湿疹是一种变态反应性炎症性皮肤病,近期研究表明以CD^(+)_(4)T细胞亚群如Th1/Th2、Th17/调节性T细胞(regulatory T cells,Treg)细胞分化失衡导致湿疹发病中出现过度炎症应答,而中药以改善CD^(+)_(4)T细胞亚群分化平衡干预湿疹免疫微环...湿疹是一种变态反应性炎症性皮肤病,近期研究表明以CD^(+)_(4)T细胞亚群如Th1/Th2、Th17/调节性T细胞(regulatory T cells,Treg)细胞分化失衡导致湿疹发病中出现过度炎症应答,而中药以改善CD^(+)_(4)T细胞亚群分化平衡干预湿疹免疫微环境具有较好的调节作用。以湿疹炎症应答前沿研究动态,探讨中药在改善调控CD^(+)_(4)T细胞亚群分化干预湿疹致病的作用优势,为中药在改善湿疹临床症状及机制研究提供一定的理论指导。展开更多
Adoptive cell therapy using chimeric antigen receptor T (CAR-T) cells, which is a promising cancer immunotherapy strategy, has been developing very rapidly in recent years. CAR-T cells are genetically modified T cells...Adoptive cell therapy using chimeric antigen receptor T (CAR-T) cells, which is a promising cancer immunotherapy strategy, has been developing very rapidly in recent years. CAR-T cells are genetically modified T cells that can specifically recognize tumor specific antigens on the surface of tumor cells, and then effectively kill tumor cells. At present, exciting results are being achieved in clinical applications of CAR-T cells for patients with hematological malignancies. The research and development of CAR-T cells for various targets and for the treatment of solid tumors have become a hot topic worldwide, so an increasing number of investigational new drug applications (INDAs) and new drug applications (NDAs) of CAR-T cell products are expected to be submitted in future. The quality control and nonclinical research of these products are of great significance in ensuring the safety and effectiveness of these products;however, they also present great challenges and difficulties. This article discusses the general principles of and key issues regarding the quality control and nonclinical research of CAR-T cell products based on their product characteristics and on relevant guidelines for gene and cell therapy products.展开更多
Baoshan Iron ＆ Steel Co.,Ltd., （referred to as Baosteel） in China first succeeded in developing the U-ing-O- ing-Expanding （UOE） longitudinal submerged arc welded pipes （SAWLs） offshore linepipe of a maximum th...Baoshan Iron ＆ Steel Co.,Ltd., （referred to as Baosteel） in China first succeeded in developing the U-ing-O- ing-Expanding （UOE） longitudinal submerged arc welded pipes （SAWLs） offshore linepipe of a maximum thickness/ outside diameter （T/D） 0.042 in 2011. Described in this paper is the research and development of the X70 UOE SAWL pipes by the company. The result shows that the said X70 linepipe has been in compliance with relevant requirements as specified in Specifications DNV-OS-F101 ,and has been successfully used in the South China Sea deepwater gas pipeline project.展开更多
Chengdu University of Technology (CDUT), located on the eastern edge of the Qinghai—Tibet Plateau, a higher education and research institution with a focus on geosciences, has paid special attention to scientific res...Chengdu University of Technology (CDUT), located on the eastern edge of the Qinghai—Tibet Plateau, a higher education and research institution with a focus on geosciences, has paid special attention to scientific research on Q—T Plateau. In the earlier 1950s Professor Zhang Zhuoyuan, the former president of CDUT and Professor Ren Tianpei joined the geological survey in Tibet as members of the Tibetan geological working group organized by the Central Government of China. Since the 1980s, research on the Q—T Plateau has reached a golden age, and recognized this, CDUT established the Resources and Environment Research Center of Qinghai—Tibet Plateau in order to lead and coordinate the research around the Plateau continuously and smoothly. There are often more than 50 geologists involved in research during any given year. Scientists from CDUT are now conducting many kinds of research programs covering the whole area of the Plateau, from the Himalayas in the south to the Tianshan Mountains in the north, from the Longmen Mountains and the West Yunnan Plateau in the east to Ali area in the west. Scientists from CDUT have completed cooperative research programs with foreign scientists from the U. S., France, U.K., Japan, Austria, Canada, Germany and Australia. Research subjects include National Key Basic Research, State Scientific Key Projects, National Natural Scientific Foundation Projects, National Outstanding Young Scientists Foundation Projects, as well as Basic Geological Survey, Mineral Resources Evaluation, Analysis of Potential Oil and Gas Resources, Geohazard Protection.. More than 40 projects and 6 geological maps in different scales (1∶1000000, 1∶200000, 1∶50000) have been completed.. Research funding has increased to billions of yuan. Thousands relevant research papers and works have been published. More than 20 projects have won scientific achievement awards at national, ministerial and provincial levels. Meanwhile, a research group of young and middle\|aged scientists led by Prof. Wang Chengshan has formed and is determined to devote itself to the Q—T geological research. Many of them have broken established rules and have become professors or gained prizes. To strengthen Q—T research, the Ministry of Land and Resources specially established the Laboratory of Continental Dynamics of the Qianghai—Tibet Plateau at CDUT in 1999. Academicians, Li Tingdong and Liu Baojun, are the Honorary Directors of the Lab and the Academic Committee of the Lab respectively. Professor Wang Chengshan and Prof. Zhu Jieshou are the Directors.展开更多
Using long-term optical, ultraviolet(UV) and X-ray data, we present a study of a classical T Tauri star CV Cha. The V-band light curve obtained from the All Sky Automated Survey(ASAS) shows short as well as long-term ...Using long-term optical, ultraviolet(UV) and X-ray data, we present a study of a classical T Tauri star CV Cha. The V-band light curve obtained from the All Sky Automated Survey(ASAS) shows short as well as long-term variability. The short-term variability could be due to rotational modulation of CV Cha. We derive the rotational period of 3.714 ± 0.001 d for CV Cha. UV light curves obtained from Swift also show the variations. X-ray light curves from XMM-Newton and Swift do not show any significant short as well as long-term variability. However, the light curve from Chandra appears to be variable, which could be due to the emergence of flaring activities. X-ray spectra from all observations are explained well by the single temperature plasma of 0.95 keV with X-ray luminosity of 1030.4erg s-1in the 0.5–7.5 keV energy band. It appears that variability in optical and UV bands could be due to the presence of both hot and cool spots on the surface, while X-ray emission is dominated by magnetic processes.展开更多
The paper is to determine the types of approaches preferred by medical and pharmacy directors of US payer organizations to enhance the Pharmacy ＆ Therapeutic decision-making process and how medications accepted onto ...The paper is to determine the types of approaches preferred by medical and pharmacy directors of US payer organizations to enhance the Pharmacy ＆ Therapeutic decision-making process and how medications accepted onto the formulary should be covered. An online interactive survey of US medical and pharmacy directors was conducted in 2012. In addition to a 10-point Likert scale （10 = agree completely, 1 = disagree completely）, qualitative responses and interpretive analysis were used to explore beliefs about certain statements. The results showed that the 30 respondents （20 medical directors and 10 pharmacy directors） rated current progress in obtaining usable CER （comparative-effectiveness research） at only an average of 4.17 on the 10-point scale. They hoped to regularly utilize CER information in formulary decision making by 2015 （average rating, 6.03）. The rating of evidence-based medicine use in coverage decision making today was somewhat higher, at an average of 7.08 （medical directors, 7.38; pharmacy directors, 6.40）. The survey participants believe that emerging CER results will greatly affect the following areas： optimization/improvement of clinical guidelines, medical/pharmacy benefit management, assessments of the value and appropriateness of interventions, and pharmaceutical research and development. Therefore, payers expect CER to play an increasing role in helping them determine the value of new therapies.展开更多
Genetic transformation experiments of the different explants from Citrus grandis cv. Changshou Shatian You infected with Agrobacterium rhizogenes were carried out in darkness or in light. The optimizing culture system...Genetic transformation experiments of the different explants from Citrus grandis cv. Changshou Shatian You infected with Agrobacterium rhizogenes were carried out in darkness or in light. The optimizing culture system of Ri T-DNA transformed roots for C. grandis cv. Changshou Shatian You was constructed as follows： After the ventral wounded striations on the single activation cotyledon were inoculated by A. rhizogenes A4 （logarithmic period）, they were cocultured at （25 ±2）℃ in darkness for 25-30 days; some transformed roots were generated from wounded striations of most cotyledons. The genetically transformed ratio is （83 ± 11）%. Axenic Ri T-DNA transformed roots （hairy roots） were harvested after five subcultures. Explants were activated on MT medium. The MS medium was used for subculture of transformed roots. Mass Ri T-DNA transformed roots in which the hormone was produced independently were harvested from this optimizing culture system. White, fresh Ri T-DNA transformed roots were （1.14 ±0.07） cm long, （0.73 ±0.04） mm wide, and the growth direction of transformed roots was negative geotropism.展开更多
Research papers play a crucial role in graduate study.The profound benefit of writing research papers are being discussed in three respects respectively.The writing task will contribute to the development of logical a...Research papers play a crucial role in graduate study.The profound benefit of writing research papers are being discussed in three respects respectively.The writing task will contribute to the development of logical and coherent thoughts,the honest and serious attitudes obtained in the process of writing as well as creative and original ideas improved in the research progress.The benefit gained in writing research papers will ultimately work further in researchers,future study and success.展开更多
文摘湿疹是一种变态反应性炎症性皮肤病,近期研究表明以CD^(+)_(4)T细胞亚群如Th1/Th2、Th17/调节性T细胞(regulatory T cells,Treg)细胞分化失衡导致湿疹发病中出现过度炎症应答,而中药以改善CD^(+)_(4)T细胞亚群分化平衡干预湿疹免疫微环境具有较好的调节作用。以湿疹炎症应答前沿研究动态,探讨中药在改善调控CD^(+)_(4)T细胞亚群分化干预湿疹致病的作用优势,为中药在改善湿疹临床症状及机制研究提供一定的理论指导。
文摘Adoptive cell therapy using chimeric antigen receptor T (CAR-T) cells, which is a promising cancer immunotherapy strategy, has been developing very rapidly in recent years. CAR-T cells are genetically modified T cells that can specifically recognize tumor specific antigens on the surface of tumor cells, and then effectively kill tumor cells. At present, exciting results are being achieved in clinical applications of CAR-T cells for patients with hematological malignancies. The research and development of CAR-T cells for various targets and for the treatment of solid tumors have become a hot topic worldwide, so an increasing number of investigational new drug applications (INDAs) and new drug applications (NDAs) of CAR-T cell products are expected to be submitted in future. The quality control and nonclinical research of these products are of great significance in ensuring the safety and effectiveness of these products;however, they also present great challenges and difficulties. This article discusses the general principles of and key issues regarding the quality control and nonclinical research of CAR-T cell products based on their product characteristics and on relevant guidelines for gene and cell therapy products.
文摘Baoshan Iron ＆ Steel Co.,Ltd., （referred to as Baosteel） in China first succeeded in developing the U-ing-O- ing-Expanding （UOE） longitudinal submerged arc welded pipes （SAWLs） offshore linepipe of a maximum thickness/ outside diameter （T/D） 0.042 in 2011. Described in this paper is the research and development of the X70 UOE SAWL pipes by the company. The result shows that the said X70 linepipe has been in compliance with relevant requirements as specified in Specifications DNV-OS-F101 ,and has been successfully used in the South China Sea deepwater gas pipeline project.
文摘Chengdu University of Technology (CDUT), located on the eastern edge of the Qinghai—Tibet Plateau, a higher education and research institution with a focus on geosciences, has paid special attention to scientific research on Q—T Plateau. In the earlier 1950s Professor Zhang Zhuoyuan, the former president of CDUT and Professor Ren Tianpei joined the geological survey in Tibet as members of the Tibetan geological working group organized by the Central Government of China. Since the 1980s, research on the Q—T Plateau has reached a golden age, and recognized this, CDUT established the Resources and Environment Research Center of Qinghai—Tibet Plateau in order to lead and coordinate the research around the Plateau continuously and smoothly. There are often more than 50 geologists involved in research during any given year. Scientists from CDUT are now conducting many kinds of research programs covering the whole area of the Plateau, from the Himalayas in the south to the Tianshan Mountains in the north, from the Longmen Mountains and the West Yunnan Plateau in the east to Ali area in the west. Scientists from CDUT have completed cooperative research programs with foreign scientists from the U. S., France, U.K., Japan, Austria, Canada, Germany and Australia. Research subjects include National Key Basic Research, State Scientific Key Projects, National Natural Scientific Foundation Projects, National Outstanding Young Scientists Foundation Projects, as well as Basic Geological Survey, Mineral Resources Evaluation, Analysis of Potential Oil and Gas Resources, Geohazard Protection.. More than 40 projects and 6 geological maps in different scales (1∶1000000, 1∶200000, 1∶50000) have been completed.. Research funding has increased to billions of yuan. Thousands relevant research papers and works have been published. More than 20 projects have won scientific achievement awards at national, ministerial and provincial levels. Meanwhile, a research group of young and middle\|aged scientists led by Prof. Wang Chengshan has formed and is determined to devote itself to the Q—T geological research. Many of them have broken established rules and have become professors or gained prizes. To strengthen Q—T research, the Ministry of Land and Resources specially established the Laboratory of Continental Dynamics of the Qianghai—Tibet Plateau at CDUT in 1999. Academicians, Li Tingdong and Liu Baojun, are the Honorary Directors of the Lab and the Academic Committee of the Lab respectively. Professor Wang Chengshan and Prof. Zhu Jieshou are the Directors.
基金the Italian CNAA and MURST (COFIN) grantsthe DST-RFBR project INT/RUS/RFBR/P271BRICS grant number DST/IMRCD/BRICS/PilotCall1/ProFCheap/2017(G) for part of the present work
文摘Using long-term optical, ultraviolet(UV) and X-ray data, we present a study of a classical T Tauri star CV Cha. The V-band light curve obtained from the All Sky Automated Survey(ASAS) shows short as well as long-term variability. The short-term variability could be due to rotational modulation of CV Cha. We derive the rotational period of 3.714 ± 0.001 d for CV Cha. UV light curves obtained from Swift also show the variations. X-ray light curves from XMM-Newton and Swift do not show any significant short as well as long-term variability. However, the light curve from Chandra appears to be variable, which could be due to the emergence of flaring activities. X-ray spectra from all observations are explained well by the single temperature plasma of 0.95 keV with X-ray luminosity of 1030.4erg s-1in the 0.5–7.5 keV energy band. It appears that variability in optical and UV bands could be due to the presence of both hot and cool spots on the surface, while X-ray emission is dominated by magnetic processes.
文摘The paper is to determine the types of approaches preferred by medical and pharmacy directors of US payer organizations to enhance the Pharmacy ＆ Therapeutic decision-making process and how medications accepted onto the formulary should be covered. An online interactive survey of US medical and pharmacy directors was conducted in 2012. In addition to a 10-point Likert scale （10 = agree completely, 1 = disagree completely）, qualitative responses and interpretive analysis were used to explore beliefs about certain statements. The results showed that the 30 respondents （20 medical directors and 10 pharmacy directors） rated current progress in obtaining usable CER （comparative-effectiveness research） at only an average of 4.17 on the 10-point scale. They hoped to regularly utilize CER information in formulary decision making by 2015 （average rating, 6.03）. The rating of evidence-based medicine use in coverage decision making today was somewhat higher, at an average of 7.08 （medical directors, 7.38; pharmacy directors, 6.40）. The survey participants believe that emerging CER results will greatly affect the following areas： optimization/improvement of clinical guidelines, medical/pharmacy benefit management, assessments of the value and appropriateness of interventions, and pharmaceutical research and development. Therefore, payers expect CER to play an increasing role in helping them determine the value of new therapies.
基金The research was supported by the Science Fund of China Post Ph.D （2003034492）Science Foundation of Chongqing Educational Committee （040216）, China.
文摘Genetic transformation experiments of the different explants from Citrus grandis cv. Changshou Shatian You infected with Agrobacterium rhizogenes were carried out in darkness or in light. The optimizing culture system of Ri T-DNA transformed roots for C. grandis cv. Changshou Shatian You was constructed as follows： After the ventral wounded striations on the single activation cotyledon were inoculated by A. rhizogenes A4 （logarithmic period）, they were cocultured at （25 ±2）℃ in darkness for 25-30 days; some transformed roots were generated from wounded striations of most cotyledons. The genetically transformed ratio is （83 ± 11）%. Axenic Ri T-DNA transformed roots （hairy roots） were harvested after five subcultures. Explants were activated on MT medium. The MS medium was used for subculture of transformed roots. Mass Ri T-DNA transformed roots in which the hormone was produced independently were harvested from this optimizing culture system. White, fresh Ri T-DNA transformed roots were （1.14 ±0.07） cm long, （0.73 ±0.04） mm wide, and the growth direction of transformed roots was negative geotropism.
文摘Research papers play a crucial role in graduate study.The profound benefit of writing research papers are being discussed in three respects respectively.The writing task will contribute to the development of logical and coherent thoughts,the honest and serious attitudes obtained in the process of writing as well as creative and original ideas improved in the research progress.The benefit gained in writing research papers will ultimately work further in researchers,future study and success.
