This paper addresses the problem of the fuzzy H ∞state feedback control for a class of uncertain nonlinear systems with time delay. The Takagi Sugeno (T S) mo del with time delay and parameter uncertainties is ...This paper addresses the problem of the fuzzy H ∞state feedback control for a class of uncertain nonlinear systems with time delay. The Takagi Sugeno (T S) mo del with time delay and parameter uncertainties is adopted for modeling of nonlinear system. The systematic design procedure for the fuzzy robust controller based on linear matrix inequality (LMI) is given. Some sufficient conditions are derived for the existence of fuzzy H ∞ state feedback controllers such that the closed loop system is asymptotically stable and the effect of the disturbance input on controlled output is reduced to a prescribed level. An example is given to demonstrate the effectiveness of the proposed method.展开更多
In this paper, we study chaos control of the new 3D chaotic system. We use three feedback methods （the linear, speed, doubly-periodic function controller） to suppress the chaos to unstable equilibrium. As a result, ...In this paper, we study chaos control of the new 3D chaotic system. We use three feedback methods （the linear, speed, doubly-periodic function controller） to suppress the chaos to unstable equilibrium. As a result, some controllers are obtained. Moreover, numerical simulations are used to verify the effectiveness of the obtained controllers.展开更多
Systemic lupus erythematosus （SLE） is a typical autoimmune disease involving multiple systems and organs. Ample evidence suggests that autoreactive T cells play a pivotal role in the development of this autoimmune d...Systemic lupus erythematosus （SLE） is a typical autoimmune disease involving multiple systems and organs. Ample evidence suggests that autoreactive T cells play a pivotal role in the development of this autoimmune disorder. This study was undertaken to investigate the mechanisms of interaction between antigen presenting cells （APCs） and an autoreactive T cell （ATLI） clone obtained from lupus-prone BXSB mice. ATLI cells, either before or after 7-ray irradiation, were able to activate naive B cells, as determined by B cell proliferation assays. Macrophages from BXSB mice were able to stimulate the proliferation of resting ATL 1 cells at a responder/stimulator （R/S） ratio of 1/2.5. Dendritic cells （DCs） were much more powerful stimulators for ATLI cells on a per cell basis. The T cell stimulating ability ofmacrophages and B cells, but not DCs, was sensitive to T-ray irradiation. Monoclonal antibodies against mouse MHC-Ⅱ and CD4 were able to block DC-mediated stimulation of ATL 1 proliferation, indicating cognate recognition between ATL 1 and APCs. Our data suggest that positive feedback loops involving macrophages, B cells and autoreactive T cells may play a pivotal role in keeping the momentum of autoimmune responses leading to autoimmune diseases.展开更多
Regulatory T cells （Treg） play important roles in immune system homeostasis, and may also be involved in tumor immunotolerance by suppressing Th1 immune response which is involved in anti-tumor immunity. We have pre...Regulatory T cells （Treg） play important roles in immune system homeostasis, and may also be involved in tumor immunotolerance by suppressing Th1 immune response which is involved in anti-tumor immunity. We have previously reported that immunization with attenuated activated autologous T cells leads to enhanced anti-tumor immunity and upregulated Thl responses in vivo. However, the underlying molecular mechanisms are not well understood. Here we show that Treg function was significantly downregulated in mice that received immunization of attenuated activated autologous T cells. We found that Foxp3 expression decreased in CD4＋CD25＋ T cells from the immunized mice. Moreover, CD4＋CD25＋Foxp3＋ Treg obtained from immunized mice exhibited diminished immunosuppression ability compared to those from naive mice. Further analysis showed that the serum of immunized mice contains a high level ofanti-CD25 antibody （about 30 ng/ml, p〈0.01 vs controls）. Consistent with a role ofanti-CD25 response in the downregulation of Treg, adoptive transfer of serum from immunized mice to naive mice led to a significant decrease in Treg population and function in recipient mice. The triggering of anti-CD25 response in immunized mice can be explained by the fact that CD25 was induced to a high level in the ConA activated autologous T cells used for immunization. Our results demonstrate for the first time that immunization with attenuated activated autologous T cells evokes anti-CD25 antibody production, which leads to impeded CD4＋CD25＋Foxp3＋ Treg expansion and function in vivo. We suggest that dampened Treg function likely contributes to enhanced Thl response in immunized mice and is at least part of the mechanism underlying the boosted anti-tumor immunity.展开更多
To meet the exponentially growing demand fbr bandwidth in Optical Transport Networks （OTNs）, 100-Gb/s （100G） coherent technology based oil Polarization-Division Multiplexed Quadrature Phase Shift Keying （PDM-QPSK...To meet the exponentially growing demand fbr bandwidth in Optical Transport Networks （OTNs）, 100-Gb/s （100G） coherent technology based oil Polarization-Division Multiplexed Quadrature Phase Shift Keying （PDM-QPSK）, which enables the capacity of a Wavelength Division Multiplexing （WDM） system to approach 10 Tb/s, is being widely deployed globally. As the first vendor to intro- duce a single-carrier 100G solution, A1- catel-Lucent has developed key transponder and network management technologies, which are reviewed in this paper together with their commercial evolution to 400G. Focusing on the Chinese market, we also review some key bench-mark testing results obtained in partner- ship with major Chinese operators. Finally, we discuss enabling technologies that are currently being researched to allow interfaces to scale to Terabit/s rates.展开更多
To improve the control performance of nonlinear ultra-supercritical(USC)thermal power units,an improved min-max fuzzy model predictive tracking control(FMPTC)strategy is proposed.First,a T-S fuzzy model is established...To improve the control performance of nonlinear ultra-supercritical(USC)thermal power units,an improved min-max fuzzy model predictive tracking control(FMPTC)strategy is proposed.First,a T-S fuzzy model is established to approximate the dynamics of the nonlinear boiler-turbine system.Then,based on an extended fuzzy model containing state variables and output variables,a min-max FMPTC is derived for output regulation while ensuring the closed-loop system stability and the inputs in their given constraints.For greater controller design freedom,the developed controller adopts a new state-and output-based objective function.In addition,the observer estimation error is regarded as a bounded disturbance,ensuring the stability of the entire closed-loop control system.Simulation results on a 1000 MW USC boiler-turbine model illustrate the effectiveness of the proposed approach.展开更多
The local multiple regression fuzzy(LMRF)model based on Takagi-Sugeno fuzzy logical system and its application in traffic forecasting is proposed. Besides its prediction accuracy is testified and the model is proved m...The local multiple regression fuzzy(LMRF)model based on Takagi-Sugeno fuzzy logical system and its application in traffic forecasting is proposed. Besides its prediction accuracy is testified and the model is proved much better than conventional forecasting methods. According to the regional traffic system, the model perfectly states the complex non-linear relation of the traffic and the local social economy. The model also efficiently deals with the system lack of enough data.展开更多
SME share transfer system financing has become the main theme of a new three-panel market.The efficiency of the new board of corporate finance and has become the core focus, more controversial aspects.SMEs in SME shar...SME share transfer system financing has become the main theme of a new three-panel market.The efficiency of the new board of corporate finance and has become the core focus, more controversial aspects.SMEs in SME share transfer system market mainly private placement financing, equity financing pledge, and Transfer of Listing and mergers and acquisitions.This paper will be discussed by comparing the SMEs through SME share transfer system market financing, the use of a single sample T-test （One-Sample T Test） to verify the efficiency of the new board of corporate finance assets problem.展开更多
An energy-saving scheme for pumping units via intermission start-stop performance is proposed. Because of the complexity of the oil extraction process, Fuzzy Neural Network (FNN) intelligent control is adopted. The st...An energy-saving scheme for pumping units via intermission start-stop performance is proposed. Because of the complexity of the oil extraction process, Fuzzy Neural Network (FNN) intelligent control is adopted. The structure of the Takagi-Sugeno (T-S) fuzzy neural network model is introduced and modified. FNNs are trained with sample information from oil fields and expert knowledge. Finally, pumping unit energy-saving FNN software, which cuts down power costs substantially, is presented.展开更多
NR4A2 is a transcription factor belonging to the steroid orphan nuclear receptor superfamily.It was originally considered to be essential in the generation and maintenance of dopaminergic neurons,and associated with n...NR4A2 is a transcription factor belonging to the steroid orphan nuclear receptor superfamily.It was originally considered to be essential in the generation and maintenance of dopaminergic neurons,and associated with neurological disorders such as Parkinson's disease.Recently,NR4A2 has been found to play a critical role in some inflammatory diseases and cancer.NR4A2 can be efficiently trans-activated by some proinflammatory cytokines,such as tumor necrosis factor-α,interleukin-1β,and vascular endothelial growth factor(VEGF).The nuclear factor-κB signaling pathway serves as a principal regulator of inducible NR4A expression in immune cells.NR4A2 can trans-activate Foxp3,a hallmark specifically expressed in regulatory T(Treg) cells,and plays a critical role in the differentiation,maintenance,and function of Treg cells.NR4A2 in T lymphocytes is pivotal for Treg cell induction and suppression of aberrant induction of Th1 under physiological and pathological conditions.High density of Foxp3 + Treg cells is significantly associated with gastrointestinal inflammation,tumor immune escape,and disease progression.NR4A2 is produced at high levels in CD133 + colorectal carcinoma(CRC) cells and significantly upregulated by cyclooxygenase-2-derived prostaglandin E 2 in a cyclic adenosine monophosphate(cAMP)/protein kinase A(PKA)-dependent manner in CRC cells.The cAMP/PKA signaling pathway is the common pathway of NR4A2-related inflammation and cancer.NR4A2 trans-activates osteopontin,a direct target of the Wnt/β-catenin pathway associated with CRC invasion,metastasis,and poor prognosis.Knockdown of endogenous NR4A2 expression attenuates VEGF-induced endothelial cell proliferation,migration and in vivo angiogenesis.Taken together,NR4A2 emerges as an important nuclear factor linking gastrointestinal inflammation and cancer,especially CRC,and should serve as a candidate therapeutic target for inflammation-related gastrointestinal cancer.展开更多
OBJECTIVE CD4^＋CD25^＋ T regulatory （Treg） cells are a population of T cells which suppress an overactive immune system. CCR4 is a chemokine receptor involved in the recruitment of lymphocytes. Nasopharyngeal carci...OBJECTIVE CD4^＋CD25^＋ T regulatory （Treg） cells are a population of T cells which suppress an overactive immune system. CCR4 is a chemokine receptor involved in the recruitment of lymphocytes. Nasopharyngeal carcinoma （NPC） is resistant to immunosurveillance, owing to the increased number of tumor-infiltrating Treg cells which are recruited to the tumor bv CCR4.展开更多
In this paper,the relationship between the extended family and several mixing properties in measuretheoretical dynamical systems is investigated.The extended family eF related to a given family F can be regarded as th...In this paper,the relationship between the extended family and several mixing properties in measuretheoretical dynamical systems is investigated.The extended family eF related to a given family F can be regarded as the collection of all sets obtained as"piecewise shifted"members of F.For a measure preserving transformation T on a Lebesgue space(X,B,μ),the sets of"accurate intersections of order k"defined below are studied,Nε(A0,A1,...,Ak)=n∈Z+:μk i=0T inAiμ(A0)μ(A1)μ(Ak)<ε,for k∈N,A0,A1,...,Ak∈B and ε>0.It is shown that if T is weakly mixing(mildly mixing)then for any k∈N,all the sets Nε(A0,A1,...,Ak)have Banach density 1(are in(eFip),i.e.,the dual of the extended family related to IP-sets).展开更多
The survival of patients with hematological malignancies has been significantly improved due to the development of new therapeutic agents. However, relapse remains a major matter for concern. Recently, T cells enginee...The survival of patients with hematological malignancies has been significantly improved due to the development of new therapeutic agents. However, relapse remains a major matter for concern. Recently, T cells engineered with chimeric antigen receptor(CAR) were reported to show unprecedented responses in a range of hematological malignancies. The persistence of the CAR-T cell can last for years and tends toward long-term antitumor memory by which relapses can be effectively prevented. The primary side effects that appear in most clinical trials are cytokine release syndrome and neurotoxicity. However, these symptoms can be treated and reversed. In this review, we describe CAR structure and function and summarize recent advances in CAR-T cell therapy in hematological malignancies.展开更多
In this paper, the output consensus problem of general heterogeneous nonlinear multi-agent systems subject to different disturbances is considered. A kind of Takagi-Sukeno fuzzy modeling method is used to describe the...In this paper, the output consensus problem of general heterogeneous nonlinear multi-agent systems subject to different disturbances is considered. A kind of Takagi-Sukeno fuzzy modeling method is used to describe the nonlinear agents' dynamics. Based on the model, a distributed fuzzy observer and controller are designed based on parallel distributed compensation scheme and internal reference models such that the heterogeneous nonlinear multi-agent systems can achieve output consensus. Then a necessary and sufficient condition is presented for the output consensus problem. And it is shown that the consensus trajectory of the global fuzzy model is determined by the network topology and the initial states of the internal reference models. Finally, some simulations are given to illustrate and verify the effectiveness of the proposed scheme.展开更多
文摘This paper addresses the problem of the fuzzy H ∞state feedback control for a class of uncertain nonlinear systems with time delay. The Takagi Sugeno (T S) mo del with time delay and parameter uncertainties is adopted for modeling of nonlinear system. The systematic design procedure for the fuzzy robust controller based on linear matrix inequality (LMI) is given. Some sufficient conditions are derived for the existence of fuzzy H ∞ state feedback controllers such that the closed loop system is asymptotically stable and the effect of the disturbance input on controlled output is reduced to a prescribed level. An example is given to demonstrate the effectiveness of the proposed method.
基金The project supported by Natural Science Foundations of Zhejiang Province of China under Grant No.Y604056the Doctoral Foundation of Ningbo City under Grant No.2005A61030+1 种基金National Natural Science Foundation of China under Grant No.10401039National Key Basic Research Program of China under Grant No.2004CB318000,and the NDEF,CAS
文摘In this paper, we study chaos control of the new 3D chaotic system. We use three feedback methods （the linear, speed, doubly-periodic function controller） to suppress the chaos to unstable equilibrium. As a result, some controllers are obtained. Moreover, numerical simulations are used to verify the effectiveness of the obtained controllers.
基金supported by grants from the National Key Basic Research Programs(2001CB510007)National Natural Science Foundation of China(30371303).
文摘Systemic lupus erythematosus （SLE） is a typical autoimmune disease involving multiple systems and organs. Ample evidence suggests that autoreactive T cells play a pivotal role in the development of this autoimmune disorder. This study was undertaken to investigate the mechanisms of interaction between antigen presenting cells （APCs） and an autoreactive T cell （ATLI） clone obtained from lupus-prone BXSB mice. ATLI cells, either before or after 7-ray irradiation, were able to activate naive B cells, as determined by B cell proliferation assays. Macrophages from BXSB mice were able to stimulate the proliferation of resting ATL 1 cells at a responder/stimulator （R/S） ratio of 1/2.5. Dendritic cells （DCs） were much more powerful stimulators for ATLI cells on a per cell basis. The T cell stimulating ability ofmacrophages and B cells, but not DCs, was sensitive to T-ray irradiation. Monoclonal antibodies against mouse MHC-Ⅱ and CD4 were able to block DC-mediated stimulation of ATL 1 proliferation, indicating cognate recognition between ATL 1 and APCs. Our data suggest that positive feedback loops involving macrophages, B cells and autoreactive T cells may play a pivotal role in keeping the momentum of autoimmune responses leading to autoimmune diseases.
基金This work was supported by National Natural Science Foundation of China(No.30671945)Science and Technology Commission of Shanghai Municipality(Nos.06JC14044,05ZR14055,054319928,04DZ14902)+2 种基金Shanghai Municipal Education(No.05BZ26)Shanghai Leading Academic Discipline Project(T0206)Science Foundation of Shanghai Institute of Immunology(No.07-A04,to Ningli Li).
文摘Regulatory T cells （Treg） play important roles in immune system homeostasis, and may also be involved in tumor immunotolerance by suppressing Th1 immune response which is involved in anti-tumor immunity. We have previously reported that immunization with attenuated activated autologous T cells leads to enhanced anti-tumor immunity and upregulated Thl responses in vivo. However, the underlying molecular mechanisms are not well understood. Here we show that Treg function was significantly downregulated in mice that received immunization of attenuated activated autologous T cells. We found that Foxp3 expression decreased in CD4＋CD25＋ T cells from the immunized mice. Moreover, CD4＋CD25＋Foxp3＋ Treg obtained from immunized mice exhibited diminished immunosuppression ability compared to those from naive mice. Further analysis showed that the serum of immunized mice contains a high level ofanti-CD25 antibody （about 30 ng/ml, p〈0.01 vs controls）. Consistent with a role ofanti-CD25 response in the downregulation of Treg, adoptive transfer of serum from immunized mice to naive mice led to a significant decrease in Treg population and function in recipient mice. The triggering of anti-CD25 response in immunized mice can be explained by the fact that CD25 was induced to a high level in the ConA activated autologous T cells used for immunization. Our results demonstrate for the first time that immunization with attenuated activated autologous T cells evokes anti-CD25 antibody production, which leads to impeded CD4＋CD25＋Foxp3＋ Treg expansion and function in vivo. We suggest that dampened Treg function likely contributes to enhanced Thl response in immunized mice and is at least part of the mechanism underlying the boosted anti-tumor immunity.
文摘To meet the exponentially growing demand fbr bandwidth in Optical Transport Networks （OTNs）, 100-Gb/s （100G） coherent technology based oil Polarization-Division Multiplexed Quadrature Phase Shift Keying （PDM-QPSK）, which enables the capacity of a Wavelength Division Multiplexing （WDM） system to approach 10 Tb/s, is being widely deployed globally. As the first vendor to intro- duce a single-carrier 100G solution, A1- catel-Lucent has developed key transponder and network management technologies, which are reviewed in this paper together with their commercial evolution to 400G. Focusing on the Chinese market, we also review some key bench-mark testing results obtained in partner- ship with major Chinese operators. Finally, we discuss enabling technologies that are currently being researched to allow interfaces to scale to Terabit/s rates.
基金The National Natural Science Foundation of China(No.51936003).
文摘To improve the control performance of nonlinear ultra-supercritical(USC)thermal power units,an improved min-max fuzzy model predictive tracking control(FMPTC)strategy is proposed.First,a T-S fuzzy model is established to approximate the dynamics of the nonlinear boiler-turbine system.Then,based on an extended fuzzy model containing state variables and output variables,a min-max FMPTC is derived for output regulation while ensuring the closed-loop system stability and the inputs in their given constraints.For greater controller design freedom,the developed controller adopts a new state-and output-based objective function.In addition,the observer estimation error is regarded as a bounded disturbance,ensuring the stability of the entire closed-loop control system.Simulation results on a 1000 MW USC boiler-turbine model illustrate the effectiveness of the proposed approach.
文摘The local multiple regression fuzzy(LMRF)model based on Takagi-Sugeno fuzzy logical system and its application in traffic forecasting is proposed. Besides its prediction accuracy is testified and the model is proved much better than conventional forecasting methods. According to the regional traffic system, the model perfectly states the complex non-linear relation of the traffic and the local social economy. The model also efficiently deals with the system lack of enough data.
文摘SME share transfer system financing has become the main theme of a new three-panel market.The efficiency of the new board of corporate finance and has become the core focus, more controversial aspects.SMEs in SME share transfer system market mainly private placement financing, equity financing pledge, and Transfer of Listing and mergers and acquisitions.This paper will be discussed by comparing the SMEs through SME share transfer system market financing, the use of a single sample T-test （One-Sample T Test） to verify the efficiency of the new board of corporate finance assets problem.
文摘An energy-saving scheme for pumping units via intermission start-stop performance is proposed. Because of the complexity of the oil extraction process, Fuzzy Neural Network (FNN) intelligent control is adopted. The structure of the Takagi-Sugeno (T-S) fuzzy neural network model is introduced and modified. FNNs are trained with sample information from oil fields and expert knowledge. Finally, pumping unit energy-saving FNN software, which cuts down power costs substantially, is presented.
基金Supported by National Natural Science Foundation of China, No.81025015,30921006,91129301
文摘NR4A2 is a transcription factor belonging to the steroid orphan nuclear receptor superfamily.It was originally considered to be essential in the generation and maintenance of dopaminergic neurons,and associated with neurological disorders such as Parkinson's disease.Recently,NR4A2 has been found to play a critical role in some inflammatory diseases and cancer.NR4A2 can be efficiently trans-activated by some proinflammatory cytokines,such as tumor necrosis factor-α,interleukin-1β,and vascular endothelial growth factor(VEGF).The nuclear factor-κB signaling pathway serves as a principal regulator of inducible NR4A expression in immune cells.NR4A2 can trans-activate Foxp3,a hallmark specifically expressed in regulatory T(Treg) cells,and plays a critical role in the differentiation,maintenance,and function of Treg cells.NR4A2 in T lymphocytes is pivotal for Treg cell induction and suppression of aberrant induction of Th1 under physiological and pathological conditions.High density of Foxp3 + Treg cells is significantly associated with gastrointestinal inflammation,tumor immune escape,and disease progression.NR4A2 is produced at high levels in CD133 + colorectal carcinoma(CRC) cells and significantly upregulated by cyclooxygenase-2-derived prostaglandin E 2 in a cyclic adenosine monophosphate(cAMP)/protein kinase A(PKA)-dependent manner in CRC cells.The cAMP/PKA signaling pathway is the common pathway of NR4A2-related inflammation and cancer.NR4A2 trans-activates osteopontin,a direct target of the Wnt/β-catenin pathway associated with CRC invasion,metastasis,and poor prognosis.Knockdown of endogenous NR4A2 expression attenuates VEGF-induced endothelial cell proliferation,migration and in vivo angiogenesis.Taken together,NR4A2 emerges as an important nuclear factor linking gastrointestinal inflammation and cancer,especially CRC,and should serve as a candidate therapeutic target for inflammation-related gastrointestinal cancer.
基金the National Natural Science Foundation of China
文摘OBJECTIVE CD4^＋CD25^＋ T regulatory （Treg） cells are a population of T cells which suppress an overactive immune system. CCR4 is a chemokine receptor involved in the recruitment of lymphocytes. Nasopharyngeal carcinoma （NPC） is resistant to immunosurveillance, owing to the increased number of tumor-infiltrating Treg cells which are recruited to the tumor bv CCR4.
基金supported by National Natural Science Foundation of China(Grant Nos.10926038 and 11201157)Fundamental Research Funds for the Central Universities(Grant No.2012ZZ0073)
文摘In this paper,the relationship between the extended family and several mixing properties in measuretheoretical dynamical systems is investigated.The extended family eF related to a given family F can be regarded as the collection of all sets obtained as"piecewise shifted"members of F.For a measure preserving transformation T on a Lebesgue space(X,B,μ),the sets of"accurate intersections of order k"defined below are studied,Nε(A0,A1,...,Ak)=n∈Z+:μk i=0T inAiμ(A0)μ(A1)μ(Ak)<ε,for k∈N,A0,A1,...,Ak∈B and ε>0.It is shown that if T is weakly mixing(mildly mixing)then for any k∈N,all the sets Nε(A0,A1,...,Ak)have Banach density 1(are in(eFip),i.e.,the dual of the extended family related to IP-sets).
基金supported by the National Natural Sciences Foundation of China (81330048, 81301959, 81520108025)
文摘The survival of patients with hematological malignancies has been significantly improved due to the development of new therapeutic agents. However, relapse remains a major matter for concern. Recently, T cells engineered with chimeric antigen receptor(CAR) were reported to show unprecedented responses in a range of hematological malignancies. The persistence of the CAR-T cell can last for years and tends toward long-term antitumor memory by which relapses can be effectively prevented. The primary side effects that appear in most clinical trials are cytokine release syndrome and neurotoxicity. However, these symptoms can be treated and reversed. In this review, we describe CAR structure and function and summarize recent advances in CAR-T cell therapy in hematological malignancies.
基金supported in part by the National Natural Science Foundation of China under Grant Nos.61375105 and 61403334Chinese Postdoctoral Science Fundation under Grant No.2015M581318
文摘In this paper, the output consensus problem of general heterogeneous nonlinear multi-agent systems subject to different disturbances is considered. A kind of Takagi-Sukeno fuzzy modeling method is used to describe the nonlinear agents' dynamics. Based on the model, a distributed fuzzy observer and controller are designed based on parallel distributed compensation scheme and internal reference models such that the heterogeneous nonlinear multi-agent systems can achieve output consensus. Then a necessary and sufficient condition is presented for the output consensus problem. And it is shown that the consensus trajectory of the global fuzzy model is determined by the network topology and the initial states of the internal reference models. Finally, some simulations are given to illustrate and verify the effectiveness of the proposed scheme.
