BACKGROUND Metastatic colorectal cancer(mCRC)is a common malignancy whose treatment has been a clinical challenge.Cancer-specific survival(CSS)plays a crucial role in assessing patient prognosis and treatment outcomes...BACKGROUND Metastatic colorectal cancer(mCRC)is a common malignancy whose treatment has been a clinical challenge.Cancer-specific survival(CSS)plays a crucial role in assessing patient prognosis and treatment outcomes.However,there is still li-mited research on the factors affecting CSS in mCRC patients and their corre-lation.AIM To predict CSS,we developed a new nomogram model and risk grading system to classify risk levels in patients with mCRC.METHODS Data were extracted from the United States Surveillance,Epidemiology,and End Results database from 2018 to 2023.All eligible patients were randomly divided into a training cohort and a validation cohort.The Cox proportional hazards model was used to investigate the independent risk factors for CSS.A new nomogram model was developed to predict CSS and was evaluated through internal and external validation.RESULTS A multivariate Cox proportional risk model was used to identify independent risk factors for CSS.Then,new CSS columns were developed based on these factors.The consistency index(C-index)of the histogram was 0.718(95%CI:0.712-0.725),and that of the validation cohort was 0.722(95%CI:0.711-0.732),indicating good discrimination ability and better performance than tumor-node-metastasis staging(C-index:0.712-0.732).For the training set,0.533,95%CI:0.525-0.540;for the verification set,0.524,95%CI:0.513-0.535.The calibration map and clinical decision curve showed good agreement and good potential clinical validity.The risk grading system divided all patients into three groups,and the Kaplan-Meier curve showed good stratification and differentiation of CSS between different groups.The median CSS times in the low-risk,medium-risk,and high-risk groups were 36 months(95%CI:34.987-37.013),18 months(95%CI:17.273-18.727),and 5 months(95%CI:4.503-5.497),respectively.CONCLUSION Our study developed a new nomogram model to predict CSS in patients with synchronous mCRC.In addition,the risk-grading system helps to accurately assess patient prognosis and guide treatment.展开更多
Having carried out investigations on ship collision accidents with bridges in waterway in China, a database of ship collision with bridge (SCB) is developed in this paper. It includes detailed information about more t...Having carried out investigations on ship collision accidents with bridges in waterway in China, a database of ship collision with bridge (SCB) is developed in this paper. It includes detailed information about more than 200 accidents near ship's waterways in the last four decades, in which ships collided with the bridges. Based on the information a statistical analysis is presented tentatively. The increase in frequency of ship collision with bridges appears, and the accident quantity of the barge system is more than that of single ship. The main reason of all the factors for ship collision with bridge is the human errors, which takes up 70%. The quantity of the accidents happened during flooding period shows over 3～6 times compared with the period from March to June in a year. The probability follows the normal distribution according to statistical analysis. Visibility, span between piers also have an effect on the frequency of the accidents.展开更多
目的探讨儿童青少年尤因肉瘤(ES)患者的临床特征和影响预后的因素。方法利用美国监测、流行病学及结果(surveillance,epidemiology and end results,SEER)数据库收集并筛选出2004年至2018年诊断为尤因肉瘤的5~19岁患者,使用Kaplan-Meie...目的探讨儿童青少年尤因肉瘤(ES)患者的临床特征和影响预后的因素。方法利用美国监测、流行病学及结果(surveillance,epidemiology and end results,SEER)数据库收集并筛选出2004年至2018年诊断为尤因肉瘤的5~19岁患者,使用Kaplan-Meier法建立患者生存曲线,使用Cox风险比例回归模型评价预后因素。结果纳入959例患者中男562例(58.60%),女397例(41.40%);白种人844例(88.01%),黑种人31例(3.23%),其他人种共84例(8.76%);首发部位中位于骨672例(70.07%),位于其余软组织287例(29.93%);转移阶段处于局限310例(32.33%),局部浸润344例(35.87%),远处转移305例(31.80%);接受化疗938例(97.81%),未接受化疗21例(2.19%);接受放疗488例(50.89%),未接受放疗471例(49.11%);接受手术651例(67.88%),未接受手术308例(32.12%);肿瘤直径<8 cm 465人(48.49%),≥8 cm 494例(51.51%)。多因素回归模型分析结果显示,肿瘤进展阶段(P<0.001)和患者是否接受过针对ES的手术(P=0.005)为影响预后的独立因素。结论对于儿童青少年ES患者,肿瘤进展和未接受过针对性手术为影响预后的危险因素,临床上应当重点关注。展开更多
背景:纳米材料是抗肿瘤药物的理想载体,具有重要的科学价值和应用价值,为临床抗肿瘤提供了新的有效手段。目的:系统评价纳米给药系统在肿瘤靶向治疗的基础研究及临床应用。方法:以"nanoparticle,cancer,drug delivery system,nanot...背景:纳米材料是抗肿瘤药物的理想载体,具有重要的科学价值和应用价值,为临床抗肿瘤提供了新的有效手段。目的:系统评价纳米给药系统在肿瘤靶向治疗的基础研究及临床应用。方法:以"nanoparticle,cancer,drug delivery system,nanotube,nanosphere"为关键词,计算机检索北美临床试验注册中心及Web of Science数据库2000-01-01/2012-12-31发表的纳米给药系统在肿瘤靶向治疗相关临床试验注册项目及文献。根据纳入与排除标准筛选文献,将检索结果以注册号、注册题目、项目状态、干预措施、试验的申办者、试验的疾病种类导出进行评价质量及文献分析。结果与结论:①北美临床试验注册中心关于纳米给药系统在肿瘤靶向治疗的相关临床试验研究开始于1999年,共检索到注册项目489项,经查阅后,共有429项纳入了分析。美国注册的纳米载体肿瘤靶向给药临床试验项目最多,共112项,其次为加拿大24项。中国注册的临床试验有22项,其中大陆注册8项,香港地区注册4项,台湾地区注册10项。研究的注册数量2003年跌至谷底,只有5项注册项目,之后数量大幅度升高,在2008年注册项目数量达到顶峰,为56项。2008年后,注册的项目数量处于波动状态。②北美临床试验注册中心纳米给药系统在肿瘤靶向治疗的相关临床试验项目样本量在1-2000之间,以50人以下的小样本研究为主。研究的肿瘤类型以乳腺癌为主,其次为内分泌腺瘤及淋巴瘤。③2000-01-01/2012-12-31在Web of Science数据库发表的纳米载体肿瘤靶向给药相关文章4497篇,其中,美国发文量占总数比重最大(66.42%),发表文章2987篇。高被引文章主要发表在Proceedings of the National Academy of Sciences of the United States of America(《美国科学院院刊》)。展开更多
目的利用美国流行病学监测和结果(surveillance,epidemiology,and end results,SEER)数据库构建老年鼻咽癌患者(≥60岁)生存预后风险预测列线图,预测老年鼻咽癌患者的总生存率,为临床决策提供科学依据。方法从数据库中提取2004—2015年...目的利用美国流行病学监测和结果(surveillance,epidemiology,and end results,SEER)数据库构建老年鼻咽癌患者(≥60岁)生存预后风险预测列线图,预测老年鼻咽癌患者的总生存率,为临床决策提供科学依据。方法从数据库中提取2004—2015年期间的老年鼻咽癌患者共1366例,随机分为建模组和验证组。对建模组采用Cox比例风险回归模型分析患者的预后影响因素,再构建列线图。利用一致性指数(C-index)和校正曲线对列线图进行验证,评估其预测价值。结果建模组的Cox比例风险回归模型结果表明:年龄、婚姻、种族、肿瘤分化等级、组织学类型、TNM分期及放化疗均是老年鼻咽癌患者的预后影响因素(均P<0.05),均被用于构建风险预测列线图。风险预测列线图的验证结果表明,建模组的C指数为0.732(95%CI为0.708~0.756),验证组为0.762(95%CI为0.729~0.795);2组的校正曲线均表现出良好的一致性。结论本研究构建的老年鼻咽癌患者生存预后的风险预测列线图具有良好的预测价值,可快速准确对患者进行个体化的生存预后评估;有远处转移的80岁以上鼻咽癌患者或许是预立医疗照护计划的切入点。展开更多
文摘BACKGROUND Metastatic colorectal cancer(mCRC)is a common malignancy whose treatment has been a clinical challenge.Cancer-specific survival(CSS)plays a crucial role in assessing patient prognosis and treatment outcomes.However,there is still li-mited research on the factors affecting CSS in mCRC patients and their corre-lation.AIM To predict CSS,we developed a new nomogram model and risk grading system to classify risk levels in patients with mCRC.METHODS Data were extracted from the United States Surveillance,Epidemiology,and End Results database from 2018 to 2023.All eligible patients were randomly divided into a training cohort and a validation cohort.The Cox proportional hazards model was used to investigate the independent risk factors for CSS.A new nomogram model was developed to predict CSS and was evaluated through internal and external validation.RESULTS A multivariate Cox proportional risk model was used to identify independent risk factors for CSS.Then,new CSS columns were developed based on these factors.The consistency index(C-index)of the histogram was 0.718(95%CI:0.712-0.725),and that of the validation cohort was 0.722(95%CI:0.711-0.732),indicating good discrimination ability and better performance than tumor-node-metastasis staging(C-index:0.712-0.732).For the training set,0.533,95%CI:0.525-0.540;for the verification set,0.524,95%CI:0.513-0.535.The calibration map and clinical decision curve showed good agreement and good potential clinical validity.The risk grading system divided all patients into three groups,and the Kaplan-Meier curve showed good stratification and differentiation of CSS between different groups.The median CSS times in the low-risk,medium-risk,and high-risk groups were 36 months(95%CI:34.987-37.013),18 months(95%CI:17.273-18.727),and 5 months(95%CI:4.503-5.497),respectively.CONCLUSION Our study developed a new nomogram model to predict CSS in patients with synchronous mCRC.In addition,the risk-grading system helps to accurately assess patient prognosis and guide treatment.
文摘Having carried out investigations on ship collision accidents with bridges in waterway in China, a database of ship collision with bridge (SCB) is developed in this paper. It includes detailed information about more than 200 accidents near ship's waterways in the last four decades, in which ships collided with the bridges. Based on the information a statistical analysis is presented tentatively. The increase in frequency of ship collision with bridges appears, and the accident quantity of the barge system is more than that of single ship. The main reason of all the factors for ship collision with bridge is the human errors, which takes up 70%. The quantity of the accidents happened during flooding period shows over 3～6 times compared with the period from March to June in a year. The probability follows the normal distribution according to statistical analysis. Visibility, span between piers also have an effect on the frequency of the accidents.
文摘目的探讨儿童青少年尤因肉瘤(ES)患者的临床特征和影响预后的因素。方法利用美国监测、流行病学及结果(surveillance,epidemiology and end results,SEER)数据库收集并筛选出2004年至2018年诊断为尤因肉瘤的5~19岁患者,使用Kaplan-Meier法建立患者生存曲线,使用Cox风险比例回归模型评价预后因素。结果纳入959例患者中男562例(58.60%),女397例(41.40%);白种人844例(88.01%),黑种人31例(3.23%),其他人种共84例(8.76%);首发部位中位于骨672例(70.07%),位于其余软组织287例(29.93%);转移阶段处于局限310例(32.33%),局部浸润344例(35.87%),远处转移305例(31.80%);接受化疗938例(97.81%),未接受化疗21例(2.19%);接受放疗488例(50.89%),未接受放疗471例(49.11%);接受手术651例(67.88%),未接受手术308例(32.12%);肿瘤直径<8 cm 465人(48.49%),≥8 cm 494例(51.51%)。多因素回归模型分析结果显示,肿瘤进展阶段(P<0.001)和患者是否接受过针对ES的手术(P=0.005)为影响预后的独立因素。结论对于儿童青少年ES患者,肿瘤进展和未接受过针对性手术为影响预后的危险因素,临床上应当重点关注。
文摘背景:纳米材料是抗肿瘤药物的理想载体,具有重要的科学价值和应用价值,为临床抗肿瘤提供了新的有效手段。目的:系统评价纳米给药系统在肿瘤靶向治疗的基础研究及临床应用。方法:以"nanoparticle,cancer,drug delivery system,nanotube,nanosphere"为关键词,计算机检索北美临床试验注册中心及Web of Science数据库2000-01-01/2012-12-31发表的纳米给药系统在肿瘤靶向治疗相关临床试验注册项目及文献。根据纳入与排除标准筛选文献,将检索结果以注册号、注册题目、项目状态、干预措施、试验的申办者、试验的疾病种类导出进行评价质量及文献分析。结果与结论:①北美临床试验注册中心关于纳米给药系统在肿瘤靶向治疗的相关临床试验研究开始于1999年,共检索到注册项目489项,经查阅后,共有429项纳入了分析。美国注册的纳米载体肿瘤靶向给药临床试验项目最多,共112项,其次为加拿大24项。中国注册的临床试验有22项,其中大陆注册8项,香港地区注册4项,台湾地区注册10项。研究的注册数量2003年跌至谷底,只有5项注册项目,之后数量大幅度升高,在2008年注册项目数量达到顶峰,为56项。2008年后,注册的项目数量处于波动状态。②北美临床试验注册中心纳米给药系统在肿瘤靶向治疗的相关临床试验项目样本量在1-2000之间,以50人以下的小样本研究为主。研究的肿瘤类型以乳腺癌为主,其次为内分泌腺瘤及淋巴瘤。③2000-01-01/2012-12-31在Web of Science数据库发表的纳米载体肿瘤靶向给药相关文章4497篇,其中,美国发文量占总数比重最大(66.42%),发表文章2987篇。高被引文章主要发表在Proceedings of the National Academy of Sciences of the United States of America(《美国科学院院刊》)。
文摘目的利用美国流行病学监测和结果(surveillance,epidemiology,and end results,SEER)数据库构建老年鼻咽癌患者(≥60岁)生存预后风险预测列线图,预测老年鼻咽癌患者的总生存率,为临床决策提供科学依据。方法从数据库中提取2004—2015年期间的老年鼻咽癌患者共1366例,随机分为建模组和验证组。对建模组采用Cox比例风险回归模型分析患者的预后影响因素,再构建列线图。利用一致性指数(C-index)和校正曲线对列线图进行验证,评估其预测价值。结果建模组的Cox比例风险回归模型结果表明:年龄、婚姻、种族、肿瘤分化等级、组织学类型、TNM分期及放化疗均是老年鼻咽癌患者的预后影响因素(均P<0.05),均被用于构建风险预测列线图。风险预测列线图的验证结果表明,建模组的C指数为0.732(95%CI为0.708~0.756),验证组为0.762(95%CI为0.729~0.795);2组的校正曲线均表现出良好的一致性。结论本研究构建的老年鼻咽癌患者生存预后的风险预测列线图具有良好的预测价值,可快速准确对患者进行个体化的生存预后评估;有远处转移的80岁以上鼻咽癌患者或许是预立医疗照护计划的切入点。
