Racemic 2-n-butylbutanedioic acid 4-t-butyl esters were synthesized from methyl hexanoate and t-butyl α-iodoacetate via alkylation and subsequently selective hydrolyzation. The （R）-and （S）-2-n-butylbutanedioic ac...Racemic 2-n-butylbutanedioic acid 4-t-butyl esters were synthesized from methyl hexanoate and t-butyl α-iodoacetate via alkylation and subsequently selective hydrolyzation. The （R）-and （S）-2-n-butylbutanedioic acid 4-t-butyl esters were obtained by the resolution of the above-mentioned racemic compounds with（S）-（ - ） or（R）-（ ＋ ）-α- methylbenzylamine, respectively. The e.e. values of the two optical active products were determined to be above 99% by HPLC after the formation of two pairs of diastereoisomers with（R）-（ ＋ ）-α-methylbenzylamine and（S）- phenylalanine methyl ester.展开更多
t-Butyl 4’-bromomethylbiphenyl-2-carboxylate was prepared from 4’-methylbiphenyl-2-carbonitrile by hydrolysis, esterification and bromination with an overall yield of 61%。
基金Supported by the National Basic Research Priority Program(No. 2003CCA027).
文摘Racemic 2-n-butylbutanedioic acid 4-t-butyl esters were synthesized from methyl hexanoate and t-butyl α-iodoacetate via alkylation and subsequently selective hydrolyzation. The （R）-and （S）-2-n-butylbutanedioic acid 4-t-butyl esters were obtained by the resolution of the above-mentioned racemic compounds with（S）-（ - ） or（R）-（ ＋ ）-α- methylbenzylamine, respectively. The e.e. values of the two optical active products were determined to be above 99% by HPLC after the formation of two pairs of diastereoisomers with（R）-（ ＋ ）-α-methylbenzylamine and（S）- phenylalanine methyl ester.
文摘t-Butyl 4’-bromomethylbiphenyl-2-carboxylate was prepared from 4’-methylbiphenyl-2-carbonitrile by hydrolysis, esterification and bromination with an overall yield of 61%。
