On the morphological characteristics, growth environment and quality, rarity, and wood characteristics and value of Huanghuali, this paper discusses the development ways of Hainan Huanghuali It is suggested that Halna...On the morphological characteristics, growth environment and quality, rarity, and wood characteristics and value of Huanghuali, this paper discusses the development ways of Hainan Huanghuali It is suggested that Halnan Huanghuali could be well grown by guiding farmers to make full use of wasteland, slopes, scattered land, roadside and other resources; the landscaping greenbelt of the courtyard area and the residential area could be planned with nature as a main consideration for planting Huanghuali; and landscaping-type Huanghuali planting could make full use of local environment and surrounding local resources, highlighting the personalized landscaping greenbelt, forming good transition between residential area and urban space and creating a natural kindly living environment for the residents, so as to play the best ecological, social and economic benefits.展开更多
Baoshan Iron ＆ Steel Co.,Ltd., （referred to as Baosteel） in China first succeeded in developing the U-ing-O- ing-Expanding （UOE） longitudinal submerged arc welded pipes （SAWLs） offshore linepipe of a maximum th...Baoshan Iron ＆ Steel Co.,Ltd., （referred to as Baosteel） in China first succeeded in developing the U-ing-O- ing-Expanding （UOE） longitudinal submerged arc welded pipes （SAWLs） offshore linepipe of a maximum thickness/ outside diameter （T/D） 0.042 in 2011. Described in this paper is the research and development of the X70 UOE SAWL pipes by the company. The result shows that the said X70 linepipe has been in compliance with relevant requirements as specified in Specifications DNV-OS-F101 ,and has been successfully used in the South China Sea deepwater gas pipeline project.展开更多
Cancer is one of the leading causes of death worldwide. Recent advances in cellular therapy have demonstrated that this platform has the potential to give patients with certain cancers a second chance at life. Unlike ...Cancer is one of the leading causes of death worldwide. Recent advances in cellular therapy have demonstrated that this platform has the potential to give patients with certain cancers a second chance at life. Unlike chemical compounds and proteins, cells are living, self-replicating drugs that can be engineered to possess exquisite specificity. For example, T cells can be genetically modified to express chimeric antigen receptors (CARs), endowing them with the capacity to recognize and kill tumor cells and form a memory pool that is ready to strike back against persisting malignant cells. Anti-CD19 chimeric antigen receptor T cells (CART19s) have demonstrated a remarkable degree of clinical efficacy for certain malignancies. The process of developing CART19 essentially follows the conventional “one gene, one drug, one disease” paradigm derived from Paul Ehrlich’s “magic bullet” concept. With major players within the pharmaceutical industry joining forces to commercialize this new category of “living drugs,” it is useful to use CART19 as an example to examine the similarities and differences in its development, compared with that of a conventional drug. In this way, we can assimilate existing knowledge and identify the most effective approach for advancing similar strategies. This article reviews the use of biomarker-based assays to guide the optimization of CAR constructs, preclinical studies, and the evaluation of clinical efficacy;adverse effects (AEs);and CART19 cellular kinetics. Advanced technologies and computational tools that enable the discovery of optimal targets, novel CAR binding domains, and biomarkers predicting clinical response and AEs are also discussed. We believe that the success of CART19 will lead to the development of other engineered T cell therapies in the same manner that the discovery of arsphenamine initiated the era of synthetic pharmaceuticals.展开更多
An integration processing system of three-dimensional laser scanning information visualization in goaf was developed. It is provided with multiple functions, such as laser scanning information management for goaf, clo...An integration processing system of three-dimensional laser scanning information visualization in goaf was developed. It is provided with multiple functions, such as laser scanning information management for goaf, cloud data de-noising optimization, construction, display and operation of three-dimensional model, model editing, profile generation, calculation of goaf volume and roof area, Boolean calculation among models and interaction with the third party soft ware. Concerning this system with a concise interface, plentiful data input/output interfaces, it is featured with high integration, simple and convenient operations of applications. According to practice, in addition to being well-adapted, this system is favorably reliable and stable.展开更多
For a long time spleen has been an important field of study for researchers.However,details about changes of microscopic structure in spleen during the fetal period are far less available in literature.Our goals were ...For a long time spleen has been an important field of study for researchers.However,details about changes of microscopic structure in spleen during the fetal period are far less available in literature.Our goals were to determine distribution of white pulp as well as its relationship with blood vessels and to observe development and distribution of blood vessels and arrangement of CD4+and CD8+lymphocytes.The study was carried out on 16 specimens of fetal spleens.After standard histological hematoxylin and eosin(H&E)staining,the specimens were stained with immunohistochemical methods.Antibodies for CD4+,CD8+and vascular endothelial cells were used.Qualitative,semi-quantitative and quantitative analyses were performed.The results were statistically analyzed and graphically presented.By the 19th week of gestation lymphocytes can be found in spleen.The 24th week of gestation is the period of the formation of a white pulp of the spleen with centrally placed blood vessels in the follicles.Also,during this week the arterioles were completely surrounded by the CD4+lymphocytes.The number of arterioles in spleen increases during fetal development.With the increase of gestational age of the fetus,lymphatic tissue in the parenchyma of the spleen increases,as well as the number of the arterioles,while the number of capillary blood vessels decreases.展开更多
It is said that nobody can conquer nature so we have to accept what she renders. With this view always in mind, we（Nepali） are living tolerating the catastrophe of the Krishnabhir（polular landslide） and Trisuli ri...It is said that nobody can conquer nature so we have to accept what she renders. With this view always in mind, we（Nepali） are living tolerating the catastrophe of the Krishnabhir（polular landslide） and Trisuli river. Where hundreds of people have to sacrifice their lives every year during rainy season. These two places have become the greatest source of income for the rulers＇ personal benefit during every incident.展开更多
Objective To investigate the possible influence of immunosuppressive therapy,including sirolimus ( SRL) and calcineurin inhibitors ( CNI,tacrolimus) ,on level of Treg in liver allo - graft recipients. Methods Forty - ...Objective To investigate the possible influence of immunosuppressive therapy,including sirolimus ( SRL) and calcineurin inhibitors ( CNI,tacrolimus) ,on level of Treg in liver allo - graft recipients. Methods Forty - seven liver transplant recipients with stable liver function were assessed for at least 2 years,and divided into展开更多
The floral-organ-number mutant fon（t） was firstly discovered in the progeny of a cross between a diploid （Chunjiang 683） and a haploid （SARⅣ/-620-A） rice cultivar. The fon（t） mutant showed normal vegetative d...The floral-organ-number mutant fon（t） was firstly discovered in the progeny of a cross between a diploid （Chunjiang 683） and a haploid （SARⅣ/-620-A） rice cultivar. The fon（t） mutant showed normal vegetative development and produced normal inflorescence structures. Difference between the mutant and the wild type was observed when the stamen primordia began to form. The mature flowers offon（t） mutant showed open-hull phenotypes, which resulted in the exposure of stamens and stigmas. Normally, a single fon（t） floret consisted of six to nine stamens and one or two pistils. In addition, stamen/pistil-like structures and bulged tissues near ovaries were also observed in a few fon（t） florets. But homeotic transformation of lodicules into palea/lemma-like organs was observed almost in all the open-hull florets. The phenotypes offon（t） flowers also suggested thatfon（t） gene might affect flower organ identity in the inner whorls. Genetic analysis showed that thefon（t） mutant was controlled by a single recessive gene.展开更多
基金Supported by the Special Project for Application Technology Development and Demonstration of Hainan Province(ZDXM2014101)~~
文摘On the morphological characteristics, growth environment and quality, rarity, and wood characteristics and value of Huanghuali, this paper discusses the development ways of Hainan Huanghuali It is suggested that Halnan Huanghuali could be well grown by guiding farmers to make full use of wasteland, slopes, scattered land, roadside and other resources; the landscaping greenbelt of the courtyard area and the residential area could be planned with nature as a main consideration for planting Huanghuali; and landscaping-type Huanghuali planting could make full use of local environment and surrounding local resources, highlighting the personalized landscaping greenbelt, forming good transition between residential area and urban space and creating a natural kindly living environment for the residents, so as to play the best ecological, social and economic benefits.
文摘Baoshan Iron ＆ Steel Co.,Ltd., （referred to as Baosteel） in China first succeeded in developing the U-ing-O- ing-Expanding （UOE） longitudinal submerged arc welded pipes （SAWLs） offshore linepipe of a maximum thickness/ outside diameter （T/D） 0.042 in 2011. Described in this paper is the research and development of the X70 UOE SAWL pipes by the company. The result shows that the said X70 linepipe has been in compliance with relevant requirements as specified in Specifications DNV-OS-F101 ,and has been successfully used in the South China Sea deepwater gas pipeline project.
基金support from the Center for Cellular Immunotherapiesthe Abramson Cancer Center at the Perelman School of Medicine,University of Pennsylvania+1 种基金the Parker Institute for Cancer ImmunotherapyPeking University
文摘Cancer is one of the leading causes of death worldwide. Recent advances in cellular therapy have demonstrated that this platform has the potential to give patients with certain cancers a second chance at life. Unlike chemical compounds and proteins, cells are living, self-replicating drugs that can be engineered to possess exquisite specificity. For example, T cells can be genetically modified to express chimeric antigen receptors (CARs), endowing them with the capacity to recognize and kill tumor cells and form a memory pool that is ready to strike back against persisting malignant cells. Anti-CD19 chimeric antigen receptor T cells (CART19s) have demonstrated a remarkable degree of clinical efficacy for certain malignancies. The process of developing CART19 essentially follows the conventional “one gene, one drug, one disease” paradigm derived from Paul Ehrlich’s “magic bullet” concept. With major players within the pharmaceutical industry joining forces to commercialize this new category of “living drugs,” it is useful to use CART19 as an example to examine the similarities and differences in its development, compared with that of a conventional drug. In this way, we can assimilate existing knowledge and identify the most effective approach for advancing similar strategies. This article reviews the use of biomarker-based assays to guide the optimization of CAR constructs, preclinical studies, and the evaluation of clinical efficacy;adverse effects (AEs);and CART19 cellular kinetics. Advanced technologies and computational tools that enable the discovery of optimal targets, novel CAR binding domains, and biomarkers predicting clinical response and AEs are also discussed. We believe that the success of CART19 will lead to the development of other engineered T cell therapies in the same manner that the discovery of arsphenamine initiated the era of synthetic pharmaceuticals.
基金Project(51274250)supported by the National Natural Science Foundation of ChinaProject(2012BAK09B02-05)supported by the National Key Technology R&D Program during the 12th Five-year Plan of China
文摘An integration processing system of three-dimensional laser scanning information visualization in goaf was developed. It is provided with multiple functions, such as laser scanning information management for goaf, cloud data de-noising optimization, construction, display and operation of three-dimensional model, model editing, profile generation, calculation of goaf volume and roof area, Boolean calculation among models and interaction with the third party soft ware. Concerning this system with a concise interface, plentiful data input/output interfaces, it is featured with high integration, simple and convenient operations of applications. According to practice, in addition to being well-adapted, this system is favorably reliable and stable.
文摘For a long time spleen has been an important field of study for researchers.However,details about changes of microscopic structure in spleen during the fetal period are far less available in literature.Our goals were to determine distribution of white pulp as well as its relationship with blood vessels and to observe development and distribution of blood vessels and arrangement of CD4+and CD8+lymphocytes.The study was carried out on 16 specimens of fetal spleens.After standard histological hematoxylin and eosin(H&E)staining,the specimens were stained with immunohistochemical methods.Antibodies for CD4+,CD8+and vascular endothelial cells were used.Qualitative,semi-quantitative and quantitative analyses were performed.The results were statistically analyzed and graphically presented.By the 19th week of gestation lymphocytes can be found in spleen.The 24th week of gestation is the period of the formation of a white pulp of the spleen with centrally placed blood vessels in the follicles.Also,during this week the arterioles were completely surrounded by the CD4+lymphocytes.The number of arterioles in spleen increases during fetal development.With the increase of gestational age of the fetus,lymphatic tissue in the parenchyma of the spleen increases,as well as the number of the arterioles,while the number of capillary blood vessels decreases.
文摘It is said that nobody can conquer nature so we have to accept what she renders. With this view always in mind, we（Nepali） are living tolerating the catastrophe of the Krishnabhir（polular landslide） and Trisuli river. Where hundreds of people have to sacrifice their lives every year during rainy season. These two places have become the greatest source of income for the rulers＇ personal benefit during every incident.
文摘Objective To investigate the possible influence of immunosuppressive therapy,including sirolimus ( SRL) and calcineurin inhibitors ( CNI,tacrolimus) ,on level of Treg in liver allo - graft recipients. Methods Forty - seven liver transplant recipients with stable liver function were assessed for at least 2 years,and divided into
基金This work was supported by the Program for Changjiang Scholars and Innovative Research Team in University (No. IRTO453)
文摘The floral-organ-number mutant fon（t） was firstly discovered in the progeny of a cross between a diploid （Chunjiang 683） and a haploid （SARⅣ/-620-A） rice cultivar. The fon（t） mutant showed normal vegetative development and produced normal inflorescence structures. Difference between the mutant and the wild type was observed when the stamen primordia began to form. The mature flowers offon（t） mutant showed open-hull phenotypes, which resulted in the exposure of stamens and stigmas. Normally, a single fon（t） floret consisted of six to nine stamens and one or two pistils. In addition, stamen/pistil-like structures and bulged tissues near ovaries were also observed in a few fon（t） florets. But homeotic transformation of lodicules into palea/lemma-like organs was observed almost in all the open-hull florets. The phenotypes offon（t） flowers also suggested thatfon（t） gene might affect flower organ identity in the inner whorls. Genetic analysis showed that thefon（t） mutant was controlled by a single recessive gene.
