The transcription factor forkhead box protein A2(FOXA2, also known as hepatocyte nuclear factor 3β or transcription factor 3β), has been found to play pivotal roles in multiple phases of mammalian life, from the ear...The transcription factor forkhead box protein A2(FOXA2, also known as hepatocyte nuclear factor 3β or transcription factor 3β), has been found to play pivotal roles in multiple phases of mammalian life, from the early development to the organofaction, and subsequently in homeostasis and metabolism in the adult. In the embryonic development period, FOXA2 is require d for the formation of the primitive node and notochord, and its absence results in embryonic lethality. Moreover, FOXA2 plays an important role not only in lung development, but also in T helper type 2(Th2)-mediated pulmonary inflammation and goblet cell hyperplasia. In this article, the role of FOXA2 in lung development and Th2-mediated pulmonary inflammation, as well as in goblet cell hyperplasia, is reviewed. FOXA2 deletion in airway epithelium results into Th2-mediated pulmonary inflammation and goblet cell hyperplasia in developing lung. Leukotriene pathway and signal transducers and activators of transcription 6 pathway may mediate this inflammation through recruitment and activation of denditric cell during lung developments. FOXA2 is a potential treatment target for lung diseases with Th2 inflammation and goblet cell hyperplasia, such as asthma and chronic obstructive pulmonary disease.展开更多
Allergic diseases,mainly mediated by T helper type 2(Th2)immunity,have become a worldwide public health problem.Traditional Chinese medicine(TCM)has long been used in treating and preventing allergic symptoms.As the n...Allergic diseases,mainly mediated by T helper type 2(Th2)immunity,have become a worldwide public health problem.Traditional Chinese medicine(TCM)has long been used in treating and preventing allergic symptoms.As the new target of anti-allergy TCM,basophils,after approximately 140 years since their discovery,are just now gaining respect as important contributors in the pathogenesis underlying allergic inflammation and disease.In addition to their role as effector cells,basophils can release early IL-4,migrate from circulatory system into draining lymph nodes,present antigen to naive CD4^+T cells,and promote the differentiation of Th2 cells.Herein,we briefly summarized the recent research advances of the essential contributions of basophils in the initiation of Th2 immune responses.展开更多
基金The National Natural Science Foundation of China,Nos.30871118,30971325,81270129 and 81470268(FL)grants from Department of Science and Technology of Sichuan Province,Nos.09ZQ026-020 and 2009SZ0190(FL)
文摘The transcription factor forkhead box protein A2(FOXA2, also known as hepatocyte nuclear factor 3β or transcription factor 3β), has been found to play pivotal roles in multiple phases of mammalian life, from the early development to the organofaction, and subsequently in homeostasis and metabolism in the adult. In the embryonic development period, FOXA2 is require d for the formation of the primitive node and notochord, and its absence results in embryonic lethality. Moreover, FOXA2 plays an important role not only in lung development, but also in T helper type 2(Th2)-mediated pulmonary inflammation and goblet cell hyperplasia. In this article, the role of FOXA2 in lung development and Th2-mediated pulmonary inflammation, as well as in goblet cell hyperplasia, is reviewed. FOXA2 deletion in airway epithelium results into Th2-mediated pulmonary inflammation and goblet cell hyperplasia in developing lung. Leukotriene pathway and signal transducers and activators of transcription 6 pathway may mediate this inflammation through recruitment and activation of denditric cell during lung developments. FOXA2 is a potential treatment target for lung diseases with Th2 inflammation and goblet cell hyperplasia, such as asthma and chronic obstructive pulmonary disease.
基金supported by the National Natural Science Foundation of China(NSFC)(No.81873066).
文摘Allergic diseases,mainly mediated by T helper type 2(Th2)immunity,have become a worldwide public health problem.Traditional Chinese medicine(TCM)has long been used in treating and preventing allergic symptoms.As the new target of anti-allergy TCM,basophils,after approximately 140 years since their discovery,are just now gaining respect as important contributors in the pathogenesis underlying allergic inflammation and disease.In addition to their role as effector cells,basophils can release early IL-4,migrate from circulatory system into draining lymph nodes,present antigen to naive CD4^+T cells,and promote the differentiation of Th2 cells.Herein,we briefly summarized the recent research advances of the essential contributions of basophils in the initiation of Th2 immune responses.
