Significant losses in rice yield occurred as a result ofthe disease’s epidemic, making it imperative to monitor RBLB at a large scale. With the development of remotesensing technology, the broad-band sensors equipped with red-edge channels over multiple spatial resolutionsoffer numerous available data for large-scale monitoring of rice diseases. However, RBLB is characterized by rapiddispersal under suitable conditions, making it difficult to track the disease at a regional scale with a single sensorin practice. Therefore, it is necessary to identify or construct features that are effective across different sensors formonitoring RBLB. To achieve this goal, the spectral response of RBLB was first analyzed based on the canopyhyperspectral data. Using the relative spectral response (RSR) functions of four representative satellite or UAVsensors (i.e., Sentinel-2, GF-6, Planet, and Rededge-M) and the hyperspectral data, the corresponding broad-bandspectral data was simulated. According to a thorough band combination and sensitivity analysis, two novel spectralindices for monitoring RBLB that can be effective across multiple sensors (i.e., RBBRI and RBBDI) weredeveloped. An optimal feature set that includes the two novel indices and a classical vegetation index was formed.The capability of such a feature set in monitoring RBLB was assessed via FLDA and SVM algorithms. The resultdemonstrated that both constructed novel indices exhibited high sensitivity to the disease across multiple sensors.Meanwhile, the feature set yielded an overall accuracy above 90% for all sensors, which indicates its cross-sensorgenerality in monitoring RBLB. The outcome of this research permits disease monitoring with different remotesensing data over a large scale.
文摘The integration of wearable technologies and artificial intelligence (AI) has revolutionized healthcare, enabling advanced personal health monitoring systems. This article explores the transformative impact of wearable technologies and AI on healthcare, highlighting the development and theoretical application of the Integrated Personal Health Monitoring System (IPHMS). By integrating data from various wearable devices, such as smartphones, Apple Watches, and Oura Rings, the IPHMS framework aims to revolutionize personal health monitoring through real-time alerts, comprehensive tracking, and personalized insights. Despite its potential, the practical implementation faces challenges, including data privacy, system interoperability, and scalability. The evolution of healthcare technology from traditional methods to AI-enhanced wearables underscores a significant advancement towards personalized care, necessitating further research and innovation to address existing limitations and fully realize the benefits of such integrated health monitoring systems.
文摘Smart energy monitoring and management system lays a foundation for the application and development of smart energy. However, in recent years, the work efficiency of smart energy development enterprises has generally been low, and there is an urgent need to improve the application efficiency, resilience and sustainability of smart energy monitoring and management system. Digital twin technology provides a data-centric solution to improve smart energy monitoring and management system, bringing an opportunity to transform passive infrastructure assets into data-centric systems. This paper expounds on the concept and key technologies of digital twin, and designs a smart energy monitoring and management system based on digital twin technology, which has dual significance for promoting the development of smart energy field and promoting the application of digital twin.
文摘This article proposes a comprehensive monitoring system for tunnel operation to address the risks associated with tunnel operations.These risks include safety control risks,increased traffic flow,extreme weather events,and movement of tectonic plates.The proposed system is based on the Internet of Things and artificial intelligence identification technology.The monitoring system will cover various aspects of tunnel operations,such as the slope of the entrance,the structural safety of the cave body,toxic and harmful gases that may appear during operation,excessively high and low-temperature humidity,poor illumination,water leakage or road water accumulation caused by extreme weather,combustion and smoke caused by fires,and more.The system will enable comprehensive monitoring and early warning of fire protection systems,accident vehicles,and overheating vehicles.This will effectively improve safety during tunnel operation.
基金supported by Earthquake Sciences Spark Programs of China Earthquake Administration(No.XH22020YA)Science Innovation Fund granted by the First Monitoring and Application Center of China Earthquake Administration(No.FMC202309).
文摘An automatic monitoring method of the 3-D deformation is presented for crustal fault based on laser and machine vision.The laser source and screen are independently set up in the headwall and footwall,the collimated laser beam creates a circular spot on the screen,meanwhile,the industrial camera captures the tiny deformation of the crustal fault by monitoring the change of the spot position.This method significantly reduces the cost of equipment and labor,provides daily sampling to ensure high continuity of data.A prototype of the automatic monitoring system is developed,and a repeatability test indicates that the error of spot jtter can be minimized by consecutive samples.Meanwhile,the environmental correction model is determined to ensure that environmental changes do not disturb the system.Furthermore,the automatic monitoring system has been applied at the deformation monitoring station(KJX02)of China Beishan underground research laboratory,where continuous deformation monitoring is underway.
文摘To ensure the safety of residents’lives and property by using automatic opening and closing of ordinary windows,this article designs an intelligent window automatic monitoring system.The article proposes a software and hardware design scheme for the system,which comprises a microcontroller control module,temperature and humidity detection module,harmful gas detection module,rainfall detection module,human thermal radiation induction module,Organic Light-Emitting Diode(OLED)display module,stepper motor drive module,Wi-Fi communication module,etc.Users use this system to monitor environmental data such as temperature,humidity,rainfall,harmful gas concentrations,and human health.Users can control the opening and closing of windows through manual,microcontroller,and mobile application(app)remote methods,providing users with a more convenient,comfortable,and safe living environment.
文摘Volatile organic compounds(VOC)gas detection devices based on semiconductor sensors have become a common method due to their low cost,simple principle,and small size.However,with the continuous development of materials science,various new materials have been applied in the fabrication of gas sensors,but these new materials have more stringent requirements for operating temperature,which cannot be met by existing sensor modules on the market.Therefore,this paper proposes a temperature-adjustable sensor module and designs an environmental monitoring system based on the STM32F103RET6 microprocessor.This system primarily utilizes multiple semiconductor gas sensors to monitor and record the concentrations of various harmful gases in different environments.It can also monitor real-time temperature,humidity,and latitude and longitude in the current environment,and upload the data to the Internet of Things via 4G communication.This system has the advantages of small size,portability,and low cost.Experimental results show that the sensor module can achieve precise control of operating temperature to a certain extent,with an average temperature error of approximately 3%.The monitoring system demonstrates a certain level of accuracy in detecting target gases and can promptly upload the data to a cloud platform for storage and processing.A comparison with professional testing equipment shows that the sensitivity curves of each sensor exhibit similarity.This study provides engineering and technical references for the application of VOC gas sensors.
文摘Blood loss in peacetime is mainly due to the normal menstrual cycle in women or diseases with surgical intervention. In wartime, blood loss in military personnel is a characteristic sign of a closed or open injury of the body during internal or external bleeding. Access to clinical care for wounded military personnel injured on the battlefield is limited and has long delays compared to patients in peacetime. Most of the deaths of wounded military personnel on the battlefield occur within the first hour after being wounded. The most common causes are delay in providing medical care, loss of time for diagnosis, delay in stabilization of pain shock and large blood loss. Some help in overcoming these problems is provided by the data in the individual capsule, which each soldier of the modern army possesses;however, data in an individual capsule is not sufficient to provide emergency medical care in field and hospital conditions. This paper considers a project for development of a smart real-time monitoring wearable system for blood loss and level of shock stress in wounded persons on the battlefield, which provides medical staff in field and hospital conditions with the necessary information to give timely medical care. Although the hospital will require additional information, the basic information about the victims will already be known before he enters the hospital. It is important to emphasize that the key term in this approach is monitoring. It is tracking, and not a one-time measurement of indicators, that is crucial in a valid definition of bleeding.
基金supported by the Department of Electrical Engineering at the National Chin-Yi University of Technology.
文摘Indonesia is a producer in the fisheries sector,with production reaching 14.8 million tons in 2022.The production potential of the fisheries sector can be optimally optimized through aquaculture management.One of the most important issues in aquaculture management is how to efficiently control the fish pond water conditions.IoT technology can be applied to support a fish pond aquaculture monitoring system,especially for catfish species(Siluriformes),in real-time and remotely.One of the technologies that can provide this convenience is the IoT.The problem of this study is how to integrate IoT devices with Firebase’s cloud data system to provide reliable and precise data,which makes it easy for fish cultivators to monitor fishpond conditions in real time and remotely.The IoT aquaculture fishpond monitoring use 3 parameters:(1)water temperature;(2)pHwater level;and(3)turbidity level of pond water.IoT devices use temperature sensors,pH sensors,and turbidity sensors,which are integrated with a microcontroller and Wi-Fi module.Data from sensor readings are sent to the Firebase cloud via theWi-Fi module so that it can be accessed in real time by end users with an Androidbased mobile app.The findings are(1)the IoT-based aquaculture monitoring system device has a low error rate in measuring temprature,pH,and turbidity with a percentage of 1.75%,1.94% and 9.78%,respectively.Overall,the total average error of the three components is 4.49%;(2)in cost analysis,IoT-based has a cost-effectiveness of 94.21% compared to labor costs.An IoT-based aquaculture monitoring system using Firebase can be effectively used as a technology for monitoring fish pond conditions in real-time and remotely for fish cultivators that contribute to providing an IoT-based aquaculture monitoring system that produces valid data,is precise,is easy to implement,and is a low-cost system.
基金financially supported by the National Key R&D Program of China(Grant No.2022YFB4200705)the National Natural Science Foundation of China(Grant No.52109146)。
文摘The real-time dynamic deformation monitoring of offshore platforms under environmental excitation is crucial to their safe operation.Although Global Navigation Satellite System-Precise Point Positioning(GNSS-PPP)has been considered for this purpose,its monitoring accuracy is relatively low.Moreover,the influence of background noise on the dynamic monitoring accuracy of GNSS-PPP remains unclear.Hence,it is imperative to further validate the feasibility of GNSS-PPP for deformation monitoring of offshore platforms.To address these concerns,vibration table tests with different amplitudes and frequencies are conducted.The results demonstrate that GNSS-PPP can effectively monitor horizontal vibration displacement as low as±30 mm,which is consistent with GNSS-RTK.Furthermore,the spectral characteristic of background noise in GNSS-PPP is similar to that of GNSS-RTK(Real Time Kinematic).Building on this observation,an improved Complete Ensemble Empirical Mode Decomposition with Adaptive Noise(CEEMDAN)has been proposed to de-noise the data and enhance the dynamic monitoring accuracy of GNSS-PPP.Field monitoring application research is also undertaken,successfully extracting and analyzing the dynamic deformation of an offshore platform structure under environmental excitation using GNSS-PPP monitoring in conjunction with improved CEEMDAN de-noising.By comparing the de-noised dynamic deformation trajectories of the offshore platform during different periods,it is observed that the platform exhibits reversible alternating vibration responses under environmental excitation,with more pronounced displacement deformation in the direction of load action.The research results confirm the feasibility and potential of GNSS-PPP for dynamic deformation monitoring of offshore platforms.
基金supported by the National Natural Science Foundation of China,No.82101461(to ZL)。
文摘Central nervous system injuries have a high rate of resulting in disability and mortality;however,at present,effective treatments are lacking.Programmed cell death,which is a genetically determined fo rm of active and ordered cell death with many types,has recently attra cted increasing attention due to its functions in determining the fate of cell survival.A growing number of studies have suggested that programmed cell death is involved in central nervous system injuries and plays an important role in the progression of brain damage.In this review,we provide an ove rview of the role of programmed cell death in central nervous system injuries,including the pathways involved in mitophagy,pyroptosis,ferroptosis,and necroptosis,and the underlying mechanisms by which mitophagy regulates pyroptosis,ferroptosis,and necro ptosis.We also discuss the new direction of therapeutic strategies to rgeting mitophagy for the treatment of central nervous system injuries,with the aim to determine the connection between programmed cell death and central nervous system injuries and to identify new therapies to modulate programmed cell death following central nervous system injury.In conclusion,based on these properties and effects,interventions targeting programmed cell death could be developed as potential therapeutic agents for central nervous system injury patients.
基金supported by China’s National Natural Science Foundation (U19A2081,61802270,61802271)Ministry of Education and China Mobile Research Fund Project (MCM20200102,CM20200409)Sichuan University Engineering Characteristic Team Project 2020SCUNG129.
文摘With the advantages of lightweight and high resource utilization,cloud-native technology with containers as the core is gradually becoming themainstreamtechnical architecture for information infrastructure.However,malware attacks such as Doki and Symbiote threaten the container runtime’s security.Malware initiates various types of runtime anomalies based on process form(e.g.,modifying the process of a container,and opening the external ports).Fortunately,dynamic monitoring mechanisms have proven to be a feasible solution for verifying the trusted state of containers at runtime.Nevertheless,the current routine dynamic monitoring mechanisms for baseline data protection are still based on strong security assumptions.As a result,the existing dynamicmonitoringmechanismis still not practical enough.To ensure the trustworthiness of the baseline value data and,simultaneously,to achieve the integrity verification of the monitored process,we combine blockchain and trusted computing to propose a process integrity monitoring system named IPMS.Firstly,the hardware TPM 2.0 module is applied to construct a trusted security foundation for the integrity of the process code segment due to its tamper-proof feature.Then,design a new format for storing measurement logs,easily distinguishing files with the same name in different containers from log information.Meanwhile,the baseline value data is stored on the blockchain to avoidmalicious damage.Finally,trusted computing technology is used to perform fine-grained integrity measurement and remote attestation of processes in a container,detect abnormal containers in time and control them.We have implemented a prototype system and performed extensive simulation experiments to test and analyze the functionality and performance of the PIMS.Experimental results show that PIMS can accurately and efficiently detect tampered processes with only 3.57% performance loss to the container.
基金Funding for this study was received from the Deputyship for Research&Innovation,Ministry of Education in Saudi Arabia through the project number“IFPHI-021–135–2020”and King Abdulaziz University,DSR,Jeddah,Saudi Arabia.
文摘Increasing renewable energy targets globally has raised the requirement for the efficient and profitable operation of solar photovoltaic(PV)systems.In light of this requirement,this paper provides a path for evaluating the operating condition and improving the power output of the PV system in a grid integrated environment.To achieve this,different types of faults in grid-connected PV systems(GCPVs)and their impact on the energy loss associated with the electrical network are analyzed.A data-driven approach using neural networks(NNs)is proposed to achieve root cause analysis and localize the fault to the component level in the system.The localized fault condition is combined with a parallel operation of adaptive neurofuzzy inference units(ANFIUs)to develop a power mismatch-based control unit(PMCU)for improving the power output of the GCPV.To develop the proposed framework,a 10-kW single-phase GCPV is simulated for training the NN-based anomaly detection approach with 14 deviation signals.Further,the developed algorithm is combined with the PMCU implemented with the experimental setup of GCPV.The results identified 98.2%training accuracy and 43000 observations/sec prediction speed for the trained classifier,and improved power output with reduced voltage and current harmonics for the grid-connected PV operation.
文摘This research presents the remote sensing data on hotspots in four national parks located in Chiang Mai province, Thailand: Sri Lanna National Park, Huai Nam Dang National Park, Doi Pahom Pok National Park, and Doi Inthanon National Park. To mitigate the devastating impacts of these wildfires, effective monitoring and management strategies are necessary. Remote sensing technology provides a promising approach for mapping burnt areas and understanding fire regimes at a regional scale. The primary focus of this research is to employ the MODIS Aqua/Terra satellite system for obtaining historical remote sensing data on hotspots. The advantages of remote sensing include accurate identification and mapping of burnt areas, regular monitoring, rapid data acquisition, and historical data analysis. The MODIS sensor, specifically designed for fire monitoring, offers enhanced fire detection and diagnosis, multiple channels for qualitative and quantitative analysis, and precision positioning capabilities. The research results presented in the analysis contribute to the understanding of fire incidents and hotspot occurrences within the four national parks studied. This paper suggests the optimization of early detection of forest and land fires through the utilization of Artificial Intelligence (AI), presenting it as a recommendation for future endeavors. The research emphasizes the significance of implementing efficient policies and management strategies to effectively tackle the challenges associated with fires in these ecologically significant areas.
基金National Natural Science Foundation of China(Nos.42171444,42301516)Beijing Natural Science Foundation Project-Municipal Education Commission Joint Fund Project(No.KZ202110016021)Beijing Municipal Education Commission Scientific Research Project-Science and Technology Plan General Project(No.KM202110016005).
文摘Natural disaster risk monitoring is an important task for disaster prevention and reduction.In the case of immovable cultural relics,however,the feedback mechanism,risk factors,monitoring logic,and monitoring indicators of natural disaster risk monitoring are complex.How to achieve intelligent perception and monitoring of natural disaster risk for immovable cultural relics has always been a focus and a challenge for researchers.Based on the analysis of the concepts and issues related to the natural disaster risk of immovable cultural relics,this paper proposes a framework for natural disaster risk monitoring for immovable cultural relics based on the digital twin.This framework focuses on risk monitoring,including the physical entities of natural disaster risk for immovable cultural relics,monitoring indicators,and virtual entity construction.A platform for monitoring the natural disaster risk of immovable cultural relics is proposed.Using the Puzhou Ancient City Site as a test bed,the proposed concept can be used for monitoring the natural disaster risk of immovable cultural relics at different scales.
文摘Many Internet of Things(IoT)systems are based on the intercommunication among different devices and centralized systems.Nowadays,there are several commercial and research platforms available to simplify the creation of such IoT systems.However,developing these systems can often be a tedious task.To address this challenge,a proposed solution involves the implementation of a unified program or script that encompasses the entire system,including IoT devices functionality.This approach is based on an abstraction,integrating the control of the devices in a single program through a programmable object.Subsequently,the proposal processes the unified script to generate the centralized system code and a controller for each device.By adopting this approach,developers will be able to create IoT systems with significantly reduced implementation costs,surpassing current platforms by more than 10%.The results demonstrate that the single program approach can significantly accelerate the development of IoT systems relying on device communication.
基金supported by the Researchers Supporting Program(TUMA-Project2021-27)Almaarefa University,RiyadhSaudi Arabia.Taif University Researchers Supporting Project number(TURSP-2020/161)Taif University,Taif,Saudi Arabia.
文摘Learning Management System(LMS)is an application software that is used in automation,delivery,administration,tracking,and reporting of courses and programs in educational sector.The LMS which exploits machine learning(ML)has the ability of accessing user data and exploit it for improving the learning experience.The recently developed artificial intelligence(AI)and ML models helps to accomplish effective performance monitoring for LMS.Among the different processes involved in ML based LMS,feature selection and classification processesfind beneficial.In this motivation,this study introduces Glowworm-based Feature Selection with Machine Learning Enabled Performance Monitoring(GSO-MFWELM)technique for LMS.The key objective of the proposed GSO-MFWELM technique is to effectually monitor the performance in LMS.The pro-posed GSO-MFWELM technique involves GSO-based feature selection techni-que to select the optimal features.Besides,Weighted Extreme Learning Machine(WELM)model is applied for classification process whereas the parameters involved in WELM model are optimallyfine-tuned with the help of May-fly Optimization(MFO)algorithm.The design of GSO and MFO techniques result in reduced computation complexity and improved classification performance.The presented GSO-MFWELM technique was validated for its performance against benchmark dataset and the results were inspected under several aspects.The simulation results established the supremacy of GSO-MFWELM technique over recent approaches with the maximum classification accuracy of 0.9589.
基金Supported by National Natural Science Foundation of China,No.81770776,No.81973378,and No.82073909The Shanxi Provincial Central Leading Local Science and Technology Development Fund Project,No.YDZJSX2022A059Postgraduate Education Innovation Project of Shanxi Province,No.2022Y354.
文摘BACKGROUND Commonly used glucocorticoids replacement regimens in patients with hypopituitarism have difficulty mimicking physiological cortisol rhythms and are usually accompanied by risks of over-treatment,with adverse effects on glucose metabolism.Disorders associated with glucose metabolism are established risk factors of cardiovascular events,one of the life-threatening ramifications.AIM To investigate the glycometabolism profile in patients with hypopituitarism receiving prednisone(Pred)replacement,and to clarify the impacts of different Pred doses on glycometabolism and consequent adverse cardiovascular outcomes.METHODS Twenty patients with hypopituitarism receiving Pred replacement[patient group(PG)]and 20 normal controls(NCs)were recruited.A flash glucose monitoring system was used to record continuous glucose levels during the day,which provided information on glucose-target-rate,glucose variability(GV),period glucose level,and hypoglycemia occurrence at certain periods.Islet β-cell function was also assessed.Based on the administered Pred dose per day,the PG was then regrouped into Pred>5 mg/d and Pred≤5 mg/d subgroups.Comparative analysis was carried out between the PG and NCs.RESULTS Significantly altered glucose metabolism profiles were identified in the PG.This includes significant reductions in glucose-target-rate and nocturnal glucose level,along with elevations in GV,hypoglycemia occurrence and postprandial glucose level,when compared with those in NCs.Subgroup analysis indicated more significant glucose metabolism impairment in the Pred>5 mg/d group,including significantly decreased glucose-target-rate and nocturnal glucose level,along with increased GV,hypoglycemia occurrence,and postprandial glucose level.With regard to islet β-cell function,PG showed significant difference in homeostasis model assessment(HOMA)-β compared with that of NCs;a notable difference in HOMA-βwas identified in Pred>5 mg/d group when compared with those of NCs;as for Pred≤5 mg/d group,significant differences were found in HOMA-β,and fasting glucose/insulin ratio when compared with NCs.CONCLUSION Our results demonstrated that Pred replacement disrupted glycometabolic homeostasis in patients with hypopituitarism.A Pred dose of>5 mg/d seemed to cause more adverse effects on glycometabolism than a dose of≤5 mg/d.Comprehensive and accurate evaluation is necessary to consider a suitable Pred replacement regimen,wherein,flash glucose monitoring system is a kind of promising and reliable assessment device.The present data allows us to thoroughly examine our modern treatment standards,especially in difficult cases such as hormonal replacement mimicking delicate natural cycles,in conditions such as diabetes mellitus that are rapidly growing in worldwide prevalence.