Objective： To investigate the effect of electroacupuncture （EA） on the T-lymphocyte subsets and lymphocyte transformation in patients with gastrointestinal tumor during peri-operative and peri-chemotherapy periods....Objective： To investigate the effect of electroacupuncture （EA） on the T-lymphocyte subsets and lymphocyte transformation in patients with gastrointestinal tumor during peri-operative and peri-chemotherapy periods. Methods： A total of 44 cases with gastrointestinal tumor were allocated into 4 groups of surgical removal （SR）, SR ＋ electroacupuncture （EA）, SR ＋ chemotherapy, and SR ＋ chemotherapy ＋ EA. Then changes of T-lymphocyte subsets in varying stages of gastrointestinal tumor were determined using a flow cytometer. Results： On the 3rd day after operation, the patients＇ CD3＋ cell percentage and lymphocyte transformation were significantly lower than that before operation （P〈0.05, P〈0.01）; the CD3＋ cell percentage and lymphocyte transformation of patients who received EA were not significantly reduced, showing a statistic difference when compared with the SR group （P〈0.05）. On the 10th day after operation, the patients＇ lymphocyte transformation was almost restored to the level before operation, the CD8＋ cells in patients who received EA were significantly reduced （P〈0.05） and their CD4＋/CD8＋ ratios were markedly elevated （P〈0.05）. On the 3rd day after operation coupled with chemotherapy, the CD3＋ cell percentage and CD4＋/CD8＋ ratios were somewhat reduced, but not showing a statistic difference. Upon EA intervention, the CD3＋ cell percentage and CD4＋/CD8＋ ratios on the third day after operation coupled with chemotherapy were significantly increased （P〈0.05）. The intra-group comparison before and after treatment has shown that EA can improve the lymphocyte transformation of patients after operation and chemotherapy （P〈0.01）. Conclusion： EA can substantially improve the cellular immune function in patients with gastrointestinal tumor during peri-operative and peri-chemotherapy periods.展开更多
基金Key Project of Traditional Chinese Medicine by the Shanghai Municipal Health Bureau
文摘Objective： To investigate the effect of electroacupuncture （EA） on the T-lymphocyte subsets and lymphocyte transformation in patients with gastrointestinal tumor during peri-operative and peri-chemotherapy periods. Methods： A total of 44 cases with gastrointestinal tumor were allocated into 4 groups of surgical removal （SR）, SR ＋ electroacupuncture （EA）, SR ＋ chemotherapy, and SR ＋ chemotherapy ＋ EA. Then changes of T-lymphocyte subsets in varying stages of gastrointestinal tumor were determined using a flow cytometer. Results： On the 3rd day after operation, the patients＇ CD3＋ cell percentage and lymphocyte transformation were significantly lower than that before operation （P〈0.05, P〈0.01）; the CD3＋ cell percentage and lymphocyte transformation of patients who received EA were not significantly reduced, showing a statistic difference when compared with the SR group （P〈0.05）. On the 10th day after operation, the patients＇ lymphocyte transformation was almost restored to the level before operation, the CD8＋ cells in patients who received EA were significantly reduced （P〈0.05） and their CD4＋/CD8＋ ratios were markedly elevated （P〈0.05）. On the 3rd day after operation coupled with chemotherapy, the CD3＋ cell percentage and CD4＋/CD8＋ ratios were somewhat reduced, but not showing a statistic difference. Upon EA intervention, the CD3＋ cell percentage and CD4＋/CD8＋ ratios on the third day after operation coupled with chemotherapy were significantly increased （P〈0.05）. The intra-group comparison before and after treatment has shown that EA can improve the lymphocyte transformation of patients after operation and chemotherapy （P〈0.01）. Conclusion： EA can substantially improve the cellular immune function in patients with gastrointestinal tumor during peri-operative and peri-chemotherapy periods.
