期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
计算解析异常代谢对乳腺癌微环境重塑的调控机制 被引量:1
1
作者 万羽鑫 朱欣雨 +3 位作者 赵宇 孙娜 江天彤妃 徐娟 《遗传》 CAS CSCD 北大核心 2024年第10期871-885,共15页
肿瘤微环境(tumor microenvironment,TME)中T细胞亚群的组成和肿瘤特异的T细胞互作促进了乳腺癌异质性的形成。此外,肿瘤的异常代谢通常与T细胞的抗肿瘤免疫功能失调关联密切,识别影响免疫细胞互作的关键代谢基因能够为乳腺癌治疗提供... 肿瘤微环境(tumor microenvironment,TME)中T细胞亚群的组成和肿瘤特异的T细胞互作促进了乳腺癌异质性的形成。此外,肿瘤的异常代谢通常与T细胞的抗肿瘤免疫功能失调关联密切,识别影响免疫细胞互作的关键代谢基因能够为乳腺癌治疗提供潜在靶点。本研究利用乳腺癌单细胞转录组数据,重点研究了乳腺癌发展过程中肿瘤特异性T细胞亚群及其互作子网,进一步评估肿瘤特异性激活的T细胞亚群的代谢通路活性。结果显示,肠促胰岛素的合成、分泌和失活的代谢通路以及果糖分解代谢通路显著影响了多个T细胞亚群的互作。整合肿瘤中T细胞显著上调以及影响互作的代谢通路,依此筛选出核心T细胞互作相关的异常代谢基因,并进一步构建乳腺癌风险评估模型。利用异常代谢显著相关预后基因表达谱与药物IC50值预测靶向药物,最终获得潜在靶向药物GSK-J4、PX-12等。本研究整合分析乳腺癌微环境中T细胞互作的重塑与代谢通路异常在癌症恶性进展中的作用,为新型乳腺癌抗癌疗法提供线索。 展开更多
关键词 乳腺癌 微环境重塑 异常代谢 t细胞互作
下载PDF
A Mathematical Model of Breast Cancer and Mediated Immune System Interactions
2
作者 Kodwo Annan Mickayla Nagel Hannibel A. Brock 《Journal of Mathematics and System Science》 2012年第7期430-446,共17页
Mathematical model that describes breast cancer and immune interactions were presented using system of differential equations to provide analytic and nnmeric framework of cancer-immune dynamics. Four types of immune c... Mathematical model that describes breast cancer and immune interactions were presented using system of differential equations to provide analytic and nnmeric framework of cancer-immune dynamics. Four types of immune cells-CTLs (cytotoxic T lymphocytes), macrophages, NK (natural killer) and helper T cells-known to play the most significant roles in developing breast cancer immunity were modeled using differential equations. The model was then applied to different cancer growth rates and simulated using MATLAB software tool. The parameters of the model were based on experimental and clinical results from published articles. Results supported clinical studies that maximal breast cancer immunity depends mostly on each of the four immune cell types chosen. It was observed that for a given breast cancer growth rate, there was an optimal activation that maximized the response of the immune system. The effectiveness of the immune system resulted in the decrease in breast cancer killing rates. These results highlighted the importance of immune system activations in breast cancer development and treatment. Therefore, the model and its simulation provided a robust framework to better understand breast cancer progression and response to the immune system. 展开更多
关键词 Breast cancer immune system mathematical model.
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部